查询词典 FAS

The expression level of metabolitic enzyme (CYP1A1, CYP1B1) and its correlation with cell differentiation /apoptosis were studied as well. The influence of resveratrol in cell cycle was determined with FCM. Results 1 Resveratrol not only suppresses the growth of medulloblastoma cells in a dose and time related fashion but also induces cell differentiation and apoptosis. Resveratrol promotes differention of UW228-1,-2 cells to forward glia, UW228-3 and Med-3 cells to neuron. A treatment of resveratrol in the concentration of 100μM for 48hrs comit most of cells die of apoptosis. 2 Among the four cell lines Fas and Caspase-3 were constantly expessed, whereas FasL was absent irrespective to the drug treatment. 3 ICC, RT-PCR, Western-blot hybridization and EROD enzymatic activity assay demonstrated that expression of CYP1A1 is different after treatment with resveratrol in four cell lines, up-regulated in three UW228 cell lines in a dose dependent manner but down-regulated in Med-3 cells. Suppressive effect of resveratrol on CYP1B1 expression is the same among four medulloblatoma cell lines. 4 Cell cycle distribution of UW228-3 was greatly changed after treatment.

结果：1、白藜芦醇以时间和剂量依赖性方式抑制髓母细胞瘤细胞生长，同时促进细胞的分化和凋亡：白藜芦醇促使UW228-1、-2靶细胞向神经胶质细胞方向成熟分化，UW228-3、Med-3细胞向神经元细胞方向成熟分化，以100μM作用48小时效果显著；2、四个细胞系均有Fas和Caspase-3表达，但无Fas-L基因表达和蛋白活性产生，因此难以形成Fas相关性死亡通路；3、白藜芦醇处理前后CYP1A1基因的表达在各细胞系略有不同：UW228-1，-2，-3三个细胞系白藜芦醇以剂量相关性方式上调CYP1A1的表达，而Med-3细胞系，白藜芦醇却抑制CYP1A1的表达；四个细胞系在白藜芦醇处理后CYP1B1的表达均受到抑制；4、UW228-3细胞系经白藜芦醇作用后细胞周期有较大改变，表现在G0/G1期在整个细胞周期中所占的比例增加，而其它时期则相应减少。

The Fas ligand appears overexpression in some AML. The pathway of Fas/Fas Ligand may involve in the mechanism of immune escape in AML.

Fas配基在部分急性髓性白血病中高表达，Fas/Fas配基途径可能参与这部分急性髓性白血病的免疫逃避。

Objective:To investigate the possible roles of Fas and Fas-L in the mechanisms of Pemphigus Vulgaris and Bullous Pemphigoid.

目的 ：探讨 Fas和 Fas- L在寻常型天疱疮和大泡性类天疱疮皮损发生发展中的作用。

This study had cloned full reading frame Fas/FasL gene of the normal human being, and constructed its eukaryotic expression vector, providing a basis for further study on the function of Fas/FasL.

采用RT-PCR方法成功克隆了正常人Fas/FasL基因并正确构建了其真核表达载体，为进一步研究Fas/FasL基因的功能奠定了基础。

A portion of ductal cells and individual serous acinic cells of the minor salivary gland also expressed Fas not only in membranous but also in cytoplasmic pattern.

结果发现，在正常鼻咽粘膜表面及隐窝的假复层纤毛柱状上皮细胞胞膜、部分小涎腺的导管上皮和个别浆液性腺泡上皮细胞的胞膜和胞浆Fas阳性表达；鳞状化生上皮的表层细胞胞膜有Fas表达，但基底细胞未见Fas表达；浸润的淋巴细胞也不表达Fas.45.9%（17/37）的鼻咽非角化性癌Fas阳性，但只有不足10%的癌细胞胞膜微弱表达Fas。

Objective To study the relationship between the abnormal expression of Bcl-2,Fas and Fas-L in granulosa cells and polycystic ovary syndrome.

目的 探讨Bcl-2、Fas、Fas-L的异常表达与多囊卵巢综合征的发病关系。

The results showed: there is the apoptosis of the myocardial cells during the period of I/R. The further study showed that there is the express of Bcl-2, Bax and Fas in the model of the cultured myocardial cells which were treated with ischemia-reperfusion The express of Bax, Fas proteins increase obviously. The overexpress of Bcl-2 is weak positive which shows that there is certain relationship between the apoptosis of the myocardial cells and the higher express of Fas and the ratio descent of the Bcl-2/Bax.

结果表明：在I/R过程中确有心肌细胞凋亡现象，而且进一步研究发现在培养的心肌细胞缺血-再灌注的模型中均见Bcl-2、Bax、Fas的表达，Bax、Fas蛋白的过度表达明显增加，Bcl-2的过度表达仅呈弱阳性，表明心肌细胞的凋亡与Fas的高表达，Bcl-2/Bax的比例下调有一定的必然联系。

Methods The model of subacutely aging rats were made by injecting Dgal into the rats, abdominal cavity continually. After lavaging HSWY, the apoptosis rate and the levels of Fas and FasL mRNA were measured by TUNEL and RTPCR; the expressions of Fas/Fasl protein were detected by SP immunocytochemistry.

采用D半乳糖连续腹腔注射致亚急性衰老大鼠模型，同时以何首乌饮灌胃作为延缓衰老组；造模后应用脱氧核糖核苷酸末端转移酶介导的缺口末端标记法检测各组大鼠卵巢细胞凋亡情况；测定各组Fas和FasL的信使核糖核酸水平；SP免疫组化法检测卵巢细胞Fas和FasL蛋白的表达情况。

Methods:The expression of Fas/Fas-L and apoptosis were assayed by flow cytometry.

用流式细胞仪检测细胞凋亡和Fas、Fas-L的表达。

To investigate the expressions of Fas and FasL on tumor cells and TILs in patients with so as to understand the potential role of Fas system in immune escape and counteratteck involved in HCC,the expression levels of Fas and FasL were detected on tumor cells,noncancorous liver cells,TILs and PBLs in patients with HCC by means of indirect fluorescent immunoassay flow cytometry.

为研究肝细胞癌患者肿瘤细胞、肿瘤浸润淋巴细胞Fas抗原与FasL配体的表达水平，探讨Fas系统在肝细胞癌免疫逃逸及免疫反击中的作用，采用间接免疫荧光流式细胞术检测20例肝细胞癌患者肿瘤细胞、肿瘤浸润淋巴细胞和外周血淋巴细胞Fas与FasL的表达。

Neither the killing of Mr Zarqawi nor any breakthrough on the political front will stop the insurgency and the fratricidal murders in their tracks.

在对危险的南部地区访问时，他斥责什叶派民兵领导人对中央集权的挑衅行为。

In fact,I've got him on the satellite mobile right now.

实际上 我们已接通卫星可视电话了