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Mice in control group were administered intragastricly at a dose 0.01 mL·g-1 for 10 d;PL were administered intragastricly for 10 d;CTX were administered parenterally every other day for 10 d.

空白对照组每日灌胃给予蒸馏水0.01 mL·g-1;CTX为隔日腹腔注射给药;PL为每日灌胃给药,连续给药10 d。

M{rX*o0 OBJECTIVE: To investigate the effects of neuronal nitric oxide synthase inhibitor 7-nitroindazole (7-NI) on smoke inhalation pulmonary injury in rats. METHODS: Forty healthy male SD rats were randomly divided into three groups: control group (n=8), smoke inhalation model group (n=16) and 7-NI treatment group (n=16). After reproducing the smoke inhalation model, to the 7-NI treatment group rats 7-NI (20 mg/kg in 2 ml arachis oil) was administered by intraperitoneal injection, while in the control group and the model group, 2 ml arachis oil was administered by intraperitoneal injection.

探讨神经型一氧化氮合酶抑制剂7-硝基吲唑(7-NI)在烟雾吸入性肺损伤中的作用。40只SD雄性大鼠被随机分为正常对照组(n=8)、烟雾吸入性肺损伤模型组(n=16)和7-NI治疗组(n=16),建立烟雾吸入性肺损伤模型。7-NI治疗组在致伤后立即腹腔注射7-NI 20 mg/kg(溶于2 ml花生油中);正常对照组及模型组腹腔注射2 ml花生油。

After reproducing the smoke inhalation model, to the 7-NI treatment group rats 7-NI (20 mg/kg in 2 ml arachis oil) was administered by intraperitoneal injection, while in the control group and the model group, 2 ml arachis oil was administered by intraperitoneal injection.

探讨神经型一氧化氮合酶抑制剂7-硝基吲唑(7-NI)在烟雾吸入性肺损伤中的作用。40只SD雄性大鼠被随机分为正常对照组(n=8)、烟雾吸入性肺损伤模型组(n=16)和7-NI治疗组(n=16),建立烟雾吸入性肺损伤模型。7-NI治疗组在致伤后立即腹腔注射7-NI 20 mg/kg(溶于2 ml花生油中);正常对照组及模型组腹腔注射2 ml花生油。

Rats were administered intraperitoneally 30 min prior to reperfusion via Danshen served as Danshen Group and the rest were administered intraperitoneally via NS instead served as contrast group.6 rats with the left cremaster muscles open served as normal contrast group.

采用夹闭SD大鼠左侧提睾肌主滋养动脉法造模,将66只SD大鼠用随机抽样法抽出6只作为正常组,另外60只分为对照组和丹参组,每组各30只。

In conclusion, althoughthe doses of anesthetics administered were larger than thoseused clinically, the present results suggest that bupivacaineis less neurotoxic than lidocaine when administered intrathecallyat equipotent concentrations in the rat model.

综上所述,虽然本实验中所用利多卡因和布比卡因的剂量高於临床使用剂量,本实验研究显示大鼠利多卡因鞘内注射,其神经毒性高於相同浓度的布比卡因,。

Taipei City is a special municipality administered directly under the Executive Yuan, while Taipei County and Keelung City are administered as part of Taiwan Province.

台北市是一个特殊的直辖市直接管理下的行政院,而台北县,基隆市管理的一部分,台湾省。

The effect of gossypol acetate was possibly concerned with its concentration and the administration time. There was no effect in the group administered with gossypol acetate at the dose of 50 mg/kg in 20 days, but not in the group administered with gossypol acetate at the doses of 120 mg/kg and 200 mg/kg.

醋酸棉酚对雄鼠生殖系统的影响可能与其浓度和药物作用的时间有关。50 mg/kg组在20 d内对小白鼠生育能力没有影响,120 mg/kg和200 mg/kg组在20 d内对小白鼠生育能力有影响。

There was no effect in the group administered with gossypol acetate at the dose of 50 mg/kg in 20 days, but not in the group administered with gossypol acetate at the doses of 120 mg/kg and 200 mg/kg.

mg/kg组在20 d内对小白鼠生育能力没有影响,120 mg/kg和200 mg/kg组在20 d内对小白鼠生育能力有影响。

Results:There are alleviating drugs in 79% of the cases, and controlling drugs in 54% of the cases,inhalant was administered in only 8 cases, during which only 5 one took it with correct method, poor compliance were found in 54% of all, controlling and alleviating drugs could not be discriminated in 58% of these cases ,The Dosage was correct in only 3 one, out of the five case who were administered by glucocorticoid inhalant,in no case asthmatic diary or spike current meter was used, The drug adverse reaction was completely non - know in 7 cases.

结果:79%的病人有缓解药,58%有控制药,吸入给药的病人只有8例,其中只有5例使用方法正确,54%的病人用药依从性差,58%的病人不能正确区分控制药与缓解药,在吸入糖皮质激素治疗的5例病人中只有3例剂量正确,无1例病人记录哮喘日记与使用峰流速仪,7例病人对药物不良反应一无所知。

The dose-response curve of histamine was shifted parallely to the right. pA2 was 9.34±0.61. The guinea-pigs were effectively reduced the rate of histamine induced death, decreased reaction extent of shock (P<0.01) and prolonged latency period of shock (P<0.05) by orally administered cetirizine ranged from 0.1, 0.2 and 0.4 mg.kg-1. The capillary permeability to intracutaneous injection of histamine was potently inhibited by orally administered cetirizine ranged from 0.0625 to 0.25 mg.kg-1 in mice, blue area obviously decreased (P<0.01), and dose-response curve existed obviously. In which the effect of these dosage groups were superior to the group of chlorphenamine.

结果:西替利嗪3×10-8~3×10-7mol.L-1可剂量依赖性地对抗组胺引起的肠肌收缩,使组胺的量效曲线平行右移,pA2为9.34 ± s 0.61,西替利嗪0.1,0.2及0.4 mg.kg-1口服给药时,能明显减轻豚鼠静脉注射组胺所致休克反应的严重程度(P<0.01),并可延长豚鼠惊厥反应的潜伏期及降低死亡率(P<0.05),西替利嗪0.0625~0.25 mg.kg-1口服给药可显著对抗组胺引起的小鼠皮肤血管通透性的增高,使蓝染面积显著缩小(P<0.01),且存在明显的量效关系,3个剂量组的作用均优于氯苯那敏组。

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