查询词典 Guthrie

China's state news agency Xinhua says Randolph Hobson Guthrie was handed over to the U.S. police Thursday.

中国官方的新华社报导，顾然地星期四被移交给美国警方。

First posed in 1852 by Francis Guthrie, a British math student,

最早在1852年由一英国学生格思里提出

Oer the next few months, his lier function and breathing recoered enough that Guthrie was ready for the next step.

在下去的几个月中，他的肝功能和呼吸功能恢复得不错，能够支持他进行下一治疗。

First pose d in 1852 by Francis Guthrie, a British math student,

最早在1852年由一英国学生格思里提出

REP: The folk-singer Woodie Guthrie chronicled the lives of ordinary Americans as they struggled with poverty and unemployment.

记者：乡村歌手伍德·古斯烈用歌声记录了那些挣扎于贫穷和失业的社会动荡之中的美国普通人当时的生活状态。

Arlo guthrie brought back in hot pursuit, and shouted:"I'm not your enemy, also not be fierce beast, not vexatious tough specimen, why you want to leave me?"

阿罗在后面苦苦追赶，并且大声叫喊：「我又不是你的仇人，也不是凶猛的野兽，更不是无理取闹的莽汉，你为什么要躲避我？

Other members included Woody Guthrie, Pete Seeger and "Butch" Hawes, who became her husband.

其他成员包括伍迪·格思里，皮特·西格和鲍尔温·霍斯。鲍尔温·霍斯后来成为她的丈夫。

Gustafson Guthrie Nichol Ltd , Seattle, Washington

古斯塔夫森格思里尼科尔有限公司，美国华盛顿州西雅图

Majority of acute leukemias in infant, either acute lymphoblastic leukemia or acute myeloblastic leukemia, posses a chromosomal translocation affecting the 11q23 chromosome region which specifically inoles the mixed-lineage leukemia gene.1-3 Most pediatric leukemias with MLL rearrangement clearly hae a remarkably short latency.1,4 MLL gene rearrangement is also associated with secondary leukemias of patients preiously treated with the topoisomerase II inhibitors.4 The latency of these secondary leukemias is similarly ery short.4 Of note, the concordance rate of leukemia with MLL rearrangement in infant monozygotic twins approximates to 100%,1,4 and identical breakpoint in the MLL gene was shared in these pairs of identical twin infants with concordant ALL.1,4 Moreoer, the unique and clonotypic MLL fusion gene was detectable in neonatal blood spots for Guthrie cards from non-twined indiiduals who subsequently deeloped ALL.1,4 These obserations indicate not only that MLL fusion is generated in utero but also that MLL fusion proteins could be capable of inducing leukemic transformation with few, if any, secondary mutations.2,3,4 Greaes et al speculate that an MLL fusion protein somehow promotes rapid transition to full-blown disease in patients ia ery rapid clonal expansion, genetic instability, or inhibition of DNA damage repair.4 In general, for clonal expansion of malignancies, tumor cells often hae acquired strategies that escape immune sureillance of the hosts.5,6 Immune escape mechanisms also contribute to the failure of graft-ersus-leukemia effect after allogeneic hematopoietic stem cell transplantation.7 Therefore, leukemia cells could acquire some immune escape mechanisms during leukemogenesis.

绪论 绝大多数的婴儿白血病，不管是急性淋巴性白血病或是急性骨髓性白血病，在染色体11q23部位有染色体易位的情况；这个部位的染色体易位牵连了混合谱系白血病基因。大多数具有MLL基因重排的儿童白血病潜伏期明显短很多。MLL基因重排也和经拓扑异构酶II抑制剂治疗后的继发性白血病有关。这些继发性白血病的潜伏期类似地都非常的短。很重要的是，单卵双胞胎婴儿同时患有或同时免于MLL基因重排阳性的白血病的一致性接近100%；并且同样患有ALL的同卵双胞胎的MLL基因的断裂点是一致的。而且，这种独特的克隆特异性的MLL融合基因能够从那些得ALL的非双生个体出生时的血斑标本中检测到。这些发现表明MLL融合基因产生在胎儿还在子宫的是后，而且MLL融合蛋白能过和其他的基因突变一起诱导白血病的产生。Greaes 等推测MLL融合蛋白在某种情况下同过快速克隆增殖，遗传的不稳定性或是DNA损伤修复的抑制促使疾病迅速地全面爆发。恶性肿瘤细胞的克隆增殖通常已经获得了逃避机体免疫监视的能力。免疫逃避机制也归因于异体外周血干细胞移植后移植物抗白血病作用的失效。所以，白血病细胞在白血病的产生过程中可能获得了某些免疫逃脱机制。

The extremists, under such leaders as Johnston of Warristoun, James Guthrie, and Patrick Gillespie, attributing their defeat to the unholy alliance with the Malignants grew in vehemence and presented to the Committee of the Estates (30 Oct., 1650) a "Remonstrance" arraigning the whole policy of Argyll's government and refusing to accept Charles as their king "till he should give satisfactory evidence of his real change" ibid.

极端分子，在这样的领袖作为约翰斯顿warristoun ，詹姆斯伽丝瑞，帕特里克葛拉斯彼，归因於他们的失败，给非神圣同盟与malignants增长，在激烈的，并提交给该委员会的屋（ 1650年10月30日）一个&谏& arraigning整个政策的阿盖尔的政府，并拒绝接受查尔斯为王&，直至他应该给令人满意的证据，证明他真正的变化&。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失