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Ultimately, vulnerable groups of neurons atrophy and die in a process that may involve excitotoxicity (overstimulation of neurotransmitter receptors on neuronal surface membranes), collapse of calcium homeostasis, inflammation, and depletion of energy and growth factors. A form of apolipoprotein E, apoE4, contributes to the abnormal accumulation of A and tau, but probably also damages mitochondria and the cellular cytoskeleton. A , tau, apoE and -synuclein interact with many other molecules and modulate diverse signalling cascades that regulate neuronal activity and survival.

最后，易感神经元会萎缩直至死亡，原因可能有兴奋性中毒（神经递质对神经元表面受体的过度刺激引起），钙稳态失衡，炎症反应，能量和生长因子的耗尽。apoE4的产生可导致A肽和tau蛋白的异常聚合，可能也损害线粒体和细胞骨架。A肽、tau蛋白、apoE和突触核蛋白可与很多分子反应，也可调节不同信号级联反应，这些级联反应对于维持神经元活动性和生存性意义重大。

Base on the problem of large quantity fatigue loads on corroded R.C. structure and small quantity study of its mechanical property, bending resistance fatigue test of corroded R.C. beams is discussed in this paper. The influence of stress ratio and re-bar weight loss ratio on bending resistance fatigue performance of corroded R.C. beams are researched, and the relation between strains of corroded re-bars and fatigue life of beams are obtained. The main research contents and conclusions are as following: 1. Under the fatigue loads, the overstrain of concrete approximately coincidences three stages strain development and accumulation rule, and the mechanical property of concrete is deteriorated. The fatigue damage of concrete is accumulated. The overstrain of re-bars increases and the increase rate decreases.

鉴于实际工程中大量存在腐蚀钢筋混凝土结构承受反复荷载作用，但其力学性能研究不多的问题，本论文进行了锈蚀钢筋混凝土梁抗弯疲劳试验，研究了应力比和钢筋锈蚀率对锈蚀钢筋混凝土梁抗弯疲劳性能的影响，得出了锈蚀钢筋的应变与构件疲劳寿命之间的关系曲线，主要研究内容及结论如下：(1)在循环荷载下，混凝土残余变形基本符合三阶段变形规律，力学性能劣化，疲劳损伤积累。

In recent years some anchors overstress their appearances and neglect the knowledge accumulation . Their programs do not have weight and lack deep connotation .

近些年一些主持人过份注重外表的包装而忽视内功的积累，主持的节目没有份量，缺少内在深厚的内涵。

The roles of nitric oxide and reactive oxygen species in abscisic acid accumulation under water stress conditions and the mechanisms through which NO/ROS regulate ABA biosynthesis were studied in this thesis.

为了探讨植物对水分胁迫信号的感受机制和水分胁迫下ABA合成的诱导机制，本论文研究了ROS和NO在水分胁迫诱导ABA积累中的作用、作用机理及其生理意义。

The subsequent Rhems Formation is apparently the product of rapid sediment accumulation during a short period of time in the early Paleocene.

之后，Rhems的形成是古新世短时期快速沉积的结果。

These features include:(1) the clear boundary being enriched with residue organic substance and the obvious fluidization feature shown by the relative accumulation of silty grains under the petrographic microscope;(2) the accompanied wrinkle structure and the palimpsest ripples which indicate the development of microbial mats on the sedimentary surface.

因此，这种粉砂岩岩墙应该解释为沉积面在曾经被微生物席封闭的情况下，相对富含有机质的细粒沉积物在早期成岩作用过程中所发生的脱气作用和脱水作用的产物，最终可以归为由微生物形成的沉积构造的一种类型。

Despite their accumulation of water treatment expertise in recent years, Hoffmann excludes General Electric, Dow Chemical and similar companies from the Palisades indexes he helped to build because their exposure to water is too small a part of overall operations.

尽管 General Electric，和 Dow Chemical于近年改进了水处理的工艺，但 Hoffmann 还是将这两家公司和其它类似的公司从他协助建立的 Palisades indexes 中除名了，因为在这些公司的总的业务中，对水的关注实在太少了。

Abstract］Objective: To investigate the effect of resveratrol on triglyceride accumulation in HepG2 cells induced by sodium palmitate.

目的：研究白藜芦醇对软脂酸钠诱导的细胞内甘油三酯沉积的影响。

Resveratrol is able to ameliorate the excessive triglyceride accumulation in HepG2 cells induced by sodium palmitate.

白藜芦醇可改善软脂酸钠诱导的肝细胞脂肪变性。

As a symbiosis existence organization, un iversity need to constantly learn from the social system, exchange and feedback all types of resources, meanwhile it must adhere to the"Entity—Relations"thinking, need to focus on the accumulation and use of social capital, need to realize oneself with system's synchronized construction and harmonious paragenesis, so as to make the progress unceasingly.

作为共生性存在的大学组织，需要不断地从社会系统中汲取、交换和回馈各类资源，需要坚持"实体—关系"思维，需要重视社会资本的积累和利用，实现自身与系统的同步构建与和谐共生，才能不断取得发展。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。