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IL-1 is elevated in tissue homogenates of temporal lobe and in cerebrospinal fluid from patients with AD. In Alzheimer patients activated immunoreactive IL-1+microglia are increased sixfold over those presenting in age matched controls and the activated IL-1+ microglia are involved in the evolution of diffuse plaque to the diagnostic neuritic plaque. IL-1 is produced by astrocytes and microglia which are components of senile plaques and induced astroglia proliferation.

AD患者颞叶脑组织及脑脊液中发现IL-1含量增高，并且IL-1免疫反应阳性的小胶质细胞比同龄的对照组高6倍，IL-1免疫反应阳性的小胶质细胞与弥散性淀粉样沉淀斑块发展成为具有诊断意义的神经纤维斑块有关。

Results: T cell anergy was antigen-specific. The state of T cell anergy can be reversed by PHA, CD3 mAb and PMA plus A23187. IL-2 can prevent the induction of T cell anergy, but it can not reverse the state of un-responsiveness. IL-2 and IFN mRNA can not express in anergic T cells. In contrast, IL-4 and IL-10 mRNA were detectable.

结果：T细胞无能为抗原特异性的，多克隆激活剂PHA、CD3单抗和PMA+A23187可以恢复无能T细胞的活性；IL-2可以阻止T细胞无能的形成，但不能逆转其耐受状态；无能T细胞IL2和IFN mRNA是关闭的，而IL-4和IL-10 mRNA则是开放的。

Transgenic expression of IL-1ra and degree of audiogenic seizure of P77PMC rats were observed after infection with pHSV-IL-1ra virus (〓 virus particles) by i. c. v injection and hippocampus injection. Results show: 1. Overexpression of IL-1ra by pHSV-IL-1ra significantly inhibited seizure attacks of P77PMC rat.

实验结果提示IL-1β可导致神经细胞NMDAR mRNA表达及受体活性增加，从而使其兴奋性增高；脑中内源性IL-1系统的异常很可能是形成P77PMC遗传癫痫易感大鼠惊厥易感性的重要因素之一；我们首次构建并鉴定了pHSV-IL-lra重组质粒，并成功地进行了脑内基因转移，使P77PMC大鼠的惊厥程度明显降低。

Results l.Serum concentrations of VCAM-1 in PIH (93.39 + 57.3)ug/ml were higher than that in normal pregnant group. Serum concentrations of VCAM-1 in moderate(97.89 + 34.07)ug/ml and severe PIH(132.24 + 60.97)ug/ml were significantly higher than that in normal group.(P.05, P.01). There was no difference between serum levels of VCAM-1 mild PIH and normal pregnant group. 2.Serum levels of IL-6 in PIH group(102.17 ?48. 31)pg/ml were significantly higher than that in normal group(49.16 + 12.9)pg/ml.Serum levels of IL-6 in moderate(95.79+31.19)pg/ml and severe PIH( 127.27+11.3 8)pg,ml were significantly higher than that in normal group. There was no difference between serum levels of PIH in mild PIH (52.13 + 12.90)pg/ml and normal pregnant group. 3. In PIH group, serum concentrations of VCAM-1 correlate with the levels of IL-6,r=0.63. 4.The expression of VCAM-1 in cytotrophoblast of spiral arteries in normal pregnant group(100%) were significantly higher than that in PIH group.Theexpression of VCAM-1 in moderate PIH(37.50%) and sever PIH were lower than that in normal group.There was no difference between the mild PIH and normal group.Conclusions The increased levels of serum of VCAM-1 may participate in the process of vascular endothelium damages in PIH.

结果 1、妊高征组血清VCAM-1浓度为(93.39±57.3)μg／ml明显高于正常妊娠组(44.87±15.60)μg／ml，差别有显著性(P＜0.05)；中、重度妊高征组VCAM-1浓度分别为(97.89±34.07)μg／ml和(132.24±60.97)μg／ml，与正常妊娠组比较，差异有显著性(p＜0.05)和非常显著性(P＜0.01)；轻度妊高征组VCAH-1为(48.46±15.60)μg／ml与正常妊娠组比较，差异无显著性(P＞0.05)。2、妊高征组血清IL-6含量为(102.17±48.31)pg／ml，明显高于正常妊娠组(49.16+12.9)pg／ml，差异有非常显著性(P＜0.01)；中、重度妊高征组IL-6含量分别(95.79±31.19)pg／ml和(127.27±11.38)pg／ml，与正常妊娠组比较，差异有显著性(P＜0.05)和非常显著性(P＜0.01)；轻度妊高征组IL-6含量为(52.13±12.90)pg／ml与正常妊娠组比较，差异无显著性(P＞0.05)。3、VCAM-1与IL-6水平呈明显正相关，r=0.63(P＜0.01)。4、子宫胎盘床螺旋动脉滋养细胞VCAM-1表达，正常妊娠组都存在阳性表达(阳性表达率100％)，妊高征组有10例阳性表达阳性表达率为叩们，差别有非常显著性河＜0.01L 中、重度妊高征组阳性表达率分别为37、50％和0，与正常妊娠组比较，差别有显著性河＜0.05）和非常显著性汀＜0.01太轻度妊高征组阳性表达率为83.33凡与正常妊娠组差别无显著性问＞0.05）。

Antigen-driven T cells maintained in culture using this combined cytokine regimen can be induced to grow and maintained functional in large numbers and survive long-term in cultrue with each antigen restimulation cycle prolonged to six weeks. The IL-2 doses used in this combined cytokine regimen can be reduced 10 to 100 times that of cultures using IL-2 alone.

