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The process comprises the subsequent steps a through e: a reacting phthalic anhydride with fluorobenzene or a derivative thereof in appropriate reaction conditions; b over reducing the product obtained in step a at the ketone moiety; c reducing the product obtained in step b with sodium dihydro-bis (2- 15 methoxyethoxy) aluminate to the corresponding alcohol ; d chlorinat ing the alcohol obtained in step c ; e inserting CO into the product obtained in step d through an appropriate Pd-containing catalytic system.

该方法包括以下步骤a～e：a使邻苯二甲酸酐与氟苯或者其衍生物在适当的反应条件中反应；b完全还原步骤a中获得的产品的酮部分；c用二氢-二(2-甲氧基乙氧基)铝酸钠将步骤b中获得的产品还原成相应的醇；d对步骤c中获得的醇进行氯化；e通过适当的含Pd的催化剂体系，将CO插入到步骤d中获得的产品中。

The growth of H. fusiformis was determined by weighting the fresh algae every two days and the photosynthetic oxygen evolution was assayed by a Clark-type oxygen electrode. To determine the contents of chlorophyll a and UV-absorbing compounds, methanol extracts from H. fusiformis were scanned from 250 to 750 nm. The concentration of chlorophyll a was calculated using the equation of Porra and the contents of UVAC per fresh mass were estimated by determining the ratio of UVAC to chlorophyll a according to Dunlap et al and multiplying the ratio of chlorophyll a content to fresh weight of the sample used.

羊栖菜的生长是通过每两天测量一次藻体的湿重来测定的，光合放氧是用Clark型氧电极测定的，为了测定藻体叶绿素a和紫外吸收物质的含量，从250 nm到750 nm对羊栖菜的甲醇提取液进行扫描，叶绿素a的浓度用Porra的公式计算，紫外吸收物质的计算是根据Dunlap的方法先计算紫外吸收物质和叶绿素a的比率，然后乘以每单位藻体叶绿素a的含量。

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Habitancy 办公室在那里那里存在心脏存在在中中部缝被耐储藏使工作作归零校正调整任职在求爱送信对是新树叶向对恰当存在向弄干东西履行刻印刷体字母在中那里在中一大早向表示敬意向自身 a 富人制做被取代向存在制做存在改变变为 a 盘旋什么来向 a 达到高潮在中使裂开下来在上存在那里在附近任职在求爱送信一点本质制造的为所作的努力向清点股票的权利办公室中心部分任职在求爱送信 Yan 使裂开向被寄送由转的缝被任职在求爱的补充自身脸存在向那里价格是对的价值注意向存在对的价值向表示敬意向存在向留下上公共厕所空间坚定支持住从里面右手击球手那个派别从里面的办公室向去那里履行切肉印刷体手写字刻印刷体字母各种各样的打击存在度向接受者使裂开下来在上坚定支持住从里面办公室在邻近的那里向表示敬意向派别标志的 Kaiate 儿子领班

Clinical Efficiency of Meningococcus Group A Capsular Polysaccharide Vaccine in Children Three Months to Five Years of Age Cellular and Humoral Components of Monocyte and Neutrophil Chemotaxis in Cord Blood Oral non-absorbed Antibiotics Prevent Infection in Acute non-lymphoblastic Leukemia Aspirin-induced Hepatotoxicity and Its Effect on Juvenile Rheumatoid Arthritis Prediction of Morbidity in Hemophilus Influenzae Meningitis Neurological Sequelae in Children Surviving Mechanical Ventilation in the Neonatal Period Developmental Effects of Prolonged Pregnancy and the Postmaturity Syndrome Long-term Outcome of Hemophilus Influenzae Meningitis Related to Antibiotic Treatment Recommendations for a National Policy on Poliomyelitis Vaccination Impaired Humoral Immunity in Treated Hodgkin's Disease Development of Immune Response during Typhoid Fever in Man In Vitro Susceptibility of Recently Isolated gram-negative Bacteria to Gentamicin, Sisomicin, Tobramycin, and Amikacin Studies of Urticaria and Acute Serum Sickness with the CI Precipitin Test Epidemic Measles in a Highly Vaccinated Population Congenital Chloride Diarrhea Acute Parotitis Associated with Influenza, Type A: Twelve Cases Urinary Tract Infection in high-risk Newborn Infants Maternal ABO Blood Group Type B: A Risk Factor in the Development of Neonatal Group B Streptococcal Disease

