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The present invention relates to sulphonyloxazolamines of general formula, wherein R, R represent independently from each other H, A,-(CH2)n-Ar or alkenyl with 2-6 C atoms, R and R together also represent a mononuclear saturated heterocycle with 1-2 N, O and/or S atoms, Z is H, A, CF3, NO2, Hal, OH, OA, NH2, NHA or NA2, A represents alkyl with 1-6 C atoms, Ar is Z-monosubstituted or Z-disubstituted phenyl, halogen is F, Cl, Br or I, n is 1 or 2 or the physiologically acceptable salts or solvates thereof.

本发明涉及式磺酰基∴唑胺或其生理上可接受的盐或溶剂化物，其中R 1 ，R 2 每一个相互独立为H、A、－(CH 2 )n－Ar或具有2到6个C原子的链烯基，R 1 和R 2 也一起为具有1到2个N、O和/或S原子的单核饱和杂环，Z为H、A、CF 3 、NO 2 、卤素、OH、OA、NH 2 。NHA或NA 2 ，A为具有1到6个C原子的烷基，Ar为被Z取代的或Z二－取代的苯基，卤素为F、Cl、Br或I，n为1或2。

Full-term pregnancy of primipara 120 cases of illness; Stochastic double divides into three groups: research of group-A group and B group. control group of C group, A group (n=40), 0.75% levobupivacaine 10mg for CSEA, B group (n=40), 3% chloroprocaine the hard membrane pericoel hinders, C group: 0.75% bupivacaine for under the arachnoidea the cavity hinders the anaesthesia, In surgery process, to A and B groups, 2% lidocaine were intermittently injected respective-ly by epidural cathete, effec not enough of anesthesia.

足月初产妇120例随机双盲分成三组：研究组为A组和B组，对照组为c组。A组(n=40)蛛网膜下腔阻滞麻醉用药为0.75%左旋布比卡因10mg，使用腰麻硬膜外联合阻滞行剖宫产术，B组(n=40)以3％氯普鲁卡因为硬膜外麻醉的局麻药，使用硬膜外麻醉阻滞行剖宫产术，c组(n=40)腰麻用药为0.75%布比卡因10mg，使用腰麻硬膜外联合阻滞行剖宫产术。

In this thesis,the AM1,MNDO,MINDO/3(mainly AM1)and INDO/S-CI semiempirical MO methods were used toinvestigate the excited-state intramolecular protontransfer reactions of salicylic acid derivatives—salicylic acid,methyl salicylate,salicylaldehyde,o-hydroxyaceto-phenone,salicylamide and 3-hydroxy-picolinamide (6 conformers and 2-3 anion species);2-(2'-hydroxy-5' methylphenyl) benzotriazole(4 conformers),2-(2' hydroxyphenyl) benzimidazole (3 conformers and 3anion species),Bis-2,5-(2-benzoxazolyl)hydroquinone(3 conformers),2-(2'-hydroxyphenyl)benzothiazole(2conformers) and 7-azaindole dimer (2 conformers).Theinvestigations were described as follows.Geometry optimization,relative stability andhydrogen bonding energy First,for sylicylic acid derivative molecules,the AM1,MNDO and MINDO/3 methods were used toinvestigate ground-state geometry optimization,energies,relative stabilities and hydrogen-bondingenergies on the five kinds of the molecules(designing 6 conformers and 2-3 anion species).Comparing with experimental data,the optimizedgeometry,the order of stability,the hydrogen-bonding energies and the distances between O-O in O-H..O hydrogen bonds by AM1 method were in agreementwith the experimental data,however,the C-C bondlengths optimized by MNDO and MINDO/3 were longer,C-O and O-H bond lengths were shorter;for C-N bondlengths,the results opitimized by MNDO method werethe same as those by AM1 method,nevertheless the C-Nbond lengths given by MINDO/3 method were muchshorter.For some sylicylic acid derivatives(e.g.methyl salicylate,salicylamide),the order ofstabilities on the conformers given by MNDO andMINDO/3 methods were not in agreement with theexisting conformers deduced by experimental methods,and the hydrogen bonding energies calculated by MNDO.and MINDO/3 methods were smaller.Second,the studyon the other systems found that the optimizedgeometry of the proton-transfered product with INDOmethod could not be obtained,only could theoptimized geometry of reactant be obtained,and thecalculated hydrogen bonding energies were greater.Many results of calculation indicated that the studyon the excited-state intramolecular proton transferreaction system using AM1 method was suitable andreliable.

