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For all of GAS toxicity factors, M protein is the most important toxicity factor. M protein is a membrane protein which have α-helical coiled coil structure on the plasma membrane. It helps GAS to attack the host and have resistance to the immune system.

在A型链球菌所有的毒性因子中，M蛋白是最重要的毒性因子。M蛋白是A型链球菌上的一种膜蛋白，在A型链球菌细胞膜上形成α-helical coiled coil结构。M蛋白帮助A型链球菌侵入宿主并且逃避宿主的免疫系统攻击。

Group A Streptococcus is a Human pathogen which causes 18.1 million cases disease and 0.51 million people dies. GAS causes severe disease including scarlet fever, rheumatic fever, rheumatic heart disease and acute glomerulonephritis, the rheumatic heart disease is the major reason which causes heart disease in the children and young people.

A型链球菌是是一种人类的致病菌，在全球每年会有大约1800万人受到A型链球菌的影响，且会有51万人死於A型链球菌所造成的疾病。A型链球菌所造成的疾病包含猩红热、风湿热、风湿性心脏病、急性肾丝球肾炎等，其中风湿性心脏病是造成孩童以及年轻人得到心脏病的主要原因。

The most outlandish people can be the stimulus for love.A man may be a doddering great-grand-father and still love only a strange girl he saw in the streets of Cheehaw one afternoon two decades past.The preacher may love a fallen woman.The beloved may be treacherous, greasy-headed,and given to evil habits .

最古怪的人，可刺激love.a男子可能是一个老态龙钟曾孙--父亲和爱情仍只是一个陌生的女孩，他看到在街上cheehaw一个下午二十年past.the布道者五月爱塌woman.the亲爱的，可老婆的，油腻的头脑，给邪恶的习惯。

Methods Twenty-four SD rats were randomized into group A and group B with 12 rats each group. The chemicals were given by gavage. Each rat in group A was administered 2 ml distilled water once everyday, and that in group B a mixture of 30 mg/kg melamine and 30 mg/kg cyanuric acid was given once everyday.

将24只SD大鼠随机分成A组和B组，每组12只，A组大鼠每只每天以蒸馏水2 ml灌胃一次，B组每天以30 mg/kg三聚氰胺和30 mg/kg三聚氰酸联合灌胃一次。

Results: The peak responses of postprandial glucose and C-peptide were postponed; their values and the incremental area under curve of glucose responses of gruels were obviously lower than that of steamed bun (P.05). While both glycemic index and C-peptide index of steamed bun were set as 100, the glycemic index and C-peptide index of gruel A were 67, 99, and of gruel B were 57, 97 in NIDDM patients, 53, 69 in healthy subject.

结果 1。三组餐后血糖、C肽峰值显著低于馒头，血糖反应增值面积有显著性差异，以C组最低，A组最高；2.A、B两组C肽曲线增值面积显著低于C组；3.A、B、C三组血糖、C肽指数分别为67、99，57、97和53、69；4.B、C组血糖指数显著低于A组，C组的C肽指数明显低于A、B组。

I'll just play a little bit to see how it feels...Three hours later, I realized I was addicted. Which is awful, because I really thought I was done playing this game in 1990. The thing is, they put in just enough new features compared to the original game that all my old reflexes from the Apple II, two-button joystick are worse than useless.Just when I think I've got it wired, I hold the A button pressed a half-second too long and die a horrible death. It makes me want to kill whoever designed it.

我觉得我会再看看手感如何。。。3个小时后我被吸引住了，就像90年时的感觉一样，简直无语了，他们放了足够多的新元素来对比我当初在Apple2机上的感觉，那两个摇杆不如不要的好，当我感觉我已经上手时，我多压了A半秒，结果导致一场可怕的死亡。

Another benefit to Meguiar's A-12 Cleaner Wax is it's widespread availability, and affordable price,(suggested retail is $4.95). This makes it another good choice for people with daily drivers that would like to wax their car often. And if you like to see water beading on your car's finish after washing or following a rain storm, you will not be disappointed. The chemists at Meguiar's recently reformulated A-12 Cleaner Wax to bead water like nobody's business! Water beads are small, tall and tight and last and last. Water beading, as well as darkness gets better and better with each additional coat. Easy to use, Meguiar's Cleaner Wax wipes on easy, dries fast, and removes effortlessly with a premium quality 100% cotton towel, or Meguiar's own microfiber polishing cloth, the Ultimate Wipe. Meguiar's Cleaner/Wax can be applied by hand, dual-action polisher and orbital buffers.

美克拉A-12清洁蜡的其他优势是产品随处可得和价格是人人负担得起的（建议售价是4.95美金），这使得它成为天天开车且喜欢经常为他们的爱车上蜡的人们另一个好的选择，如果你喜欢在洗完车或大雨过后看到水珠挺立在你的烤漆上，你将不会失望的，美克拉的化学家最近为了让水可以在漆面上形成水珠而重新调配A-12清洁蜡的配方，现在水珠会变得更小、直挺、紧凑、持久的，烤漆在你每多上一层涂层会变成越来越深沈，它是容易使用的，美克拉清洁蜡上蜡容易、快乾且使用一条优质的100%纯棉毛巾或美克拉生产的超细纤维布来下蜡是毫不费力的，美克拉清洁蜡可以使用手、震抛机和打蜡机来施用。

Another benefit to Meguiar's A-12 Cleaner Wax is it's widespread availability, and affordable price,(suggested retail is $4.95). This makes it another good choice for people with daily drivers that would like to wax their car often. And if you like to see water beading on your car's finish after washing or following a rain storm, you will not be disappointed. The chemists at Meguiar's recently reformulated A-12 Cleaner Wax to bead water like nobody's business! Water beads are small, tall and tight and last and last. Water beading, as well as darkness gets better and better with each additional coat. Easy to use, Meguiar's Cleaner Wax wipes on easy, dries fast, and removes effortlessly with a premium quality 100% cotton towel, or Meguiar's own microfiber polishing cloth, the Ultimate Wipe. Meguiar's Cleaner/Wax can be applied by hand, dual-action polisher and orbital buffers.

