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It is only in the presence of allergen that CD4+ CD25+ regulatory T cells secrete IL-10. So, these regulatory T cells still are in anergic.

4在功能上，患者体内的CD4~+CD25~+调节性T细胞对变应原或联合应用抗CD3单抗和抗CD28单抗的刺激不表现出增殖反应。

Rather than being selectivelyrendered anergic in vivo, circulating survivin-specific CTLswere highly functional as shown by cytotoxicity and interferongamma enzyme-linked immunospot assays in six of nine patients.Survivin-specific CD107a mobilization by T cells was found infive of five patients.

细胞毒性和γ干扰素酶联免疫印迹测定法显示，9例中有6例的外周血survivin特异性CTLs具有高度的活性，该结果与体内选择性提取时无细胞免疫反应的T细胞不同。5例患儿血标本均可检测到T细胞动员的sruvivin 特异性CD107a。

TJU103 combined with CTLA4-Ig could induce tolerance of donor CD4〓 T-cell to the given antigen, and the tolerance could be transferred by the anergic CD4〓 T-cell and supernatants.

TJU103联合CTLA4-Ig应用，能够调节Th细胞分化，诱导Th细胞发生免疫偏离，使辅助性T细胞更多地向Th2细胞方向分化，有利于免疫耐受的形成。

Wenxin capsule can promote endolethial cells releasing CO and synthesing 〓, enhance activity of HO, induce angiectasis through activating guanylic cyclase and adenglate cyclate of intracellar of vessel smooth muscle cell to enhance content of intracellar cGMP and AMP. 3. Wenxin capsule can inhibit releasing of platelet activiting factor 〓 which inhibit platelet aggregation and have antithrombosis function. 4. Wenxin capsule can promote activity of t-PA, reduce activity of PAI-1, strengthen fibrinolytic function, therefore inhibit fibrin disposition. 5. Wenxin capsule can inhibit synthesis of smooth muscle cellular DNA. Its function don't kill it directly but prevent transformation from period Go to peried S. 6. Wenxin capsule is an effective prescription of anti-coronary atherosclerosis atherosis. The results of image pattern analysis tastifies that area of lipid plaque in treating group reduce 54% and 58% in contrast with that in control group. The results of light, electro- microscopy show that structure of endolethial cell and smooth muscle cell in treating group is more integral than that in control group.

其作用机制之一是由于该药具有良好的调脂降脂作用，其不仅能明显降低血清LDL-c及升高HDL-c含量，且能有效阻止TC沉积于血管壁，从而保护内皮细胞结构完整；此外，温心胶囊尚具有明显的抗氧化作用，该药不仅能明显降低血浆LPO含量，且能提高SOD活性，同时其对血红素在细胞内代谢的调节作用也参与了抗氧化过程。2 温心胶囊能明显促进内皮细胞释放CO及合成〓，提高HO活性，通过激活血管平滑肌细胞内鸟苷酸环化酶及腺苷酸环化酶引起细胞内cGMP、AMP浓度增加而引起血管舒张。3 温心胶囊能明显抑制血小板激活因子〓的释放，从而抑制血小板聚集，抗血栓形成。4 温心胶囊能明显提高t-PA活性，降低PAI-1活性，增强纤溶功能，从而抑制纤维蛋白沉积。5 温心胶囊能明显抑制平滑肌细胞DNA合成，其抑制作用不是直接杀伤抑制，而是阻止细胞由Go期向S期转化。6 温心胶囊是抗冠状动脉粥样硬化的有效制剂，图象分析结果证实，该药治疗组脂斑面积比对照组缩小了54％和58％，光电镜结果显示内皮细胞及平滑肌细胞结构较为完整。

Contrary to the antirealistic assumptions of high Modernism Henry James [1843-1916], Ezra Pound [1885-1972] and T.S.

与现实主义的反现实构想（亨利·詹姆斯[Henry James，1843-1916]，伊斯拉·庞德[Ezra Pound，1885-1972]，T·S·艾略特T.S。

The Van't Hoff plots (plots of ln K′ versus 1/T) of the two peptides from microtubule _ associated protein 2 were also determined under isocratic elution conditions with aquo _ acetonitrile mobile phases.

以乙腈为流动相测定肽1和肽2的Van'tHoff曲线(lnK′与1/T的关系图)时，发现两种多肽的Van'tHoff曲线分别呈二次和三次方曲线。

The mice were sacrificed on 7, 10, 14, 21 and 28 days post-inoculation and then the hearts were aseptically removed. Pathological changes in the myocardium were observed by light microscopy and the expression of the CD4+ T lymphocyte in the myocardium was determined by immunohistochemistry. ResultsThe CD4+ T lymphocyte was found in the myocardium in the CVB3 infection group.

分别于接种病毒后第7、10、14、21、28d随机取正常对照组小鼠3只、病毒感染组小鼠8只断髓处死，无菌条件下取心脏，光镜下观察心肌组织的病理变化并计算心肌病理组织学积分，应用免疫组化方法检测CD4+ T细胞在心肌中的表达，并与心肌病理组织学积分作相关性分析。

RESULTS:Amo ng the 80 patients with conceal accessory pathway,no one had episodes of T wave change by RFCA. However 20(39%) patients appeared obvious T wave change among th e 52 patients with non-conceal assessory pathway after RFCA,including the 19 pa tients they passed through cmplete accessory pathway (QRS duration≥140 ms) and only one patient is incomplete accessory pathway (QRS duration ＜140 ms).

结果：80例隐匿性旁路在射频消融术后无1例出现心脏复极改变，52例显性旁路中有20例(占39 %)术后出现明显T波变化，其中完全性旁路(QRS≥0.14 s)占19例，而不完全性旁路(QRS＜0.14 s)仅占1例。

Totally 31 patients with bacteriologically or histologically confirmed extrapulmonary tuberculosis in Peking Union Medical College Hospital received T-SPOT.TB assay to detect early secreting antigen target 6 or culture filtrate protein 10 peptides-specific T cells in the peripheral blood mononuclear cells.

对北京协和医院根据细菌学或／和组织学诊断的肺外结核患者31例，应用酶联免疫斑点技术检测6kD早期分泌靶向抗原和10kD培养滤过蛋白肽段库刺激后外周血中释放γ-干扰素的特异性T细胞。

Some patients had suffered from obstructive jaundice, pancreatitis, bilirubinemia, alkaline phosphatase raise,γ-glutamyl transpeptidase raise and/or diameter of common bile duct exceeded 0.8 cm; and for these cases intraoperative cholangiography must be carried out. 405 cases needed T-tube insertion. The common bile duct of 105 cases was sutured without T tube. Results All cases were operated successfully.

术前确诊者，术中直接行胆总管切开胆道镜取石；术前有黄疸史、胰腺炎史和直接胆红素增高、胆系酶增高者，或胆总管在0.8 cm以上者行术中造影，明确有胆总管结石的切开胆总管胆道镜取石。405例置T管引流，105例行胆总管Ⅰ期缝合。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。