查询词典 HIV

On the establishment of shielding immune cells avoid HIV viral antigens identified protein adsorption and the establishment of "biological trap" induce HIV models Summary : HIV is the human immunodeficiency virus caused AIDS virus, AIDS is not currently be fully human control, AIDS vaccine is being developed, but because the virus genetic diversity potential to change the topic of the complexity of this ban from the incidence of HIV spread T4 cells in the mechanisms by, proposed changes T4 lymphocyte surface protein CD4 receptors structure as to avoid HIV adsorption, and the establishment of "biological trap" booby HIV idea to try to turn on AIDS treatment to the conversion of protein structure and function, as well as synthetic direction.

提要：HIV即人类免疫缺陷病毒是引起AIDS的病毒，目前爱滋病还不能被人类完全控制，AIDS的疫苗也正在研制中，但是由于病毒多样性的遗传潜能，使这一课题变的很复杂，本文试从HIV侵染T4细胞导致发病的机理入手，提出改变T4淋巴细胞表面CD4受体蛋白构象以避免HIV吸附，并设置"生物陷阱"诱杀HIV的构想，试图把对爱滋病的治疗引向对蛋白质结构与功能转化以及合成的方向。

AIM: To isolate bioactive secondary metabolites from the fruits of Schisandra rebriflora Rehd. et. Wils and study their effects on HIV-1 infectivity. METHODS: Inhibition of syncytia formation, HIV-1 reverse transcriptase and protease, protection of HIV-1 infected cells, level of HIV-1 p24 antigen,blockage of fusion were detected. RESULTS: A lignan compound, named rubrifloralignan A, was first isolated as a natural product with modest inhibition effects on syncytium formation and HIV- 1 replication and could protect HIV-1 infected cells with weak inhibition effects on fusion and RT, but it showed no effects on the replication of HIV-1 chronic H9 and PR. CONCLUSION: Rubrifloralignan A is an efficient anti-HIV-1 product with effect on early stage of HIV-1 replication.

目的：从红花五味子果实中寻找活性代谢产物，研究其抗HIV—1活性和作用机制方法：通过合胞体抑制、HIV-1感染细胞保护、HIV—1p24抗原测定、融合阻断、逆转录酶和蛋白酶活性分析等实验，检测分离化合物的抗HIV—1活性并探讨其作用机制一结果：红花五味子甲素能够抑制病毒诱导的合胞体形成，保护病毒感染细胞，抑制病毒在细胞内的复制对HIV-1感染细胞与正常CD4^＋细胞间的融合，逆转录酶活性有一定的抑制作用但是红花五味子甲素不抑制病毒在慢性感染细胞中的复制，也不抑制蛋白酶的活性、结论：首次从天然产物中分离得到红花五味子甲素，它对HIV—1病毒复制早期具有抑制作用

For most viruses,there is aneed for antimicrobials that target unique viral molecular properties.Acycloviris one such drug.It is activated into ahuman herpesvirusDNA polymerase inhibitor exclusively by HHV kinases and,thus,does not suppress other viruses.Here,we show that ACV suppresses HIV-1in HHV-coinfected human tissues,but not in HHV-free tissue or cell cultures.However,addition of HHV-6-infected cells renders these cultures sensitive to anti-HIV ACV activity.We hypothesized that such HIV suppression requires ACV phosphorylation by HHV kinases.Indeed,an ACV monophosphorylated prodrug bypasses the HHV requirement for HIV suppression.Furthermore,phosphorylated ACV directly inhibits HIV-1reverse transcriptase,terminating DNA chain elongation,and can trap RT at the termination site.These data suggest that ACV anti-HIV-1activity may contribute to the response of HIV/HHV-coinfected patients to ACV treatment and could guide strategies for the development of new HIV-1RT inhibitors.

