查询词典 ABL

ABL is a typical application system of very high energy laser, with the property of high motorized, high accurate and lightning attack to the goal,and also with the ability to deal several objects a crushing blow.

"ABL"系统是一个非常典型的高能激光应用系统，具有高度机动、高度精确及对目标进行闪电打击的特性，以及对多个目标进行毁灭性打击的能力。

In the early 1990s, knowing that the constitutively activated kinase had a major role in CML, Druker approached scientists at what was then Ciba-Geigy with a proposal to find a small molecule that would inhibit the BCR-ABL tyrosine kinase activity.

在90年代早期，Druker认识到组成性活化的激酶在CML中的重要作用，并向当时的汽巴-嘉基药厂的科学家们提议寻找一种可抑制BCR-ABL酪氨酸激酶活性的小分子物质。

Objective To investigate the effect of bcr-abl fusion gene on CML cell apoptosis.

目的 研究bcr-abl融合基因在慢性粒细胞白血病细胞凋亡调控中的作用。

Objective To study the express of bcr-abl mRNA transcripts in patients with CML in different phases.

目的 探讨慢性粒细胞白血病不同病期bcr-abl基因的表达。

"This is an important point," Dr. Sawyers told Medscape in an interview,"as it shows that the drug target continues to mutate and that BCR-ABL is the escape mechanism." Hence, further drug development should continue to focus on BCR-ABL and not on any of the other mechanisms that are thought to also be involved, he commented.

Sawyers医师在一项访谈中向Medscape表示，这是个重点，当这项研究显示药物的标的持续在突变，且BCR-ABL基因有逃脱机转，他评论，之后的药物研发应该继续针对BCR-ABL且不应针对其他被认为牵涉其中的机转。

CML is cytogenetically marked by the philadelphia chromosome, which originates from a reciprocal translocation between chromosome 9 and 22 and is molecularly marked a chimeric bcr-abl gene, resulting from juxta-positive of the abl proto-oncogene on chromosome 9 with the bcr gene, which is normally located on chromosome 22. The chimeric bcr-abl gene expression an 8. 5kb hybrid mRNA transcript giving rise to a 210-KD fusion protein (P210〓) with increased tyrosine kinase activity. P210〓 plays a key role in the pathogenesis of CML. The continuous cell line K562 was established from the pleural effusion of a 53-year-old female with CML in terminal blast crisis, and was a human erythroleukemia line, contained Ph chromosome.

绝大多数慢粒患者白血病细胞中具有Ph染色体，是由9号染色体长臂3区4带和22号染色体长臂1区1带相互易位形成，即t（9；22），使位于9q〓的c-abl原癌基因在第二外显子的5'端断裂并易位到22 q〓的M-bcr基因第2或第3外显子的3'端，形成异常的bcr-abl嵌合基因，该基因转导出异常的mRNA，编码并翻译出P210蛋白，该蛋白具有很强的酪氨酸激酶活性，使粒细胞发生恶性增殖。K562细胞属于慢粒急变、红白血病细胞株，具有Ph染色体。

Objective: The first aim of this study was to investigate bcr-abl associated T cell receptorVαand Vβgene repertoire by analyzing the restricted usage and clonal expansion of TCRVαand Vβsubfamily T cells from the normal individual peripheral blood induced bybcr-abl peptideso The second aim was to construct the idiotype TCR Vα-PIRES-TCR Vβeukaryotic vector and investigate its expression in vitro. The data will be expected toprovided the methods in development of the leukemia antigen specific cytotoxic Tlymphocyte modified by the specific TCR.

目的：通过分析bcr-abl多肽诱导正常人T细胞克隆性增殖和TCR Vα和TCR Vβ基因选用情况，获得识别bcr-abl多肽的特异性TCR基因，并构建TCR Vα和TCR Vβ双基因表达载体及分析其体外转染细胞和表达特点，从而为研制TCR转基因获得白血病抗原特异T细胞的研究提供实验依据。

Oncogenic transformation of c-abl to v-abl occurs by insertional activation that results in deletions of specific N-terminal amino acids.

由abl癌基因编码的转化蛋白。c-abl到v-abl的致癌性转化由于插入激活而发生并引起特异性氨基末端氨基酸删除。

P210bcr/abl plays a central role in the pathophysiology of CML. The purpose of this study was to construct a cell line model that bcr/abl expression can be regulated by Tetoff inducingexpressionsystem. The fulllength b3a2 bcr/abl cDNA was subcloned into the pTRE2hyg expression vector to construct the pT2P210 plasmid.

CML是目前致病分子信号基础研究最为清楚的肿瘤之一，1960年Nowell和Hungerford在CML患者的白血病细胞中发现Ph染色体［1］，1973年Rowley等［2］进一步应用染色体分带技术证明，Ph染色体是由9q34的abl基因和22q11 的 bcr 基因相互易位形成的 bcr/abl 融合基因。

Detected by FISH technology, 34 cases(85%) were BCR/ABL positive, 6 cases(15%) were BCR/ABL negative.

应用FISH技术检测，BCR/ABL融合基因阳性34例（含14例Ph染色体阴性中的8例），占85%；BCR/ABL阴性6例，占15%。

Singer Leona Lewis and former Led Zeppelin guitarist Jimmy Page emerged as the bus transformed into a grass-covered carnival float, and the pair combined for a rendition of "Whole Lotta Love".

歌手leona刘易斯和前率领的飞艇的吉他手吉米页出现巴士转化为基层所涵盖的嘉年华花车，和一双合并为一移交&整个lotta爱&。

This is Kate, and that's Erin.

这是凯特，那个是爱朗。