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CA inhibition may not be an important contributor since CA II expression and CA activity was intact in anhidrotic mice treated with topiramate.

来源：ABCca论文02网www.abclunwen.com

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗(来源：A44B8787C论文网www.abclunwen.com)功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

Immunofluorescence confirmed that sweat glands in normal mice did not present gamma-aminobutyric acid receptor subtype GABAA andα-amino-3-hydroxy-5-methylisoxazole-4-propionic acid/kainic acid subtype of glutamate receptor.Mature mice with reactive sweat glands that declined more than 25% compared to baseline were defined as anhidrotic mice.

免疫组织荧光染色未发现在正常小鼠皮肤组织及汗腺的分泌细胞存在γ-氨基丁酸A型(gamma-aminobutyric acid，GABAA)受体α1亚单位、谷氨酸受体亚型α-氨基羟甲基恶唑丙酸α-amino(来源：Ad1d1BC论文网www.abclunwen.com-3-hydroxy-5-methylisoxazole-4-propionic acid ， AMPA GluR1/2/3/4亚单位和海人酸(kainic acid，KA)受体GluR5/6/7亚单位的表达。

In the vast cosmic exchanges the universal life goes comes in unknown quantities, rolling entirely in the invisible mystery of effluvia, employing everything, not losing a single dream, not a single slumber, sowing an animalcule here, crumbling to bits a planet there, oscillating winding, making of light a force of thought an element, disseminated invisible, dissolving all, except that geometrical point, the I; bringing everything back to the soul-atom; expanding everything in God, entangling all activity, from summit to base, in the obscurity of a dizzy mechanism, attaching the flight of an insect to the movement of the earth, subordinating, who knows?

在宇宙广袤无边的运动中，无量数的空间活动交相往来，把一切都卷进那神秘无形的散漫中，并也利用 www.8 t t t8。 com 一切，即使是任何 dd dtt。 com 一次睡眠中的任何 dd dtt。 com 一场梦也不放弃，在这儿播下一个微生物，在那里撒上一个星球，摇摆，蛇行，把一点光化为力量，把一念变成原质，散布八方而浑然一体，分解一切，而我，几何学上的这一点，独成例外；把一切都引回到原子棗灵魂，使一切都在上帝的心中放出异彩；把一切活动，从最高的到最低的，交织在一种惊心动魄的机械的黑暗中，把一只昆虫的飞行系在地球的运转上，把彗星在天空的移动附属于棗谁知道？

However, it is also this "anonymousness" can really bring out the "evil" inside a person.

我觉得，还是发明 www.com 的那小子说的好，我最近听他在新书被采访中说，这好像是废话，但是，网络意味着咨询。

According to the Italian news agency Ansa the 32-year-old man showed up at the police headquarters in northern Vercelli asked to be arrested.

据意大利安莎社报道，这名32岁的男子出现 wWw.8tTt8.coM 在意大利北部城市维切利的警察总局，要求 dDdtt 警方将自己逮捕。

You can obtain more information about insulin injectors by visiting a company抯 Web site, such as that available from Antares Pharma, Inc.

你可以在我们的网站上得到胰岛素注射器的详细信息 www.mediject.com 。

In 2008, anti-black offenses accounted for 26 persons per 1,000 people, and anti-white crimes accounted for 18 persons per 1,000 people (victim characteristics, October 21, 2009, www.fbi.gov).

注992009年6月10日，白人至上主义者和新纳粹分子布伦在华盛顿纳粹大屠杀遇难者纪念馆枪杀黑人保安约翰斯，打伤2人。

In the past, their motives were often rooted in shared anti-communism.

过去它们 www.Dddtt.com 这样做的动机通常都根源于反对***（"be rooted in"表示"根源于"，"明显受……影响"），而现在 dd dtt。

Then there was Mr Berlusconi's own exploitation of "anti-politics", his depiction of himself as an outsider—a technique that allowed him to tap into a rich vein[5]of support among mainly poor, rural poorly educated voters who distrusted the institutions.

其次，贝鲁斯科尼独创了"反政治学"，亦即把自己说成是"一个局外人"——这一伎俩使他赢得了贫困、乡村以及没怎么受过教育的选民的支持，这些人往往www.

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。