美克拉A-12清洁蜡的其他优势是產品随处可得和价格是人人负担得起的（建议售价是4.95美金），这使得它成為天天开车且喜欢经常為他们的爱车上蜡的人们另一个好的选择，如果你喜欢在洗完车或大雨过後看到水珠挺立在你的烤漆上，你将不会失望的，美克拉的化学家最近為了让水可以在漆面上形成水珠而重新调配A-12清洁蜡的配方，现在水珠会变得更小、直挺、紧凑、持久的，烤漆在你每多上一层涂层会变成越来越深沉，它是容易使用的，美克拉清洁蜡上蜡容易、快乾且使用一条优质的100%纯棉毛巾或美克拉生產的超细纤维布来下蜡是毫不费力的，美克拉清洁蜡可以使用手、震抛机和打蜡机来施用。

Bleach主题曲 life is like a boat 歌曲:Life Is Like A Boat 歌手:Rie Fu Life Is Like A Boat 演唱: Rie fu 词/曲: Rie fu Nobody knows who I really am I never felt this empty before And if I ever need someone to come along Who's gonna comfort me, and keep me strong We are all rowing the boat of fate The waves keep on comin' and we can't escape But if we ever get lost on our way The waves would guide you thru another day 远くで息をしてる透明になったみたい暗暗に思えたけど目隠しされてただけ祈りをささげて新しい日を待つ鲜やかに光る海その果てまで Nobody knows who I really am Maybe they just don't give a damn But if I ever need someone to come along I know you would follow me, and keep me strong 人の心はうつりゆく抜け出したくなるつきはまた新しい周期で舟を连れてく And every time I see your face The oceans heave up to my heart You make me wanna strain at the oars And soon I can see the shore Ah, I can see the shore ...

life is like a boat http：//www.cg-ring.com/music/riefu01.wma 刷吧我认了 Life is like a boat 歌词大意：没有人知道我究竟是谁我以前从未感觉到如此虚无空荡如果我需要有人来陪伴谁会安慰我并让我更加坚强我们都在命运之湖上荡舟划桨波浪起伏这而我们无法逃离孤航但是假使我们迷失了方向波浪将指引着我们穿越另一天的曙光在遥远的地方呼吸着仿佛变成了透明一般还以为是周遭的黑暗却只是被蒙住了双眼虔诚地祈祷着期待新的一天的到来直到闪耀着亮丽光芒的大海边际没有人知道我究竟是谁或许他们并不会指责我的荒唐但如果我需要有人来陪伴我知道你会追随我并使我坚强想从不断变迁的人心中挣脱又一轮阴晴圆缺的月亮牵引着我向前每一次我看见你的脸庞海洋奋力托起我的心脏你令我在荡桨时感到紧张转眼我竟看不到岸的彼方啊，我看不到岸的彼方。。。。。。

Methods:(1) Dissoluble PGN and CpG DNA were immobilized onto the surface of biotin cuvette for establishing target. Another effective tracking approach was established by immobilizing Escherichia lipid A F583 onto the surface of Non-derivatised cuvett. The biosensor technology was applied to screen anti-inflammatory TCM targeting on three key molecules.(2) The active compositions were isolated by AB-8 macroreticular resin from lycium bark. After the activities of compositions were evaluated, the most effective compositions was confirmed. In vitro, the affinities of different concentrations composition E binding with PGN, CpG DNA and lipid A were measured separately. The effect of composition E on vigor of RAW264.7 cells were tested by MTT and CCK-8, and its inhibition on TNF-α, which was released from RAW264.7 cells induced by PGN, CpG DNA and LPS, was also tested by ELISA. In vivo, murine sepsis models were made by intravenously heat-killed E.coli and heat-killed S.aureus, then protection of composition E on mice sepsis model were observed.

(1)将PGN及CpG DNA包被于生物素样品池，将lipid A包被于非衍生样品池，分别建立以PGN、CpG DNA及lipid A为靶点的技术平台，对114种抗炎中药水提物进行筛选、评价其活性物质含量，并评估出针对上述三种病原分子均具有较高结合活性的中药；(2)利用生物传感器跟踪检测技术、大孔吸附树脂分离技术，从地骨皮中定向分离与PGN、CpG DNA及lipid A均具有较高亲和力的活性组分；在体外实验中，测定不同浓度活性组分与PGN、CpG DNA及lipid A亲和力；MTT法及CCK-8法检测活性组分对RAW264.7细胞活力的影响；ELISA法检测活性组分对PGN(2μg/ml)、CpG DNA(10μg/ml)及LPS(100ng/ml)刺激小鼠RAW264.7细胞分泌TNF-α的抑制作用；在体内实验中，采用尾静脉注射致死剂量热灭活大肠杆菌和热灭活金黄色葡萄球菌，建立细菌脓毒症小鼠模型，观察活性组分对脓毒症模型小鼠的保护作用。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。