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The transforming growth factor-β superfamily, a large group of highly conserved growth factors including TGF-βs, activins and BMPs, regulate a wide variety of cellular functions such as proliferation, differentiation, apoptosis and migration. Signals from these growth factors are transduced by a group of Smad proteins. To date, there are nine vertebrate Smads, including the receptor-activated Smads , Smadsl-3, 5 and 8, the common mediator Smad4 and Smad4β, and the inhibitory Smads, Smad6 and 7. Signaling is initiated when the ligand induces assembly of a heteromeric complex of type Ⅱ and type Ⅰ TGFβ receptors. Then R-Smads are directly phosphorylated by activated type I TGF-β receptors.
在多种SMADS中,SMAD5令我们产生兴趣,基于三个原因:1、Smad5基因敲除胚胎中发现卵黄囊的异位造血以及CFU-GM祖细胞数目增加,表明SMAD5可能是早期造血发育的负向调控基因。;2、应用反义核酸封闭Smad5可以逆转TGF-β对祖细胞增殖的抑制效应,表明它可能介导TGF-β信号转导,后者的异常,包括某些SMADS的功能异常,和白血病紧密相关;3、Smad5基因定位在人染色体5q21,此区域的缺失和急性髓系白血病和骨髓增生异常综合症相关,因此,Smad5被怀疑为白血病抑制基因。
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Methods 63 cases of suffering bacterila corneal ulcer who were not cured through conventional drug treatment after 10~14 days were divided randomly into two groups. In A group(35 cases), the surface of cornea was covered with fresh amnion and autoblood was detained in closed amnion space; In B group(28 cases), antibiotics was subconjunctivally injected Relieving of Postoperative ocular region Irritation,restoring of keratohelcosis and vision were observed.
我们把经常规的药物治疗10~14天未治愈的细菌性角膜溃疡63例(63眼),随机分为A、B两组。A组35例(35眼),采用新鲜羊膜遮盖角膜表面在封闭羊膜空间留置自血;B组28例(28眼)用结膜下注射抗生素。
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Lene wanted to show a group of women in L.A., and I've seen a group of women very similar to us.
C要展现一群在洛杉矶生活的女人,而我也曾看过一群和我们非常相似的女人。
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A relaxing five-star holiday turns into an all out battleground for Marine recon sniper Joe Linwood when a group of local rebels seize control of the hotel taking the billionaire owner, and a group of guests, including Joe's wife, hostage.
当一个轻松愉快的五星级度假变成了所有的海军侦查狙击手joe linwood的战场时,当一群叛军控制了当地的酒店和抓住了一些亿万富翁和一群客人,同时也包括Joe的妻子为人质,Joe 考虑到了自己的这个行动是为了拯救他必死无疑的老婆,出生入死
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A relaxing five-star holiday turns into an all out battleground for Marine recon sniper Joe Linwood when a group of local rebels seize control of the hotel taking the billionaire owner, and a group of guests, including Joes wife, hostage.
当一个轻松愉快的五星级度假变成了所有的海军侦查狙击手joe linwood的战场时,当一群叛军控制了当地的酒店和抓住了一些亿万富翁和一群客人,同时也包括Joe的妻子为人质,Joe 考虑到了自己的这个行动是为了拯救他必死无疑的老婆,出生入死
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A relaxing five-star holiday turns into an all out battleground for Marine recon sniper Joe Linwood when a group of local rebels seize control of the hotel taking the billionaire owner, and a group of guests, including Joe's wife, hostage.
海军陆战队侦查狙击手Joe Linwood正惬意地享受着豪华五星级度假,然而却被突然发生的绑架事件所打断。
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Histopathological observation: 4 weeks after operation, diffuse presence of empty lacunae and pyknotic nuclei of osteocytes were found in the trabeculae, and few newborn micrangium could been seen in group A; lots of empty lacunae and a small quantity of newborn micrangium could been found in group B; and large amounts of osteoblats and newborn micrangium were found around the necrosis regions in groups C and D.
组织病理学观察,术后4周A组见空骨陷窝,无新生毛细血管;B组空骨陷窝较多,有少量新生毛细血管:C、D组空骨陷窝减少,坏死区有大量增生活跃的成骨细胞及新生毛细血管。D组空骨陷窝阳性数及微血管密度分别为19.30 1.52和7.08 1.09,与其他组比较差异有统计学意义(P〈0.05)。
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And Chinese community is among them a the biggest group, be in the minority the 40% above of population of a group of things with common features descendants, and most person uses a network often to get information.
而华人社区则是其中最大的一个群体,占少数族裔人口的百分之四十以上,而且大多数人频繁使用网络获取信息。
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I lose my former favorite thing, yet in return, I get something I miss out for so long: a group of friends with whom I can discuss technical problems, a group of fellow students from whom I can benefit a lot, a association from which I can see my dream in childhood.
但是,我明白,我得到了我曾经一直没有机会得到的东西:一群可以和我讨论技术的朋友,一些能够真正意义上指导自己的学长学姐,一个让我看得见童年梦想的社团。
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A global technology group president Gaiermasi, in order to secure a place in the childrens toy market, so the commands top toy designers to create a group of combat soldiers, they are peace-loving Gaogan Corps, as well as Cheng Yong militant The devil Corps, they were implanted computer chips used in military, quiet town into a battlefield of their true.
一家全球性科技集团的总裁盖尔马斯,为了在儿童玩具市场取得一席之地,于是命令旗下最顶尖的设计师制造出一群战斗玩具兵,他们是爱好和平的高竿兵团,还有逞勇好战的魔鬼兵团,他们都被植入了军事用的电脑晶片,宁静的小镇变成了他们的真实战场。
- 推荐网络例句
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In the negative and interrogative forms, of course, this is identical to the non-emphatic forms.
。但是,在否定句或疑问句里,这种带有"do"的方法表达的效果却没有什么强调的意思。
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Go down on one's knees;kneel down
屈膝跪下。。。下跪祈祷
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Nusa lembongan : Bali's sister island, coral and sand beaches, crystal clear water, surfing.
Nusa Dua :豪华度假村,冲浪和潜水,沙滩,水晶般晶莹剔透的水,网络冲浪。