查询词典 acute-angled

Objective:To observe the therapeutic efficacy and side effect of all-trans retinoic acid combined with arsenic trioxide(As2O3)on newly-diagnosed patients with acute promyelocytic leukemia.

目的：观察全反式维甲酸联合三氧化二砷(As2O3)治疗初发急性早幼粒细胞白血病的疗效和不良反应。

AbstractObjectiveTo observe the therapeutic efficacy of all-trans retinoic acid combined with arsenic trioxide(As2O3) on acute promyelocytic leukemia.

中文摘要：摘要目的研究全反式维A酸联合三氧化二砷治疗急性早幼粒细胞性白血病可产生的协同作用。

Acute promyelocytic leukemia ; All-transrefinoic acid ; Arsenic

急性早幼粒细胞白血病；全反式维甲酸；砷剂

An D-dimeride analysis of the therapeutic effects and reactions in treating acute promyelocytic leukemia with intravenous arsenic trioxide or all-trans retinoic acid.

三氧化二砷不同给药方法治疗急性粒细胞白血病的临床观察和随访。

ABSTRACT］ Objective To observe the efficacy and side effects of combined therapy with alltrans retinoic acid, arsenic trioxide (As2O3) and chemotherapeutics for newly diagnosed acute promyelocytic leukemia.

急性早幼粒细胞白血病是急性髓系白血病中的一种独特类型(M3型)，以特异的染色体易位t(15，17)(q22，q21)为特征，形成PMLRARa融合基因，该融合基因是APL发病的分子基础和分子标志。

Over the past year, the group evaluated the seven-year follow-up results of therapeutic effects of all-trans retinoic acid and arsenic trioxide (As2O3) combined treatment in newly diagnosed acute promyelocytic leukemia. We also studied the mechanism of therapeutic effects of Imatinib and As4S4 combined treatment in CML cell line and animal model. These two papers were published on PNAS.

过去的一年中，本课题组总结完成了全反式维甲酸和三氧化二砷联合治疗初发急性早幼粒细胞白血病的七年临床随访资料的疗效评估；在慢性粒细胞性白血病，完成了应用As4S4和STI571联合治疗作用的细胞、分子和整体动物水平的机制研究，这两部分工作均已发表于PNAS。

Methylation of CpG islands in the promoters induces gene silencing. The multiple tumor suppressor gene P16, located at chromosome 9p21, regulating normal proliferation of cells with a functional unit constituting of p16, cyclin D1 and pRb together. Methylation of P16 gene has been detected in several lymphocytic and plasmacytic malignancies such as lymphoma, acute lymphocytic leukemia and multiple myeloma and shows relationships with the pathogenesis of these diseases. Application of demethylation agents or arsenical to refresh the gene functions will be expected to be a new treatment for hemopoietic malignancies.

基因启动子区CpG岛甲基化常导致基因沉默。P16基因是一定位于9p21的多种肿瘤抑制基因，通过pl6INK4Acyclin D1-PRb通路维持机体细胞的有序增殖。P16基因甲基化在淋巴瘤、急性淋巴细胞性白血病、多发性骨髓瘤等多种淋巴细胞浆细胞肿瘤中被检测到，并与疾病的发生、发展存在一定关系，应用甲基化抑制因子或砷剂去甲基化治疗，恢复基因功能可望成为血液恶性肿瘤治疗的一种新手段。

Methods 38 cases of confirmed acute arsine poisoning patients with kidney damage were conducted conventional renal ultrasonography, and compared with clinical manifestation and related biochemical examination results.

对已确诊的38例急性砷化氢中毒肾损害患者，进行常规肾脏超声检查，与临床表现和有关生化检查结果相对照。

"Acute exposure to the gas arsine causes destruction of red blood cells and kidney damage; chronic exposure causes weakness , skin disorders, anemia, and nervous-system disorders."

人在接触砷以后，红血球的破坏和肾脏的损伤最为明显。慢性中毒较常见的反应是逐渐无力、皮肤色素沉着、精神错乱、贫血。

So it is a simple but acute way of measuring arterial stiffness.

因此，该方法是对动脉僵硬度的一个简单精确的测量方式。

The basic concept of FOP can be summarized as to further optimize effective prescription according to the standard of curative effects and with the aid of modern science and technology and theories of traditional Chinese medicine.

其基本内涵可概括为：以确有疗效的中药复方为研究对象，以现代科学技术和传统中医药理论为技术支持，以该复方所治病证的药效响应为评价标准，以优化重组疗效更优的新复方为研究目的。

Ever since our world has been a world, native forests have been indiscriminately exploited by man.

自从我们的世界一直是世界原生森林被任意剥削人。