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"This research was aimed at defining the best specific cognitive tests for predicting conversion from amnestic MCI to AD," Dr.

&这项研究旨在确定预测遗忘型MCI向AD转变的最特异的认知测验方法，&Fleisher博士告诉路透社健康记者。

BACKGROUND: Alzheimer's disease pathology is common in patients with amnestic mild cognitive impairment without dementia, but the prevalence of AD pathology in patients with subjective cognitive impairment and non-amnestic mild cognitive impairment is unknown.

背景：阿尔茨海默病的病理改变在伴遗忘型轻度认知功能障碍的非痴呆患者较为常见；然而，伴主观性认知功能损害和非遗忘型轻度认知功能障碍患者AD病理改变情况仍不清楚。

AD patient β- the content standard of amylaceous appearance albumen is basic as the accentuation of GDS degree heighten.

AD患者β-淀粉样蛋白的含量水平基本随着GDS程度的加重而增高。

β - content of amylaceous appearance protein can serve as AD and VD disease to diagnose index, its trends detects the process to understanding a disease, observe the curative effect of medicaments, judgement prognosis all has important sense.

结论β-淀粉样蛋白含量可作为AD和VD病诊断指标，其动态检测对于了解疾病的过程，观察药物的疗效，判定预后均有重要意义。

The method uses radiative immunity analysis, determine 43 senile domentia and 33 hemal sexes are gawkish (the β in VD) patient and plasma of 58 healthy old people - the content; analysis of amylaceous appearance albumen and β of observation AD patient - the variable relation of the content of amylaceous appearance albumen and GDS process is reached and treat from beginning to end.

方法应用放射免疫分析，测定43例老年性痴呆和33例血管性痴呆患者及58例健康老年人血浆中的β-淀粉样蛋白的含量；分析和观察AD患者β-淀粉样蛋白的含量和GDS进程的变量关系及和治疗前后β-淀粉样蛋白含量的变化。

It may have a preventional function from Alzheimer's disease. Molecular biological studies are shown that apoE isoform has a isoform-specific role to neurodegeneration. ApoE〓 and apoE〓 aid to sustain the stabilization of cytoskeleton protein tau, while apoE〓 hyperphosphorylates tau to destabilize the microtubule protein, which will make neurocyte easy to form neurofibrillary tangles in AD. Clearance of amyloidal peptide by apoE〓 and apoE〓 is more effective than by apoE〓. ApoE〓 has the strongest ability to clear the amyloidal peptide. It is shown that apoE〓 has a stronger prevention from Alzheimer's disease.

分子生物学研究发现，apoE异构体对神经细胞退化表现出异构体特异作用，apoE〓和apoE〓有助于维持微管的稳定性，而apoE〓则使tau蛋白超磷酸化，破坏微管的稳定性，使神经细胞易于形成神经纤维缠结。apoE〓和apoE〓对A β的清除率远远高于apoE〓，apoE〓对A β的清除能力最强，可见apoE〓对AD的发生具有较强的阻止作用。

Methods: The interhemispheric fissure width,cerebral transverse diameter,width of anterior horn of lateral ventricle,bifrontal index,minimal thickness of medial temporal lobe,interuncal distance,hippocampal height,width of the choroid fissure and width of the temporal horn of lateral ventricle were measured by MRI in 22 patients with mild AD and 20 normal senile subjects subjects respectively.

分别对22例轻度痴呆的AD患者和20例正常老年人进行纵裂宽度，大脑横径，侧脑室额角宽度，双额指数，中颞叶最小厚度，钩回间距，海马高度，脉络膜裂宽度和颞角宽度等指标测量。

The results Showed that twenty isolates have the following biological aspects:① Capability of forming capsule,② Growth at 37℃ within 3days,③ Forming brown colonies on Niger seed agar, CACA agar,④ Urea hydrolysis test positive within 96 hours.⑤ No blue colonies were found on CGB agar.⑥ The genus could be identified by ID32 identification kid, but the species could not.⑦ The sequence of the LSUrDNA D1/D2 region analyzed confirmed to be C. neoformans var neoformans.⑧ Serotype A and AD were found in these isolates, Serotype A was predominant(83.33%),⑨ Some biodiversities of isolates existed.

结果 20株菌皆具有以下特征：①形成英膜，②37℃3天内生长试验皆为阳性，③咖啡酸玉米琼脂和油菊籽培养基皆可以产生褐色菌落，④尿素酶试验96h皆呈阳性，⑤CGB培养基未见蓝色菌落生长，⑥ID32鉴定板可以鉴定到属，种的鉴定结果各不相同，⑦大亚基核糖体DNA的D1/D2区域序列分析证实皆为新生隐球菌的新生变种，⑧血清型仅见A和AD二型，以A型为多数(83.33%)，⑨20株临床分离株随机扩增DNA多态性分析有一定的生态多样性。

Then we examine whether NMDA receptor is involved in the protective effect of carnosine on Aβ42-induced neurotoxicity because of the important role of NMDA receptor in AD.

由于NMDA受体在AD病理过程中的重要地位，本实验进一步检测NMDA受体的表达变化。

Meanwhile, as a putative neurotransmitter in the brain, carnosine has a protective effect in many diseases such as AD, because of its abundant functions such as an anti-oxidant, in anti-glycation, anti-aging.

同时，有研究表明肌肽作为脑内一种重要的神经递质，对多种神经系统疾病如AD具有保护作用。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。