查询词典 Lymphocytes

Objective: To investigate immunostimulatory activity of CpG ODN against immunosuppression mice, aged mice, pregnant mice and their newly born mice; To screen a CpG ODN that its immunostimulatory activity against human cord blood lymphocytes is stronger than others; To observe immunostimulatory activity of CpG ODN against premature infants cord blood lymphocytes and to observe its cytolysis against Kse2 cells.

摘要目的：探讨CpG ODN对免疫抑制小鼠、老年鼠、孕鼠及其新生小鼠的免疫刺激作用；筛选对人脐血淋巴细胞免疫刺激作用较强的一种CpG ODN；观察其对早产儿脐血淋巴细胞的免疫刺激作用及刺激NK细胞对K_(562)细胞的杀伤活性，为开发适合人类新型疫苗佐剂奠定基础。

Compared with classical cytotoxic T lymphocytes , NK cells are superior in the following aspects: NK cells are among the first cell types to be activated after intracellular pathogen stimuli, the activity of NK cells peaked between 1 to 3 days, retained during the first 7-10 days, and the T cells response emerged only after 7 days when the NK cell responses begin to decline; though comprising of only 10％-15％ of peripheral lymphocytes, NK cells mobilize most of the cell populations in a strong and high level response to different invasions, and act as key factors at early defense before a specific immune response could mount, while only certain clones were involved in T cell response; NK cells kill virus-infected or malignant transformed cells without pre-sensitization and without restriction by major histocompatibility antigen, which is usually a mechanism of immune escape to T cell recognition by virus-infected or tumor cells, thus NK cell in complementary with T cells play crucial roles in tumor and virus eradication.

NK细胞以其强大的细胞毒活性为特征，与细胞毒性T细胞相比，NK细胞具有如下特点：NK细胞虽然只占外周血淋巴细胞的10-15％，但是对刺激性因素产生应答的过程十分迅速，一次可以调动大多数细胞共同参与，而不是几个克隆的活化，免疫应答的强度高；病毒感染或恶性转化细胞的一个主要特征是细胞表达的MHCⅠ类分子下降或消失，并借助这一机制逃避特异性T细胞应答的识别，NK细胞介导的杀伤活性无需抗原刺激，不受MHCⅠ分子表达的限制，从而与T细胞应答互为补充发挥免疫防御的功能；NK细胞的免疫活性可以被多种细胞因子上调，其中IFNα，IL-2，IL-12，IL-15和IL-18具备更强的作用；NK细胞具有强大的细胞因子分泌功能，对于启动T细胞特异性应答必不可少。

This immunogenetics study of couples with recurring pregnancy loss finds that there are vital relationships between the specific genes for human leukocyte antigen-C and the receptors carried on natural killer lymphocytes, enabling the lymphocytes to see this transplantation antigen.

这篇关于再生性流产的免疫遗传学研究，发现了人类白细胞抗原-C的特异基因和自然杀伤性淋巴细胞受体之间的必要联系，使得在淋巴细胞上观察该移植抗原。

Apoptosis of lymphocytes in bone marrow, spleen, thymus and bursa was detected by light microscope, electron microscope and terminal- deoxynucleotidyl transferase UIP nick end labeling. The results showed ALV-J could induce incoordinate apoptosis of lymphocytes in thymus, bursa and spleen, which was mainly found in early time. And the apoptosis was much more obvious in thymus than in other immune organs.

以电镜观察和HE染色、原位末端标记染色光镜观察对ALV-J感染和混合感染鸡的骨髓、脾脏、胸腺、法氏囊等免疫器官中淋巴细胞的凋亡进行了形态学研究，首次发现ALV-J可诱导胸腺、法氏囊和脾脏中不同程度的淋巴细胞凋亡，凋亡主要见于早期，ALV-J与REV混合感染时淋巴细胞凋亡尤为显著，以胸腺中最为明显。

Objective To explore the significance of apoptosis of rabbit small intestinal mucosal epithelial cells and lymphocytes, and lymphocytes of lumbrical process at early postburn stage.

目的 探讨严重烧伤早期家兔小肠粘膜上皮细胞、淋巴细胞以及蚓状突淋巴细胞凋亡及其意义。

Results In 50 patients with toxoplasmal lymphadenitis, 16 patients were positive for Toxoplasma antigen. 5-HT and 5-HTI AR positive markers between the positive and negative groups were similar, which were distributed in the T lymphocytes in cortex of lymph gland and the B lymphocytes and macrophages in lymph follicle germinal center.

