查询词典 DMD

Denis Duboc at Cochin Hospital in Paris and colleagues, who published their findings in the September issue of American Heart Journal, randomly assigned 28 DMD patients with normal heart function to take 2 to 4 milligrams of perindopril per day; and another 29 patients, also with normal heart function, to take a placebo.

巴黎Cochin医院的Denis Duboc与其同仁於九月份的美国心脏期刊发表其研究发现。随机选择28位心脏功能正常的DMD病患，每天给予2~4毫克的perindopril；另外29位也是心脏功能正常的患者，则给予安慰剂。

Herein, we report the enantioselective total syntheses of slagenins A-C and their antipodes. Starting from readily available ethyl -4-chloro-3-hydroxy-butanonate, elongation of the carbon chain with diazomethane, followed by oxidation of the given α-diazoketone using distilled DMD, afforded a key intermediate α-ketoaldehyde .

本文从方便易得的-4-氯-3-羟基-丁酸乙酯出发，经重氮甲烷延伸碳连、DMD氧化相应的α-重氮酮，制得α-酮醛；该化合物与尿素在氢氟酸作用下，以协同方式非对映选择性的直接构建了cis-四氢呋喃并[2，3-d]咪唑啉-2-酮双环结构，进而合成了天然产物slagenins A、B、和C的对映体。

DMD is one of the most common fatal genetic disorders to affect children around the world.

DMD是最常见的致命的遗传疾病之一，影响到世界各地的儿童。

In principle, approximately 80% of all DMD patients could be treated with exon–skipping drugs.

原则上，大约有80例DMD％可以治疗外显子跳跃的药物。

Normal muscle showed accumulation of glycolytic and oxidatie metabolism capacity with increased age, but this accumulation failed in DMD.

正常肌肉显示随着年龄增加糖酵解和氧化代谢能力逐渐增加，而在DMD病人中TGF-beta 通路明显诱导强化，并且在DMD肌纤维中尚可发现TGFbeta II型受体和凋亡信号调节酶1表达增加。

Results These two patients were confirmed to suffer from DMD. They were characterized by typical features of DMD including typical clinical manifestations, increased serum enzymes, EMG presenting myogenic impairment, HE staining presentation belonging to DMD, negative dystrophin in brother, and inconstantly positive on the sarcolemma of sister. Furthermore, no deletion or duplication was found in the 1-79 exons of dystrophin gene. The suffering brother and sister carried the same maternal X chromosome.

结果 兄妹二人符合DMD诊断，具有典型的DMD临床表现，肌酸激酶、肌酸激酶同工酶、乳酸脱氢酶、羟丁酸脱氢酶和谷草转氨酶的水平均显著高于正常值，肌电图呈肌源性损害，肌肉HE染色符合DMD，男患者的抗肌萎缩蛋白表达阴性，女患者的少量肌纤维仍可见不连续膜阳性，两患者抗肌萎缩蛋白基因的1~79号外显子未见缺失和重复突变，女患者与男患者携带相同的母源性X染色体。

Methods The Diaphragmatic muscle, latissimus dorsi and gastrocnemius muscles of the C57BL/10ScSn-Dmd/J and C57BL/6J mice were collected at the age of 2, 3, and 4 weeks, respectively. Each group selected 3 mice for experiments. Dmd gene were amplified and analyzed by RT-PCR.

选取2、3和4周龄C57BL/10ScSn-Dmd上标(上标 mdx/J模型小鼠及C57BL/6J小鼠各3只，分别采集膈肌、背阔肌和腓肠肌的肌肉组织，利用RT-PCR方法扩增分析Dmd基因的结构特点；采用Western bolt方法分析β-dystroglycan的表达差异。

Based on the number of families with at least one affected girl and the number of patients per sibship among these pedigrees, the proportion of families with DMD inherited as an AR trait was estimated.

结果：常染色体隐性遗传的类DMD患者独立行走的平均时间为（1.47±1.00）岁，症状出现的平均时间为（8.11±4.32）岁，血清肌酸激酶平均水平为（2785.10±1500.29）U/L，这种常染色体隐性遗传型类DMD占DMD的9.4%。

It is completely or partly deficient on the sarcolamma of the skeletal muscle and in the arrector pili muscles in the patients with the DMD and BMD; Some as the skeletal muscle biopsy, the skin biopsy is also a useful, easy and trustworthy method to molecular pathological diagnose the DMD and BMD.

DMD和BMD患者肌营养不良蛋白在骨骼肌肌纤维膜、皮肤立毛肌呈完全/不完全欠损，与骨骼肌活检相同，皮肤活检也是分子病理学诊断DMD、BMD简便、易行、可靠的方法。

Objective: To verificate culture、amplification、induction anddifferentiation of myoblast and Mesenchymal stem cells of themouse in vitro; to transplant the myoblast and MSCs to mdx mice, themodel animal of DMD, by vena caudalis; To observe the growth andfusion of myoblast and MSCs in the host after transplantation.

目的：研究成肌细胞及骨髓间充质干细胞体外培养、扩增、诱导分化；利用成肌细胞及骨髓间充质干细胞经尾静脉注射移植治疗DMD模型鼠mdx小鼠；观察移植后的细胞在宿主体内的生长及融合情况；探讨基因治疗DMD的方法及可行性。

The reasons of iron ions content overproof in grade Ⅱ desalting water system,such as variation water quality,contamination of regenerant , operation adjustment of pretreatment system and switching operation of bed were discussed.

对二级脱盐水系统中铁离子含量超标的原因，如来水水质发生波动、再生剂受到污染、预处理系统操作调整、床体运行切换等进行了论述。

You were hired to drum up new business, so go and do it.

公司雇你招徕新业务，你就做你的事好了。