本论文用AM1、MNDO、MINDO/3（主要是AM1）和INDO/S-CI半经验分子轨道方法对水杨酸衍生物系列——水杨酸、水杨酸甲酯、水杨醛、O-羟基乙酰苯酮、水杨酰胺和3-羟基吡啶酰胺（6种异构体和2-3种阴离子）；2-（2'-羟基-5'-甲基苯基）苯并三〓唑（4种异构体）；2-（2'-羟基苯基）苯并咪唑（3种异构体和3种阴离子）；2，5-二间氮杂氧茚氢醌（3种异构体）；2-（2'-羟基苯基）间〓杂硫茚（2种异构体）和7-〓吲哚二体（2种异构体）的激发态分子内质子转移反应在以下几个方面进行了较系统的理论研究：几何构型优化和相对稳定性及氢键能首先以水杨酸衍生物系列分子为例，用AM1、MNDO和MINDO/3方法考察了5种分子（每种分子设计6种异构体和2-3种阴离子）的基态几何构型优化，能量、相对稳定性和氢键能计算，通过和实验数据进行比较，AM1方法给出的优化几何构型、稳定性次序、氢键能和O—H。。。O氢键的0—0距离与实验数据吻合最好，MNDO和MINDO/3方法优化的C-C键长偏长，C-O键和O-H键长偏短；对于C-N键长，MNDO和AM1优化结果差别不大，而MINDO/3给出了过短的C-N键长，MNDO和MINDO/3方法给出的有些水杨酸衍生物分子（如水杨酸甲酯和水杨酰胺）异构体的稳定性次序和实验上推测的可存在异构体结果不一致，MNDO和MINDO/3方法给出的氢键能偏低，对其他体系的研究发现INDO方法常常不能得到质子转移产物的优化几何构型，只能得到反应物的优化构型，并且估算的氢键能偏高，大量的计算结果表明AM1方法对本论文研究的激发态分子内质子转移反应体系是适宜和可靠的。

The crystal structures of two complexes have been determined by X-ray diffraction as: complex (11) is distorted octahedron configuration,α=15. 9002 (6), b=16. 2413 (5), c=23. 4401 (8)〓,β=90°, V=6053. 2 (4)〓, Z=8 and R=0.0531; complex (8) is trigonal bipyramidal configuration,α=9. 3476 (8), b=17. 4236 (13), c=9. 7836 (8)〓,β=91. 197 (3)°, V=1593. 1 (2)〓, Z=2 and R=0.0325, which shows that three secondary amine groups (N-1, N-2, N-3) of the glycosylamine ligand forms the equatorial plane, and the tertiary amine (N-4) and one Cl〓 are pointed on the apical positions.

分别对其进行X-ray衍射分析可以得出：配合物(11)的晶体数据为α=15.9002(6)，b=16.2413(5)，c=23.4401(8)〓，β=90°，V=6053.2(4)〓，Z=8 and R=0.0531，为畸变的八面体构型，而配合物(8)中，α=9.3476(8)，b=17.4236(13)，c=9.7836(8)〓，β=91.197(3)°，V=1593.1(2)〓，Z=2 andR=0.0325，为三角双锥构型，糖胺配体的三个氮原子（N-1，N-2，N-3）位于赤道平面上，而另外一个氮原子（N-4）和一个Cl〓位于轴向上。

Attributed to the lubricant-effect of flexible LCPB,cold crystallization was observed in stereoblock PB.Bd-Ip block copolymersHTPB-b-PI,C-(PI-b-HTPBn,C-n,and PI-b-HTPB -b-PI and Bd-St block copolymersHTPB-b-PS,C-(PS-b-HTPBn,C-n, and PS-b-HTPB-b-PS containing crystallizable HTPB were well synthesized,the microstructures and properties of the copolymers were investigated in detail.

