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Western culture in the red is a derogatory very strong word, is "fire","blood" of the association, it is a symbol of brutality, bloodshed, such as (1) The red rules oftooth and claw killing and violence, rule ,(2) red revenge bloody revenge,(3) a red battle bloody; it a symbol of radical, violent revolution, such as (1) red hotpolitical campaign heated political campaign,(2)a red revolution Red revolution,(3) red activities leftist radical activity; it is also a symbol of danger, tension, such as (1) red alert air raid alarm,(2) a red adventure story of a nerve-wrecking adventures,(3) a red flag danger signal flags; it a symbol of debauchery, obscenity, such as (1) a red waste of his youth(2) a red light district demi-monde,(3) Is she really sored as she is painted?

西方文化中的红色则是一个贬意相当强的词，是&火&、&血&的联想，它象征着残暴、流血，如（1）The red rules oftooth and claw残杀和暴力统治，（2）red revenge血腥复仇，（3）ared battle血战；它又象征激进、暴力革命，如（1）red hotpolitical campaign激烈的政治运动，（2）a red revolution 赤色革命，（3）red activities左派激进活动；它也象征危险、紧张，如（1）red alert空袭报警，（2）a red adventure story一个令人紧张的冒险故事，（3）a red flag危险信号旗；它还象征着放荡、淫秽，如（ 1）a red waste of his youth他那因放荡而浪费的青春，（2）ared light district花街柳巷，（ 3）Is she really sored as she is painted？

A two-step A/D converter consists of 2 stages, while a pipe-line A/D converter generally consists of N stages, each including a SHA, an A/D converter, a D/A converter, a subtractor and an amplifier.

采用两步A / D转换器由2阶段，而管线A / D转换器一般包括氮阶段，每一个包括沙， A / D转换器，一个D / A转换器，一个放大器。

The results of its intrinsic fluorescence spectroscopy and fluorescence phase diagram showed that when the guanidine hydrochloride concentration in denaturation solution was about 1.0 mol/L, there existed a partially folded intermediate of Bacillus amyloliquefaciens a-amylase during its unfolding procedure, which followed a three-state model; the result of its fluorescence probe showed that when the guanidine hydrochloride concentration in denaturation solution was about 1.0 mol/L, there existed some stable hydrophobic regions, which could interact with a hydrophobic reagent 8-anilino-1-naphthalene sulfonic acid, in the partially folded intermediate of Bacillus amyloliquefaciens a-amylase; and the results of fluorescence quenching using acrylamide and potassium iodide as quenchers showed the distribution of Trp residues in Bacillus amyloliquefaciens a-amylase in different denaturation solution, with the maximum number (8) of tryptophan residues in a partially folded intermediate Bacillus amyloliquefaciens a-amylase molecule could be quenched by potassium iodide; and the results of their protein electrophoresis and SEC showed that no aggregate or aggregate precipitation of Bacillus amyloliquefaciens a-amylase formed during the whole unfolding procedure of Bacillus amyloliquefaciens a-amylase induced by guanidine hydrochloride.

内源荧光光谱和荧光相图结果表明，当变性液中盐酸胍浓度约为1.0 mol/L时，芽孢杆菌a-淀粉酶的去折叠过程中出现一个部分折叠中间体，其去折叠过程符合&三态模型&；荧光探针结果表明，在溶液中盐酸胍浓度约为1.0 mol/L时，中间态芽孢杆菌a-淀粉酶分子中存在着能够与探针分子1-苯胺基-8-萘磺酸结合的稳定的疏水区域；荧光猝灭研究给出了不同程度变性的淀粉液化芽孢杆菌a-淀粉酶中的Trp的分布情况，结果表明中间态芽孢杆菌a-淀粉酶分子中能够被碘化钾猝灭的位于分子表面的色氨酸残基数目达到最大的8个；蛋白电泳和体积排阻色谱结果表明，在盐酸胍诱导的芽孢杆菌a-淀粉酶分子的整个去折叠过程中，不会以共价键或非共价键形式形成芽孢杆菌a-淀粉酶分子之间的集聚体或集聚体沉淀。

