查询词典 CML

CML is cytogenetically marked by the philadelphia chromosome, which originates from a reciprocal translocation between chromosome 9 and 22 and is molecularly marked a chimeric bcr-abl gene, resulting from juxta-positive of the abl proto-oncogene on chromosome 9 with the bcr gene, which is normally located on chromosome 22. The chimeric bcr-abl gene expression an 8. 5kb hybrid mRNA transcript giving rise to a 210-KD fusion protein (P210〓) with increased tyrosine kinase activity. P210〓 plays a key role in the pathogenesis of CML. The continuous cell line K562 was established from the pleural effusion of a 53-year-old female with CML in terminal blast crisis, and was a human erythroleukemia line, contained Ph chromosome.

绝大多数慢粒患者白血病细胞中具有Ph染色体，是由9号染色体长臂3区4带和22号染色体长臂1区1带相互易位形成，即t（9；22），使位于9q〓的c-abl原癌基因在第二外显子的5'端断裂并易位到22 q〓的M-bcr基因第2或第3外显子的3'端，形成异常的bcr-abl嵌合基因，该基因转导出异常的mRNA，编码并翻译出P210蛋白，该蛋白具有很强的酪氨酸激酶活性，使粒细胞发生恶性增殖。K562细胞属于慢粒急变、红白血病细胞株，具有Ph染色体。

It is concluded that IFN-α selectively inhibits the later CFU-GM of CML cells and the development of stromal cells, the combination of IFN-α and LTBMC might exert a synergically purging effect on Ph CML cells

上述结果表明IFN-α优先抑制晚期CFU-GM，对基质细胞也有抑制作用，LTBMC联合INF-α对PhCML细胞有协同净化作用。

And the frequency of TCR VγⅢ in CP and CR patients is markedly lower than that from healthy adults（P=0.013,P=0.043）. The most frequency used VγⅡsubfamily of clonally expanded T-cells were identified in both CP and CR patients.

CP和CR期病人TCR VγⅢ的表达率明显低于健康对照组（2.9±0.32）（P=0.013，P=0.043），基因扫描显示CML-CP 和CML-CR出现克隆模式的改变主要集中在TCR VγⅡ亚家族。

Dr. Sawyers, another CML expert said that it can take a low level mutation as much as 5 years to show up and proliferate and this connects up to Dr. Druker's observation that the coast is clear after 5 years in CCR.

另一位 CML 专家 Sawyers 医生说，低水平上的基因突变可能发展缓慢，也许会用5年的时间显露出来并发生繁殖，这也和 Druker 医生说的持续取得5年 CCR 之后才确保安全是一致的。

Objective : To investigate the effect of bcr/abl fusion gene on the growth of chronic myeloid leukemia cells and to explore the feasibility of ribozyme in CML gene therapy.

目的：研究bcr/abl融合基因在慢性粒细胞白血病中的作用以及探索CML基因治疗的可能性。

In contrast to ABL, breakpoints within BCR localize to 1 of 3 so-called breakpoint cluster region.

CML具特征性的Ph染色体，由其形成的bcr-abl融合基因在CML的发病中起重要作用。

It was also found that 17 genes only expressed in blastic phaseof CML.

此外还发现17个基因仅在急变期的CML中表达，而在慢性期无表达。

CC can be used as a basic tool to monitor the change of tumor load in CML during treatment.

CC可作为监测CML患者治疗过程中肿瘤负荷水平的基本手段。

Analysis of the LDH mye be helpful in the diagnosis and prognosis of CML.

结论检测血清LDH有助于CML的诊断和预后评估。

CML derived MSCs showed normal karyotype and ultrastructure, they did not express BCR/ABL gene.

CML来源的MSCBCR／ABL融合基因阴性，不具备体内和体外致瘤性。

However, as the name（read－only memory）implies, CD disks cannot be written onorchanged in any way.

然而，正如其名字所指出的那样，CD盘不能写，也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口，替代木托盘，免薰蒸，符合欧盟、北美各国对出口货物包装材料的法令要求；喷涂钢托盘适用于重载上货架之用，托盘表面根据需要制作成平板状、波纹状及间隔形式，满足不同的使用要求。