查询词典 ERKS

However, the activation of ERKs was significantly suppressed after the COS7 cells were transfected with C289A and Q257A. The result indicated that C289A and Q257A were the stretch sensitive region.

结果提示AT1受体上位于257位的谷氨酰胺和289位的胱氨酸在机械牵张引起的AT1受体激活中起了重要作用。

Angiogenesis is regulated by signals derived from receptors for both growth factors and ECM molecules. Recent studies have shown that activation of ERKs is closely involved in the migration or tubular-like formation of endothelial cells and induced by various angiogenic factors.

血管新生可以受到许多来自於生长因子受器及胞外基质受器的讯息所调控，而近年的研究也显示ERK的活化不但会受到许多促血管新生因子的诱导，而且跟内皮细胞的移型及管状形成作用有很大的关系。

Extracellular-regulated kinase 3(ERK3) is an atypical member of ERKs, lacking the threonine and tyrosine residues in the activation loop, carrying a unique C-terminal extension and being mainly regulated by its own protein stability.

其活化环不同于一般的ERK，缺少苏氨酸和酪氨酸残基，拥有一段独特的C端延伸序列。ERK3蛋白是一个不稳定的蛋白，它的生物学活性主要依靠其蛋白稳定性和激酶活性调节。

RESULTS The results indicated that PCF could significantly increase the viability of thymocytes and enhance the activities of SOD, GSH-Px, CAT in cells. PCF decreased the amounts of ROS and the rate of apoptosis in cells. PCF inhibited the morpholog alteration of the thymocytes irradiated by UVB and maintained the ultrastructure of cells in normal. PCF attenuated UVB caused DNA fragmentation in thymocytes. While combined ERKs inhibitor yielded typical DNA fragmentation, co-treatment of thymocytes with PCF and JNKs and p38 kinase inhibitors completely blocked UVB-induced DNA fragmentation.

结果 PCF能显著提高UVB辐射后小鼠胸腺淋巴细胞的活性；提高胞浆中SOD、GSH-px、CAT的活性，降低ROS含量及细胞凋亡率；抑制UVB辐射所致的胸腺淋巴细胞凋亡的形态学改变，维持细胞的正常超微结构；抑制UVB所致的胸腺淋巴细胞DNA片段的出现；预先应用ERK抑制剂使DNA片段增加，给予JNK和P38抑制剂后协同PCF使DNA片段带减少。

Mechanical strains also regulated the protein and mRNA expression of several differentiation markers, as well as the activation of extracellular signal-regulated kinases, p38 MAP kinase and protein kinase B in a frequency-dependent manner. Furthermore, the inhibition of p38 pathway could block the strain-frequency induced the phenotype modulation of VSMCs, neither ERKs nor Akt. Frequency of mechanical strain, not conditioned medium, regulated the phenotype of VSMCs in a frequency-dependent manner. Rho-GDI alpha was suppressed by the mechanical strain at 1Hz.

采用免疫细胞化学法检测VSMCs形态和排列的变化；RT-PCR和Western blotting检测表型标志分子α-肌动蛋白、肌球蛋白重链(SM1/2)、肌动蛋白相关蛋白SM22α和调宁蛋白(h1-calponin)的mRNA和蛋白水平的变化；抑制剂或RNA干扰阻断可能的信号调节分子的活性或表达，包括p38、细胞外信号调节激酶1/(2extracellular signal-regulated kinases， ERK1/2)、蛋白激酶B和Rho-鸟苷酸解离抑制因子(Rho-guanine nucleotide dissociation inhibitor， Rho-GDI alpha)，研究了不同频率张应变对VSMCs表型转化的影响及其调节机制。

They weren't aggressive, but I yelled and threw a rock in their direction to get them off the trail and away from me, just in case.

他们没有侵略性，但我大喊，并在他们的方向扔石头让他们过的线索，远离我，以防万一。

In slot 2 in your bag put wrapping paper, quantity does not matter in this case.

在你的书包里槽2把包装纸、数量无关紧要。