通过与异戊二烯或者苯乙烯共聚，合成了含高反式聚丁二烯的丁二烯-异戊二烯嵌段共聚物包括HTPB-b-PI，C-(PI-b-HTPBn，C-n和PI-b-HTPB-b-PI和丁二烯-苯乙烯嵌段共聚物包括HTPB-b-PS，C-(PS-b-HTPBn，C-n和PS-b-HTPB-b-PS，对嵌段共聚物的结构和性能进行了系统的研究。

Attributed to the lubricant-effect of flexible LCPB,cold crystallization was observed in stereoblock PB.Bd-Ip block copolymersHTPB-b-PI,C-(PI-b-HTPBn,C-n,and PI-b-HTPB -b-PI and Bd-St block copolymersHTPB-b-PS,C-(PS-b-HTPBn,C-n, and PS-b-HTPB-b-PS containing crystallizable HTPB were well synthesized,the microstructures and properties of the copolymers were investigated in detail.

加热器通过与异戊二烯或者苯乙烯共聚，合成了含高反式聚丁二烯的丁二烯-异戊二烯嵌段共聚物包括HTPB-b-PI，C-(PI-b-HTPBn，C-n和PI-b-HTPB-b-PI和丁二烯-苯乙烯嵌段共聚物包括HTPB-b-PS，C-(PS-b-HTPBn，C-n和PS-b-HTPB-b-PS，对嵌段共聚物的结构和性能进行了系统的研究。

The resultsshowed that one electron was photochemically transfered from rich electron part inside the C〓 derivatives to C〓 football. On the other hand,two step PET took place between C��� and additional electron donor Et〓N, and so C〓anion as well as C〓 dianion could be detected in C���/ Et〓N system.

结果表明：C〓衍生物分子内的富电子部分与C〓区域间发生分子内光诱导的一步单电子转移过程，对比而言，C〓分子与外加给体Et〓N间可相继发生两步光诱导电子转移反应，依次生成C〓和C〓阴离子自由基。

The present invention concerns the compounds having the formula N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R1 and R8 each are H, optionally substituted C1-6alkyl, C2-6alkenyl, C3-7cycloalkyl, aryl, Het1, Het2; R1 may also be a radical of formula (R11aR11b)NC(R10aR10b)CR9-; t is 0, 1 or 2; R2 is H or C1-6alkyl; L is -C-,-O-C-,-NR8-C-,-O-C1-6alkanediyl-C-,-NR8-C1-6alkanediyl-C-,-S2-,-O-S2-,-NR8-S2 ; R3 is C1-6alkyl, aryl, C3-7cycloalkyl, C3-7cycloalkylC1-4alkyl, or arylC1-4alkyl; R4 is H, C1-4alkylOC, carboxyl, aminoC, mono- or di(C1-4alkyl)aminoC, C3-7cycloalkyl, C2-6alkenyl, C2-6alkynyl or optionally substituted C1-6alkyl; R5 and R6 are H or C1-6alkyl.

本发明涉及右式化合物其N-氧化物、盐、立体异构形式、外消旋混合物、前药、酯及代谢物，其中R 1 及R 8 各是氢、C 1-6 烷基、C 2-6 烯基、C 3-7 环烷基、芳基、Het 1 、Het 2 ；R 1 也可以是式(R 11a R 11b )NC(R 10A R 10b )CR 9 -之基；t是0、1或2；R 2 是氢或C 1-6 烷基；L是-C-、-O-C-、-NR 8 -C-、-O-C 1-6 烷二基-C-、-NR 8 -C 1-6 烷二基-C-、-S 2 -，-O-S 2 -、-NR 8 -S 2 -；R 3 是C 1-6 烷基、芳基、C 3-7 环烷基、C 3-7 环烷基C 1-4 烷基或芳基C 1-4 烷基；R 4 是氢、C 1-4 烷基OC、羧基、氨基C、一-或二(C 1-4 烷基)氨基C、C 3-7 环烷基、C 2-6 烯基、C 2-6 炔基或任选被取代的C 1-6 烷基；R 5 及R 6 是氢或C 1-6 烷基。