对大多数病毒而言，都需要有针对其分子特性的靶向杀毒剂阿昔洛韦就是这样一种靶向药物在人疱疹病毒酶的特定作用下，阿昔洛韦被激活成为人疱疹病毒DNA聚合酶抑制剂，因此不能再抑制其它的病毒我们的研究发现阿昔洛韦在共感染人疱疹病毒的组织中可以抑制HIV-1，但在无人疱疹病毒感染的组织或细胞中无此作用然而，加入人疱疹病毒-6感染的细胞却使得其对抗HIV的阿昔洛韦变得敏感我们推测这种抑制作用依赖于人疱疹病毒酶导致的阿昔洛韦磷酸化实际上，单磷酸化的阿昔洛韦前体药物无需人疱疹病毒的参与即可抑制HIV此外，磷酸化的阿昔洛韦能直接抑制HIV-1逆转录酶，将其阻止在终止位点，从而终止DNA链的延长这些结果提示阿昔洛韦的抗HIV-1活性决定了艾滋病病毒/人疱疹病毒共感染的患者对阿昔洛韦的治疗反应，也有助于开发新的HIV-1逆转录酶抑制剂

Objective This study was designed to investigate the different status of provirus HIV DNA in non-progressor and progressor of HIV-1 infected persons.Methods HIV RNA, HIV DNA were detected with long-distance PCR,reverse-transcription PCR,Southern blot and molecular hybridization from plasma and peripheral blood mononuclear cells, using primers locating between long terminal repeats LTR(U5)-LTR and so on.

HIV是一种变异非常活跃的病毒，这种变异既有可能医疗增强病毒在宿主体内的适应性和生存，又有可能医疗使病毒复制受到阻碍，影响病毒在宿主体内的生存，为了更进一步掌握HIV变异规律，阐明HIV致病机理，我们用逆转录PCR、长片段PCR、Southern转印、分子杂交等对HIV感染无进展者和进展者HIV RNA、CD4细胞、HIV DNA及存在状态进行了研究。

Objective This study was designed to investigate the different status of provirus HIV DNA in non-progressor and progressor of HIV-1 infected persons.Methods HIV RNA, HIV DNA were detected with long-distance PCR,reverse-transcription PCR,Southern blot and molecular hybridization from plasma and peripheral blood mononuclear cells, using primers locating between long terminal repeats LTR(U5)-LTR and so on.

HIV是一种变异非常活跃的病毒，这种变异既有可能增强病毒在宿主体内的适应性和生存，又有可能使病毒复制受到阻碍，影响病毒在宿主体内的生存，为了更进一步掌握HIV变异规律，阐明HIV致病机理，我们用逆转录PCR、长片段PCR、Southern转印、分子杂交等对HIV感染无进展者和进展者HIV RNA、CD4细胞、HIV DNA及存在状态进行了研究。

The EC_(50) of QKL against the formation of syncytia of MT-2 induced by HIV-1_ was 1/198.02 with a SI of 5.36. By detecting the survival rate of co-culturing H9/HIV-1_ cells and MT-2 cells or MT-2 cell direct infected by HIV-1_ QKL was found to be protective to cells. The EC_(50) was 1/166.67 and 1/144.93 with SI of 4.51 and 3.92 respectively. The EC_(50) of QKL against P24 antigen production was 1/175.44 with SI of 4.75. The drug serum of QKL was also found to be effective to inhibit the cell fusion and protect cells infected by HIV-1_.

结果：QKL对H9／HIV-1_细胞和MT-2细胞的CC_(50)分别为1／50.76和1／36.97；抑制H9／HIV-1_细胞和MT-2细胞早期融合的EC_(50)=1／235.29，SI=6.36；抑制HIV-1_细胞诱导MT-2细胞形成合胞体的EC_(50)=1／198.02，SI=5.36；H9／HIV-1_细胞和MT-2细胞混合培养和HIV-1_感染MT-2细胞时，QKL保护病毒感染细胞免于死亡的EC_(50)分别为1／166.67和1／144.93，SI分别为4.51和3.92；抑制p24抗原产生的EC_(50)=1／175.44，SI=4.75；QKL药物血清也可抑制H9／HIV-1_细胞和MT-2细胞的早期融合，保护细胞免于死亡。

It was isolated from the mosquito stomach HIV, found that absorption of the mosquito's blood after AIDS patients, HIV can survive in the mosquito stomach three to four days, but the amount of virus in mosquitoes can cause the number of HIV transmission is not clear, and the mosquitoes In a suction blood, at least three to four days no longer vampire bites, and some died soon; Some people also said: mosquitoes but the remnants of blood containing HIV will be transmitted to humans.

