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Currently activities involve (1) Investigation of dye-DNA interaction by using spectroscopic methods to probe the binding sites between chromophore and DNA and to identify various DNA conformational structures, particularly the telomeric DNA;(2) Investigation of the structure-activity correlation of anti-telomerase agents;(3) Design and synthesis new compounds for antitumor agents and fluorescence biomarkers;(4) Monitoring the folding and unfolding of quadruplex structure, tracing the pathway of drug delivery and probing drug-target interaction by using single molecule microscopy and spectroscopy.

目前 的研究重点分别是(1)利用光谱方法探讨探针分子与DNA的交互作用，特别是作用位置与结构变化；(2)研究抗端粒酵素作用分子之结构与生物活性之关系；(3)设计及合成抗肿瘤药剂或萤光生物标记；(4)建立单分子萤光光谱与影像技术，研究 DNA的多变型结构之变化机制，监测药物输送的路径过程及其在细胞中与标的物的作用。

This thesis introduces the basic principle of the least square data fitting.. According to the least square data fitting ,the paper studies and analyzes the linear least square fitting ,the quantic least square fitting and nonlinear least square fitting respectively . By using the mathimatic instrument Matlab , this paper shows a lot of examples of interrelated questions. Using Matlab makes the theory of data fitting easier to be understood.

本文介绍了最小二乘数据拟合法的基本原理，并根据最小二乘数据拟合方法，分别针对线性最小二乘拟合、多项式最小二乘拟合，非线性最小二乘拟合（lsqcurvefit、nlinfit、lsqnonlin、以及非线性的线性化）、多元最小二乘拟合进行了分析和研究，并通过数学工具Matlab实现了对相关问题的举例应用，使相关数据拟合理论更加生动易懂。

According to the working characteristics of high-speed railway station, the principles to track using are formulated. Regarding the system of receiving and dispatching trains as a queuing system, the working process of making track plan is studied through analyzing the working process of queuing system. Moreover, the adjustment principles and measures for track plan are studied, and then the working process of making the adjustment plan on track using is set down.

根据高速铁路车站作业特点制定了到发线使用原则，并把车站接发车系统看作一个排队系统，通过分析排队系统作业过程研究了编制到发线运用计划的工作流程；进而研究了当列车运行波动时，到发线运用计划的调整原则和调整方法，制定了编制到发线调整计划的工作流程。

The motionless backgroup situation usually happens at the video camera parked to opposite quiescent condition , the first wipe off yawp by using pretreatment method,the second using the method of difference Statistic in two frame to analyse and compute background , Above this base to utilize the resumeed background and present frame message detect movement target and it"s movement track ; In dynamic backgroup movement image,it is very difficult to exactly compute ground since the background is varied complexly , the article research the optical flow model、 background model、 moving object detection based on entropy,and depart target from background in movement picture , detect moving target and plain it"s track.

静止背景的情况通常发生在摄像机相对静止状态，首先用预处理的方法去除噪声，其次采用帧间差分统计的方法进行分析计算背景，在此基础之上利用恢复的背景及当前帧的信息检测运动目标及其运动轨迹；对于动态背景的运动图像，由于背景是不断变化且呈现出复杂的特征，因此很难准确求出静止背景，本文在光流矢量场和配准方法的基础上探讨研究了光流模型、背景模型和基于熵的方法，在动态图像上分离不同的目标与背景，直接检测出运动目标并画出相应的轨迹。针对运动图像的复杂性，本文提出了构建模型知识库的设想。

You set the quiz options using the administration program and the competators attend the quiz by using the client quiz program(the main quiz program - quiz.exe).

你使用管理程序来设置测试的选项，使用客户端测试程序将竞争对手增加到测试中(主要的测试程序是：quiz.exe)。

The QPF results, before and after the mean-field bias adjustment using a multiplicative factor determined based on radar–rain gauge comparisons of the last hour, were compared using rain gauges.

用外推开始前1小时的雷达1小时累积降水和雨量计测值计算平均校准因子，对外推得到的雨量场进行校准后，可以明显提高外推1小时流域面雨量的精度，对外推2小时流域面雨量的精度也有所提高。

The QPF results, before and after the mean-field bias adjustment using a multiplicative factor determined based on radar–rain gauge comparisons of the last hour, were compared using rain gauges. Results show that the QPF results after the adjustment were better than the QPF results before the adjustment.

