查询词典 adjuvant

Glioma is still one of refractory disease in the neurosurgical field; the development of new primary and adjuvant treatment is vital. Recently, the gene therapy of glioma is developed rapidly and there are many methods about the gene therapy that include: suicide gene therapy, immunologic gene therapy, drug resistangce gene therapy, angiostatin gene therapy and so on. The sucide gene therapy is the most potential approach of antitumer, these nonmammalian genes encode enzyme that convert nontoxic prodrugs into highly toxic metablites. Cells transfected with suicide genes are targeted for specific negative selection, witch can be induced by administrtion of the corresponding produg. Among the enzyme/produg combinations, two of the best characterized system are herpes simplex virus thymidine kinase /ganciclovir and Escherichia coli cytosine deaminase /5-flourocytosine (5-FC). The formor can convert the antiviral nucleoside analogs acyclovir , ganciclovir to their nucleoside monophosphate derivatives, the monophosphate forms are subsequently phosphorylated by endogenus cellular kinases to triphosphates, these molecules are potent inhibitors of DNA synthesis.

近年来脑胶质瘤的基因治疗发展迅速，应运而生的方法有自杀基因、免疫基因、多药耐药基因以及抗血管生成基因等，其中自杀基因被认为是最有前景的基因治疗方法，它又称病毒介导的酶／药物前体疗法，是利用转基因技术将哺乳动物细胞中所不含有的自杀基因转入到哺乳动物肿瘤细胞中，该基因表达的产物可将无毒的药物前体转化为毒性药物，从而选择性杀伤该肿瘤细胞，常用的自杀基因有单纯疱疹病毒-胸苷激酶基因和大肠杆菌胞嘧啶脱氨酶基因，前者催化无毒性抗病毒核苷类似物如丙氧鸟苷、无环鸟苷等成为单磷酸核苷衍生物，然后在内源性细胞激酶作用下转化为具有明显毒性的三磷酸核苷，作为DNA合成链的终止剂和DNA合成酶的抑制剂，干扰细胞DNA的合成；后者编码的胞嘧啶脱氨酶可催化5-氟胞嘧啶（5-FC）脱氨成为5-氟尿嘧啶（5-FU），然后代谢为有毒性的5-氟尿嘧啶-5′三磷酸（5-FUTP）和5-氟-2′脱氧尿嘧啶-5′磷酸（5-FdUTP），5-FUTP通过与UTP竞争性结合而抑制mRNA和tRNA的合成，5-FdUTP则作用于胸苷合成酶，导致TMP衰竭而阻止DNA的合成，最终诱导肿瘤细胞凋亡。

Previous researches indicated that patients of young or premenopausal age, nonspecial type invasive carcinoma, highly malignant histological degree, advanced tumor stage, negative hormone receptor status and without standard adjuvant therapy would increase the recurrent and metastastic risk of breast cancer after surgery.

既往研究表明，年轻或绝经前患者、浸润性非特殊类型癌、组织学分级恶性程度高、肿瘤分期较晚、激素受体阴性、未进行标准的辅助治疗等均是乳腺癌术后复发转移的高危因素。

The recombinant protein was purified by Ni-NTA affinity chromatography and gel filtration chromatography. The inbred C57BL/6 strains and outbred KM strains of mice were subcutaneously immunized with the protein formulated by either adjuvant ISA720 or aluminium hydroxide.

表达产物通过Ni-NTA亲和层析和凝胶过滤层析方法纯化，再分别与ISA720和Al3佐剂乳化后，免疫C57BL/6和昆明小鼠，通过尾蚴膜反应和ELISA反应检测特异性抗体。

Prosthetic replacement, intramedullary nails, PMMA augmentation, and adjuvant radiation can be performed safely to patients with peritrochanteric metastasis for pain relief and recovery of ambulatory function.

结论采用假体置换、股骨交锁髓内钉或Recon钉固定、局部病灶刮除和骨水泥充填结合辅助治疗，可以安全地治疗股骨转子周围转移性肿瘤，缓解疼痛，恢复行走功能，对提高患者的生存质量有较大意义。

Here, we report a case of acute Q fever complicated with mild jaundice and pleuritis. He did not respond well to doxycycline or levofloxacin initially, but recovered subsequently with adjuvant steroid therapy.

在此报告一例急性Q热合并黄疸及肋膜炎的个案，病患住院接受doxycycline及levofloxacin治疗但反应不佳，合并类固醇治疗后痊愈。

Here, we report a case of acute Q fever complicated with mild jaundice and pleuritis. He did not respond well to doxycycline or levofloxacin initially, but recovered subsequently with adjuvant steroid therapy.

在此报告一例急性Q热合併黄疸及肋膜炎的个案，病患住院接受doxycycline及levofloxacin治疗但反应不佳，合併类固醇治疗后痊癒。

Appropriate anesthetic, resuscitative, and adjuvant medications are required at each level.

所有单位都应该有适当的麻醉、急救和辅助药物。

It is mainly used for adjuvant treatment of high blood pressure; the most common use of rutaceae is treatment of allergies, which can slow down the speed that the mast cell releases histamine, while histamine is right the chemical substance causing general allergic reaction.

主要用於高血压辅助治疗；芸香素的最常见用途是治疗过敏，它可减缓肥大细胞释放组织胺的速度，而组织胺正是引起一般过敏反应的化学物质。

In this paper,studying find that using sandless kaolin and tallow esters as filler and adjuvant can improve dimetachlone's total suspension s.

通过对菌核净的助剂与填料的研究发现，采用含沙量较少的高岭土及脂肪酸酯类表面活性剂可提高菌核净的总悬浮率。

Nine psychiatric outpatients aged between 20 and 63 with a primary diagnosis of OCD had completed 10 weeks' treatment with sarcosine. Five of them received sarcosine as mono-therapy and 4 of them as an adjuvant to their current SRIs therapies.

九名完成试验之受试者包括单独服用sarcosine者五名（三名曾用过血清素回收抑制剂，两名从未用过药物治疗），sarcosine合并使用中的SRIs者四名。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。