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The 20S catalytic core of the 26S proteasome has the shape of a barrel made of four rings which are composed of seven differentαsubunitsα_1-α_7 at two outer rings and seven differentβsubunitsβ_1-β_7 at two inner rings at which the catalytic sites locate. Three of theβsubunits contain proteolyses sites, which are sequestered in the hollow interior of the 20S particle. Substrates enter the 20S through a narrow channel formed by theβsubunits, whose N-termini, depending on their conformation, can either obstruct or allow substrate entry and thus function as a gate. This entry channel is narrow and only permits passage of unfolded, linearized polypeptides.

哺乳动物26S蛋白酶体是由一个20S催化颗粒(catalytic particle，CP)和两个19S调节颗粒(regulatory particle，RP)组成的ATP(adenosine-triphosphate，ATP)依赖性蛋白水解酶复合体。20S CP是26S蛋白酶体的催化核心，它是由4个圆环堆叠形成的桶状复合物，其中两侧外环每个环是由α_1-α_7亚基组成，两个内环每个环是由β_1-β_7亚基组成，4个环的中央形成一个狭窄的内腔。2个β内环形成了20S CP的催化中心空腔，其内壁为催化活性位点所在地；外侧α环中心的孔道是底物到达催化中心空腔的通道，一般被α亚基上的N末端所封闭，阻止胞内非目的靶蛋白进入20S CP内被降解破坏。

This morning, I took a bullhead fish and ride toward to the old factory rapidly, I found the cat lying under the megranate tree, in front a shed from a building's windows threw several case layer upon layer on the ground, there are three or four paper cases had been thrown out the building's window, when I saw this scene, my first idea is about the little cat, if the scene had been in n years ago, Teacher Huang should say to another young teacher Huang and me for we had been in favor of raising many ducks:" You have the catface of mother loving!"

今天天气晴好，早上，我带了大头鱼，朝老厂区的方向迅速地骑车，找到了正卧在石榴树下面的猫，前面车棚前的大楼楼道里往窗外扔下重重的纸盒箱，有三四个纸箱已经被扔了出来，看见这幅场景，我的第一个念头是想到了那只小猫，如果在 n ……年前，黄老师一定会对我另一位年轻的黄老师对养鸭子的爱好程度给予有力的讽刺的："母爱的畸形变态！"

L; H0 ~' n$? Take Shaun Wright-Phillips. He was so unable to affect games when coming on as a substitute until recently. Yet, once again, here he was yesterday starting a move in his own half, getting on the end of it to reach the by-line, and pulling the ball back for what eventually became Michael Ballack's winner.

c9 g( N# a8 v) k \ a$ a 以肖恩·莱特-菲利浦斯为例吧，直到最近，他还都不能在那些仅有的替补出场时间中对比赛造成任何重大的影响——而在昨晚的比赛中，他再一次延续了近来的状态，在己方半场策动进攻、在对方半场接球带至底线、把球回敲，最终让巴拉克打进了制胜的一球。

In this thesis, multi-wall carbon nanotubeswas worked as a modified agent. The working electrode was a glassy carbon electrode or graphite electrode. A saturated calomel electrode and a platinum electrode were used as the reference and the auxiliary electrode respectively. Some pharmaceutics'electro-chemical behavior has been studied with great details. The main researches were summarized as follows: The acid-treated CNT was successfully dispersed into the DMF by using ultrasound technology.

本论文以多壁碳纳米管为修饰剂，以玻碳电极和石墨电极为工作电极，铂丝电极为对电极，饱和甘汞电极为参比电极，研究了几种药物的电化学行为及其检测方法，取得了以下研究结果：以N，N-二甲基甲酰胺为分散介质，将酸化后的MWNT超声分散于DMF中，获得分散液。

All ofthese reactions were carried out under mild conditions and are new effective methodsfor the preparation of indolizine derivatives. The reaction of phthalazinium and quinoxalinium N-ylides with electron-deficientolefins in the presence of oxidants have also been studied, it has been found that activemanganese dioxide could behave as a dehydrogenating oxidant. Pyrrolo[2,1-a]phthalazines and pyrrolo[1,2-a]quinoxalines are obtained in this way.

