查询词典 IL

Results: 1 The capacity of engulfment of A549 cells started enhancing at the 1h of preincubation with dexamethasone, reached the highest at the 4h of preincubation,At the 8h、24h of preincubation the capacity of engulfment evidently reduced. 2 Glucocorticoid cytosolic receptors antagonist RU38486 inhibited the improved engulfment ability by dexamethasone. 3Phagocytosing apoptotic eosinophils did not change the release of IL-6 and IL-8,but can inhibited the release of IL-6 and IL-8 from A549 cells stimulated by lipopolysaccharide. 4Increasely uptaking by dexamethasone also did not agitate the release of IL-6 and IL-8 from A549 cells. Conclusion: 1Dexamethasome improve the phagocyte capacity for apoptotic eosinophils of A549 cells by glucocorticoid cytosolic receptors, and the effect presents time-dependently. 2Phagocytosis of apoptotic eosinphils can degrade inflammatory reflection, so it is likely to be critical in the control of asthma inflammation.

结果： 1 A549细胞在地塞米松诱导后1小时吞噬能力开始升高，4小时吞噬能力达最高峰，8小时、24小时吞噬能力明显下降 2加入RU38486后抑制了地塞米松所增强的吞噬能力 3凋亡嗜酸粒细胞的吞噬并不能改变A549细胞释放IL-6和IL-8，但能抑制脂多糖刺激A549细胞后IL-6、IL-8的分泌 4地塞米松增加的吞噬也不激发A549细胞释放IL-6和IL-8 结论： 1地塞米松促进A549细胞吞噬凋亡的嗜酸粒细胞是通过A549细胞糖皮质激素胞浆受体发挥作用的，并且具有时间依赖性 2 A549细胞吞噬凋亡的嗜酸粒细胞能降低炎症反应，对哮喘炎症的控制具有重要意义

Results Combined treatment with IL-12 and IL-2 could significantly delayed the peak of parasitemia and prolonged survival time of the P.berghei infected mice when compared with the treatment with IL-12 or IL-2 alone.

结果 IL-12联合IL-2处理组可较单独IL-12或单独IL-2及感染对照组显著推迟原虫血症达峰值的时间与明显延长小鼠的存活时间，IL-12或联合IL-2组小鼠在原虫血症达30%时开始死亡，而单独IL-2或感染对照组小鼠在原虫血症低于13%时已全部死亡。

Results The functions of major organs in group HVHF improved obviously,and the MODS morbidity and mortality reduced significantly,compared with that in group HVHF. ENIAF and ECKR combining activity in group HVHF decreased much slowly through the treatment or HVHF than that in group MODS(P 0.01). After hemofiltration the plasma levels of TNF α IL-1β IL-6 IL-8 in group HVHF descended significantly compared with those in group MODS (P.01).Except TNF α, IL-1β.IL-6 IL-8 and IL-10 were detectable in ultrafiltrate.

结果 与MODS组相比，HVHF组各主要脏器功能指标明显改善，MODS的发生率和死亡率显著降低，滤过治疗后ENIAF和ECKR结合活性下降幅度明显趋缓；HVHF组各促炎因子血浆水平明显下降，与MODS组相比有显著差异(P.01)；除TNFα外，IL-1β、IL-6、IL-8、IL-10均在超滤液中检测到。

Conbining previous results with our results, we conclude that the soluble gp130 mutant containing CBD can antagonize the biological activities of IL-6 by competitively binding IL-6/IL-6Rα with wild-type gp130, and the membraneanchored mutant could transduce IL-6 signal, but its efficiancy was much lower than that of wild-type gp130, therefore, we thought the Ig-like module also played an important role in IL-6 signal transduction by involving in the formation of a hexameric IL-6 receptor complex.

结合以前的研究结果，我们认为只含胞外CBD区的gp130突变体通过与膜结合型gp130竟争结合IL-6／IL-6Rα复合物而具有拮抗IL-6功能的作用；而只含胞外CBD区的gp130突变体，尽管仍能传导IL-6信号，但其效率远低于野生型gp130，因此，我们认为gp130的Ig样区在IL-6转导中也起着十分重要的作用。

T includes three correlative genes: IL-1A, IL-1B and IL-1RN. They code IL-1 alpha, IL-1 beta, and IL-1ra partitively.

L-1 基因簇包含IL-1A、IL-1B 和IL-1RN 三个相关基因，位于人类染色体2q13-q21，分别编码细胞因子IL-1α、IL-1β和IL-1ra。

Results In HFRS cases from febrile stage to polyuric stage,serum levels of TNFα、IL-1β、IFNγ、IL-2、E-selectin、L-selectin and ICAM-1 were significantly increased as compared with control group( P ＜0.05～0.01),on the contrary, serum IL-4 and TGFβ-1 were significantly decreased and the IFNγ/IL-10 ratio was remarkablely elevated at the same time, though serum IL-10 level was higher than normal values.

