查询词典 Rho

According to these findings, we suggest that PT-262 is a potential anticancer drug, which regulates the actomyosin contractility and migration inhibition mediating by Rho/ROCK/MLC pathway in the human lung cancer cells.

综合以上结果，我们推测PT-262是一种有潜力的抗癌药物，经由抑制Rho/ROCK/MLC路径，调控人类肺癌细胞肌动球蛋白的收缩和抑制癌细胞移行的作用。

Objective To investigate whether Rho/Rho kinase is involved in the pathogenesis of aldosterone/salt-induced renal injury.

目的 观察Rho/Rho激酶通路是否参与醛固酮加氯化钠诱导的肾脏损伤并探讨可能的机制。

Since dominant negative Rac1 or Cdc42 failed to affect cytokinesis, it was concluded that only Rho is required.

再加上dominant-negative Rac1 和Cdc42 并会造成前述的现象，所以我们推只有Rho 对早期斑马鱼胚的及原肠化是必须的。

Objective To observe the role of Rho kinase in vascular hyporeactivity following hemorrhagic shock in rats.

目的 观察Rho 激酶在失血性休克大鼠血管低反应发生中的作用。

RhoA is an important member of Rho GTPases and is involved in leukocyte migration.

RhoA是Rho GTP酶的重要成员，其参与白细胞移动。

Similarly, there are simple randomized in-place algorithms for primality testing such as the Miller-Rabin primality test , and there are also simple in-place randomized factoring algorithms such as Pollard's rho algorithm .

类似地，对於质数测试有简单的随机化原地算法像是米勒-拉宾检验，也有简单原地随机化整数分解算法像是 Pollard's rho 算法。

In our previous study we have successfully expressed Rho in Pichia pastoris and showed that recombinant Rho retains its activity and structure.

在前期的研究中我们成功地用酵母菌Pichia pastoris 表现Rho 并证实重组 Rho 具有正确的活性及结构。

The expression of p-p38 and Rho GDIαwas upregulated in LCA by either low shear stress or hypertension. However, the highest expression of p-p38 and Rho GDIαwas observed in LCA of low shear stress accompanied by hypertension.(4) Effect of low shear stress on both decreasing apoptosis and increasing proliferation of VSMCs in LCA was reversed by tributyrin, a HDAC inhibitor.

当高血压伴有低切应力时，两者的协同作用诱导p-Akt的表达水平进一步增加；(3)高血压和低切应力都可以诱导颈总动脉p38和Rho GDIα表达增加；当高血压伴有低切应力时，两者的协同作用诱导颈总动脉p38和Rho GDIα表达进一步增加；(4)HDAC抑制剂Tributyrin可以通过抑制VSMCs增殖，促进VSMCs凋亡，在干预低切应力诱导的血管重建中发挥作用。

Mechanical strains also regulated the protein and mRNA expression of several differentiation markers, as well as the activation of extracellular signal-regulated kinases, p38 MAP kinase and protein kinase B in a frequency-dependent manner. Furthermore, the inhibition of p38 pathway could block the strain-frequency induced the phenotype modulation of VSMCs, neither ERKs nor Akt. Frequency of mechanical strain, not conditioned medium, regulated the phenotype of VSMCs in a frequency-dependent manner. Rho-GDI alpha was suppressed by the mechanical strain at 1Hz.

采用免疫细胞化学法检测VSMCs形态和排列的变化；RT-PCR和Western blotting检测表型标志分子α-肌动蛋白、肌球蛋白重链(SM1/2)、肌动蛋白相关蛋白SM22α和调宁蛋白(h1-calponin)的mRNA和蛋白水平的变化；抑制剂或RNA干扰阻断可能的信号调节分子的活性或表达，包括p38、细胞外信号调节激酶1/(2extracellular signal-regulated kinases， ERK1/2)、蛋白激酶B和Rho-鸟苷酸解离抑制因子(Rho-guanine nucleotide dissociation inhibitor， Rho-GDI alpha)，研究了不同频率张应变对VSMCs表型转化的影响及其调节机制。

Recent studies showed that Rho GTPase played a key role in the reorganization of cytoskeleton and in Swiss 3T3 cells, Cdc42, Rac1 and RhoA, three members of Rho superfamily of small GTPase, regulated the polymerization of actin to produce filopodia , lamellipodia, stress fiber and focal adhension, respectively.

近年来的研究表明，Rho家族小G蛋白是细胞骨架肌动蛋白的重要调节因子，目前众多的研究集中在Rho小G蛋白家族成员中的Cdc42、Rac1和RhoA，其中Cdc42促进丝状伪足的形成，Rac1调节板装伪足的生成和膜皱缩，RhoA则促进粘着斑连接和张力纤维的装配。

By the time of its fall, most of the prisoners were writers who had written against the corruptions of the government.

到它被攻陷的时候，里面多数的犯人是写了反对政府贪污文章的作家。

The most obvious variation to ovum morphological character was that the color was changed from light green to sepiaceous in embryonic development, and all the ovums were almost hatched after 96h.

在胚胎发育过程中卵的形态特征最明显的变化是颜色从淡绿到深褐色，卵在发育96h后卵基本全部孵化。