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There are four kind of isoforms of endothelin in human and other mammals named ET-1, ET-2, ET-3 and ET-β, which are slightly different in construction and pharmacological effect. In human beings, ET-1 is the dominative subtypes. ET-1 remains in blood at a low level about 5ng per liter on physical state. It is synthesized, stored, released and metabolized locally. The half-life of ET-1 is about 1 hour. ET-1 is the most potent vasoconstrictive factor till now, and it is more functional in vein than in artery. In vascular bed, there are two kind of ET receptors. Type A mainly located in smooth muscle cells, whereas type B in endothelial cells. The latter can stimulate intimal hyperplasia via a parasecretion way and activate some oncogenes such as c-fos and c-myc and then enhance their expression. These alterations result in constriction of blood vessels, thus the SMC steps into proliferate state from silent state.

人及哺乳动物体内有四种结构及药理学性质略有差异的异物体，分别为ET-1、ET-2、ET-3、ET-β，而在人主要是ET-1，在生理条件下，ET-1在血浆中含量较低，约为5ng〓，故ET-1不是一个循环激素，而是局部合成释放，局部起作用的活性物质，半衰期约1小时，ET-1是目前已知的最强的血管收缩剂，对静脉的作用比动脉强，在血管床，ET受体有A、B两型，A型主要分布在平滑肌细胞，B型主要分布在内皮细胞，它可以通过旁分泌途径刺激内膜增生，具有有丝分裂原效应，可以激活某些癌基因如C-fos、C-myc使其表达增强引起血管收缩，使静止期SMC进入增殖期，还可以通过信号传导途径，与bFGF、GTF-β、PDGF等生长因子协同作用，起共有丝分裂原作用。

The multivariate linear regression analysis on specific absorption coefficients for pheophytin and chlorophyll a indicates that the specific absorption coefficients for pheophytin was much larger than chlorophyll a at 412 nm; slightly larger than pheophytin at 440nm; and about 3 times larger than pheophytin at 670 nm and 675 nm.

结果表明，412nm波段脱镁叶绿素的比吸收系数远大于叶绿素a；440nm波段，叶绿素a的比吸收系数略大于脱镁叶绿素；670、675nm波段，叶绿素a的比吸收系数约为脱镁叶绿素的3倍。

Accordingly, the Q bands of them blue shifted by 6mn and 13nm, respectively. The fluorescence emission wavelengths of Cd-pheophytin a and Cd-pheophytin b observed at 660nm and 649nm, respectively, which were shorter than those of corresponding pheophytin a and pheophytin b by 10nm and 9nm, respectively.

研究发现：在光吸收性质上，与脱镁叶绿素a和b相比，镉叶绿素a和b在Soret带的吸收峰位置分别红移了19nm和11nm，而在Q带则分别蓝移了6nm和13nm；在荧光性质上，镉叶绿素a和b的荧光发射波长比脱镁叶绿素a和b分别蓝移了10nm和9nm。

The invention provides a phomopsis compound of sea weed fungus with strong antibacterial activity and application in antibacterial drugs, a relative preparation method and an application, wherein the sea weed fungus is hzla01-1(Phomopsis sp.hzla01-1) as phomopsis compound A and B, compound A is colorless oily substance, and the compound B is colorless acicular crystal.

提供一类来源于海藻真菌的具有强抗菌活性，可应用于抗菌药物的拟茎点菌素化合物及其制备方法和应用。海藻真菌为拟茎点属hzla01-1(Phomopsis sp.hzla01-1)。化合物分别为拟茎点菌素化合物A和B，化合物A为无色油状物，化合物B为无色针状晶体。

Results On the basis of the percentage of GPI-anchored PLAP conversion,the sera GPI-PLD activities of total 172 patients,included 26 severe acute viral hepatitis as group A,29 liver cirrhosis as group B,32 chronic viral hepatitis as group C,55 mild acute viral hepatitis as group D,30 primary hepatocellular carcinoma as group E,were measured.As compared with 182 healthy presons as control group,the sera GPI-PLD activities of group A and B were significantly reduced;By contraries,the activities of group D and E were significantly raised.The sera GPI-PLD activities of group C compared with healthy control group were not significantly altered.However,when paired Q-test,the changes of serum GPI-PLD activity between all paired groups among this five groups were remarkable.