结果表明：单独使用IL-2或IL-7均能增强T细胞对ConA或特异性抗原刺激诱导的增殖反应，但联合使用IL-2和IL-7具有更加显著的协同刺激作用。C57BL/6小鼠抗FBL-3肿瘤特异性T细胞系在IL-2与IL-7联合培养系统中，不但T细胞数量明显增加，且能在保持特异性功能的同时，延长T细胞体外抗原刺激周期。

CINC-2、LIX、TNF-α、VEGF were in a persistent heighten tendency in the model groups during the whole period of exeriment while CINC-3、GM-CSF、IFN-γ、IL-1β、Leptin heightened gradually and Fractalkine、IL-6、IL-1αfluctuated. MCP-1 increased significantly at third week but surgeless after that. MIP-3a、TIMP-1 changed little during the whole period.

在大鼠动脉壁泡沫细胞形成的整个过程中，4种细胞因子处于持续升高趋势，包括CINC-2、CNTF、LIX、VEGF；6种呈现逐渐升高趋势，包括CINC-3、GM-CSF、IFN-γ、IL-1β、Leptin、β-NGF； 5种因子包括Fractalkine、IL-6、IL-1α、IL-10、TNF-α处于波动状态；MCP-1在3周时明显升高，其它时相点变化幅度不大，MIP-3a、TIMP-1、IL-4在整个病变过程中变化幅度始终较平稳。

Methods Detected IL-2, IL-5, IL-10 and EOS of 60 cases in patients with eczema and 40 cases health controls by ABC-ELISA and detect counting method.Analyzed the data with the SPSS 11.5 software. Results The IL-2 in patients with eczema wase lower than that of the health groups.

采用双抗夹心法和直接计数法分别检测湿疹患者60例和正常健康体检者40例的血清IL-2，IL-5，IL-10和血液中EOS的水平，应用SPSS11.5统计软件包对结果作统计学分析。

Meanwhile, IL-4, IL-5 and IL-10 derived from livers and bone marrows of infected mice were observed at wk 8, 10 and 12 after infection.

结果及结论：在感染小鼠肝脏， IL－4， IL－5 和IL－10 随感染时间的延长而明显升高，且以IL－4 最为明显。

The experiment of BALB/c mice immunized with the DNA vaccines showed that pA and pEA could induce simultaneously specific antibodies against serotypes A, Asia1, and O FMDV, and the highest antibody titres were found in the pEA and inactivated vaccine groups compared to pA vaccinating mice. Compared with the control, the levels of IL-2, IFN-γ, IL-4, and IL-10 expression by splenic lymphocytes from mice immunized with pA and pEA were significantly increased.

小鼠免疫实验表明， pA和pEA免疫组的血清抗体均能分别与O型、A型和AsiaI抗原反应，与对照组相比差异较显著，且pEA免疫组和灭活疫苗免疫组抗体水平均显著高于pA免疫组；同时pA和pEA免疫小鼠细胞因子IL-2、IFN-g、IL-4和IL-10较对照组显著提高，且pEA免疫组的IL-2、IFN- g和IL-4水平明显高于pA免疫组。

The results showed that over 500.0 μg/L of Jagged-1/Fc led to the obvious enhancement of the proportion of CD4+CD25+ T cells within the day 4 to 6 of induction, which was abrogated with an anti-Jagged-1/Fc monoclonal antibody. This induction action of Jagged-1/Fc on CD4+CD25+ T cells was also inhibited by the block of a Notch signal pathway with N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester. The level of IL-4 and IL-10 in the supernatant of T cell culture and their intracellular level were elevated by the induction of Jagged-1/Fc,and the level of TGF-β1 in the supernatant was not altered.

结果显示，超过500.0 μg/L剂量的Jagged-1/Fc使CD4+CD25+ T细胞百分比明显增高，诱导时间需要4～6天，抗Jagged-1单抗能抵消Jagged-1/Fc的诱导作用，用DAPT阻断Notch信号通路的活化也能抑制Jagged-1/Fc的诱导作用，Jagged-1/Fc诱导分化的T细胞培养上清中IL-4和IL-10的水平明显增高，TGF-β1无明显变化，胞内IL-4，IL-10，IL-2和TNF-α的水平也呈增高趋势。

By the time of its fall, most of the prisoners were writers who had written against the corruptions of the government.

到它被攻陷的时候，里面多数的犯人是写了反对政府贪污文章的作家。

The most obvious variation to ovum morphological character was that the color was changed from light green to sepiaceous in embryonic development, and all the ovums were almost hatched after 96h.

在胚胎发育过程中卵的形态特征最明显的变化是颜色从淡绿到深褐色，卵在发育96h后卵基本全部孵化。