After amplying a 2.2kb fragment form the PPV-SC1 RF-DNA,we clone the fragment into pMD 18-T,named pTNSl.The whole sequence which is 1989 bp long was determined by sequencing, including the complete ORF of PPV-SC1 NS1 which encoding 662 amino acids.Alignment of pairs of sequence indicates that there are 98% and 99% similary with other porcine parvovirus strains Kresse and NADL-2, respectively. Multiple sequence alignment discloses that there are a few difference between ppv-scl nsl gene and other ppv nsl gene: A-G at 39nt,T-C at 153nt,A-G at 175nt, A-C at 1117nt, A-C at 1535nt .Alternative codon in ppv-scl nsl have distinctly different frequentfy by codonbias analysis at EMBOSS(http://genopole.toulouse.inra.fr/bioinfo/emboss). Thereis not distinct hydrophobicity and transmenbrane helices in ppv-scl nsl protein. Struction domain anslysis of PPV-SC1 NS1 protein indicate that there are a ATP/GTP-binding site motif A at 398-405,16 Protein kinase C phosphorylation site,21 Casein kinase II phosphorylation site,and 3 cAMP/cGMP-dependent protein kinase phosphorylation site.At the same time ,there is a same motif between ppv-scl nsl and Poxvirus D5 protein-like which may share in the same fuction which is necessary during virion duplication.

将PPV-SC1 NS1序列与其他PPV NS1基因进行多序列比对，结果显示，PPV-SC1 NS1与其他的PPV NS1的同源性较高，仅存在个别的差异，分别是第39位A→G，第153位T→C，第175位A→G，第1117位A→C，第1535位A→C；同源搜索比较表明，PPV-SC1与PPV NS1同源性可达98％、99％，与其他的细小病毒NS1基因也存在很大的保守性；密码子偏向性分析结果表明PPV-SC1 NS1基因在同一氨基酸的不同密码子的选择上存在一定的偏向性；PPV-SC1 NS1蛋白总体上说具有亲水性不存在明显的疏水性区段，用swiss TMPRED软件预测PPV-SC1 NS1的跨膜区，返回的结果并没有得到有显著意义的跨膜区的存在；根据基于motif数据库的结构域预测，PPV-SC1 NS1的第393-415位氨基酸残基存在潜在的ATP／GTP结合位点，该蛋白还存在16个蛋白激酶C磷酸化位点，21个酪蛋白激酶2磷酸化位点，3个cAMP-／cGMP依赖蛋白激酶磷酸化位点，PPV-SC1 NS1蛋白与POX_D5(痘病毒D5蛋白)具有一致的保守结构域，推测NS1可能与POX_D5有类似的功能。

In this round of global stock market adjustment, the Hang Seng Index has fallen far less than the Shanghai Composite Index, but Hong Kong shares end stronger reason, there are several: First, A shares The current average price-earnings ratio of 15 times, while Hong Kong stocks average price-earnings ratio of only 8 times, funds flow to the lower, resulting in the recent Hong Kong stocks rose, while the A shares are still hesitate to move forward; Secondly, the central rate repurchase focus on the H shares, a price comparison of the most typical is now China's oil price of A shares for more than 10 yuan, while the H shares with the right stocks, only 5 more than the Hong Kong dollar, of course, which流通盘size factor, but China's oil major shareholders to buy back its own shares will not take this factor into consideration, if the major shareholders have to consider if the cost of repurchase, H shares more attractive is beyond doubt; and thirdly, the size of the non-lifting of the ban is still in circulation is the pressure in the A share market, the head of a big mountain, but a typical example is the recent Haitong Securities to the size of the non-lifting of the ban period, the outstanding shares for 2.3386 billion shares of Haitong Securities, the size of the non-even up to 79.9396 billion shares, although the size of non-release is gradual, all in circulation there is a process, but it hung a "barrier lake" effect of the market fears.

