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The analgesic effect elicited by morphine injected into amygdala was in turn blocked by naloxone administered to habenula.

杏仁核内注射吗啡产生的镇痛作用可被缰核内注射NX所阻断。

Our results have shown that the analgesic effect of morphine administered to nucleus accumbens was blocked by intra-habenula injection of naloxone or ME antiserum, whereas the analgesic effect of morphine injected into habenula was attenuated by intra-PAG administration of naloxone or muscimol, and enhanced by bicuculline methochoride (BMC, an antagonist of GABA receptor).

本工作实验结果表明,在伏核内注射吗啡产生的镇痛作用可被缰核内注射NX或ME抗体所大部阻断,而缰核内注射吗啡产生的镇痛作用又可被PAG内注射NX或γ-氨基丁酸受体激动剂异鹅羔胺所削弱,被GABA受体阻断剂氯甲基荷包牡丹碱所增强。

Thus, the analgesic effect of morphine injected into PAG was significantly attenuated by β-EP AS injected into the nucleus accumbens, and vice versa. This antagonistic effect was totally abolished by lesioning of the ARH. Moreover the analgesic effect of morphine injected into nucleus accumbens could be blocked byβ-EP AS administered te amygdala or habenula.

在PAG内注射吗啡产生的镇痛作用可被伏核内注射β-EP抗体所削弱,损毁家兔的ARH后这一对抗效应基本消失;在伏核内注射吗啡产生的镇痛作用可被PAG内注射β-EP抗体所对抗,损毁ARH后上述对抗效应基本消失;伏核内注射吗啡产生的镇痛作用亦可被杏仁核内或缰核内注射β-EP抗体所阻断。

METHODS: D-galactose (1 000 mg·k-1·d-1 ) was injected into mice hypodermically for 8 weeks to induce aging animal model, and Vit-E (100 mg·kg-1; 250 mg·kg-1) was administered for 6 weeks by ig at the 3rd week of making model. After Vit-E treatment for 8 weeks, water maze test was used to determine the ability of mice's learning and memory. The activities of glutathione peroxidase and succinate dehydrogenase, the content of nitric oxide and activity of nitric oxide synthase in the brain tissue were detected separately.

小鼠连续皮下注射D-半乳糖(1 000 mg·k-1·d-1)8周制备衰老模型,并于第3周开始给予维生素E(100 mg· kg-1;250 mg· kg-1)处理;8周后采用水迷宫测定小鼠学习记忆能力,并取脑组织测定谷胱甘肽过氧化物酶和琥珀酸脱氢酶活性,测定一氧化氮含量和一氧化氮合酶活性。

To explore the influence on the expression of orexin A in the hypothalamus and orexin type 1 receptor (OX1R) in the medulla of neonatal rats after prenatal nicotine exposure, the 20 pregnant rats were divided into 2 groups randomly. Either nicotine (6 mg/kg per day) or normal saline solution (as same volume as nicotine group) was administered into the pregnant rats hypodermically from the fifth day to the end of gestation.

为了观察出生前尼古丁暴露对新生大鼠下丘脑orexin A及延髓内orexin 1型受体(OX1R)表达的影响,本实验将20只雌性成年大鼠随机均分为二组,怀孕后第5 d开始每天分别皮下注射尼古丁6 mg/kg或等量的生理盐水,直至分娩。

Methods: Twenty-eight patients with advanced gastrointestinal tumors entered into this study. Octreotide was administered hypodermically at a dosage of 0.2 mg once even 12 hours, till the disease progressed or the patients became intolerable to the therapy. The CBR was assessed by comprehensive evaluation, the serum level of IGF-Ⅰ was detected by double-antibody sandwich enzyme-linked immunosorbent assay before and one month after treatment.

予28例晚期消化道肿瘤患者奥曲肽0.2 mg,每12h皮下注射1次,直至病情进展或不能耐受治疗为止,综合评估CBR;采用双抗体夹心酶联免疫吸附测检测治疗前和治疗1个月后的血清IGF-Ⅰ水平。

In this study, oral tolerance was induced by tube-feeding transgenic mice with 0.5mg/day OVA protein daily, simultaneously sensitized by OVA protein with aluminum hydroxide. Oral-administered OVA protein (0.5mg/day for 5 or 10 consecutive days) resulted in significant lowered airway hypersensitivity as well as reduced inflammative cells infiltration, titer of serum OVA-specific IgE, IL-5 secretion in bronchoalveolar lavage fluid, and IL-4 secretion in splenocyte.

首先,本实验於小鼠中成功诱发了呼吸道过敏、大量OVA特异性IgE抗体生成、及嗜酸性白血球不正常聚集等现象;致敏前,同以连续管餵小鼠OVA抗原(0.5mg/day) 5天或10天后,结果显示皆能缓和呼吸道阻力、减低肺部发炎细胞浸润现象、降低血清中OVA特异性IgE抗体的生成量、也减少肺部冲洗液及脾脏细胞内第二型辅助T细胞(type II helper T cell, Th2)细胞激素的分泌(IL-4、IL-5)。

All the mice were administered via intragastric way per day for 4 weeks continuously.

各组小鼠每天灌胃给药一次,连续四周。

The rats in Group 1 and 2 were administered intramuscularly with normal saline.

另外2组接受照射+1或5mg/kg地塞米松治疗。

A basic polypeptide antibiotic administered intramuscularly in the treatment of tuberculosis.

一种多肽用来治疗肺结核疾病的多肽抗生素。

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