查询词典 SLE

The clinical and laboratory findings of 2197 cases of systemic lupus erythematosus were reviewed and analyzed to reveal the abnormal incidence of each item and their value and specificify for the diagosis of the disease,Accor- ding to the realistic conditions of our country and the experience of many authors, a new set of diagnostic criteria for SLE was established and systematized into a computer program.

本文通过复习2197例SLE临床及实验室资料，分析各项目发生的异常率、早期表现率和对诊断的特异性，结合国内具体情况和多数学者的经验，综合分析拟定SLE评分诊断标准，并编成计算机诊断程序。经223例非SLE和92例SLE病例资料验证，其特异性为91.9％，敏感性达95.7％。

The major symptoms of SLE are the following: butterfly shaped Malar rash particularly on cheeks, discoidal rash, Photosensitivity, regular oral ulcers, nonerosive Arthritis, Pleuritis or Pericarditis, renal disorder, neurologic disorder, hematologic disorder, immunologic disorder, Anti-nuclear Antibody Test positive. Patients who are present any four of above symptoms can be clinically classifi-ed as SLE patients.

SLE的主要临床徵候包含：脸上呈蝴蝶状分布的红斑、身体出现圆盘状红斑、对阳光过敏、经常口腔溃疡、多发性关节炎、胸膜炎或心包膜炎、肾功能障碍、神经系统异常、血球计数异常、免疫系统异常、抗核抗体（Anti-nuclear Ab，ANA）阳性；只要在以上11项中出现四项以上即符合SLE的诊断。

Objective To detect the expression of CD70 in peripheral T lymphocytes of patients with systemic lupus erythematosus and the effect of azacitidine, an inhibitor of DNA methylation, on it. Methods Blood samples were obtained from 10 patients with active SLE （SLEDAI score ≥5）, 10 patients with nonactive SLE （SLEDAI score 5） and 10 normal human controls.

目的 通过研究共刺激分子CD70在SLE患者外周血T淋巴细胞的表达水平，以及DNA甲基化抑制剂氮杂胞苷对正常人外周血T淋巴细胞表达CD70分子的影响，探讨DNA甲基化在SLE患者外周血T淋巴细胞表达CD70分子中的调控作用。

Results The frequency of CD70+CD4+ lymphocytes was 14.55%± 5.49% in normal control group, 85.25%± 14.08% in active SLE group, 77.65%± 18.77% in nonactive SLE group, and 81.54%± 8.71% in methylation-inhibited group. Compared with the normal control group, a significant increase was observed in both the frequency of CD70+CD4+ lymphocytes （all P 0.01） and the expression of CD70 expression （all P 0.05） in other three groups.

结果 正常人外周血CD4+CD70+ T淋巴细胞阳性率为14.55%± 5.49%，活动期、非活动期SLE分别为85.25%± 14.08%和77.65%± 18.77%，甲基化抑制组为81.54%± 8.71%，与正常人对照组相比，活动期、非活动期SLE患者和甲基化抑制组CD70+CD4+ T淋巴细胞阳性率均明显升高（P 0.01），其外周血T淋巴细胞CD70 mRNA表达水平亦明显增加（P 0.05）；SLE患者外周血CD70+CD4+ T淋巴细胞阳性率与SLE疾病活动度呈显著正相关（r = 0.72，P 0.05）。

In this paper,we designed to investigate the frequencies of tumor necrosis factor receptor 2(TNFR2)polymorphisms at nt587 and nt694 in south Chinese SLE patients and healthy individuals and explore whether genetic variants in TNFR2 gene is involved in the pathogene- sis of SLE.

本研究通过调查中国南方SLE人群和健康对照人群中TNFR2基因两个位点(nt587，nt694)的多态性频率，探讨TNFR2基因多态性是否与中国汉族SLE人群的易感性相关。

Results 73 differentially expressed protein peaks were found between SLE patients and normal controls (P＜0.05), in which, 44 peaks had very significant difference (P＜0.01). Detection model of protein mass spectrometry (10542 Da m/z and 2554 Da m/z) was set up by ZUCIPDAS software with the discriminate rate and accuracy rate as 100%, which could distinguish the sample from SLE and normal persons. 10542 Da protein expression peak missed in SLE might be the mixed protein fragments peak of HLA gene family, while the 2554 Da protein expression peak might be a SLE-specific unknown protein.

结果SLE患者治疗前与正常人比较，找出差异表达蛋白峰73个（P.05），其中44个峰有非常显著性差异（P.01），用ZUCIPDAS软件建立的蛋白质质谱检测模型（10542 Da m/z和2554 Da m/z）的判别率和正确率均为100%，可以通过以上两个峰将SLE与正常人区别开来，10542 Da SLE缺失表达的质荷峰可能是HLA基因家族相关的多个蛋白片段的混合峰，而2554 Da可能是SLE特异表达的未知蛋白峰。

The incidence of ONFH in patients with SLE is relatively hish within the first 3 years of SLE.The SLE Patients with ONFH are mole likely to have such clinical features as vasculitis,osteoporosis,high level of blood platelet,serum LDL-C and fibrinogen and exposed to high-dose glucocorticoid therapy.

在SLE病程3年之内发生ONFH的危险性相对较高，SLE并发ONFH患者多数具有皮肤溃疡、坏疽等皮肤血管炎以及血小板、Fib、LDL-C升高和骨密度低的表现，且多数患者经过大剂量糖皮质激素治疗。

Results The late-onset SLE patients accounted for19.7% of the homochronous admission SLE cases.

收集晚发SLE(发病年龄≥50岁)102例和同期早发SLE(发病年龄＜50岁)415例患者资料，比较分析两组的临床表现、实验室指标。

Methods Eighty-three hospitalized patients with SLE admitted between 1996 to 2002,42 patients with neuropsychiatric lupus,41 patients with no clinical neuropsychitric disorders of SLE.

方法对83例SLE患者进行回顾性分析总结。42例为神经精神狼疮患者；41例为无临床神经精神症状的SLE对照组。

Results:The levels of CD4+T cells in active and remissive SLE were significant lower than normal controls; the positive rate of CD4+CD25+T cells in both active and remissive SLE was higher than that in normal controls; the levels of IL10 in active stage of SLE were significant higher than in remissive stage of SLE or in normal controls.

结果：活动性和非活动性SLE 患者CD4+T细胞总数均低于正常对照者；活动性和非活动性SLE患者CD4+CD25+T细胞阳性率高于正常对照者；活动性SLE患者IL10浓度显著高于非活动性SLE患者和正常对照者。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