查询词典 Impaired

Hypospadiac patients were clearly impaired in sexual psychology and penile development. The severity of hypospadias and number of operations were key factors that influenced the sexual psychology of patients.

可见尿道下裂患者术后的性心理及阴茎发育都受到明显的损害，尿道下裂的严重程度、手术次数的多少是影响患者性心理的重要因素。

The results showed an increased mean jitter value, fiber density and abnormal percentage both in EDC and AT muscles in group 1 and II diabetic patients comparing to the normal controls. These findings suggest an impaired or immatured neuromuscular junctions and an evidence of reinnervation through axonal sprouting in the diabetic patients either with or without nerve conduction abnormalities. In conclusion, the changes of axonal degeneration and reinnervation are the main pathophysiological mechanism of diabetic neuropathy, and the SFEMG is more sensitive than routine nerve conduction study in the diagnosis of diabetic neuropathyKeyword Axonal degeneration , diabetes mellitus , neuropathy , single fiber electromyography

结果显示两组糖尿病病患的连续间值差异，肌纤维密度及不正常比率比对照组显著增加(t试验，依序p.01)，在第一组糖尿病患中，伸指总肌的连续波间值差异比第二组高(p.05)，而连续波间值差异与纤维密度之间也成线性相关的增加(伸指总肌，r=0.471，p.01；胫前肌，r=0.386，p.02)，在伸指总肌测得的连续波间值差异上，第一组糖尿病患有75%不正常，第二组有33.3%不正常，而在胫前肌的连续波间值差异上，第一组糖尿病患有83.3%的不正常，第二组有75%不正常，在肌纤维密度的测定中，第一组糖尿病患的伸指总肌有27.8%不正常，胫前肌有58.3%不正常，第二组病患的伸指总肌有25%不正常，胫前肌有41.7%不正常，此结果表示糖尿病神经变造成的神经肌像交接处不稳定及有神经轴再生的重分布现象，因此也证实糖尿病神经病变的主要病理机转为神经的退化所致，而在诊断上单纤维肌电图检查的敏感度也比运动神经传导速度检查为高。

Results are as followed:1 Exposure of HELF cells to BP caused c-Jun activation,and increased the activity of MAPK,PI-3K,p53 and cyclin D1 pathway.2 BP-induced c-Jun activation was inhibited by dominant negative mutants of extracellular signal-regulated protein kinase or c-Jun NH_2-terminal kinase,but not by p38,impling that JNK and ERK pathways medicate c-Jun activation induced by BP.3 Overexpression of dominant-negative mutants PI-3K and Akt potently blocked phosphorylations of c-Jun and ERK,but not JNK in response to BP,suggesting that PI-3K/Akt pathway positively regulates BP-induced c-Jun activation through ERK.4 Inhibition of p53 by its chemical or molecular inhibitor markedly increased the phosphorylation levels of c-Jun,Akt and ERK upon BP stimulation,indicating that p53 negatively medicates BP-induced c-Jun activation through PI-3K/Akt/ERK pathway.5 The cell lines expressed TAM67 exhibits no significant affecting normal cell growth properties.6 TAM67 was able to significantly block G_1-S transition and subsequent cell proliferation,suggesting that c-Jun is essential for cell cycle alternations elicited by BP.7 Overexpression of TAM67 impaired BP-induced cyclin D1 activation,decreasing expression of E2F1 and pRb,indicating that c-Jun participates in the modulation of BP-induced activation of cyclin D1/pRb/E2F1 pathway.8 Stably expression of TAM67 led to the increases in the expression levels of p53 and p21,elevating phosphorylation level of p53,clearly indicating that c-Jun regulates p53/p21 pathway activation induced by BRCollectively,PI3K/Akt/ERK pathway mediated BP-induced c-Jun activation through p53-dependent mechanism.

