查询词典 Alzheimer's disease

On creating model of cultured hippocampal neurons injured by amyloid, we studied the mechanisms of close interrelation between amyloid and Alzheimer"s disease at cell and molecular level with advanced test methods. For example, the technique of optical lens and electron microscope , immunohistochemical method,biochemistry.molecular biology and HPLC, so as to deeply probe into the mechanisms that Decotion of Rehamanniae prelects and treats Alzheimer"s disease.

本课题通过建立β淀粉蛋白损伤离体培养的海马神经元模型，运用光、电镜技术及免疫组化、生物化学、高效液相及分子生物学等先进的检测手段和方法，从细胞及分子水平进一步探索了Aβ与老年性痴呆发生、发展密切相关的综合机制，从而全面深入地探讨了地黄饮子防治AD的作用机理。

"We advocate, based on these findings, that the criteria for the diagnosis of Alzheimer's disease should include MRI scans," said the study's lead author Ranjan Duara, MD, medical director of the Wien Center for Alzheimer's Disease and Memory Disorders at Mount Sinai Medical Center.

"我们主张，基于这些发现，该标准诊断阿尔茨海默病应包括核磁共振成像仪说，"这项研究的领导者兰詹赞奇，医学博士，医务主任的维也纳中心的阿尔茨海默氏病和记忆障碍在西奈山医疗中心。

It may have a preventional function from Alzheimer's disease. Molecular biological studies are shown that apoE isoform has a isoform-specific role to neurodegeneration. ApoE〓 and apoE〓 aid to sustain the stabilization of cytoskeleton protein tau, while apoE〓 hyperphosphorylates tau to destabilize the microtubule protein, which will make neurocyte easy to form neurofibrillary tangles in AD. Clearance of amyloidal peptide by apoE〓 and apoE〓 is more effective than by apoE〓. ApoE〓 has the strongest ability to clear the amyloidal peptide. It is shown that apoE〓 has a stronger prevention from Alzheimer's disease.

分子生物学研究发现，apoE异构体对神经细胞退化表现出异构体特异作用，apoE〓和apoE〓有助于维持微管的稳定性，而apoE〓则使tau蛋白超磷酸化，破坏微管的稳定性，使神经细胞易于形成神经纤维缠结。apoE〓和apoE〓对A β的清除率远远高于apoE〓，apoE〓对A β的清除能力最强，可见apoE〓对AD的发生具有较强的阻止作用。

The model of Alzheimer 's disease was made in Wistar rats by injecting the ibotenic acid into the bilatertal substantia innominata of rat brain. The content of t3 and the activity of T45-monodeinase in the rat brain was measured.

利用中枢胆碱能系统损害所致的Alzheimer病大鼠模型，测定了大鼠脑组织内源T3含量及T45－脱单碘酶活性，发现它们在90天时开始下降，180天时明显下降。

Structural magnetic resonance imaging include lineal mesure, volume measure and volume rendered. They can detect the abnormal brain structure, especially the change of mesial temporal lobe in early onset of Alzheimer s disease. Recent studies more focused on functional imaging which can find the functional changes in brain. Prior to structural changes, functional changes happen, so it can reflect the sutile pathological process in Alzheimer s disease.

磁共振成像结构影像学主要介绍了磁共振成像线性和面积测量、磁共振成像体积测量和磁共振容积再现三方面，其研究热点主要集中于阿尔茨海默病患者异常脑结构的分布，以及特征性结构内侧颞叶，尤其是海马，杏仁核，以及内嗅皮质在结构在阿尔茨海默病早期诊断治疗中的作用。

Its research interests include: psychiatric genetics, particularly the dementias and schizophrenia; clinical and molecular genetic studies; genetic epidemiology of Alzheimer's disease; psychiatric reactions to trauma, including the treatment of post-traumatic reactions and biological markers of such reactions; molecular neuropathology of Alzheimer's disease.