有人从蚊子胃内分离出HIV，发现蚊子吸了艾滋病病人的血之后，HIV可在蚊子胃内存活3~4天，但蚊子体内带毒量的多少才可引起HIV传播尚不清楚，而蚊子在吸一次血之后，至少3~4天不再叮咬吸血，有的很快死去了；又有人说：蚊子嘴上残留的血液含有HIV会传染给人。

HIV-1B 'strain is endemic in Asia's three major HIV-1 strain of the blood collection in the central region of China's HIV infected persons in the broad popular. B 'strain with other subtypes of HIV-1 strains combine, hastened the birth of a variety of HIV-1 recombinant virus.

HIV-1B'毒株是亚洲流行的HIV-1三大主要毒株之一，在我国中部地区采供血HIV感染者中广泛流行。B'毒株与其他HIV-1亚型毒株结合，催生了多种HIV-1重组型病毒。

Injection drug use history was the main risk factor among FSWs(adjusted OR=9.8);(2) The self reported illicit drug-using behaviors and high risk sexual behaviors among close-cohort of FSWs who attended all the three cross-sectional surveys decreased accompanied with the survey time.The decrease of STIs prevalence and urine positive rate among them confirmed their decreased high risk behaviors;(3)The incidence of HIV was 1.4(95%CI 0.5～3.3)/100 Person Year in the open-cohort.FSWs who were recently HIV-infected had obvious high risk sexual behaviors with clients and 4/5 of them were not illicit-drug using FSWs;(4) 42.1%(16/38) of BED-CEIA positive specimens were false positives(＞155 days),but after eliminating the misclassified long-term HIV infected specimens,the BED-CEIA estimated HIV incidence were similar with that of the cohort survey among the same FSWs2.1/100PY vs.2.0/100PY;0.4/100PY vs.

注射吸毒行为是FSWs人群HIV感染的主要危险因素(aOR=9.8)：(2)连续参加过三次横断面调查的封闭式FSWs队列中，自报吸毒行为及高危性行为随调查时间均出现了降低的趋势，另外其性病感染率及尿吗啡阳性率的降低也印证了其自报高危行为特征的下降；(3)开放式FSWs队列中的HIV发病密度为1.4(95%CI0.5～3.3)/100人年，HIV新发感染FSWs与嫖客之间的高危性行为十分突出，以非吸毒FSWs为主(4/5)：(4)BED-CEIA阳性标本中的假阳性率为42.1%(16/38)，但在排除误检的既往HIV感染标本后，BED-CEIA及开放式队列研究估计的HIV发病密度十分接近2.1/100人年vs.2.0/100人年：0.4/100人年vs.0.6(来源：4eABC论f5f5文网www.abclunwen.com/100人年。

With this in mind, the researchers then reanalysed data from knowingly HIV-positive heterosexual subjects in Uganda and Zambia who had HIV-negative sexual partners. Those with a viral load of one million particles per millilitre were more than ten times more likely to accidentally infect their partners each year than those with a load of one thousand.But when the researchers calculated the transmission potential over the entire predicted asymptomatic period, those with viral loads between ten thousand and a hundred thousand copies per millilitre of blood were the most likely to infect their partners. HIV-positive subjects with viral counts of 50,000 infected roughly twice as many people as those with counts of one million.

伦敦帝国学院流行病学家Christophe Fraser和他的同事对收集于1982年到1993年之间的100多例HIV阳性的男性同性恋者的数据进行分析，并结合分析来自乌干达和赞比亚的已知有HIV阴性性伴侣的HIV阳性异性恋受调查者的资料，他们发现中度病毒负荷而无症状的HIV携带者更易播散HIV，这是因为中度病毒负荷的HIV携带者的无症状期较长，而那些高病毒负荷而无症状的HIV携带者虽然传染性稍强，但其传染的持续时间却很短，并且在未经治疗的HIV携带者个体中中度病毒负荷是最常见的人群。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。