查询词典 Promoter

In this paper, we describe an approach for understanding transcriptional regulation from both gene expression and promoter sequence data.

在这篇文章中，我们描述了从基因表达和启动子序列数据中理解转录调控的一种方法。

In normal growth conditions, the RNR3 promoter is transcriptionally silent.

在正常生长条件下，RNR3基因不转录，当酵母细胞DNA受损伤，如UV、MMS作用；或是DNA合成阻断剂如HU都可以诱导RNR3的转录。

MOTIVATION: In order to facilitate a systematic study of the promoters and transcriptionally regulatory cis-elements of the yeast Saccharomyces cerevisiae on a genomic scale, we have developed a comprehensive yeast-specific promoter database, SCPD.

动机：为了促进在基因组范围上对酵母中启动子和转录调控顺式调控元件的系统性研究，我们开发了一个全面的酵母特异的启动子数据库----SCPD。

An annotation is any feature that can be tied to genomic sequence, such as an exon, transcript, promoter, or transposable element.

注释是可以束缚在基因组序列上的任何特征，例如外显子、转录物、启动子或转座元件。

The recombinant MA can undergo trimerization and the NC contains an I domain that can promoter Gag-Gag interaction. Previous studies have shown that the assembly function of NC in Gag can be replaced by sequences that dimerize or multimerize.

MA有聚合的能力，而NC上的I domain也能促进Gag-Gag之间的聚合作用，研究证实，以一种能促使蛋白间产生聚合作用的序列可取代NC 在Gag组装过程中的角色。

This implies that DNA methylation of promoter exon 1_7 may not underly the mechanism of GR up-regulation in GLP-1 -programmed rats.5 Hippocampal expression of GLP-1R and NGFI-A mRNAHippocampal GLP-1R (p =.009) and NGFI-A (p =.001) gene mRNA expression were significantly up-regulated in GP group as compared to VP group.Taken together, neonatal intramuscular injection of plasmid DNA encoding GLP-1 affects behavior and hippocampal GR expression in adolescent rats.

提示GR exon 1_7启动子区域DNA甲基化可能不参与GLP-1导致的GR转录上调。6海马GLP-1R和NGFI-A mRNA表达GP组大鼠GLP-lR(P=。009)和NGFI-A(P=。001)表达均显著高于VP组，表明肌肉注射GLP-1可能通过作用于其海马受体提高NGFI-A表达，进而调控GR表达。

In uninduced HEL cells, GATA-2 transcription factor can specifically bind to the regulatory elements of human β-globin gene, including the proximal regulatory element (theβ-promoter) and the distal regulatory elements (the DNaseⅠ hypersensitive sites in the locus control region, HS2-HS4 core sequences).

在非诱导的HEL细胞的核蛋白中，能够与β—珠蛋白基因的近端启动子调控序列及远侧端LCR调控序列（HS2，HS3和HS4核心DNA序列）相结合的蛋白质主要是GATA—2转录因子，而在羟基脲诱导的HEL细胞核蛋白中，与上述调控序列相结合的蛋白质主要是GATA—1转录因子。

The promoter and partial GAG domain of CFG1 element are unmethylated, however, the partial RT domain is highly methylated.

CFG1元件的启动子和部分组特异性抗原域处于未甲基化状态，而部分RT域则处于高度甲基化状态。

HTERT is expressed in cancer cell lines despite promoter DNA methylation by preservation of unmethylated DNA and active chromatin around the transcription start site.

人端粒酶逆转录酶是一种核糖核蛋白酶，由端粒RNA和端粒酶蛋白组成的一种特殊逆转录酶，在激活端粒酶的过程中起限速作用，能以自身RNA为模板合成端粒序列以稳定端粒长度使细胞获得永生，也是人类端粒酶的活性中心，其表达是端粒酶活化的必须前题［2～4］。

The gene chip detecting methylation changes of 3 CpG in promoter region of p16 gene was constructed by designing a pair of probes which contain one methylated and one unmethylated probes. This pair of probes was used to detect 3 consecutive sites of CpG island in p16 gene.

设计1组特殊荧光标记探针以构建1种检测p16基因启动子区3个CpG位点甲基化改变的芯片，特殊荧光标记探针包括1对非甲基化探针和甲基化探针，检测相邻的3个CpG位点甲基化的程度。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。