查询词典 RA

Scientists compared gene expression patterns of 11 pairs of monozygotic twins, who shared the same egg and were genetically identical, but only one of them had RA.

美国密歇根大学医学院研究人员在风湿性关节炎或者风湿病中发现了三种过量表达基因，研究人员先前并不知道这三种基因与这些疾病有关。

After the second PCR amplification, sixteen differential bands were screened out, of which eleven were co-expressed in P35 female and P45 male, five were only expressed in female at P45, which might underlie the genetic mechanism of the RA dimorphic development in white-rumped munia.

二次PCR扩增后，进一步筛选出16个差异条带，其中11个为P35雌性和P45雄性共同表达的，5个是P45雌性特异表达的。

Results:(1) FSN can inhibit secondary joints swelling and multi-arthritis evidently, improve the whole condition of rats; at the same time, it can also lighten the synovial inflammation and hyperplasia of lesion joints distinctly, and prevent the joint cartilage and bone from destruction; the collective efficiency of FSN is better than TWP.(2) FSN can raise AA rats low LTT of spleen to normal nearly, remedy the disorder of Th / Ts and Thl / Th2 cells balance in peripheral blood, restrain exorbitant TNF- a ? IL-1 produced by PM O , thereof exert anti-inflammatory and immunoregulation effect.(3) Inside the lesion joints, FSN can depress abnormal hyper-expression of TNF- a mRNA and NF-kB in synovial tissues, as well as advance the expression of Caspase-3 (a proteolytic enzyme of apoptosis), reduce synovial immflamination and proliferation.(4) FSN can lower the expression of VEGF in synovial tissue,reduce neogenetic veins, so inhibit the growth of pannus tissue and the damage of cartilage and bone by that.(5) The above effect of FSN are in proportion to its dosage.Conclusions: FSN has inhibitory effects on symptom and condition of experimental RA, which is better than TWP as a whole.

结果：(1)FSN有明显的抗炎作用，可显著抑制AA大鼠足跖肿胀与多关节炎，改善大鼠的全身情况，同时明显减轻病变关节滑膜炎症与增生，防止关节软骨及骨质的破坏，其综合作用优于TWP；(2)FSN还能使AA大鼠低下的脾LTT恢复至接近正常，纠正外周血中T细胞亚群Th／Ts及Th1／Th2平衡紊乱，抑制大鼠PHφ过高的TNF-α、IL-1分泌，而发挥抗炎和免疫调节作用；(3)在病变关节局部，FSN能显著抑制AA大鼠滑膜细胞异常增高的TNF-αmRNA的表达，降低滑膜组织中NF-kB表达，并增加凋亡蛋白酶Caspase-3表达，从而抑制滑膜的炎症与增殖；(4)FSN还可下调滑膜组织中VEGF表达，减少血管新生，由此抑制血管翳的形成及其对软骨和软骨下骨的侵蚀；(5)FSN的上述作用皆呈现一定的量效依赖关系，高剂量组作用优于低剂量组。

FSN can raise AA rats low LTT of spleen to normal nearly, remedy the disorder of Th/Ts and Th1/Th2 cells balance in peripheral blood, restrain exorbitant TNF-α、IL-1 produced by PMφ, thereof exert anti-inflammatory and immunoregulation effect.(3) Inside the lesion joints, FSN can depress abnormal hyper-expression of TNF-αmRNA and NF-kB in synovial tissues, as well as advance the expression of Caspase-3 (a proteolytic enzyme of apoptosis), reduce synovial immflammation and proliferation.(4) FSN can lower the expression of VEGF in synovial tissue, reduce neogenetic veins, so inhibit the growth of pannus tissue and the damage of cartilage and bone by that.(5) The above effect of FSN are in proportion to its dosage. Conclusions: FSN has inhibitory effects on symptom and condition of experimental RA, which is better than TWP as a whole.

