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YMDD mutation: HBV YMDD mutation were developed in 12 lamivudine recipients, whereas the treated group had no incidence of HBV YMDD variation, there were significant difference between two groups (p=0.000). YMDD mutation resulted in increase of the mean HBVDNA levels (p=0.000), but no contribution to serum ALT diversification (p>0.05). 2. Precore nt1896 mutation: Precore nt1896 mutation incidence had no difference between lamivudine recipients and objects who received combination therapy of Kidney-invigorating Granule and Marine Injection, and patients of HBeAg negative and HBeAg positive had a close incidence of precore mutation as well as. Precore nt1896 mutation had no influence on serum ALT level. The occurrence of precore nt1896 mutation contributed to serum HBVDNA load increased and worse response of HBVDNA extenuation. 3. HBV genotype: The baseline of serum HBVDNA gradually increase in turn of genotype B, genotype C and genotype B/C. Genotype B seemed to obtain higher rate of serum HBVDNA loss and HBeAg/anti-HBe seroconversion after combination therapy of Kidney-invigorating Granule and Marine Injection, differencing with lamivudine therapy.

疗效相关因素研究:1YMDD变异:对照组有12例检出YMDD变异,治疗组无1例检出,两组比较有显著性差异(P=0.000);发生YMDD变异者血清HBVDNA和ALT水平均有所升高,HBVDNA平均水平高于非变异者(P=0.000);血清ALT与非变异者无明显差异(P>0.05)。2前C区nt1896变异:前C区nt1896变异发生率在治疗组和对照组以及HBeAg阴性和HBeAg阳性患者之间均无明显差异(P>0.05);1896c变异对血清ALT水平无明显影响;治疗组发生1896c变异者,其HBVDNA平均水平较之未变异者明显升高(P<0.05),治疗后HBVDNA下降幅度明显低于未发生1896c变异者(P=0.000)。3HBV基因型:血清HBVDNA基础水平在B、C、B/C混合型间存在明显差异(P<0.05),按B型、C型、B/C混合型依次升高;治疗组HBVDNA阴转率、HBeAg/抗-HBe血清转换率,B型似乎高于C型和B/C混合型,但无统计学意义(P>0.05);对照组HBVDNA阴转、HBeAg/抗-HBe改变在B、C、B/C混合型间无明显差异(P>0.05)。

The crystal structure of pure Pd is of face centered cubic and it is a hydrogen absorbing metal.

钯是一种面心立方结构的吸氢金属,氢原子溶解在晶格中,占据八面体间隙位,形成fcc的子晶格,吸氢时晶格发生等方性膨胀;氢在钯中的扩散路径为O T O跃迁,存在反同位素效应;钯氢化物的氢同位素分离因子较大,并受到温度、氢浓度等因数的影响;钯氢体系的p c等温线表现出良好的坪台性,Pd H和Pd D均存在临界点,尚未确定Pd T有无临界点;单晶钯氢反应动力学与不同的晶面有关;钯氚体系存在氚老化效应

Q; z/ M% _ Jeremy Hampden has a large circle of friends and is very popular at parties.

P c b; o 杰里米·汉普登交际甚广,是各种聚会上深受大家欢迎的人。

But the hydrolysate has strong bitter taste and has to get rid of during the following process. Mucor has been used in sufu, a well-known delicious Chinese cheese that is made with soybean curd, making in China for hundreds years.

腐乳毛霉能够产生一定数量的蛋白酶,可以将豆腐坯中的大豆球蛋白(11S)水解为分子量较小的肽类(P.C.L0)并具有良好的风味,毛霉蛋白酶有可能成为制备大豆多肽的优选酶种。

The results show that there were no significant differences among the four forage rations in rumen pH, the concentrations of total volatile fatty acids, acetate, propionate, the ratios of acetate to propionate, butyrate, isobutyrate and valerate(P﹥0.05). Only in 11:30, the concentrations of isovalerate caused by ration A and B were significantly higher than the other two rations(P﹤0.05).The milk yield caused by the ration C was significantly lower than the others (P﹤0.05). However, there were also no significantly differences among these four rations in the DM, fat, sugar, protein and scc of the milk. The milk fat and sugar of ration B and C were higher than ration A and D in number as well.

试验结果显示:各粗料组合日粮对各个时间点的瘤胃发酵指标:pH、TVFA、乙酸、丙酸、乙酸/丙酸、丁酸、异丁酸、戊酸浓度均无显著差异(P﹥0.05),只在11:30时,日粮A、B的异戊酸浓度显著低于日粮C、D (P﹤0.05);日粮C的产奶量显著低于其它三个日粮,而在乳干物质、乳脂、乳糖、乳蛋白、体细胞数上,各日粮均无显著差异,从数值上看,日粮B、C的乳脂和乳糖高于A、D。

Miguel Cairo muffed a fly in the sun in left, but his wasn't the most glaring misplay.

u' ~* M/ g; Q4 P/ C Cairo因为阳光的关系追丢了一个飞球,但是这不是最令人发指的一个失误。

Effects on reproductive performance: The normal delivery of group B,C and D were 80%、93.33%、93.33%,respectively,were improved by a certain extent comparing with the control group; The mean birth weight of calves were not significantly different between the trial and control groups.But numerical datas shown that supplementing Zn-Met in dietary had the tendency to increase the birth weight of calves; Supplementing Zn-Met in dietary can make dairy cows express empathema earlier,and significantly(P.05).Among the trial groups,the advanced extent of the group C was comparatively large(5.8d);The oestrous cycles were all in normal range and not significantly different; The levels of serum PRL of group B,C and D were significantly(P.05) 1.46 ng/ml、3.08 ng/ml、3.45 ng/ml higher than the group A.

