查询词典 RA

Material and MethodsRA Rabbit Model group: 15 early RA rabbits of the same weight and variety Control group:10 normal rabbits of the same weight and varietyMethods of making RA rabbit model:elect 15 normal rabbits of the same weight and variety, dissolve Ovalbumin in 0.9% sodium chloride solution, to make the solution of 20mg/ml concengtration, blend the same quantity of complete Freund′s Adjuvant equably ,inject the mixed solution into endermic tissue of the rabbit′s scapular section, making the rabbits allergic, inject 1 ml of the mixed solution to one rabbit every time, inject 1 ml of the mixed solution in 5 different places of the rabbit′s scapular section, inject the rabbit one time every week,inject 3 weeks continuously,it turned out to be that the rabbits will be allergic, inject Ovalbumin blent with the 0.9% sodium chloride solution into the knee joint cavity of the rabbits in the fourth week, 5 mg Ovalbumin every knee joint cavity,two knees of every rabbit of the 15 rabbits are both injected,the arthrosis diameter and the exterior temperature of the knees will be added obviously in 24 hours,and they will drop gradually,at the time of the 14th or 21th day, the arthrosis diameter and the exterior temperature of the knees will get to the balance time,the incidence rate of RA is 100%.after the RA model succeeds,it is the early time of RA from the first week to the fourth week,after the fourth week,it is the late time of RA, the cartilage of the femoral condyle and the subchondral bone cortices will be changed unrecoverily.

资料与方法RA模型组：早期RA家兔模型15只，品种及体重接近。对照组：正常家兔10只，品种及体重接近。RA家兔模型制作方法：选取15只成年家兔，体重、品种接近，将卵蛋白溶解于生理盐水，配成浓度为20mg/ml的溶液，与等量完全弗氏佐剂混匀，注入家兔肩胛区皮下致敏，每只家兔每次注射1ml，于肩胛区5个不同区域注射，每周一次，连续注射3周而致敏，第4周向膝关节腔注射卵蛋白生理盐水溶液，每只关节腔注射5mg卵蛋白，15只家兔膝关节全部注射，24h内此关节直径和表面温度大幅度上升，以后缓慢下降，至14～21d达到平台期，发病率达100%。造模成功后第1～4周为早期改变，第4周以后出现不可逆的关节软骨及骨破坏。采用高频超声对RA模型组与对照组的膝关节髌上囊液体厚度、滑膜及股骨髁软骨厚度及软骨下骨皮质的回声情况进行对比观察。结果RA组模型组膝关节髌上囊积液及滑膜的厚度明显厚于对照组，其股骨髁软骨的厚度与对照组相比无明显差异，其软骨下骨皮质与对照组相比无明显改变。

RA was observed to have a tendency towards family aggregation, as the morbidity of RA was up to 30% in monovular twins, 5% in non-identical twins, which demonstrated the occurrence of RA associated to genetic factors.

有研究发现RA有家族聚集倾向，单卵双生子发病率为30％，双卵双生子为5％，说明RA发病与遗传因素有关。

PLT and PCT of RA patients in active phase were increased, and have correlation with reactive indexes. It suggests that PLT, PCT can reflect reactiveness of RA as objective indexes. XFC can not only treat inflammation and delay the aggravation of RA patient by improving platelet ultrastructure.

活动期RA患者PLT、PCT显著升高，且与各活动性指标具有相关性，提示PLT、PCT可作为反映RA活动性的客观指标；新风胶囊能通过改善血小板超微结构从而减少CD62P释放来改善RA患者的关节炎症病变，延缓病情进展。

MPV assumed to he negative correlation with arthrocele, violet and dark oral lip, scaly skin. Conclusion:(1) PLT, PCT is relevant with RA patients' condition, this can he an index of operative of disease.(2) PLT, PCT, MPV is relevant with the symptom of RA's stagnation of blood, this can he an index of laboratory.

(1)PLT、PCT与RA病情变化有关，可作为判断RA疾病活动的临床指标；(2)PLT、PCT、MPV与RA血瘀证症状相关，可作为指导临床辨证用药及判断中医药疗效的实验室指标。

Objective: RA is an autoimmune chronic systemic disease, characterized by inflammation, self-immune and the hyperplastic synovial pannus.

目的：类风湿关节炎(rheumatoid arthritis，RA)是一种慢性系统性疾病，其主要病理改变是滑膜炎和血管翳形成及其相关的血清组织中多种细胞因子、抗原抗体和粘附分子等的变化，而细胞因子是RA炎症和损伤的重要介质，对RA患者外周血及滑液中细胞因子改变已有大量研究，已证明多种细胞因子参与RA的病变过程。

There were significant differences between RA and non-RA groups in morning stiffness, symmetric arthritis, rheumatoid factor positivity, erythrocyte sedimentation rate, C-reactive protein and synovial hyperplasia, enhanced pannus, bone marrow edema as well as bone erosion.

