查询词典 activation radioactivation

The cutoff value of E2/E6, used to distinguish the pure episomal form from a mixed form of episomal and integrated HPV16 DNA, was 0.81 in the multiplex real-time PCR test. c） HPV16 existed as episomes in most of the CIN Ⅰ lesions, and 42.9% of them had mixed episomal/integrated HPV16. The integrated form of HPV16 constituted the majority in most of the CIN Ⅱand CIN Ⅲ cases. In squamous cervical carcinomas, the HPV16 was mostly integrated into the host chromosome. d） The rate of HPV16 integration was associated with the degree of cervical lesions and the rate increased with the progression of cervical disease, e） The rate of pure integrated HPV16 in stage Ⅱ and Ⅲ（88%） was higher than that in stage Ⅰ（33.3%）. Conclusions: a） Multiplex real-time PCR is a rapid and sensitive method for detection of the integration state of HPV16 DNA. b） The integration of HPV16 DNA is a very early event in the development of cervical cancer and may act as an activation mechanism for progression from preinvasive to invasive cervical cancer, c） The pure integrated HPV16 in cervical cancer may be a useful prognostic indicator.

HPV—16E2、E6标准曲线相关系数均为1.00，扩增效率均在95％以上：2）确定0，81作为多重实时PCR区分游离型和混合型HPV-16的界值、3）CINⅠ中HPV—16大多以游离方式存在，但仍有整合的发生（42，9％）；CINⅡ和CINⅢ中HPV—16以混合型为主：浸润癌中以整合型HPV—16为主。4）HPV-16整合发生率与不同程度的宫颈病变有关，并且随着宫颈病变级别的升高HPV-16整合发生率呈上升趋势-5）Ⅱ＋Ⅲ期宫颈癌中整合型HPV—16所占比例显著高于Ⅰ期宫颈癌结论：1）多重实时定量PCR是一种敏感性高、简便快速的HPV—16病毒存在状态的检测方法2）HPV-16整合是宫颈癌变的早期事件，与宫颈癌前病变的进展有关。3）宫颈癌中整合型HPV—16的发生可能具有预后价值

In this study, we investigated whether calcium-dependent kinases were involved in ERKs cascade activation after global cerebral ischemia.

方法采用四动脉结扎诱导大鼠前脑缺血，用免疫印迹的方法观察几个钙依赖性蛋白激酶含量及活性的变化。

bFGF enhances the tolerance to hypoxia of aged rat cardiomyocytes and the activation of ERKs is involved in the protective mechanism.

bFGF可以提高老年大鼠心肌细胞对于缺氧的耐受性，其保护机制涉及ERKs的活化。

The effect of AA on BEL-7402 was not significant; However, AA could effectively enhance AT-induced hepatocarcinoma cell apoptosis and lesion severity through activation of caspase-3 but not ERKs.

AA对BEL-7402无明显的作用，但能有效的通过caspase-3而不是ERKs的激活促进AT对肝癌细胞的凋亡效应。

The expression of ERK1/2 was detected by anti ERK1 and anti ERK2 immunocytochemistry, while the activation of ERKs was detected by Western blot.

结果 ERK1/ 2可在豚鼠前庭上皮细胞中表达，随年龄增加而逐渐减少。ERK1/ 2的活性随年龄的增长而逐渐降低，且 ERK2的活性高于 ERK1。

However, the activation of ERKs was significantly suppressed after the COS7 cells were transfected with C289A and Q257A. The result indicated that C289A and Q257A were the stretch sensitive region.

结果提示AT1受体上位于257位的谷氨酰胺和289位的胱氨酸在机械牵张引起的AT1受体激活中起了重要作用。

Angiogenesis is regulated by signals derived from receptors for both growth factors and ECM molecules. Recent studies have shown that activation of ERKs is closely involved in the migration or tubular-like formation of endothelial cells and induced by various angiogenic factors.

血管新生可以受到许多来自於生长因子受器及胞外基质受器的讯息所调控，而近年的研究也显示ERK的活化不但会受到许多促血管新生因子的诱导，而且跟内皮细胞的移型及管状形成作用有很大的关系。

Extracellular-regulated kinase 3(ERK3) is an atypical member of ERKs, lacking the threonine and tyrosine residues in the activation loop, carrying a unique C-terminal extension and being mainly regulated by its own protein stability.

其活化环不同于一般的ERK，缺少苏氨酸和酪氨酸残基，拥有一段独特的C端延伸序列。ERK3蛋白是一个不稳定的蛋白，它的生物学活性主要依靠其蛋白稳定性和激酶活性调节。

Cardiomyocyte hypertrophic response induced by ET-1 is mediated by ETA receptor coupled to PTX-sensitive G-protein, which involves at least two signalling pathways: PKC-mediated increase of ［Ca2+］i , and PKC-independent activation of ERKs.

ET-1主要通过ETA受体并经PTX敏感的G-蛋白介导心肌细胞肥大反应，该作用至少涉及两条途径：①通过PKC介导的心肌［Ca2+］i浓度增加；②不通过 PKC介导的ERKs激活。

Before transfected with AT1, neither AngⅡ nor stretch increased the activation of ERKs. After transfected with AT1, pretreatment with AngⅡ for 8 min or stretch for 10 min activated ERKs obviously.

COS7细胞转染AT1受体以前， AngⅡ和牵张刺激都不能引起细胞内ERKs磷酸化升高；而转染野生型AT1后，AngⅡ和牵张刺激引起细胞内ERKs磷酸化明显升高，各突变体中，Q257A和C289A转染细胞后细胞对牵张刺激的反应受到明显抑制，提示AT1的牵张感受位点在Q257A和C289A。

Alternatively, the con- trollers can use the synchronous rectifier itself or loss- less inductor current-sensing methods to provide overload protection with lower power dissipation.

另外，康威特罗勒斯可以使用同步整流器本身或亏损减少电感电流检测方法，以提供低功耗过载保护。

Mr. Dauber's other Schatz hangs in his home movie studio.

多伯把沙兹的另一件作品挂在家里的电影室。