查询词典 Acrab

The best way is to develop multiple-antibiotic-resistance regulon counteractant and efflux pump inhibitor, or to increase the expression of efflux pump.

文章对大肠埃希菌AcrAB、AcrAB-Tolc，Mar和膜孔蛋白Ompf、Ompc等多重抗生素耐药调节子的组成、功能及其影响因素进行了综述。

In this study,we have ascertained AcrAB mediated multi-resistance and set up molecular detection method in Escherichia coli isolated from livestock and avian.

本研究以畜禽大肠杆菌为研究对象，确证AcrAB介导的多重耐药性，并建立分子生物学检测方法。

And then the expressing level of AcrAB was detected by Western blotting. The results indicated that the level of resistance to fluoroquinolones of isolates appeared closely correlated with substitution in GyrA and ParC, but expressing level of AcrAB had not significant changes.

序列分析及AcrA的Western blotting检测结果表明，临床分离的鸡大肠杆菌对喹诺酮类药物的耐药水平与GyrA和ParC的突变密切相关，而AcrAB外输泵的表达水平无显著变化。

Some gene mutations of rob gene of the 5 E.coli isolates were related to animal species and to the level of drug resistance by affecting on the expression level of AcrAB efflux pump.

不同源性大肠杆菌的rob基因的核苷酸序列与其动物源性有关，该基因的核苷酸序列的个别突变位点可能影响AcrAB外输泵的表达水平，进而影响其多重耐药水平。

Keywords: Escherichia coli;AcrAB;efflux pump;resistance

中文关键词：大肠杆菌；AcrAB；外输泵；耐药性

A key regulatory gene of TetR/AcrR family, acrR, was inactivated through the introduction of an internal stop codon resulting in overexpression of AcrAB that appears to be associated with ciprofloxacin resistance.

一个TetR/AcrR家族中调控基因acrR由于在其基因中产生了终止密码子而失去了活性，导致与环丙沙星抗性相关的基因AcrAB的过量表达。

It's said that Acrab guys are constant in love, but in fact they can't assure that they only date one person at one time. They have many dates and they will only be loyal until they find the right one. But a Gemini guy isn't like this unless he is making fun of you otherwise you are the only one to him. Gemini guys are always faithful and loyal to love after finding ture love. They exert greatest restraint on themselves that they don't permit any mistakes, and thus they appear neurotic every day.

都说天蝎专一，其实他们做不到那种一段时间只和一个人交往，他有很多对象，一直到找到他要找的人才会专一，双子不会的，除非他跟你开玩笑，不然每一个都是唯一的，双子找到真爱后一样是专一不变的，甚至刻意克制自己不能有一丝的差错，整天弄的神经息息的。

Tarda AcrAB multidrug resistance system was cloned in this study. Sited-directed mutation was used to determine the promoter sequences of acrAB and acrR and the AcrR binding site.

论文克隆分析了迟缓爱德华氏菌AcrAB耐药系统，采用定点突变确定了acrAB、acrR的启动子序列和AcrR在acrAB启动子的结合位点。

The result indicated: antibacterial concentration of inner thallus increased progressively with time prolongation when added CCCP with antibacteria, proved that multi-resistance of E.coli in livestock and avian is mediated really by active efflux system; The multi-resistant level have positive correlation with AcrAB transcription and expression level; Quantitive RT-PCR,Western-blotting and fluorescence quantitive PCR can use to detect AcrAB.these results provide theory foundation to detect and study multi-resistance of E.coli in veterinary clinic and have a important scientific significance to develop neotype antibacterials.

结果表明，多重耐药株在有CCCP 存在时，菌体内抗菌药物的浓度随时间的延长而递增，证明畜禽大肠杆菌多重耐药性确实由主动外排系统介导；其多重耐药水平与AcrAB的转录、表达水平呈现正相关；定量RT-PCR、Western-blotting、荧光定量PCR可用于AcrAB水平的检测。这些结果对检测临床大肠杆菌的多重耐药水平、对研究兽医临床大肠杆菌多重耐药机制提供理论依据，对开发新型抗菌药物有重要的科学意义。

Firstly,we isolated clinically and induced artificially multi-resistant Escherichia coli,detected antibacterials intake by different resistant level strains with CCCP and fluorescence spectro method and ascerained existing active efflux system in this strains; Secondly, construced internal standard of quantitive RT-PCR and detected AcrAB mRNA level of different resistant E.coli with quantitive RT-PCR; Thirdly, prepared AcrA antibody and detected AcrAB protein level of different resistant E.coli; eventually,designed and constructed Taqman probe of AcrAB and detected AcrAB level of different resistant E.coli with fluorescence quantitive PCR.

临床分离及人工诱导大肠杆菌多重耐药株，氰氯苯腙结合荧光分光法检测不同耐药水平菌株对抗菌药物的摄入，确证主动外排系统的存在；构建了定量RT-PCR的内标准DNA，通过定量RT-PCR检测动物源性大肠杆菌AcrAB mRNA的水平；制备AcrA抗体，采用Western-Blotting检测不同耐药株AcrAB蛋白的表达水平；设计和构建AcrA、AcrB的Taqman探针，检测不同耐药菌株AcrAB的水平。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。