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The cytotoxicity of these compounds were valuated by MTT and SRB methods using three cancer cell lines: HL-60, A-549, P-388. Cyclo-shikonin, and cyclo-alkannin have high cytotoxicity against HL-60.The chiral center of side chain has no effect on their activity. 2- 1-(Acetyloxy-4-methyl-3-pentenyl -5, 8-dihydroxy-1, 4-naphthoquinone (105) has strong inhibition effect on P-388 cells. 2- 1-(isooctyloxy-4-methyl-3-pentenyl -5, 8-dihydroxy-1, 4-naphthoquinone (108) and 2- 1-(2-furoyloxy-4-methyl-3-pentenyl -5, 8-dihydroxy-1, 4-naphthoquinone (112) have high inhibition on A-549.Shikonin (1), alkannin (2), and their derivatives have the structural features of a planar chromophores and short side chain. We examined the ability to inhibit the telomerase.

抗肿瘤活性初步筛选测试采用小鼠白血病P-388肿瘤细胞和人肺癌A-549肿瘤细胞进行,结果表明侧链羟基的手性对抗肿瘤活性无明显影响;有数个化合物具有很好的体外抑制活性,特别是化合物2-(1-异辛酰氧基-4-甲基-3-戊烯基)-5,8-二羟基-1,4-萘醌(108)和2-[1-(2-呋喃甲酰氧基)-4-甲基-3-戊烯基]-5,8-二羟基-1,4-萘醌(112)体外显示对人肺癌A-549肿瘤细胞有强效;2-(1-乙酰氧基-4-甲基-3-戊烯基)-5,8-二羟基-1,4-萘醌(105)对小鼠白血病P-388肿瘤细胞有强效;环紫草素和环异紫草素对人白血病HL-60细胞有强烈抑制作用。

A car of mass m is slipping down a slope of inclination angle at a constant acceleration a.

一质量为m的小车从斜度为的斜坡以匀加速度a滑落下来。

The 'permanent truth' is close to Russell's 'apriority' of induction. However, in my opinion, this kind of permanent truth or apriority doesn't have any important sense since the principle of anti-induction, i.e., ' if a t 1 — b t b ,……, a t n — b t n then probably A ?

这种"永真性"与罗素关于归纳原则的"先验性"十分接近,然而,在笔者看来,这样的永真性和先验性没有多大意义,因为反归纳原则即如果 a t 1 — b t b ,……, a t n — b t n 则大概 A ?

There is usually a 3rd -key added in the opening of the second theme, and sometimes a new theme is composed. Then, the subordinate key is reached before the end of exposition. 5 Silence of one whole bar is frequently utilized, which not only brings profound expressive significance, but also is important to the architectonics of these sonatas. 6 The harmonization in the variation, which is the method of applying different keys to the same melody, is handled in those Andante movements. By this way, the same melody appears in variable colors of harmony, which can not only avoid dull repetition, but also keep the lyrical nature and the completeness of melody. 7 Chromatic method is applied in the periods of development, and chromatic深层线条becomes the provident feature in some periods of development. 8 Atlas motive is put to use in c minor and A major sonatas, and a lot of "sigh" tones and c sharp minor are both preferred in those three sonatas. 9 The emotional factor of "wanderer" is the roots of thoughts for the intense conflict of music.

他通常在副部的开始加入一个三度的调性,有时再加入一个新主题,最后在呈示部结束之前到达属调; 5、较多地运用整小节的休止,使其不仅具有深刻的表情意义,而且在结构乐曲中起到了不可或缺的作用; 6、舒伯特在慢板乐章中运用同一旋律异调配置的和声变奏方式来构成音乐的段落,使同一个旋律在不同的和声色彩里闪现,既避免了单调的重复,又保持了旋律的抒情性和完整性; 7、展开的段落中习惯运用半音化的发展手法,半音阶式的深层线条成为某些展开段落的显著特点; 8、c小调和A大调奏鸣曲中都运用了"阿特拉斯"动机,三首奏鸣曲中运用了大量叹息的音调,并倾向于~#c小调的运用; 9、"流浪者"的情感因素是音乐强烈冲突的深刻思想根源。

So, for example,'A' is a character constant; in the ASCII character set its value is 65, the internal representation of the character A.