结果：(1)FSN有明显的抗炎作用，可显著抑制AA大鼠足跖肿胀与多关节炎，改善大鼠的全身情况，同时明显减轻病变关节滑膜炎症与增生，防止关节软骨及骨质的破坏，其综合作用优于TWP；(2)FSN还能使AA大鼠低下的脾LTT恢复至接近正常，纠正外周血中T细胞亚群Th/Ts及Th1/Th2平衡紊乱，抑制大鼠PMφ过高的TNF-α、IL-1分泌，而发挥抗炎和免疫调节作用；(3)在病变关节局部，FSN能显著抑制AA大鼠滑膜细胞异常增高的TNF-αmRNA的表达，降低滑膜组织中NF-kB表达，并增加凋亡蛋白酶Caspase-3表达，从而抑制滑膜的炎症与增殖；(4)FSN还可下调滑膜组织中VEGF表达，减少血管新生，由此抑制血管翳的形成及其对软骨和软骨下骨的侵蚀；(5)FSN的上述作用皆呈现一定的量效依赖关系，高剂量组作用优于低剂量组。

We found that 1 mutant EG4 cells showed typical characteristics of pluripotent stem cells which had no obvious difference with wild cells; 2 When induced by 10〓 M retinoic acid , mutant EG4 cells differentiated into adipocytes with high frequency compared with mutant cells, suggested that EGFR plays a role in adipocyte differentiation; 3 when injected into nude mice, mutant teratocarcinomas contained a large amount of connective tissues as well as skeletal muscle, while wild EG4 cells produced frequently cartilage, keratinocyte and neuroepithelium.

我们建立了稳定表达胞内区功能缺失的外源EGFR cDNA片段的EG4细胞，分析其生长分化特性，发现 1）突变型细胞可在未分化状态下维持长时间的增殖，表明EGFR对EG多能干细胞表型无明显影响；2）〓 M的维甲酸A(retinoid acid A，RA)诱导后，大部分对照组细胞分化为脂肪细胞，而突变型细胞分化为脂肪细胞的比例明显较少，表明EGFR在脂肪细胞的发育分化中具有一定的调节作用；3）畸胎瘤切片分析显示，突变型瘤组织分布有大量的未分化细胞和结缔组织，分化细胞以肌肉细胞为主；对照组瘤组织含丰富的角质上皮、软骨、神经管等依赖EGFR的分化组织。

DM Armstrong, Universals and Scientific Realism: Nominalism and Realism, I; FJ Copleston, History of Philosophy, III; RA Eberle, Nominalistic Systems; R. Seeberg, Text-book of the History of Doctrines, II.

马克阿姆斯特朗，共性和科学实在：唯名论与现实主义，我；福建Copleston ，哲学史，三；类风湿性关节炎埃贝勒，唯名论系统；河西贝尔格，文字书史的理论，二。

TNF - ais one of important nosogenetic factors of RA. Insulin - like Growth Factor - 1 (IGF - 1) is a kind of polypeptid, which has similar structure to insulinogen.

胰岛素样生长因子(Insulin-like Growth Factor，IGFs)是一类结构上类似胰岛素原的多肽，在细胞的生长、分化及代谢的调节中起重要作用。

NADP-Dependent Retinol Dehydrogenase/Reductase identified from rabbit liver cytosol is involved in oxidoreduction between retinol and retinal with high activity. Therefore, NRDR plays an important role in modulation of the retinoids and RA homeostasis.

辅酶Ⅱ依赖性视黄醇脱氢/还原酶NADP(H-Dependent Retinol Dehydrogenase /Reductase NRDR是黄东阳教授等从兔肝中发现并纯化的一种酶，具有很高的催化视黄醛和视黄醇之间氧化还原反应的活性，对体内类视黄醇和维甲酸的代谢平衡起着重要的调节作用。

Results MRI results showed that synovial hyperplasia and enhanced pannus in the wrists could be seen in all the cases, while hone marrow edema, hone erosion and joint effusion could be seen in 65, 50 and 54 cases respectively.

结果78例早期RA的MKI征象：滑膜增厚78例，血管翳强化78例，骨髓水肿65例，骨侵蚀50例，关节积液54例，腱鞘炎3例。

Rheumatoid arthritis is a chronic autoimmune disease, which is characterized by synovium inflammation, hyperplasia and pannus formation, leading to bone and cartilage destruction.

类风湿性关节炎（rheumatoid arthritis，RA）是一种慢性自身免疫性疾病，以滑膜细胞炎症和细胞过度增殖、血管增生为特征，最终可导致骨和软骨的破坏。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。