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There are four kind of isoforms of endothelin in human and other mammals named ET-1, ET-2, ET-3 and ET-β, which are slightly different in construction and pharmacological effect. In human beings, ET-1 is the dominative subtypes. ET-1 remains in blood at a low level about 5ng per liter on physical state. It is synthesized, stored, released and metabolized locally. The half-life of ET-1 is about 1 hour. ET-1 is the most potent vasoconstrictive factor till now, and it is more functional in vein than in artery. In vascular bed, there are two kind of ET receptors. Type A mainly located in smooth muscle cells, whereas type B in endothelial cells. The latter can stimulate intimal hyperplasia via a parasecretion way and activate some oncogenes such as c-fos and c-myc and then enhance their expression. These alterations result in constriction of blood vessels, thus the SMC steps into proliferate state from silent state.

人及哺乳动物体内有四种结构及药理学性质略有差异的异物体，分别为ET-1、ET-2、ET-3、ET-β，而在人主要是ET-1，在生理条件下，ET-1在血浆中含量较低，约为5ng〓，故ET-1不是一个循环激素，而是局部合成释放，局部起作用的活性物质，半衰期约1小时，ET-1是目前已知的最强的血管收缩剂，对静脉的作用比动脉强，在血管床，ET受体有A、B两型，A型主要分布在平滑肌细胞，B型主要分布在内皮细胞，它可以通过旁分泌途径刺激内膜增生，具有有丝分裂原效应，可以激活某些癌基因如C-fos、C-myc使其表达增强引起血管收缩，使静止期SMC进入增殖期，还可以通过信号传导途径，与bFGF、GTF-β、PDGF等生长因子协同作用，起共有丝分裂原作用。

Because of nitrogen, the value of IAA/ABA、GA3/ABA、(IAA+GA3+ZR)/ABA in grain promoted at seed filling stage and at the mature stage.6、The adjustment of nitrogen levels on carbon and nitrogen metabolism.Nitrogen reduced the C/N in leaves and stem. When the nitrogen rate was 50 kg/hm2, the effect on stem was obvious. When the nitrogen rate was 100 kg/hm2, the effect on leaves was obvious. The C/N in roots lower before seed filling stage and the effect was not obvious after seed filling stage.7、Effect of nitrogen levels on yield traitsPlant height, pods per plant and full grain number were increased and bottom-pod height and podded node were decreased by applying nitrogen.

施氮在鼓粒期、成熟期均提高了子粒中IAA/ABA、GA3/ABA、(IAA+GA3+ZR)/ABA的值。6、氮素水平对大豆碳氮代谢的调节施氮降低了叶片和茎秆中C/N的比值，施氮量为50 kg/hm2时，对茎秆作用效果明显，施氮量为100 kg/hm2时，对叶片效果明显；施氮降低了根系鼓粒期前的C/N比值，而鼓粒期后作用效果不明显。7、氮素水平对产量性状的影响施氮增加了大豆的株高、株荚数、饱满粒数，降低大豆的结荚高度、结荚结位。

It was found that La〓 does not affect the binding affinity between calmodulin and Polistes Mastoparan, a known calmodulin binding peptide, neither the conformation of the ternary complex. Excessive amount of La〓 result in the decrease of the binding constant and the disrupted conformation. The binding affinity of La〓 to calmodulin increased in the ternary complex (La〓-CaM-Mas/Mas X), which suggested the coordination between the two global domains. The binding priority between the two global domains is also changed: La〓 more is likely to bind to the C-terminal of calmodulin than to N-terminal, thus facilitates the binding of Mas/Mas X to the C-terminal of calmodulin as the first step of the Mas/Mas X binding.

在以钙调蛋白结合肽—Polistes Mastoparan和Mastoparan X为对象的研究中，我们发现，除非过量，否则La〓的存在不影响钙调蛋白与Mas间的结合常数以及构象；过量的La〓（La〓/CaM摩尔比＞4）将引起钙调蛋白结合功能的下降，同时明显改变金属-钙调蛋白-Mas三元复合物的构象；La〓对Ca〓CaM-Mas的N末端表现高度选择性，显示了在三元复合物中两种离子间的协同效应；在三元体系中，La〓与钙调蛋白的亲和力明显上升，而且亲和力上升的程度因钙调蛋白结合肽的不同而有明显差异，显示了作用的选择性；Mas和MasX的存在改变了La〓在钙调蛋白上的结合顺序，La〓很可能优先与C末端结合，从而使Mas/Mas X首先与C末端结合，该顺序与钙离子相同；La〓的参与使三元复合物在动力学上更加稳定。

In this paper, twenty novel meso-substituted porphyrins of four series were designed and synthesized by increasing the conjugation of porphyrins or introducing substituents with high fluorescence quantum yield into the meso-position of porphine, and then red OLEDs were fabricated by doping porphyrins into a suitable host using ten porphyrins compounds and their electrolumin -escence properties were tested. The main contents and results were generalized as follows:Three meso-tetrakisporphyrins 4a-c and three conjugations of porphine-triarylamine linked by styrene 10a-c were synthesized and characterized by 1H NMR, MS, UV-vis spectra and fluorescence emission spectra.

本文通过增大卟啉分子的共轭结构或将具有高荧光量子产率的基团连接到卟吩环的中位得到了四类共20个新型的卟啉化合物，并选取其中10个化合物制备有机发光器件来考察材料的电致发光性能，具体内容包括以下几个部分：设计合成了3个中位直接被三芳胺取代的卟啉化合物4a-c和3个通过苯乙烯连接的卟吩-三芳胺共轭体10a-c，通过核磁氢谱、质谱、紫外吸收光谱和荧光发射光谱表征了新化合物的结构。

6The studies on SSR identification of P. shenzhou show that: The leaf, bud, bast and xylem of type A plant had no components of type C, showing that the above-ground of type A was already pure. Type A plant had two kinds of color roots, the rufous roots belonged to type A tissue, the yellow roots belonged to type C tissue through the SSR identification.