晨僵、对称性关节肿胀、类风湿因子(rheumatoid factor， RF)阳性、血沉(erythrocyte sedimentation rate， ESR)增快、C反应蛋白(C-reactive protein， CRP)值升高诸指标在RA组与非RA组之间具有显著差异性。MRI各主要征象中滑膜增厚、血管翁强化、骨髓水肿、骨侵蚀诸指标RA组与非RA组之间具有显著差异性。

TyPe II collagen induced arthritisln the rat ank1e joint andoVathumin as antigen induced arthritis WA in the rabbit knee joint wereestab1ish2 Qualitative evaluation of me in skin, muscle, synovium, cedilagearound joint and blood was performed by OMA3 The CIA rats were treated on day 7 after hind paw swelling and erythemaAnimals were injected intravenously with ase at a dose of 10mg/kg,tWenty minuots 1ater, one ankle of the rats random1y assigned was exPosedlaser irradiation at l00J/cm fOr l000 seconds, and another ankle wasM grouP wihout laser The other two groups is unmanipulatedcontrol group and untreated CIA group Bimaleolar ankle widthmeasuremellts were taken in all animals every tWo days using amicrometer The histopathology of the ank1e Joint was assessed at day 21after disease onset4 The pro1iferating cell nuclear antigen WCNA of CIA treated by PDT andthe HMME group without laser was doterdrined by immunohistochemiStry5 The AfA rabbits were treated on day 7 after knee swelling and erythemaThe theraPy invo1ved lntravenous injection of l0mg/kg HMME, fOl1owedby 20 minues period in dim light, and transdermal light treatment with\l00 J/cm2 fOr l000 seconds The inner sides of the treated Anees wereirradiated at first, and then the outer side did 24 hours later, the synovialtissue of the Anees joint were removed and in situ cel1 aPoptosis wasdetCCted With tednal deoxync1eotidyl transferase-mediated dUTP nickend labelingR6suIt8:l The pathologic changes of CIA and AIA include subsynovial inflammation,opovial hyPerplasia, pannus formation, cartilage and bone destructionresemble RA.2 The studies demonstrated that there are different uptake of HMME withinskin, muscle, synovium, cartilage and b1ood, and the synovium cou1draPidly uPtake more ase than skin and cartilage at the firSt 30 minuesaller intravenous injection of HMME3 The bimaleolar anke width had no different among PDT treated group,H group withollt 1aser and untreated CIA group But hlstologicalevaluation showed statiStical1y significallt reductions in synovialhyperplasia, pannus formation and cart1lage reosion, bone destruction andtotal score in PDT treated group4 Image analysis showed that the ratlo bforeen the areas of the coufltedobect to that of the entire area in PDTtreated grOup is lower than that in conirol group, but the integrated oPticaldensity had no different between the two groups5 Imape analysis showed that the ratio between the area of the countedobject to that of the e

治疗组在大鼠出现踝关节红肿后1周，炎症达到高峰时进行PDT治疗。随机治疗大鼠一侧的踝关节，另。2。一一侧作单纯HMME 对照。治疗方法是大鼠麻醉后尾静脉注入 HMME10ngkg，20分钟后踝关节照光，激光波长627.sum，功率密度 100mwcm'，照射时间1000秒，能量密度100）／。治疗后避光喂养72 小时。隔日一次测量大鼠的踝关节左右横径，治疗后两周取关节进行病理d 观察。 4。大鼠CIA模型用上述方法进行PDT治疗后，治疗组和单纯HMME 组用兔疫组化SP法检测石蜡切片的核增殖抗原。 5。兔AIA模型在关节炎出现第七天进行PDT治疗，随机治疗一侧膝关节，另一侧作自身对照。兔耳静脉注入I'arrainrelomg／Kg，20分钟后，膝关节用金蒸气激光照射，激光能量密度100）儿旷。24 ／J'时后取膝关节滑膜作病理检查，并用脱氧核昔酸末端转移酶介导的缺口末端标记法原位检测凋亡细胞。结果： 1。模型观察：CIA大鼠炎症高峰期滑膜下炎细胞浸润明显，滑膜细胞明显增殖，炎症达到高峰后二周，血管缀形成，并侵蚀和破坏软骨和骨， CIA模型病理改变与人类RA相似。兔AIA模型膝关节滑膜病理可见滑膜细胞增生，滑膜下炎细胞浸润，也与人类RA滑膜改变相似。 2。关节周围组织中光敏剂含量的测定结果表明，各组织对HMME 的吸收速度和吸收量不同，荧光值一时间曲线不同，滑膜组织比皮肤和软骨对 HMME的吸收多，在 2 0分钟时即有明显差异。 3.PDT对CIA模型的治疗结果表明：PDT治疗后关节炎组、单纯 HMME组和治疗组踝关节左右横径统计学检验差异没有显著性，但病理评分PDT治疗组滑膜增生、血管资形成及软骨破坏、骨破坏和总分比关节炎对照组和HMME对照组好，统计学检验差异有显著性。。3＿军医进修学院硕士学位论文中文摘要 4.PDT治疗组PCNA阳性细胞较对照组少，图像分析结果表明面密度（阳性染色的面积总和与统计视野面积的比值）治疗组小于对照组，统计学检验差异有显著性。。 5.PDT治疗组凋亡阳性细胞较对照组明显增多，图像分析结果单位视野内阳性细胞数和面密度PDT治疗组高于对照组，统计学检验差异有显著性。凋亡细胞核直径PDT治疗组较小，与对照组相比，统计学检验差异有显著性。结论：二。CIA、AIA的病理改变类似人类RA，可作为研究RA病因、发病机制、检查及治疗方法的模型。 2。各组织对HMME的吸收速度和吸收量不同，滑膜组织比皮。