恒生指数的跌幅远远高于上海综合指数，但香港股市年底更有理由较少，有几个：首先，A股目前的平均价格市盈率为15倍，而香港股市的平均市盈率仅8倍的比例，资金流量较低，在最近香港股市上涨造成的，而A股仍毫不犹豫地向前推进；第二，中央率，H股回购的焦点，一个最典型的价格比较现在是中国的石油A股超过10元的价格，同时拥有股票的H股中，只有5比港币，当然，而流通盘的大小的因素，但中国的石油大股东回购自己的股票将不考虑这一因素，如果大股东要考虑如果回购成本，H股更具吸引力是毋庸置疑的，第三，大小非解禁仍是流通是在A股市场的压力，一座大山的头部，但一个典型的例子是最近海通证券的大小非，禁售期间解除为2338600000的海通证券，在大小非流通股股份，甚至高达799.396亿股，虽然大小非释放是渐进的，所有流通有一个过程，但挂着&堰塞湖&影响市场的担忧。

In this round of global stock market adjustment, the Hang Seng Index has fallen far less than the Shanghai Composite Index, but Hong Kong shares end stronger reason, there are several: First, A shares the current average price-earnings ratio of 15 times, while Hong Kong stocks average price-earnings ratio of only 8 times, funds flow to the lower, resulting in the recent Hong Kong stocks rose, while the A shares are still hesitate to move forward; secondly, The focus of the central enterprises to buy back into the H shares, a price comparison of the most typical is now China's oil price of A shares for more than 10 yuan, while the H shares with the right stocks, only 5 more than the Hong Kong dollar, of course, there are流通盘size factor, but China's oil major shareholders to buy back its own shares will not take this factor into consideration, if the major shareholders have to consider if the cost of repurchase, H shares more attractive is beyond doubt; and thirdly, the size of the non-lifting of the ban circulation is still pressure in the A share market, the head of a big mountain, but a typical example is the recent Haitong Securities to the size of the non-lifting of the ban period, the outstanding shares for 2.3386 billion shares of Haitong Securities, the size of the non-even up to 79.9396 billion shares, Despite the size of the non-release is gradual, all in circulation there is a process, but it hung a "barrier lake" effect of the market fears.

恒生指数的跌幅远远高于上海综合指数，但香港股市年底更有理由较少，有几个：首先，A股目前的平均价格市盈率为15倍，而香港股市的平均市盈率仅8倍的比例，资金流量较低，在最近香港股市上涨造成的，而A股仍毫不犹豫地向前推进；第二，重点中央企业将购回的H股，一个最典型的价格比较现在是中国的石油A股超过10元的价格，同时拥有股票的H股中，只有5较港元当然，有流通盘的大小的因素，但中国的石油大股东回购自己的股票将不考虑这一因素，如果大股东要考虑如果回购成本，H股更具吸引力是毋庸置疑的以及第三，大小非流通的禁令解除仍然在A股市场的压力，一座大山的头部，但一个典型的例子是最近海通证券的非规模的解除班期间，二十三点三八六亿海通证券，在大小非流通股股份，甚至高达7993960.0万股份，尽管大小非释放是渐进的，所有的流通有一个过程，但它挂1 &堰塞湖&市场担忧的影响。

A method for making Bisphenol A with a purity of more than 99.7% by reacting phenol and acetone using an acid catalyst, separating a BPA-phenol adduct by crystallisation and removing phenol from the adduct, in which involves continuous suspension crystallisation with a total dwell time of more than 4 hours in at least 3 crystallisers, by cooling first to 50-70 C in two parallel crystallisers and then to 40-50 C in a third crystalliser connected in series with the first two.; A method for the production of Bisphenol A with a purity of more than 99.7%, by reacting phenol with acetone in presence of an acid catalyst, separating a BPA-phenol adduct from the product mixture by crystallisation, filtration and washing, and removing the phenol from the adduct, in which stage involves continuous suspension crystallisation in at least three crystallisers connected in such a way that the mixture is first cooled to 50-70 C in two crystallisers in parallel and then cooled to 40-50 C in a third crystalliser in series with the first two, the total residence time of the mixture over all crystallisers being more than 4 hours.