结果50例淋巴结炎组织中有16例弓形虫阳性。5-HT与5-HT1AR阳性标志物在两组淋巴结炎组织中分布大致相似，主要位于副皮质区的T淋巴细胞、淋巴滤泡生发中心B淋巴细胞及巨噬细胞等部位。5-HT在两组的表达强度有显著性差异（P〈0.005），而5-HT1AR在两组的表达强度无差异（P〉0.05）。

Results The frequency of CD70+CD4+ lymphocytes was 14.55%± 5.49% in normal control group, 85.25%± 14.08% in active SLE group, 77.65%± 18.77% in nonactive SLE group, and 81.54%± 8.71% in methylation-inhibited group. Compared with the normal control group, a significant increase was observed in both the frequency of CD70+CD4+ lymphocytes （all P 0.01） and the expression of CD70 expression （all P 0.05） in other three groups.

结果 正常人外周血CD4+CD70+ T淋巴细胞阳性率为14.55%± 5.49%，活动期、非活动期SLE分别为85.25%± 14.08%和77.65%± 18.77%，甲基化抑制组为81.54%± 8.71%，与正常人对照组相比，活动期、非活动期SLE患者和甲基化抑制组CD70+CD4+ T淋巴细胞阳性率均明显升高（P 0.01），其外周血T淋巴细胞CD70 mRNA表达水平亦明显增加（P 0.05）；SLE患者外周血CD70+CD4+ T淋巴细胞阳性率与SLE疾病活动度呈显著正相关（r = 0.72，P 0.05）。

The slice of pathology showed: the control group of infected the small intestines mucosa grew thiner,mucosa grew swelling and congesting,many lymphocytes infiltrated,villus failed off;The small intestines mucosa didnt swell and congest in the group of the leaf of Psidium guajava,little lymphocytes infiltrated under the mucosa and the villus were well; The small intestines mucosa grew swelling and congesting in the control group of treatment,many lymphocytes infiltrated under the villus.

病理切片展示：感染对照组的小肠粘膜变薄，粘膜肿胀、充血，大量淋巴细胞浸润，绒毛脱落；番石榴叶组的小肠粘膜无明显肿胀、充血，粘膜下少负淋巴细胞浸润，绒毛清楚；治疗对照组小肠粘膜肿胀、充血，粘膜－－F人量淋巴细胞浸润。

Results: Wallerian degeneration was observed in the proximal and distal ends of all grafts of nerves harvested at 2 weeks post-engraftment; infiltration of T lymphocytes at the grafts in group B was significant, less T lymphocytes were seen in group C, D and E, while no T lymphocytes were seen in group A and F.

结果：术后2周，所有移植段近端，移植远端神经均有不同程度Wallerian变性，B组移植段见明显T淋巴细胞浸润，C，D，E组次之，A组及F组未见T淋巴细胞。B组以大量成纤维细胞增生为主，A，F组以SC增生为主，C，D，E组介于两者之间。

Results The activation of NF-κB, proliferation response, and expression of IL-4 and I L-5 mRNA and protein in T lymphocytes stimulated by PMA were significantly hig her than those of their blank control (P.01), while those indexes of T l ymphocytes stimulated by PMA and PDTC simultaneously were significantly lower th an those stimulated by PMA alone (P.01). The apoptotic index of T lympho cytes stimulated with PMA were significantly lower than that of their blank cont rol (P.01), and the apoptotic index of asthmatic guinea pig T lymphocytes stimulated with PMA and PDTC simultaneously were significantly higher than that stimulated by PMA alone (P.01). The significant positive correlations w ere found between the activation of NF-κB and the proliferation (r=0.64, P.001), and the expression of IL-4 and IL-5 mRNA and protein of T lymph ocytes, respectively (r=0.55-0.68, P.001). There was also signific ant negative correlation between the activation of NF-κB and apoptosis of T l ymphocytes (r=0.62, P.001). Conclusions NF-κB may participate in the signal conduction of PKC regulated proliferation, apoptosis and expression of IL-4 and IL-5 of T lymphocytes in asthma.

结果加入PMA培养的哮喘组T淋巴细胞NF-κB的活化、细胞增殖反应、IL-4和IL-5的mRNA和蛋白质的表达均显著高于其空白对照(P.01)，而同时加入PMA和PDTC培养的哮喘组T 淋巴细胞以上指标均显著低于只加入PMA培养的哮喘组T淋巴细胞(P.01)；加入PMA 培养的哮喘组T淋巴细胞的凋亡指数显著低于其空白对照(P.01)，而同时加入PMA 和PDTC培养的哮喘组T淋巴细胞凋亡指数显著高于只加入PMA培养的哮喘组T淋巴细胞(P 。01)。T淋巴细胞NF-κB的活化与增殖反应呈显著正相关(r=0.64，P.00 1)，与IL-4和IL-5的mRNA和蛋白质的表达也均呈显著正相关(r=0.55-0.68，P 。001)，而与凋亡指数呈显著负相关(r=-0.62，P.001)。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。