查询词典 Beckmann rearrangement

In addition, the application of the RTILs (BF4, PF6) in the Beckmann rearrangement have been firstly studied. On the conditions of the reducing the oil of vitriol, the effects of the two RTILs in the Beckmann rearrangement have been reviewed and contrast experiment.

另外，首次将咪唑类离子液体应用于Beckmann重排反应体系，考察了在减少发烟硫酸用量的情况下，两种离子液体对Beckmann重排反应的影响并做了空白实验。

We studied DBU-mediated Ireland-Claisen rearrangement. Using DBU as the base for enolization of allylic esters of unsaturated acids 9-16, we found a novel DBU-mediated tandem Ireland-Claisen rearrangement /isomerization reactions and established a consecutive Ireland-Claisen rearrangement /Cope rearrangement.

利用DBU作为烯醇化碱，对含有活泼质子的烯酸烯丙酯类化合物9-16的Ireland-Claisen重排进行了系统的研究，创建了一条新颖的DBU-促进的Ireland-Claisen重排/异构化串联反应及Ireland-Claisen重排/Cope重排的串联反应路线。

The reactions include, organometallic reactions (grignard reaction, organolithium -zinc, and -copper chemistry ), metal catalyzed reactions, mannich reaction, nitration, hydrogenation, azidation, amino-protection reactions, organoalluminum catalyzed beckmann rearrangement, schmidt rearrangement, epoxidation, epoxide ring opening reactions, swern oxidation etc.

这些反应包括：有机金属反应(格利亚反应，有机锂，有机锌和有机铜反应)，金属催化反应堆(suzuki 反应， negish 反应)， mannish 反应，硝化反应，氢化反应，叠氮反应，各种基团的保护和脱保护反应，有机铝催化的贝克曼重排反应，斯密特重排反应，环氧化反应，环氧烷开环反应， swern 氧化反应等。

The rearrangement reaction of Oxim is a typical Beckmann rearrangement reaction.

环己酮肟重排反应是一典型的贝克曼重排反应。

Majority of acute leukemias in infant, either acute lymphoblastic leukemia or acute myeloblastic leukemia, posses a chromosomal translocation affecting the 11q23 chromosome region which specifically inoles the mixed-lineage leukemia gene.1-3 Most pediatric leukemias with MLL rearrangement clearly hae a remarkably short latency.1,4 MLL gene rearrangement is also associated with secondary leukemias of patients preiously treated with the topoisomerase II inhibitors.4 The latency of these secondary leukemias is similarly ery short.4 Of note, the concordance rate of leukemia with MLL rearrangement in infant monozygotic twins approximates to 100%,1,4 and identical breakpoint in the MLL gene was shared in these pairs of identical twin infants with concordant ALL.1,4 Moreoer, the unique and clonotypic MLL fusion gene was detectable in neonatal blood spots for Guthrie cards from non-twined indiiduals who subsequently deeloped ALL.1,4 These obserations indicate not only that MLL fusion is generated in utero but also that MLL fusion proteins could be capable of inducing leukemic transformation with few, if any, secondary mutations.2,3,4 Greaes et al speculate that an MLL fusion protein somehow promotes rapid transition to full-blown disease in patients ia ery rapid clonal expansion, genetic instability, or inhibition of DNA damage repair.4 In general, for clonal expansion of malignancies, tumor cells often hae acquired strategies that escape immune sureillance of the hosts.5,6 Immune escape mechanisms also contribute to the failure of graft-ersus-leukemia effect after allogeneic hematopoietic stem cell transplantation.7 Therefore, leukemia cells could acquire some immune escape mechanisms during leukemogenesis.

绪论 绝大多数的婴儿白血病，不管是急性淋巴性白血病或是急性骨髓性白血病，在染色体11q23部位有染色体易位的情况；这个部位的染色体易位牵连了混合谱系白血病基因。大多数具有MLL基因重排的儿童白血病潜伏期明显短很多。MLL基因重排也和经拓扑异构酶II抑制剂治疗后的继发性白血病有关。这些继发性白血病的潜伏期类似地都非常的短。很重要的是，单卵双胞胎婴儿同时患有或同时免于MLL基因重排阳性的白血病的一致性接近100%；并且同样患有ALL的同卵双胞胎的MLL基因的断裂点是一致的。而且，这种独特的克隆特异性的MLL融合基因能够从那些得ALL的非双生个体出生时的血斑标本中检测到。这些发现表明MLL融合基因产生在胎儿还在子宫的是后，而且MLL融合蛋白能过和其他的基因突变一起诱导白血病的产生。Greaes 等推测MLL融合蛋白在某种情况下同过快速克隆增殖，遗传的不稳定性或是DNA损伤修复的抑制促使疾病迅速地全面爆发。恶性肿瘤细胞的克隆增殖通常已经获得了逃避机体免疫监视的能力。免疫逃避机制也归因于异体外周血干细胞移植后移植物抗白血病作用的失效。所以，白血病细胞在白血病的产生过程中可能获得了某些免疫逃脱机制。

Described in chapter 3 is the immediate application of the Clemmensen reductive rearrangement reaction to the polycyclic system as illustrated in a elaboration of the 5-6-7 tricyclie core skeleton of Stemona alkaloids in 5 steps: N-alkylation, [3, 2] -sigmatropic rearrangement, Dieckmann condensation, oxidative cyclization, reductive rearrangement, starting from ethyl pipecolinate hydrochloride.

我们以哌啶酸乙酯为起始原料，经氮烷基化，[3，2]-σ重排，Dieckmann缩合，自由基环化，6-6-6元环系到5-6-7元环系的还原重排五步反应，高收率地构筑了百部生物碱的5-6-7氮杂三环骨架，并用X射线晶体衍射法确定了其结构。

of determination of cyclohexanone oxime concentration in esters gained in liquid phase Beckmann rearrangement is set up in the paper, which is a basis of the above reaction kinetics.

本文建立了己内酰胺液相重排反应转位酯中环己酮肟含量的测定方法，为环己酮肟液相重排反应动力学的研究奠定了基础。

The oxime of 10 underwent the abnormal Beckmann rearrangement to yield a major product 12 smoothly.

对11生成的肟进行非正常Beckmann重排反应，顺利地得到了主要产物12（Scheme 4）。

Under the conditions of acidity and dehydration, the abnormal Beckmann rearrangement usually occurs in α-electrofugally substituted cyclic ketoximes and gives a ring opened alkene-nitrile compound.

一。非正常Beckmann重排反应在甾体-17-酮肟中的应用对甾体18-甲基修饰是制备生物学重要的18-去甲基甾体的有效方法之一。

Beckmann rearrangement reaction is that amide is formed by ketoxime under the condition of acid catalyzer.

酮肟在酸性催化剂作用下，生成酰胺的反应称为&贝克曼重排反应&。

Blod lactid acid ; Wushu ; unarmed combat ; training ; training method

血乳酸；武术；散手；运动训练；训练法

At the onset of 2009, Transiting Rahu is Capricorn and Ketu is in Cancer.

大部分诞生在这个月座的人精力充沛、坚强、上进、勇敢、适应环境能力强、有野心、动力强大并坦率。