脑膜炎双球菌A羣被囊多醣类疫苗接种在3个月到5岁大小孩之临床效果脐带血内单核球及嗜中性球化学向性之细胞成分及体液成分口服不被吸收的抗生素可预防性急非淋巴球性白血症病人罹患感染阿斯匹灵引起之肝毒性及其对幼年性风湿样关节炎之影响流行感冒杆菌脑膜炎预后之预测新生儿时期接受人工呼吸器其日后神经系统上之后遗症过期妊娠及过度成熟徵候对发育之影响流行感冒杆菌脑膜炎之长期预后与抗生素治疗之关系对&小儿麻痹预防接种的国家政策&的建议 Hodgkin's disease治疗后体液免疫之缺损伤寒患者免疫反应的研究目前分离出来的革兰氏阴性菌在体外对Gentamicin，Sisomicin，Tobramycin和Amikacin之感受性荨麻疹和急性血清病CI沉淀素试验的研究在大多数接种人羣发生的麻疹流行先天性氯腹泻与influenza A型病毒有关的急性腮腺炎：12病例报告高危险性新生儿的尿道感染母亲血型B型：为新生儿发生B羣链球菌疾病之个危险因素

Results: Both Pur and Hup-A improved learning memory ability of I/R mice, the effect of Pur group was better and the effect of combination group was the most significant. Both Pur and Hup-A decreased neuron apoptosis and raised content of monoamine nervous transmitter of I/R mice. The cortex neuron apoptosis rate in combination group was lower than that in Hup-A group,the homovanillic acid level of cerebral cortex in combination group was higher than that of Pur group.

结果：Pur（120 mg/kg）或Hup-A（400 μg/kg）都可提高I/R小鼠的学习记忆成绩，Pur组的作用优于Hup-A组，联合用药组（Hup-A 200 μg/kg+Pur 60 mg/kg）作用最强；各用药组都可降低大脑皮层细胞凋亡率，升高大脑皮层某些单胺类递质水平，其中，联合用药组的大脑皮层细胞凋亡率低于Hup-A组，大脑皮层高香草酸水平高于Pur组。

The invention provides a dual redundant CAN bus controller, which is arranged on a crewel CAN bus, characterized in that: two CAN bus transceiving modules, two initializing modules are respectively corresponding to the CAN bus controller module A and CAN bus controller module B; the two CAN bus controller modules are respectively connected to the two CAN bus via a driver shifting control unit; the initializing module is connected to the bus control initializing register for initializing the e CAN bus controller modules; a protocol processing module is connected to the FIFO buffer; the FIFO buffer is connected to the node processor via the logical interface; a intermitting process unit sends the corresponding intermitting control signal to the CAN bus transceiving modules according to the CAN bus controller modules; one path of the CAN bus controller module is directly connected to the protocol processing module; another path is connected to the protocol processing module via the bus receiving buffer.

本发明提供了一种双冗余CAN总线控制器，设置于双线CAN总线上，其特征在于：两个CAN总线收发模块、两个初始化模块分别与CAN总线控制器模块A和CAN总线控制器模块B相对应；两个CAN总线控制器模块通过驱动器切换控制单元分别与两条CAN总线相连；初始化模块与总线控制器初始化寄存器相连，对所对应的CAN总线控制器模块进行初始化；协议处理模块与FIFO缓存器相连；FIFO缓存器通过逻辑接口与节点处理器连接；中断处理单元根据CAN总线控制器模块的控制命令对CAN总线收发模块发出相应的中断控制信号；CAN总线收发模块一路与协议处理模块直接相连，另一路通过总线接收缓存器与协议处理模块相连。

CaN Aβ gene silencing can reduce myocardial hypertrophy in cultured cells, si1280 (21bp) of CaN Aβ gene is the most effective target site for siRNA. The method of intrapericardial injection of plasmid, microbubbles and erzymes can improve transfection efficiency of non-viral plasmid with satisfying targeted transfection. But the scope of transfected myocytes is still limited. CaN Aβ shRNA expressing plasmid transfection in vivo by pericardial injection results in decreased CaN Aβ protein expression of small part of myocytes, and CaN Aβ mRNA only shows decreased trend. The dosage of non-viral vector and the parameters of ultrasound energy should be optimized in further study.