At the same time, most WDR neurons failedto respond to the light brush applied to the receptive fields, but they couldbe intensively excited by the noxious pinch.(5) The latency of the latedischarges was shortened from 118.83 ± 3.67ms to 50.72 ± 1.36ms (n〓32, P〓0. 01).(6) Preceding graded number of A〓fiber conditioning inputs (〓mA, 100 μs) delayed the C-activity evoked by the following nociceptive teststimulus activating both A- and C-fiber applied to the sciatic nerve. The latedischarges decreased from 9.29 ± 0.97 to 6.71 ± 0.68 with the A-fiberconditioning stimulus increasing from 1 to 5 (n〓8, P〓0. 05).(7) The intervalbetween the conditioning stimulus and test stimulus (C-T interval) wasincreasing, the inhibition tended to plateau off. At shorter time intervalsthe inhibition became more effective. When C-T interval was limited in 50ms,the inhibitory effects was the strongest, here, the late discharges reducedfrom 12.57±1.21to 2.29±0.42 (n=11, P＜0. 01).(8) Behavior research showedthat the rat model of snake venom exhibited neuropathic pain with heathyperalgesia, cold and mechanical allodynia, which corresponding to the acuteelectrophysiological findings.

此时轻刷WDR神经元的感受野不能引起其活动改变，但伤害性齿镊夹捏仍可引起WDR神经元放电增多；〓5〓晚成分放电的潜伏期缩短，即宁静期的时程变短，由给蛇毒前的118.83〓3.67ms降至50.72〓1.36ms〓n〓32，P〓0.01〓；〓6〓在正常动物，如果预先给予只激活A纤维的弱条件电刺激〓mA，100μs〓可抑制随后的伤害性检验刺激所诱发的WDR神经元的晚成分放电，当条件刺激个数从1增加至5时，每次伤害性检验刺激所诱发的晚成分放电数从9.29〓0.97个降至6.71〓0.68个〓n〓8，P〓0.05〓；〓7〓固定条件刺激数为1个，当条件刺激与检验刺激之间的间隔增大时，A纤维条件刺激对WDR神经元晚成分放电的抑制作用逐渐减弱，当条件刺激与检验刺激之间的间隔在50 ms以内时，抑制效应最为显著，此时，晚成分放电数由正常时的12.57〓1.21个降至2.29〓0.42个〓n〓11，P〓0.01〓；〓8〓与急性研究中的WDR神经元电活动的变化结果相匹配，利用蛇毒制备的大鼠模型在行为学上表现为热痛觉过敏、冷觉的痛性感觉异常及机械痛觉过敏等慢性痛症状。

These results suggested that in chloroplast ATP synthase, both the N-terminus and C-terminus of the ε subunit show importance in regulation of the ATPase activity. Furthermore, the N-terminus of the ε subunit is more important for its interaction with γ and some CF〓 subunits, and crucial for the blocking of proton leakage. Compared with the ε subunit from E. coli, the chloroplast ε subunit is more sensible to N-terminal or Cterminal truncations.

从这些实验结果中可以看出：（1）叶绿体ATP合酶ε-亚基的N端和C端对于其功能的发挥都很重要；（2）ε亚基N端和C端氨基酸在抑制ATP水解和堵塞质子泄漏两个功能上起着不同的作用；（3）与细菌ATP合酶相比，叶绿体ATP合酶ε亚基N端和C端的缺失对其功能的影响更为显著。

The labia have now been sutured together almost completely.The drains and the Foley catheter come out at the top.

此刻阴唇已经几乎完全的缝在一起了，排除多余淤血体液的管子和Foley导管从顶端冒出来。

To get the business done, I suggest we split the difference in price.

为了做成这笔生意，我建议我们在价格上大家各让一半。