结果显示：1BP刺激细胞可促进c-Jun活化，并伴随着MAPK、PI-3K、p53和cyclinD1通路各组成成分的活性增强。2利用MAPK通路的显性失活突变体分别阻断细胞外信号调节激酶和c-Jun氨基末端激酶活性，均可明显抑制BP诱导的c-Jun活化，但阻断p38活性对BP引起的c-Jun活化无明显影响，提示JNK和ERK通路参与调控BP诱导的c-Jun活化。3过表达PI-3K和Akt的显性失活突变体也可显著抑制BP诱导的c-Jun活化，并降低磷酸化ERK的表达水平，但对磷酸化JNK的表达水平无明显影响，说明PI-3K/Akt通路通过ERK正性调控了BP诱导的c-Jun活化。4p53的化学/分子抑制剂能使BP作用的细胞内c-Jun活性明显增加，并同时诱导Akt和ERK的磷酸化水平的升高，表明p53可通过PI-3K/Akt/ERK通路对BP诱导的c-Jun活化进行负性调控。5随后观察转染细胞的生长情况，发现TAM67对细胞正常生长和形态无明显影响。6稳定表达TAM67可有效抑制BP诱导的S期细胞数的增加，提示c-Jun在BP致细胞周期改变的过程中发挥了重要作用。7TAM67过表达能够抑制BP诱导的cyclin D1活化，降低磷酸化Rb以及E2F1蛋白表达水平，表明c-Jun参与调控BP诱导的cyclin D1/Rb/E2F1通路的活化。8过表达TAM67可使BP刺激的细胞中p53、p21总蛋白以及p53磷酸化的表达水平明显升高，可见c-Jun也参与调控BP诱导的p53/p21通路活化。

In order to react all kinds of ecto-stimulus, LPA can delivery from vairies cells, including impaired endodermis agent, activated collagenoblast, intercapillary cells, phlegmasia cell.

在多种重大疾病如心脑血管病、肾病、肿瘤的发生、发展中起着重要作用。

While bilateral area lying along the intraparietal sulcus showed decreased activity during arithmetic with disruption, which might be related to the impaired arithmetic processing in dual task.

反之，双侧沿顶内沟区在心算受到干扰后的激活却显著弱于无扰时的激活，这或许是由加干扰后无法很好地完成心算造成的。

Leitzmann, MD, from the National Institutes of Health in Bethesda, Maryland, and colleagues."Whether dietary zinc intake affects intraprostatic zinc levels is unknown. However, ingestion of 150 mg/day or more of zinc has undesirable metabolic effects, such as immune dysfunction and impaired antioxidant defense that are potentially related to prostate cancer."

Leitzmann博士表示，虽然日常饮食的锌摄取量是否会影响前列腺中的锌含量仍然未知，但是前列腺中拥有较高的锌浓度可能会对於前列腺的健康造成影响，但是，每天服用150mg以上的锌，对於代谢会造成不良影响，如免疫功能障碍并造成与前列腺癌有关的抗氧化剂之缺损。

Objective\ To investigate the changes of serum leptin levels and the relationships between serum leptin levels and body mass index, age, gender, glycometabolism, lipometabolism and some hormones in initially diagnosed patients with type 2 diabetes and impaired glucose tolerance.

①目的探讨初诊的 2型糖尿病与糖耐量低减病人血清瘦素水平的变化及其与年龄、性别、体质量指数、糖代谢、脂代谢以及其他激素的关系。

Inactivation of anterior cingulate cortex and parafascicular or mediodorsal thalamic nuclei, which comprise the medial pain system representing pain affection, substantially impaired this observational fear learning, whereas inactivation of sensory thalamic nuclei had no effect.

前扣带回皮质、束旁或背中部丘脑核组成了代表痛苦感的内侧疼痛系统，一旦失活将会大大损害通过观察习得恐惧感的能力，而感觉丘脑核失活则没有影响。

The classic features of haemorrhagic rash, meningism, and impaired consciousness deeloped late (median onset 13–22 h).

典型的临床症状包括出血性皮疹，男性，和逐渐出现意识不清楚（平均在13-22小时）。

The classic features of haemorrhagic rash, meningism, and impaired consciousness deeloped late (median onset 13–22 h).

临床表现为出血性皮疹，假性脑膜炎症状，意识清醒程度逐渐下降，（中位时间为13~22小时）。

And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47：5 法老对约瑟说，你父亲和你弟兄们到你这里来了。

Additionally, the approximate flattening of surface strip using lines linking midpoints on perpendicular lines between geodesic curves and the unconditional extreme value method are discussed.

提出了用测地线方程、曲面上两点间短程线来计算膜结构曲面测地线的方法，同时，采用测地线间垂线的中点连线和用无约束极值法进行空间条状曲面近似展开的分析。