结论RNAi技术抑制CaN Aβ基因表达可有效减轻Ald诱导的心肌细胞肥大程度；CaN Aβ基因中si1280(21bp)片段为实现RNAi的更有效片段；微泡+酶类心包腔内注射超声导入的方法可有效改善非病毒载体在体心肌的转染效率，同时具有一定的靶向性，但总的转染范围仍然有限；采用这一方法进一步进行&一肾一夹&心肌肥大模型大鼠在体心肌细胞的CaNAβ的RNAi干预，发现心肌肥大大鼠心外膜下局部心肌细胞CaN Aβ蛋白水平降低，CaN AβmRNA水平虽有下降趋势，但无统计学差异，提示质粒的用量及超声导入的参数有待进一步研究使其优化。

An antibody binding to IGF-IR and inhibiting the binding of IGF-I and IGF-II to IGF-IR which is characterized in that said antibody is a is ofIgG1 isotype, b shows a ratio of IC50 values of inhibition of the binding of IGF-I to IGF-IR to the inhibition of binding of IG-II to IGF-IR of 1:3 to 3:1, c inhibits for at least 80% at a concentration of 5 nM IGF-IR phospohrylation in a cellular phosphorylation assay using 3T3 cells providing 400,000 to 600,000 molecules IGF-IR per cell in a medium containing 0.5% heat inactivated fetal calf serum when compared to such an assay without said antibody, and d shows no IGF-IR stimulating activity measured as IGF-IR phophorylation at a concentration of 10 M in a cellular phosphorylation assay using 3T3 providing 400,000 to 600,000 molecules IGF-IR per cell in a medium containing 0,5% heat inactivated fetal calf serum when compared to such an assay without said antibody has improved properties in antitumor therapy.

一种已经提高了抗肿瘤治疗的特性的抗体，所述抗体结合IGF-IR并且抑制IGF-I和IGF-II与IGF-IR结合，其特征在于所述抗体a是IgG1同种型，b显示其对IGF-I与IGF-IR结合的抑制的IC 50 值与其对IGF-II与IGF-IR结合的抑制的IC 50 值的比率为1∶3-3∶1，c当与没有所述抗体的这种测定比较时，其在5nM的浓度上，在包含0.5％的热灭活胎牛血清的培养基中，使用3T3细胞的细胞磷酸化测定中，抑制至少80％的IGF-IR磷酸化，所述3T3细胞提供400，000-600，000分子IGF-IR/细胞，和d当与没有所述抗体的这种测定相比，在包含0.5％的热灭活胎牛血清的培养基中，使用3T3的细胞磷酸化测定中，其在10μM的浓度上没有显示作为IGF-IR磷酸化所测量的IGF-IR刺激活性，所述3T3提供400，000-600，000分子IGF-IR/细胞。

The first one is built up by the single affairs of X and Y and thus shows a microcosmic space which leads to a overthrown to the common rules; the second one, composed by a serials of affairs such as A, B, C, D and so on, is a circle space which usually over thrown the types of literature; and the third one, including affairs of A ,B, C, D, etc, is a juxtapositional space which upset the styles of literature.

在余华小说的三种叙事空间中，第一空间是X与Y单个事件形成的微观空间，指向的是对常理的颠覆；第二空间是A、B、C、D……等系列事件所形成的循环圈空间，指向的是对文类的颠覆；第三空间是A、B、C、D……等系列事件所形成的并置链空间，指向的是对文体的颠覆。

Only Lamin A was observed to be able to be co-immunoprecipitated with 8B7 spectrin.Lamin A is a component in lamin and functions as a common anchoring site for many proteins.It plays important roles in maintaining normal morphology of nuclear envelope,presenting anchoring site for chromatin and reconstructing of nucleus.8B7 spectrin may function through interaction with Lamin A.

Lamin A是核纤层的组成成分，由LMNA基因编码，是核内许多蛋白分子的共同锚定物，在维持核膜的正常形态，提供染色质的锚定位点以及在核的重组过程中可能发挥重要作用。8B7血影蛋白可能经由Lamin A发挥功能。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。