该系的研究兴趣包括：精神病遗传学，尤其是痴呆和精神分裂症；临床和分子基遗传学研究；阿尔海默茨病疾病的遗传流行病；对创伤性精神病学反应，包括创伤后治疗反应和这些反应的生物学标记；阿尔海默茨病疾病的分子神经病理。

Alzheimer's disease is the most common dementing disorder.

Alzheimer氏病是最常见的痴呆。

Detail Contents: Genetic disorders -- Immune deficiencies -- Breast cancer -- Colon cancer -- Melanoma -- Cystic fibrosis -- Hemophilia -- Liver disease -- Cardiovascular disease -- Muscular dystrophy -- Alzheimer's disease -- Parkinson's disease -- Huntington's disease -- Viruses: the cornerstone of gene therapy -- Viruses are living crystals -- Viral genomes may be RNA or DNA -- Viruses evolved from plasmids -- Viruses know how to infect cells -- The virus as a gene vehicle -- Viruses used in gene therapy -- Ashi DeSilva: a promising start -- Clinical trials defined -- Cells of the immune system -- Adenosine deaminase -- Preliminary research -- Clinical procedure for ADA gene therapy -- The DeSilva clinical trial -- Jesse Gelsinger: down to earth -- Ornithine transcarbamylase -- Preliminary research -- Clinical procedure for OTC gene therapy -- The Gelsinger clinical trial -- The investigation -- Concluding remarks -- Future prospects -- Safer vehicles -- Reducing immune rejection of the vector -- Improved risk assessment -- Redesigning human anatomy and physiology -- Ethics of gene therapy -- The Belmont report -- Clinical trials -- Physiological enhancement -- Cosmetic applications -- Legal issues -- Regulatory agencies -- The Gelsinger legal trial -- International regulation -- Resource center -- Eucaryote cell primer -- Recombinant DNA primer -- The human genome project -- X-linked severe combined immunodeficiency (SCID-X1)-- Alzheimer's disease -- Huntington's disease.

细节内容︰遗传疾病-免疫的缺乏-乳腺癌-结肠癌-黑瘤-囊性纤维变性-血友症-肝疾病-心血管疾病-肌营养不良-早老性痴呆病-帕金森疾病-亨廷顿疾病-病毒︰基础的基因治疗-病毒在活著水晶--病毒的基因可能是RNA或者DNA --病毒从plasmids被逐步形成--病毒知道怎样感染细胞--作为一辆基因车辆的病毒--基因治疗使用的病毒-Ashi DeSilva︰有希望开始-临床试验确定--细胞的这免疫系统-Adenosine deaminase-初步研究-临床程式给埃达基因治疗--这DeSilva临床试验-婕西Gelsinger︰到地球-Ornithine transcarbamylase-初步研究-临床程式给OTC基因治疗-- Gelsinger临床试验-调查-达成评论-前景-更安全的车辆--矢量的降低免疫的拒绝-改进风险估计-重新设计人解剖学和生理学--伦理学的基因治疗-那些贝拉蒙特报告-临床试验-生理提升-美容应用-法律问题-协调机构-- Gelsinger 合法审讯-国际管理-资源中心人物-Eucaryote信元第一-Recombinant DNA 入门--人类基因工程-- X 连结的严重的结合的免疫缺陷(SCID-X1)-早老性痴呆病--亨廷顿的疾病。

Alzheimer's disease is the most common cause.

Alzheimer症是最普遍的原因。

A study Shea coauthored with Amy Chan, PhD, published last year in the Journal of Alzheimer's Disease , found that mice suffering from the equivalent of normal human age-related memory loss or early Alzheimer's disease got a memory boost when they consumed a daily dose of apple juice.

去年什亚与艾米·陈共同发表在《阿尔茨海默病期刊》的一项研究发现，当老鼠遭遇与人类相同的因为年龄而产生的记忆丧失或早期阿尔茨海默病时，它们每天喝一定量的苹果汁后它们的记忆力增强了。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。