查询词典 FAS

Objective To study the expressions of Fas and Fas-Ligand genes in rats with acute pancreatitis and their relation to apoptosis of pancreatic acinar cells.

目的 探讨凋亡调控基因Fas、FasL在大鼠急性胰腺炎中的表达及其与腺泡细胞凋亡的关系。

Aim To design and synthesize a series of novel γ-butyrolactone derivatives with FAS inhibition activities, C75 as the lead compound.

摘要目的以C75为先导化合物，设计、合成γ-丁内酯类衍生物，并研究其脂肪酸合成酶（fatty acid synthase， FAS）的抑制活性，以期发现新颖的FAS抑制剂。

However it was shown its eventually inhibiting effect on apoptotic myocyte cells during I〓 R〓h (P＜0.05); The PKC inhibitors chelerythrine and scutellarein have no effect on expression of Fas protein, whereas they can significantly upregulate the expression of Bcl-2 protein.

4PKC激活剂PMA可下调Fas基因的蛋白表达，对Bcl-2蛋白的表达也有抑制作用，它对缺血30min、再灌注24h后心肌凋亡细胞的最终影响为抑制效应(P＜0.05)，而PKC抑制剂CHE、灯盏花素对Fas基因蛋白表达无明显干预影响，但对Bcl-2蛋白表达呈显著上调作用，故对心肌细胞凋亡的抑制作用更为明显(P＜0.01)。

The results showed that the surface and cryptal lining cells of the pseudostratified ciliated columnar epithelium and the superficial squamous cells of the metaplastic squamous epithelium both underwent membranous expression of Fas, but the basal cells did not.

为了探讨Fas在鼻咽癌癌细胞凋亡过程中的作用，我们对37例未经治疗的非角化性人体鼻咽癌组织癌细胞Fas表达进行了研究。

Fig.3 The astrocytes in the area of gliosis around the anaplastic astrocytoma displayed Fas expression.

在多形性胶质母细胞瘤中内增生的血管内皮旦Fas强阳性，瘤细胞变为Fas阳性

Results 1. The expression of P53, KI-67, hTERT and ToPo II a protein was higher in astrocytoma than that in nomal brain tissue, the expression of these markers was obversely correlated to the grade of astrocytoma (P.05). The expression of Fas was higher in astrocytoma than that in nomal brain tissue, on the contrary, expression of P16 was lower in astrocytoma than that in nomal brain tissue.

结果 1、星形细胞瘤中P53、KI-67、hTERT与ToPoⅡα蛋白表达阳性率高于正常脑组织，P53、KI-67、hTERT与ToPoⅡα蛋白表达与星形细胞瘤的病理组织学分级呈显著正相关(P.05)；Fas蛋白在星形细胞瘤中的表达高于正常脑组织，而P16蛋白表达低于正常脑组织，Fas、P16蛋白表达与组织学分级无显著相关性。

Objective: To study the pathogenetic role and expression of Fas antigen and Fas ligand in severe cases of hepatitis D.

目的：探讨Fas／FasL途径介导的肝细胞凋亡在丁型肝炎重型化机制中的作用。

RA up-regulated Fas expression and translocalization from cytoplasm to cell membrane of the treated cells. Neither RA nor DDP could trigger apoptosis but in combination could effectively induce apoptosis.

与DDP不同，RA可明显上调Fas表达并使Fas蛋白从胞浆移至细胞表面；但仅在它与DDP联用时，才能诱导靶细胞凋亡。

Objective To explore the expression of Fas ligand in urogenital malignant cell lines and renal cell carcinoma.

Fas系统（包括Fas分子和FasL及其信号传导分子）在恶性疾病中的生物学作用还没有完全了解，但它在凋亡中的作用表明了它可以做为肿瘤生长的抑制因子。

In this study, we explore the change on expression of Fas and FasL of promoting apoptosis at different period of time after spinal cord injury by making the model of transecting injury completely in SD rat and applying to the immunohistochemical method.

通过制备SD大鼠脊髓全横断性损伤模型，应用免疫组织化学ABC法，揭示促凋亡因子Fas和FasL与脊髓在完全性损伤后的不同时间点之间的相互变化趋势，以探讨Fas和FasL在脊髓损伤中的作用。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。