本文还对六员二氮杂环化合物酞嗪和喹喔啉的N-叶立德在氧化剂存在下与缺电子烯烃的l，3-偶极环加成反应作了研究，发现活性二氧化锰也是一个优良的氧化剂，并分别合成得到了吡咯并[2，1-a]酞嗪和吡咯并[1，2-a]喹喔啉衍生物。

The method includes dividing a digital image, formed from M rows and N columns of pixels, into a plurality of band-shaped areas by partitioning at each of a prescribed number of rows; averaging, for each column, the gradation values of pixels in said band-shaped areas for each of said plurality of band-shaped areas; computing an approximation line which approximates, in each of said plurality of band-shaped areas, a distribution of said average of gradation values; and judging whether there exists a succession of d columns at which the difference between said gradation value derived from said approximation line and said average of gradation values for each column exceeds a prescribed threshold.

该方法包括：通过以规定行数为单位进行分割，将由M行N列个像素形成的数字图像划分为多个带状区域；对于所述多个带状区域的每一个，针对各列来对所述带状区域中的像素的浓淡值求平均；计算近似线，该近似线在所述多个带状区域的每一个中近似于所述浓淡值的平均值的分布；并且判断是否存在如下连续的d个列，在所述连续的d个列中，从所述近似线得到的所述浓淡值与针对各列的所述浓淡值的平均值之间的差值超出一指定阈值。

The results show that coal and gangue are involved in the microbial role; the quantity of inoculums is directly related to the quantities of gas and the contents of methane, at the same time it has a certain degree of impact on the contents of NO(superscript - subscript 3)-N, NH(superscript + subscript 4)-N, S(superscript 2-), SO(superscript 2- subscript 4), and metals; moreover, because of the microbial anaerobic fermentation, the contents of NH(superscript + subscript 3) are seriously substandard; overall, the group B which has a smaller proportion of gangue has a less impact to the environment compared to the group A which has a larger proportion of gangue.

结果表明：煤、煤矸石参与了微生物作用；接种物的加入量与产气量和甲烷含量密切相关，并对硝酸盐氮、氨氮、硫化物、硫酸盐和金属也有一定程度的影响；同时由于微生物厌氧发酵的关系，氨氮严重超标；矸石比例较小的B组对环境的影响略小于矸石比例较大的A组。

A series of novel double helicates,{A[Mo2VIO4LnIII(H2O)6(C4H2O6)2]·4H2O}n (Ln = Sm, Eu, Gd, Ho, Yb, Y; C4H2O6 = L-tartaric acid; A = NH4 or H3O), have been synthesized from the reactions of chiral ligands L-tartaric acid with molybdates as well as lanthanide cations.

利用简单的手性有机配体L-酒石酸成功地合成出了一系列类似DNA螺旋构型的左、右旋的一维链状聚合物：{A[Mo2VIO4LnIII(H2O)6(C4H2O6)2]·4H2O}n (Ln = Sm， Eu， Gd， Ho， Yb， Y； C4H2O6 = L-或 D-酒石酸； A = NH4 或 H3O)。

Loss of color as a result of scars from cuts and bites is not a fault.Faults-Any colors other than specified, and any shadings or mixtures thereof in the topcoat such as rust, brown, red, yellow or tan; absence of peppering; spotting or striping; a black streak down the back; or a black saddle without typical salt and pepper coloring-and gray hairs in the coat of a black; in blacks, any undercoat color other than black.

被割伤或咬伤留下的疤痕而引起的褪色不属于缺陷。n缺陷：除了指定颜色以外的任何颜色，如椒盐色混合了铁锈色、棕色、红色、黄色和褐色；缺乏胡椒色；斑点或条纹；背上有黑色条纹；在黑色鞍状部分没有椒盐色毛发或黑色的雪纳瑞有灰色毛发；黑色雪纳瑞有其他颜色底毛。nn n 完美、有力、敏捷、大方、正确且标准的步态是由于后腿有力而且后腿角度合理，能很好的产生驱动力。

Secondly, we study a class of automorphisms of A, i.e., we prove that the set {φ∈SL_n|φ= t is a subgroup of AutA(n,t,Finally, we mainly discuss some properties of the operation w in A, i.e., g~w = 0, f~w = 0 and Leibniz identity.

其次，讨论了A的一类自同构，即证明了集合{φ∈SL_n|φ=t}是自同构群AutA(n，t的一个子群；最后，得到了A的运算w的一些性质，即g~w=0、f~w=0和Leibniz等式。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。