The six kinds of nanoparticles water dispersion were as follows:rotenone/carboxymethyl chitosan-grafted-ricinoleic acid(Rot/CMC-g-RA), azadirachtin/carboxymethyl chitosan-grafted-ricinoleic acid(Aza/CMC-g-RA),capsaicin/ carboxymethyl chitosan-grafted-ricinoleic acid(Cap/CMC-g-RA),rotenone/ricinoleic acid sodium,capsaicin/ricinoleic acid sodium,azadirachtin/ricinoleic acid sodium.

分别为：鱼藤酮/羧甲基壳聚糖接技蓖麻油酸共聚物(Rot/CMC-g-RA)、辣椒碱/羧甲基壳聚糖接技蓖麻油酸共聚物(Cap/CMC-g-RA)和印楝素/羧甲基壳聚糖接技蓖麻油酸共聚物(Aza/CMC-g-RA)纳米粒子水分散制剂，以及鱼藤酮/蓖麻油酸钠、辣椒碱/蓖麻油酸钠和印楝素/蓖麻油酸钠纳米粒子水分散微乳液。

Expect for a few pittings,the N+1-implanted surface had a best fineness (average roughness Ra≈4.2nm), close to the unimplanted original surface.The N+2-implanted surface had a black dendritic area,and had a poorer fineness (Ra≈16nm).While in the N+10-implanted surface appeared a ripple structure,with the poorest fineness (Ra≈40nm).

但其表面形貌各异：N+1注入的表面除存在少量点蚀坑外，光洁度最高(平均粗糙度Ra≈4.2nm)，接近未注入前的原始表面(Ra≈3.5nm)；N+2注入的出现黑色枝状区域，光洁度次之(Ra≈16nm)，而N+10注入的则出现&波纹&状结构，光洁度最差(Ra≈40nm)。

It comprises: CN pages call and the page message carries the sonic service information, as the sonic service of CS region; UE responds page, and sends the sonic service information to RNC in the initial access request message; RNC receives request and makes sure it is sonic service of CS region, to decide one sonic speed parameter Rm, and based on the resource demand, to build one wireless chain and ground load between Iub interface signal and service, and the signal and service load of wireless interface; UE and CN processes QoS consultation, and CN sends the consulted Qos parameter to RNC, which comprises a sonic speed parameter Ra of this service; RNC compares parameter Ra and Rm, if Ra is higher then Rm, builds the ground load of Iu interface and sends distribution answer message to CN to continuously page answer process.

一种WCDMA系统被叫侧语音呼叫的快速建立方法，包括步骤：CN寻呼被叫，寻呼消息中携带语音业务信息，指明是CS域的语音业务；UE响应寻呼，在初始接入请求消息中将所述语音业务信息传递到RNC；RNC收到请求并获知是CS域的语音业务后，决策出一个语音速率参数Rm并基于其对资源的要求，建立Iub接口信令和业务的无线链路及地面承载，以及无线接口的信令和业务承载；UE和CN进行QoS协商，CN将协商得到的Qos参数指派给RNC，其中包括本次业务的语音速率参数Ra；RNC比较参数Ra和Rm，如果Ra≥Rm，则建立Iu接口的地面承载，向CN发送指派应答消息，继续呼叫应答过程。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。