描述用于生产纯度大于99.7％的双酚例如，双酚A(BPA的方法，这种方法包含苯酚和丙酮在有酸性催化剂参与的情况下反应形成一个包含双酚的产物混合物；通过结晶、过滤和洗涤从该产物混合物中以双酚/苯酚复合物的形式除去至少一部分双酚以提供双酚A/苯酚复合物晶体；并且从双酚/苯酚复合物晶体中除去至少一部分的苯酚以提供纯度大于99.7％的双酚；其中结晶过程包括连续的混悬液结晶，并且是在至少三个结晶装置中进行的，装置的排列使得产物混合物首先在结晶过程的第一阶段在第一个结晶装置和并联的第二个结晶装置中被冷却到50至70℃的温度，随后在结晶过程的第二阶段在与第一和第二个结晶装置下游串联的第三个结晶装置中被冷却到40至50℃的温度，并且其中产物混合物在结晶过程中的总驻留时间在4小时以上。

To investigate the function of Nogo-A in neurons, human embryonic kidney cell line 293FT was used as a model, along with the pathway profiling reporter system to check the involvement of Nogo-A in regulating the intracellular signaling pathway. It was found that over-expression of Nogo-A could activate NF-κB signaling specifically, then followed by using different Nogo-A alternative splicing isoforms and a serial of truncations, it was confirmed that the activation of NF-κB by Nogo-A relied on its N-terminal proline rich domain. Furthermore, by co-expressing the dominant negative mutants of some NF-κB pathway associated proteins, it revealed that the IκBα,TRAF6, Rac/Cdc42 were involved in Nogo-A inducing activation of NF-κB.

为探讨神经元内Nogo-A的功能，以HEK293FT细胞为模型，利用信号途径报告基因系统筛选过表达Nogo-A对多种信号途径的调控作用，发现过表达Nogo-A能特异激活NF-κB信号，利用不同的Nogo-A剪接体和截断体形式研究，证明Nogo-A激活NF-κB信号依赖于其氨基端的proline rich结构域，进一步使用NF-κB信号途径相关分子显性突变体揭示IκBα、TRAF6、 Rac/Cdc42 参与Nogo-A激活NF-κB信号。

To investigate the function of Nogo-A in neurons, human embryonic kidney cell line 293FT was used as a model, along with the pathway profiling reporter system to check the involvement of Nogo-A in regulating the intracellular signaling pathway. It was found that over-expression of Nogo-A could activate NF-KB signaling specifically, then followed by using different Nogo-A alternative splicing isoforms and a serial of truncations, it was confirmed that the activation of NF-kB by Nogo-A relied on its N-terminal proline rich domain. Furthermore, by co-expressing the dominant negative mutants of some NF-kB pathway associated proteins, it revealed that the IkBα,TRAF6, Rac/Cdc42 were involved in Nogo-A inducing activation of NF-kB.

为探讨神经元内Nogo-A的功能，以HEK293FT细胞为模型，利用信号途径报告基因系统筛选过表达Nogo-A对多种信号途径的调控作用，发现过表达Nogo-A能特异激活NF-kB信号，利用不同的Nogo-A剪接体和截断体形式研究，证明Nogo-A激活NF-kB信号依赖于其氨基端的proline rich结构域，进一步使用NF-KB信号途径相关分子显性突变体揭示IkBα、TRAF6、Rac/Cdc42参与Nogo-A激活NF-kB信号。

HE STARTED out as Richard A. Gekoski, a gawky American high-schooler focused only on discovering sex, and morphed into R.A. Gekoski, a fully fledged, if miserable, academic teaching English literature at a provincial British university. Only in his mid-50s, having abandoned academe and an unhappy marriage, and high-tailed it to London, did he discover who he really was: Rick Gekoski, a roly-poly book dealer with an appetite for all things big and a passion for Groucho Marx's motto:" Outside of a dog, a book is a man's best friend. Inside of a dog, it's too dark to read."

开始，他叫做理查德·A·杰柯斯基，那时他还是个上高中的傻小子，专注于探寻鱼水之乐；之后，他蜕变为R·A·杰柯斯基，一位羽翼已丰的英文文学教员，就职于一所英国地方性大学；而直到他五十五岁左右之时，在放弃了他的学术和一桩并不愉快的婚姻然并奔向伦敦后，他方才找出真正的自我——里克·杰柯斯基，一位胖滚滚的书商，对所有大块物件都有个好胃口，并痴狂于葛洛丘·马克思的名言：&书于犬外，人之挚友；书于犬内，暗不能阅。&

For a big chunk of credit-card losses; the number of filings (and thus charge-off rates) would be rising again, whether

年美国个人破产法的一个改动使得破产登记急速下降，而后引起了信用卡大规模的亏损。

Eph. 4:23 And that you be renewed in the spirit of your mind

弗四23 而在你们心思的灵里得以更新