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Results The bone mineral density of Lumber vertebra and trachanter and BGP were increased and bone pain was alleviated and serum ALP,ACP were significantly decreased and the blood,urine routine and biochemical quota were no obvious change in Bugu capsula group.

结果 补骨胶囊组腰椎及转子骨密度均升高,骨痛明显改善,与此同时,骨钙素显著提高,血清碱性磷酸酶、酸性磷酸酶明显降低,治疗后血尿常规及生化指标无明显改变。

Results The bone mineral density of Lumber vertebra and trachanter and BGP were increased and bone pain was alleviated and serum ALP,ACP were significantly decreased and the blood,urine routine and biochemical quota were no obvious change in Bugu capsula group.While the control group had no obvious change.

结果 补骨胶囊组腰椎及大转子骨密度均升高,骨痛明显改善,与此同时,骨钙素显著提高,血清碱性磷酸酶、酸性磷酸酶明显降低,治疗前后血尿常规及生化指标无明显改变。

The treatments of combine the bone block procedure and posterior capsulorrhaphy were carried out according to the pathological factors of bone and soft tissue.

对5例创伤性肩关节后不稳定患者采用气碘双重造影检查,明确导致肩关节后不稳定的病理因素,针对其骨和软组织结构异常,采用骨性手术和软组织手术联合的方法(骨阻滞联合关节囊紧缩成形术)治疗。

Results The long term results of the vascularized fibular graft varied in different types of bone defects. Nine patients with congenital pseudoarthrosis of tibia had the limb function restored in 65% and one had nonunion of fibular graft, 3 fractures(7 times), and 5 angular deformities. Three patients with congenital radial deficiency had 62% restoration of the limb function. All of them showed early closure of epiphyses of the grafted fibulae. Five cases with osteomyelitis and bone defects combined soft tissue deficiency had 94% restoration of the limb function, and only one occurred fracture of fibular graft. One case with soft tissue defect and concomitant ulnar defect, ulnar nerve and median nerve injury, 67% function of limb was recovered, and union of fibula graft was good. 100% function of limb was recovered in 1 case with cavernoma of radius and without occurring valgus deformity of donor site.

结果应用带血管腓骨移植修复骨缺损的远期效果因缺损类型的不同而存在较大差异。9例先天性胫骨假关节患者,术后肢体功能恢复65%,其中移植腓骨骨不连1例、骨折3例(7次)、成角畸形5例;3例先天性桡骨缺如患者,术后肢体功能恢复62%,3例术后均出现移植腓骨骨骺线早闭,畸形复发;5例骨髓炎、骨外露、骨缺损并软组织缺损患者,术后肢体功能恢复94%,仅1例发生移植腓骨骨折;1例前臂软组织缺损并尺骨缺损,尺神经、正中神经损伤者,术后肢体功能恢复67%,骨愈合顺利;1例桡骨海绵状血管瘤者,术后肢体功能恢复100%,骨愈合顺利。

By the end of the 2 weeks' therapy, CT was used to determine the ratio in change of the tumor size, to estimate the ratio of tumor necrosis and to record the cases of radical resection, and bone marrow centesis was used to analyze the bone marrow depression, so as to learn the effects of the two methods on tumor therapy.

将24例WT患儿按临床分期、病理分型进行配对设计研究,TACE组12例,全身化疗组12例,治疗后2周用CT测量肿瘤的体积变化,术中测量肿瘤的坏死率、记录完整切除例数、骨髓抑制例数。

Results: The lesion located in the left choana region and left sphenoidal sinus of this case involved the left pharyngeal mucous space, left infratemporal fossa and its adjacent bone structure. CT showed that the rhinoscleroma in granulomatous stage was a soft mass which was irregular in shape, with a well-defined margin, inhomogeneous density and bone destruction. MRI showed heterogeneous hyperintensity on T1WI and isointensity on T2WI with an intermediate heterogeneous enhancement.

结果:病变起源于左侧后鼻孔及左侧蝶窦区,累及左侧咽粘膜间隙、左侧颞下窝及邻近骨质;结合本病例及文献复习,肉芽肿期鼻硬结病CT表现为不规则软组织肿块,轮廓清楚,密度不均匀,可见骨质破坏,残存骨质呈硬化改变;MRI表现为T1WI高信号T2WI等信号影,信号不均匀,增强后中度不均匀强化。

Bone induction is an important theory in the early 20th century. Urist found that bone morphogenetic protein could promote mesenchymal cell to differentiate into osteoprogenitors and chondroblast in 1965, thence many scholars went in for the significant work in this research field.

诱导成骨是近代发展的重要理论,Urist首先提出间充质细胞在骨形态发生蛋白的作用下可向成骨和成软骨方向分化,此后国内外很多学者在该领域进行了广泛深入的探索。

Bone marrow containing hematopoietic stem cells has already been known , theses another group stem cells exists in bone marrow named mesenchymal stem cells. MSCs retain the potentiality of differentiating into osteoblast, chondroblast, adipoblast, tendonblast, myoblast, cardiomyoblast, neuron, etc , which displays a bright prosperity of its use in tissue enigeering, wound healing , cell transplatation and gene therapy. MSCs can be obtained and expanded easily compared to ESC without any problems of morality , law and ethic , immunology.

最早在130年前,德国病理学家Cohnheim在研究创口愈合时就推测在创口愈合过程中出现的部分细胞可能来自骨髓。20世纪70年代,Friendenstein发现一小部分骨髓中贴壁最牢固的细胞经数此传代后形成独特的纺锤形外观,具有形成成骨细胞或软骨细胞的能力。80年代以来,许多研究小组进一步证实了Friendenstein分离到的这些细胞是多能的,在体外特定诱导条件下,可以分化为成骨细胞、软骨细胞、脂肪细胞、成肌细胞、神经元等,被称为骨髓间充质干细胞(Bone MarrowMesenchymal Stem Cells,MSCs)。

Mallory trichrism staining exhibited light blue samples. Eight weeks following repair, CT showed round blunt defect edges in the coronal position, which had bony pustute connection with gel materials. Density at the defect region significantly increased. 3D reconstruction suggested that defects became small. After hematoxylin-eosin staining, abundant fibrous connective tissue appeared in defect regions, with bony tissues. Mallory trichrism staining revealed that maroon mature bone tissues were found, surrounded by light blue chondroid tissues. Twelve weeks following repair, coronal defect regions were filled with callus. 3D reconstruction showed that defects were repaired. Defect region and surrounding bony tissues had bony connection, with thick bone trabecula and mature Haversian system.

修复后8周,冠状位CT显示缺损边缘圆钝,与凝胶材料有骨性突起连接,缺损处密度增高明显,三维重建显示缺损范围较之前有所减小;标本苏木精-伊红染色后缺损部可见大量含血管成分的纤维结缔组织,有骨样组织结构形成,Mallory三色染色显示有褐红色成熟骨组织形成,其旁边有淡蓝色软骨样组织修复后12周,冠状位CT显示缺损区基本被骨痂填满,三维重建示缺损基本修复;缺损区域和周围骨组织形成骨性结合,骨小梁粗大,哈弗氏系统成熟。

Percutaneous autogenous bone marrow grafting is capable of osteogenesis in the cicatricial bone defects.

经皮自体骨髓移植在骨缺损瘢痕组织内有成骨作用,在临床上可作为治疗骨不连的方法,尤其适用于骨不连部位软组织条件差、不具备开放植骨的病例。

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