用外推开始前1小时的雷达1小时累积降水和雨量计测值计算平均校准因子，对外推得到的雨量场进行校准后，可以明显提高外推1小时流域面雨量的精度，对外推2小时流域面雨量的精度也有所提高。

First, in order to verify the correct of this retrieval month, by using the data of three-dimensional wind field, raininess field and temperature field that are output by MM5 numerical simulation, we climate the radial velocity field and echo intention field in the in-phase observation area of Dual-Doppler radar, then, on the base of the upwards retrieval theory and using the radial velocity field and echo intention field in the in-phase observation area of Dual-Doppler radar, we retrieve the atmospheric three-dimensional wind field.

首先，为检验此种反演方法的可靠性，我们使用MM5数值模式输出的三维风场、雨强场、温度场等数据，分别模拟生成两部雷达同步观测区的径向速度场和回波强度场，然后根据以上的反演理论利用模拟的双多普勒天气雷达观测到的径向速度场和回波强度场反演出大气三维风场。

This dissertation involves the study of the growth dynamics of colloidal particles under unequilibrium and irreversibility condition. Firstly, it is of interest to investigate whether the ideal diffusion or reaction-limited aggregation universal behavior can be observed for the initially polydisperse practical system of basic yttrium carbonate as well. The fractal structure of basic yttrium carbonate aggregate cluster was observed using transmission eletron microscopy. The aggregation kinetics of basic yttrium carbonate colloids was studed using dynamic 1ight-scattering techniques. At 1.00mol/l NaCl solution the fast diffusion-limited aggregation behavior was observed with an increase in the aggregate size over time described by a power law. The aggregates are characterized by a fractal dimension D=1.82. The disordered and ramified cluster is consisted of primary colloidal particles and tenuous and more open. These are in good agreement with those observed for other colloidal system such as colloidal gold (1.86), silica (1.85) and polystyrene latex (1.82) in diffusion-limited aggregation from the static and dynamic light scattering by Lin. Therefore ideal diffusion-limited aggregation behavior can be observed in practical polydisperse system as well. Smoluchwski and fractal theories were used to obtain the aggregation rate constant for initially polydisperse system for the first time.

本论文研究胶粒的非平衡不可逆聚集动态学，分为两个部分，第一部分是通过实验研究一个新的初始多分散的碱式碳酸钇胶粒实际体系中，聚集标度性质的普适性，即使用透射电子显微技术观测聚集粒子簇的分形结构，使用动态激光光散射研究碱式碳酸钇胶粒的聚集动力学，胶粒带电而产生静电排斥作用使得碱式碳酸钇胶粒处于稳定状态，当加入电解质NaCl溶液时，碱式碳酸钇胶粒间的Debye-Hückel屏蔽距离缩短，从而降低静电排斥能垒，引起胶粒发生不可逆聚集，加入电解质NaCl的浓度为1.00mol/l时，碱式碳酸钇胶粒进行快速聚集，经历扩散控制聚集机理，形成结构疏松、更为开放的分形聚集粒子簇，其分形维数为1.82，碱式碳酸钇胶粒聚集增长动力学遵循幂函数增长规律，与Lin等使用静态激光光散射和动态激光光散射测量硅胶(1.85)、金胶(1.86)和聚苯乙烯胶乳(1.82)在扩散控制聚集状态形成聚集粒子簇的分形维数值以及粒子簇聚集增长的动力学规律相一致，表明胶粒聚集标度性质的普适性质在初始多分散的实际体系中也是存在的，首次由动态激光光散射的实验数据得到初始多分散胶粒分形粒子簇的聚集速率常数，并且其值与Smoluchowski聚集速率理论预期相符。

Different noises are added to the ideal CITs which is obtained by using randle equivalent circuit ,and then, the de-noising criterion in practice for CITs using the empirical mode decomposition is obtained.

通过计算机仿真，在模拟等效电路生成的理想瞬态响应信号上加入不同形式的噪声，获得恒电量瞬态响应信号经验模式分解滤波的实际判据。

It seems likely that Kraft will return with a better offer.

看起来卡夫要重新考虑一个更好的出价了。

But he'd rather burn off my feelers and watch me squirm.

可他却放任那个家伙对我为所欲为！