6由深州杨SSR鉴定研究可得：深州杨A型植株的叶、芽、韧皮部、木质部已经检测不到深州杨C型的成分，说明深州杨A型的地上部分已经纯合：深州杨A型植株的地下部分含有红褐色和土黄色两种根，经检测，红褐色根是属于深州杨A型的纯合组织，土黄色根是属于深州杨C型的纯合组织。

Investigating the influences of processing parameters on the C/Si molar ratio of resulted nanosized SiC powders indicated that there was a direct pyrolytic reaction from DMS to SiC as well as the previous proposed two-step reaction. Under the optimized processing conditions, the silicon carbide powders of homogeneous particle size distribution, spherical shape and stoichiometrical C/Si molar ratio are obtained. The silicon carbide particle consists of β-SiC crystallite arranged randomly.

论文系统研究了工艺条件对产物粉体C／Si摩尔比、粉体颗粒尺寸和组成粉体的SiC微晶尺寸的影响；研究了粉体制备过程中可能发生的化学反应，提出了反应过程中除了分步进行的生成SiC的反应外，同时在高温区还存在一步完成的生成SiC的化学反应的观点；通过调整工艺参数，制备得到了粉体尺寸分布均匀、呈均匀球状、C／Si摩尔比符合化学计量比的颗粒尺寸为40nm的纳米SiC粉体。

The results showed that appropriate amount of potassium fertilizer could increase the contents of soluble solids and vitamin C in harvest, and reduce titratable acid content in fruits; slow down the reduction of fruit titratable acid content under refrigeration, inhibit the increase of the content of soluble solids and losses of vitamin C, and well preserve the quality of fruit and its storability.

结果表明适量增施钾肥能提高无花果采收时可溶性固形物含量和维生素C含量，降低果实可滴定酸含量；减缓冷藏期间果实可滴定酸含量的下降，抑制果实可溶性固形物含量的上升和维生素C的损失，较好地保持了果实的品质，提高了果实的耐贮性。

Methods Thirty adult New Zealand rabbits were divided into three groups, group A,B,C, with ten rabbits in each group. One full-thickness defects of articular cartilage, 4 mm×5 mm×2.5 mm in size, was made in the trochlear groove of the left femur of each rabbit. The defects of group A and B were filled with BMP/FG and FG respectively. The defects of group C were left empty.

30只新西兰种成年兔随机分为A，B，C三组，每只兔子左膝股骨髁间凹做一大小为4 mm×5 mm×2.5 mm的全层关节软骨缺损。A、B组缺损内分别填充BMP/FG及FG，C组为空白。

Methods:All the 40 Winstar rats were divided into four groups:group A:the rats were fed with normal diet,group B:the rats were fed with only high|cholesterol diet(no vitamin D3),group C:the rats were treated with one intramuscularly injection of vitamin D3(300 000 U/kg) and were denudated of endothelium,followed by high|cholesterol diet,group D:the rats were treated with 5% chitosan added into the diet besides treatment as group C.Ninety days later,the formation of atherosclerosis plaques and the activities of nitric oxide synthase in aortas in the four group rats were investigated.

40只Wistar大鼠均分为：A组；B组：饲以高脂饲料（不含维生素D3）；C组：一次性给予大鼠维生素D3（30万U/kg体重）肌肉注射，以球囊损伤主动脉内皮和饲以含维生素D3（1.25×106U/kg）的高脂饲料；D组在C组的基础上饲料中加入5%壳聚糖。90 d后检测主动脉动脉粥样硬化斑块形成及NOS的活性。

The invention discloses an optical-fiber all-optical code converter, comprising a temperature control circuit as well as optical-fiber Mach-Zed interferometer, heat sink, semiconductor refrigerator, thermosensitive resistor and radiator, where the interferometer is composed of two cascaded 3dB couplers on the heat sink, the relation between length difference delta L of two arms of the interferometer and generated delay time difference delta T is that delta L=c.delta T/n, where c is light velocity in vacuum and n is refractive index of optical fiber; the thermosensitive resistor is used to detect temperature of interferometer, the temperature control circuit is used to compare feedback voltage of the thermosenstive resistor with a given voltage to regulate working current of the semiconductor refrigerator, and the semiconductor refrigerator refrigerates or heat two arms of the interferometer by the heat sink.

本发明公开了一种光纤型全光码型转换器，它包括温控电路和位于密封盒内的光纤型马赫-泽德干涉仪、导热热沉、半导体制冷器、热敏电阻以及散热片；干涉仪由位于导热热沉上的二个3dB耦合器级联而成，两臂的长度差ΔL与产生的延时差ΔT之间的关系为ΔL＝c。ΔT/n，c为真空中光速，n为光纤折射率；热敏电阻用于对干涉仪的温度进行探测，温控电路用于比较热敏电阻反馈的探测电压和设定电压，对半导体制冷器的工作电流进行调节，半导体制冷器通过导热热沉对干涉仪两臂同时进行制冷或加热。

For a big chunk of credit-card losses; the number of filings (and thus charge-off rates) would be rising again, whether

年美国个人破产法的一个改动使得破产登记急速下降，而后引起了信用卡大规模的亏损。

Eph. 4:23 And that you be renewed in the spirit of your mind

弗四23 而在你们心思的灵里得以更新