查询词典 Fibrotic

Abstract］ objective to study the pathological features and histopathological type and differential diagnosis of hepatic focal nodular hyperplasia.methods the clinicopathological characteristics of 40 cases of fnh were studied.all were evaluted by use of paraffin embedded sections and he staining before light microcope observation.results there were 28 females and 12 males fnh patients whose age were from 16 to 62 years（median 41.3）,all alpha-fetoprotein was negative and had no hepatitis history.25 cases were classic type showed characteristic central stellate fibrotic scar,composed of fibrous connestive tissue and tortuous blood vessels.8 cases were telangiectic type,the left were mixed type and adenomatoid type.conclusion fnh is a reactive proliferation of hepatic cells to local blood vessel anomalies,it is not realy a tumor.its differential diagnosis includes hepatic adenomatous hyperplasia nodule,hepatic anaplasia nodular hyperplasia,fibrolamellar hepatocellular carcinoma and hepatocellular adenoma.

目的 探讨肝局灶性结节性增生的病理形态特点、组织分型及鉴别诊断。方法分析40例肝局灶性结节性增生的临床资料，并采用石蜡包埋he染色光镜下观察其组织学特点。结果 40例肝局灶性结节性增生患者中，女28例，男12例，年龄18~62岁，平均年龄41.3岁，所有病例术前均无肝炎病史，甲胎蛋白阴性，组织学上25例为经典型，有特征性的中央纤维瘢痕，由纤维结缔组织及扭曲血管组成。8例为毛细血管扩张型，其余为混合型及腺瘤样增生型。结论肝结节性增生是一种肝细胞对局部血管的异常反应性增生，并非真性肿瘤，主要与肝腺瘤样增生性结节、肝间变性结节状增生、肝纤维板层癌及肝细胞腺瘤鉴别。

RESULTS: Recombinant human augmenter of liver regeneration could decrease ALT, AST, LDH concentration of fibrotic rats.

观察肝纤维化大鼠血清丙氨酸转氨酶、天冬氨酸转氨酶、乳酸脱氢酶水平，肝组织胶原蛋白含量及肝脏病理学改变。

METHODS: Total 60 male Wistar rats were randomly divided into 6 groups, i.e., normal control group , DMN model group , large dose treatment group , middle dose treatment group, small dose treatment group and Dongbao gantai treatment group. The liver fibrotic model was induced by i.p. dimethylnitrosamine for 4wk. The relative herbs were given after model establishment in each treatment group and the administration lasted for 6 weeks. Decollate to get the blood and The serum hepatofibrosis indexes, hyaluronic acid, collagen IV, pro-collagen type III and laminin were measuredwith radioimmunoassay. SOD and MDA were measured with biochemistry method. The liver pathological changes were observed in each group of rats.

将60只雄性Wistar大鼠随即机分正常对照组、模型对照组、实验大剂量组(20ml/kg/d)、实验中剂量组(10ml/kg/d)、实验小剂量组(5ml/kg/d)及东宝肝泰药物对照组；腹腔注射二甲基亚硝胺制备大鼠肝纤维化模型，连续灌胃6周，断头取血，生化检测血清SOD、MDA；放射免疫法测定血清HA、LN、PCIII及IV-C；取肝左叶做HE染色和Mallory胶原染色，观察肝病理组织学改变。

The liver fibrotic model was induced by CCl4 i.p for 5wk. Telmisartan was given at the same time model establishment in each intervened group by administration lasted for 6wk. Decollate to get the blood of all rats after 7 weeks . ALT、AST and ALB of serum was detected by automatic biochemistry equipment. Hyaluronic acid was detected by ELISA detection. Liver and spleen was obtained to calculate the index. The liver pathological changes were observed in each group of rats after HE staining to evaluate the therapeutic effect of Telmisartan; TGF-β1、PPAR-γand PDGF of liver tissue was detected by the method of immunohistochemistry respectively; The mRNA expression of TGF-β1、MMP-1、TIMP-1、α-SMA、PPAR-γand iNOS was detected by RT-PCR detection, respectively.

腹腔注射CCl4制备SD大鼠肝纤维化动物模型，连续灌胃6周，处死动物取血，检测血清ALT、AST、ALB；ELISA法测定血清透明质酸；取肝、睥，并计算肝、脾指数，组织切片HE染色后进行组织病理学疗效评估；用SP免疫组化法测定肝组织TGF-β1、PPAR-γ及PDGF蛋白表达；半定量RT-PCR方法检测肝组织TGF-β1、MMP-1、TIMP-1、α-SMA、PPAR-γ和iNOSmRNA的表达。

Recently, a newly identified cell type, the fibrocyte, has been reported to contribute to wound healing and fibrotic conditions such as hypertrophic scarring.

近年来，循环成纤维细胞作为一种新型细胞被发现并鉴定，有报道表明这种细胞对创伤愈合和类似瘢痕肥大的纤维变性具有促进作用。

The tumor was excised and was found to be composed of bony trabeculae in a fibrotic stroma with many osteoclasts, a finding consistent with osteitis fibrosa.

切除肿块后发现肿块的成分为骨小梁和纤维化机制，机制中有许多破骨细胞，此发现与纤维性骨炎相符。

Results (1) Osteitis and destruction of end-plate showed long T1 and long T2.(2) Anterior and lateral abscess had long T1 and long T2 presenting even and structure-less signal.(3) The intervertebral discs showed normal or only degeneration at the early stage, and destroyed at later stage.(4) With Gd-DTPA enhancement, fibrotic granulation around abscess and destroyed area was well demonstrated.(5) Abscess in the bone and/or paraspinal abscess, destruction of end-plate were the important evidence for early diagnosis.

结果 (1)椎体骨炎及终板破坏呈长T1长T2信号，(2)椎旁或椎前冷脓肿呈长T1长T2均匀无结构信号，且上下跨越范围较大，(3)早期椎间盘信号正常或只出现退变，晚期则被破坏，(4)Gd-DTPA增强扫描可清楚显示冷脓肿周围纤维肉芽组织及椎管内侵犯，(5)骨内小脓肿和/或椎旁脓肿、椎体终板破坏是MRI诊断早期脊柱结核的重要依据。

Recent studies have indicated that collagenolytic potence was decreased in fibrotic liver, accompanied by elevated TIMP-1 as well as ...

最近的研究表明：纤维化肝脏胶原降解能力下降，其主要原因是金属蛋白酶组织抑制因子(tissue inhibitors of matrix metalloproteinase，TIMPs)-1和-2水平升高，其中以TIMP-1最为重要。

Recent studies have indicated that collagenolytic potence was decreased in fibrotic liver, accompanied by elevated TIMP-1 as well as TIMP-2 level, and the level of TIMP-1 seems to be the most important.

最近的研究表明：纤维化肝脏胶原降解能力下降，其主要原因是金属蛋白酶组织抑制因子(tissue inhibitors of matrix metalloproteinase，TIMPs)-1和-2水平升高，其中以TIMP-1最为重要。

The signal of ILK andα-SMA were detected mainly in perisinusoidal space of Disse, proliferative portal space,fibrotic septation and cells around hepatic sinusoid near to fibrotic septation.They nearly expressed in the common area.

ILK和α-SMA主要分布在肝窦周间隙，纤维增生的汇管区，纤维间隔及靠近纤维间隔的肝窦周围细胞，两者的表达几乎在共同区域。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