结果检测172例肝脏疾病患者(包括A组：26例急性重症病毒性肝炎；B组：29例肝硬化；C组：32例慢性病毒性肝炎；D组：55例急性非重症病毒性肝炎；E组：30例原发性肝癌)血清中GPI-PLD的活性，发现A、B两组患者的该酶活性较正常人(182名)显著性降低，而D、E两组则较正常人显著性增高，C组患者的酶活性与正常人无显著性差异，但A、B、C、D、E两组之间的酶活性水平改变却均有显著性。

It was found that the incidence of As and Wd in the group of juvenile poliosis and the correspondence rate of A/A and L/W were obviously lower than those of the normal contrast group,while a-b TRC value in the female patients with juvenile poliosis and the incidence of abnormal palmprint in the male, the frequency of all loop whorl,and palm patterns in the I2 area of the right hand and in the Hyarea of the left hand were evidently higher than the corresponding incidences of the normal contrast group.

发现青少年白发组的As和Wd出现率以及A/A和L/W的对应频率均显著低于正常对照组；青少年白发组女性的a-bTRC值、男性变异型掌褶纹的出现率、10指同斗频率、右手Ⅰ2区及左手Hy区的花纹出现率均显著高于正常对照组的相应出现率。

According to the data that Yahoo public praise provides, a room source plans not to roll out a week, attestation of near 2000 members is successful, the intermediary of famous house property such as all-round victory of home of ten million of course of study of buy of main rooms of Central Plains of praedial, Beijing, Shanghai, Beijing, Guangzhou joins Beijing catenary home, 21 centuries in succession in plan of A room source.

据雅虎口碑提供的数据，A 房源计划推出不到一周，将近2000名会员认证成功，北京链家、21世纪不动产、北京中原、上海上房置业、北京千万家、广州满堂红等知名房产中介纷纷加入A 房源计划之中。

The plasma Aβ42/Aβ40 ratio may be a useful premorbid biomarker for identifying cognitively normal elderly white subjects who are at increased risk for developing MCI or AD.

血浆Aβ42/Aβ40比值可能对判断认知功能正常的白种老年人发展为MCI或AD风险升高是一种有用的发病前生物标记。

Methods 150 patients with prostatitic of Ⅲa type were randomly divided into two groups. Patients in treatment group (n=75) were treated by combination of extraorgan short wave therapy (once 20 mins/day), wild chrysanthemum suppos.(a piece, once a day, take by anus) and controlled release tablets of Doxazosini Mesylas (40 mg, once a day). Patinets in control group (n=75) were treated by extraorgan short wave therapy.

将150例Ⅲa型前列腺炎患者随机分为2组，治疗组75例予体外超短波（每次20 min，每日1次）联合野菊花栓（每次1枚，每晚1次肛门给药）及甲磺酸多沙唑嗪控释片（每次4 mg，每晚1次睡前服）治疗，对照组75例单纯予体外超短波治疗。2组均14日为1个疗程，1个疗程后统计临床疗效和治疗前后慢性前列腺炎症状评分。

Methods 150 patients with prostatitic of ⅲa type were randomly divided into two groups. patients in treatment group (n=75) were treated by combination of extraorgan short wave therapy (once 20 mins/day), wild chrysanthemum suppos.(a piece, once a day, take by anus) and controlled release tablets of doxazosini mesylas (40 mg, once a day).

将150例ⅲa型前列腺炎患者随机分为2组，治疗组75例予体外超短波（每次20 min，每日1次）联合野菊花栓（每次1枚，每晚1次肛门给药）及甲磺酸多沙唑嗪控释片（每次4 mg，每晚1次睡前服）治疗，对照组75例单纯予体外超短波治疗。2组均14日为1个疗程，1个疗程后统计临床疗效和治疗前后慢性前列腺炎症状评分。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。