结果 从发热期至多尿期，血清TNFα、IL-1β、IFNγ、IL-2、E-选择素、L-选择素和ICAM-1水平均高于对照组， P ＜0.05～0.01，而IL-4、TGFβ-1则显著降低，血清IL-10虽有所增加，但其增幅远比IFNγ为低，以致IFNγ/IL-10比值显著增高；TNFα、INFγ与BUN呈一致性变化趋势，而与血小板变化趋势相反。

Methods After the wide type NCI-H446 cells and the three kinds of NCI-H446 cells transfected by three kinds of IL-15 genes respectively （Cmp transfected by the IL-15 maturation peptide gene, Cp transfected by prototypic IL-15 gene, and Csp transfected by modified IL-15 gene whose signal peptide was replaced with the IL-2 signal peptide） were treated by mitomycin, the cells （named MCw, MCmp, MCp, and MCsp, respectively） were used as stimulator cells to stimulate PBMC from healthy volunteers.

野生型NCI-H446细胞和被3种IL-15基因分别转染的3种NCI-H446细胞（Cmp：被IL-15成熟肽基因转染；Cp：被原型IL-15基因转染；Csp：被信号肽换为IL-2信号肽的改型IL-15基因转染），用丝裂霉素处理后（分别名为MCw、MCmp、MCp和MCsp）作为刺激细胞刺激健康志愿者的PBMC。

METHODS: Female BALB/c mice were treated with CCK-8 and keyhole limpet haemocyanin, splenocytes were acquired and incubated in vitro with KLH restimulation, the productions of Th1 cytokines, interferon-γ, interleukin-2 and Th2 cytokines, IL-4, IL-5 in cell culture supernatants were detected by enzyme-linked immunosorbnent assay. The mRNA expressions of IFN-γ, IL-2, IL-4 and IL-5 in splenocytes were detected by reverse transcription-polymerase chain reaction. The levels of Th1 antibody IgG2a and Th2 antibodies IgG1 in serum were also detected by ELISA.

给予BALB/c小鼠钥孔戚血蓝蛋白免疫同时体内给予不同剂量的CCK-8，酶联免疫吸附试验检测其脾细胞培养上清中Th1型细胞因子γ-干扰素、白细胞介素-2（IL-2）和Th2型细胞因子白细胞介素-4（IL-4）、白细胞介素-5（IL-5）水平，逆转录聚合酶链式反应法检测脾细胞中IFN-γ、IL-2、IL-4、IL-5 mRNA表达；ELISA法检测血清中Th1型抗KLH抗体IgG2a和Th2型抗KLH抗体IgG1水平。

It gradually increased with prolongated infection time. In the spleens of infected mice, IL-4,IL-5 and IL-10 were also elevated. However, their ranges were obviously lower than those in livers. In the colons of infected mice, IL-4,IL-5 and IL-10 slowly increased with prolongated infection time.

结果在老婆感染小鼠肝脏IL-4，IL-5，IL-10明显成年人高于正常对照(P＜0.01)，并随老婆感染时间的延长而逐步升高；在脾脏IL-4，IL-5，IL-10亦升高，但其幅度明显成年人较肝脏为低；在结肠IL-4，IL-5，IL-10随老婆感染时间延长呈缓慢升高趋势。

Newly diagnosed diabetes patients had a defect of IL-4,IL-2 secretion and an elevation of IL-1 β.TH1 bias exited in type 1 diabetic patients.The positive lineal relation between fasting insulin and IL-1 β and between fasting C-peptide and IL-12 exited.TNF-α elevated in HLA-DQB1*0301 carrier compared with non-carrier.

新诊断1型糖尿病病人存在IL-4、IL-2低下及IL-1β的分泌增高；1型糖尿病病人存在TH1优势；IL-12与IL-4正相关，表明了它们对TH1、TH2细胞的调节关系；CK与HbA1c无显著相关性；HLA-DQB1*0201携带者TNF-α较高。

By the time of its fall, most of the prisoners were writers who had written against the corruptions of the government.

到它被攻陷的时候，里面多数的犯人是写了反对政府贪污文章的作家。

The most obvious variation to ovum morphological character was that the color was changed from light green to sepiaceous in embryonic development, and all the ovums were almost hatched after 96h.

在胚胎发育过程中卵的形态特征最明显的变化是颜色从淡绿到深褐色，卵在发育96h后卵基本全部孵化。