对繁殖性能的影响:添加蛋氨酸锌组的正常分娩率为80%、93.33%、93.33%,较对照组(73.33%)有一定程度的改善;试验组犊牛初生重与对照组犊牛初生重差异不显著(P>0.05),但数据结果显示,日粮添加蛋氨酸锌有使犊牛初生重增加的趋势;日粮添加蛋氨酸锌可使奶牛产后发情提前,且差异显著(P<0.05),其中,添加蛋氨酸锌240mg/kg组提前的幅度较大,提前了5.8d;试验组发情周期与对照组差异不显著(P>0.05),均在正常范围之内;B、C、D组血清促乳素含量均比对照组高,且差异显著(P<0.05),依次增加1.46ng/ml、3.08ng/ml、3.45ng/ml,试验组B与C、D两组间也达到显著差异(P<0.05)。

The expressions of VEGF mRNA in renal cortex in B and group C increased greatly compared with A group at 8th week(P.01), And the expression was decreased more in C group than that in B group at the 8th week;④The light microscopes results showed that no pathological changes in group A; pathological changes were much obvious in group B:glomerular capillary lumen tumbling,lumens blocked,mesangial region widened,basal lamina thicking,mesenterium base inceased,the volume of glomerulus become large,cell population increased,renal tubule vacuolization, renal interstitium was infiltrated by lots of lymphocyte and mononuclear macrophage; pathological changes in group C was light,only see glomerular capillary lumen lightly stegnosis,few lymphocyte infiltrating.

免疫组化结果显示第8周B组大鼠肾皮质VEGF蛋白含量较A组显著增加(P.01),C组VEGF含量较B组有明显减少(P.01),C组较A组表达量仍然增加(P.01);③第8周B组肾皮质VEGF mRNA表达较A组有明显上调(P.01),与B组相比,辛伐他汀可以明显减少C组肾皮质VEGF mRNA表达;④光学显微镜下A组肾小球毛细血管腔均匀一致,无狭窄,肾小管-间质无炎症细胞浸润。B组则病变较明显:大鼠肾小球毛细血管袢塌陷,管腔闭塞,系膜区增宽,基膜增厚和系膜基质增多,肾小球体积增大,出现玻璃样变;肾小管尤其是近区小管肿胀、变性、空泡形成,肾间质可见大量淋巴细胞和单核巨噬细胞浸润。C组病变较轻,可见肾小球毛细血管管腔轻度狭窄,肾小管-间质见少量淋巴细胞浸润。

With the elevated glucose and time extending,the expression was lower and the translocating rates was decreased,which was Hgroup<Egroup<Bgroup,(p<0.01 or 0.05). Conclusion Short-term exposure ofβ-cells to high concentration of glucose triggers the synthesis and secretion of insulin.

结果为:A、D、G组培养24h及48h的N/C值均无统计学差异(p>0.05),B、E、H组培养24h的N/C值减少,存在统计学差异(p<0.05),48h的N/C值组间比较统计学差异显著(p<0.01)。C、F、I组培养24h的N/C值下降趋势,但无统计学差异(p>0.05),48h的N/C值组间比较存在统计学差异(p<0.01)。

4 S G#~: H% _# m. w1 p0 c# M* a' P The move left Chamberlain stunned, meandering around the infield between home plate and first base while Torre pleaded his case with the umpiring crew.

C x4 i2 {这个转变让张伯伦很震惊,当托瑞上场为他向裁判团辩护时,他茫然地在本垒和一垒间踱步。

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And discuss some key point of integrated management system design, include hazard identification and risk assessment and risk control in the occupational health and safety management, the measure of satisfaction target of customer, the flawlessness of law system, the integration of the integrated management system and enterprise standardization system, unify lead institution and work orgnization, integreted internal audit and integrated management review.

同时,论述了一体化管理体系构建中的几个主要问题,包括职业健康安全管理中的危险源辨识、风险评价和风险控制、顾客满意度的科学监测、法律、法规体系的完善、一体化管理体系与企业标准化体系的有机结合、统一的领导机构和工作机构、一体化的内部审核和管理评审。

Deepwater Taranaki is investigated for its petroleum potential, using all available seismic data tied to shallow-water wells.

运用与浅水井相关的现有全部震波探测数据考察了深海区塔拉纳基盆地的油藏前景。

If you're huffing and puffing at any point during the run, slow down and make sure you can take deep breathes.

如果你任何时候在跑步过程中气喘如牛,降低速度并且确保你能够深呼吸。