例如,'A'是一个字符常量;在ASCII字符集中其值为65(即字符A的内部表示值为65)。

Though comparing Canny operator and center B spline dyadic wavelet, the following conclusion is proven in this dissertation: a Center B spline function has tight support and Canny operator hasn't. b Center B spline function asymptotic convergence to Gaussian function and the derivative of Center B spline function asymptotic convergence to Canny operator. c The derivative of fourth order center spline B function is more suitable as a optimal edge detector than Canny operator. d Center B spline function can balance the smoothing and approximation of original data, and the fourth center B spline function is the only optimal solution of two order smoothing problem. e The error between the valve of time-frequency uncertainty of the fourth center B spline function and the lower bound of time-frequency uncertainty does not exceed 0.143% of the lower bound. f The derivative of center spline B function can construct a stability dyadic wavelet and can give a fast algorithm for multiscale edge detection, but Canny operator can do neither.

作者给出了Canny算子与中心B样条二进小波严格的比较证明,得出如下结论:a中心B样条函数具有紧支集,Canny算子不具有紧支集。b中心B样条函数的极限收敛于高斯函数,中心B样条函数的导数收敛于Canny算子。c四阶中心B样条函数的导数比Canny算子更接近最佳边缘检测滤波器。d中心B样条函数比高斯函数更能兼顾对原函数平滑和逼近的折中要求,并且四阶中心B样条函数是二阶逼近问题的唯一最优解。e四阶中心B样条函数的时频测不准关系值与时频测不准关系下界的逼近误差不超过0.143%。f中心B样条函数的导数可以构成稳定的二进小波,存在快速的多尺度算法;而Canny算子不构成稳定的二进小波,无法给出快速的多尺度算法。

The participating artists of A+A are usually equated with audaciousness and courage, and they have become a pronoun for the Future and Development.

"A+A"的参展艺术家,往往与"无畏"与"有勇气"划上等号,同时他们也正在成为"未来"与"发展"的代名词。

So, we combine CobraNet audio network technology, data transmitting technology, MCU technology and FPGA technology to develop interface and program of MCU, controlling PCB board, A/D converter PCB board, D/A converter PCB board, digital audio receive PCB board. At last, we construct a audio network and test it's performances.

本文紧密结合CobraNet 音频网络技术、数据传输技术、单片机技术和FPGA 技术,从事了单片机接口及控制程序设计、控制板设计、A/D 转换插卡设计、D/A 转换插卡设计、数字音频信号收发插卡设计,开发出了一系列音频网络设备,并组网测试。

To take just one example, consider the set theorist's axiom of extensionality : For any sets A and B , if A and B have the same members, then A is the same set as B .

举例说,考虑集合论的外延公理:对任何集合A和B,如果A和B有相同的成员,那么A作为集合和B同一。

Tested approaches where background reflectance is described as a n-degree polynomial in wavelength, resulting in a second degree polynomial (n=2) for the O2-A band, while a higher degree polynomial (n=6) was necessary for the O2-B band, as tested over a large database of many possible combinations of r and F cases.

测试(2009)方法在背景反射被描述为一个n-degree 多项式的波长,导致了第二学位多项式(n = 2),而O2-A乐队更高程度的多项式(n = 6)是必要的,O2-B乐队测试在大型数据库的吗许多可能的组合和F的病例。

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But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊!不用提了。提到肉,真是糟透了。

Tristan, I have nowhere to send this letter and no reason to believe you wish to receive it.

Tristan ,我不知道把这信寄到哪里,也不知道你是否想收到它。