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At the IV dose of 20 and 30 mg/kg, Aloin and Isobarbaloin result appear the mean terminal eliminate half-life（T1/2 β）were 54.1±28.4; 28.7±18.3 and 36.9±21.9;49.7±17.1 min, respectively. The mean area under the serum concentration curve（AUC0-∞）were about 411.655± 13.027;318.213±19.924 and 701.336±116.631;573.278± 86.870μg min/mL, respectively. The mean drug clearancewere 0.165±0.011;0.214±0.016 and 0.149±0.030;0.182±0.035 L/min, respectively.

若静脉注射剂量20和30 mg/kg后，其芦荟大黄苷及异芦荟大黄苷分别平均末端排除半衰期（T1/2 β）为54.1±28.4；28.7±18.3和36.9±21.9；49.7±17.1 min，平均稳定状态分布体积为7.668±3.155；6.343±3.522和5.146±2.490；8.525±2.683 L，平均曲线下面积（AUC0-∞）为411.655 ±13.027；318.213±19.924 和701.336±116.631；573.278±86.870 μgmin/mL，平均血浆中药物最高浓度为23.920±5.669；30.442 ±7.537和57.920±27.690；36.373±14.174 μg/mL，平均药物之清除率为0.165±0.011；0.214±0.016和0.149±0.030；0.182±0.035 L/min。

At the IV dose of 20 and 30 mg/kg, Aloin and Isobarbaloin result appear the mean terminal eliminate half-life（T1/2 β）were 54.1±28.4; 28.7±18.3 and 36.9±21.9;49.7±17.1 min, respectively. The mean area under the serum concentration curve（AUC0-∞）were about 411.655± 13.027;318.213±19.924 and 701.336±116.631;573.278± 86.870μgE min/mL, respectively. The mean drug clearancewere 0.165±0.011;0.214±0.016 and 0.149±0.030;0.182±0.035 L/min, respectively.

若静脉注射剂量20和30 mg/kg后，其芦荟大黄苷及异芦荟大黄苷分别平均末端排除半衰期（T1/2 β）为54.1±28.4；28.7±18.3和36.9±21.9；49.7±17.1 min，平均稳定状态分布体积为7.668±3.155；6.343±3.522和5.146±2.490；8.525±2.683 L，平均曲线下面积（AUC0-∞）为411.655 ±13.027；318.213±19.924 和701.336±116.631；573.278±86.870 μgEmin/mL，平均血浆中药物最高浓度为23.920±5.669；30.442 ±7.537和57.920±27.690；36.373±14.174 μg/mL，平均药物之清除率为0.165±0.011；0.214±0.016和0.149±0.030；0.182±0.035 L/min。

Leaves 29-84 cm; petiole 7-12 cm, pilose to glabrescent, often lenticellate; rachis moderately pilose to glabrescent, occasionally velutinous; leaflets usually 6-9(-12) pairs; petiolules (2-)4-12 mm, pilose/villous to glabrescent; leaflet blades lanceolate to ovate-lanceolate, 7-14(-19.5)× 3.1-6(-7) cm, often dark grayish brown, moderately pilose to glabrescent, usually with short trichomes and club-glands apically on midveins, veins basally pilose to villous/velutinous, base symmetrical to asymmetrical, margin entire, apex acuminate to occasionally acute.

叶29-84厘米；叶柄7-12厘米，具柔毛到几无毛，通常具皮孔；轴适中具柔毛到几无毛，偶尔被短绒毛；小叶通常6-9(-12)对；小叶柄(2-)4-12毫米，具柔毛/具长柔毛到几无毛；小叶叶片披针形到卵状披针形， 7-14(-19.5)* 3.1-6(-7)厘米，经常暗灰棕色，适中具柔毛到几无毛，通常在顶部中脉上具短毛和棍状腺体，脉基部具柔毛到具长柔毛/被短绒毛，基部匀称到不对称，边缘全缘，先端渐尖到偶有锐尖。

Moreover, the preliminary test of the biological activity of the 8 target derivatives showed that 7-(2-adenine)ethoxyl-2-ethyl-4"- methoxy isoflavone and 7-(2-hydroxyl-3-piperidino)propoxy-2-ethyl-4"- methoxyl isoflavone have fine biological activities on suppression of the growth of MCF-7 cell in breast cancer and the hela cell in cervical cancer of human being.

另外还对8个目标衍生物进行了初步的药理活性试验，发现7-(2-腺嘌呤)乙氧基-2-乙基-4′-甲氧基异黄酮和7-(2-羟基-3-哌啶)丙氧基-2-乙基-4′-甲氧基异黄酮均有较好的抑制人乳腺癌MCF-7细胞和人宫颈癌hela细胞生长的药理活性。

Results The infec- tious rate of out-patients was 82.63%（6939/8398）, including 18.83% monilia infections, 3.57% trichomonas Infections, 1.45% gonocoectrs infectious, 21.89% chlamydial trachomatis or mycoplasmas Infections, 28.6% bacterial vaginitis, 2.26% syphilis, 0.08%HIV infections.38.51% patients suffered from two kinds and more than two kinds infections,7 cases combining HIV infection; The infectious rate of health physical examinees was 19.93%（1656/8309）, including 7.7% monilia infections, 0.3% tri- chomonas Infections, 2.0% chlamydial trachomatis or mycoplasmas Infections,9.3% bacterial vaginitis, 0.05% gonococcus infections,4.28% persons suffered from two kinds and more than two kinds infections.

结果 门诊患者生殖道炎症为82.63%（6939/8398），霉菌感染18.83%、滴虫感染3.57%、淋球菌感染1.45%、衣原体/支原体感染21.89%、细菌性感染28.6%、梅毒感染2.26%、HIV0.08%，38.51%的人有两种或两种以上病原体感染，其中合并HIV感染7例；健康体检组生殖道炎症19.93%（1656/8309），霉菌感染7.7%、滴虫感染0.3%、淋球菌感染0.05%、衣原体/支原体感染2.0%、细菌性感染9.3%，4.28%的人有两种或两种以上病原体感染。

Results The lesion located at the basal segments of left lower lobe in 9 cases (90%), furthermore, 7(70%) at the posterior basal segments; The remainder 1 case (10%) was found at the posterior basal segment of right lower lobe; The lesion present as multiloculated cyst containing fluid and/or air in 7 cases(70%) without contrast enhancement of cyst wall, 3 cases (30%) presented as irregular mass with moderate enhancement, in which bronchiectasis with mucous impaction, calcification or cyst containing fluid may be seen; MRP, MIP and VR reconstructions showed anomalous branches arising from descending aorta in all 10 patients(100%) with draining into left atrium via pulmonary vein,which was consistent with surgery; Ipsilateral hilar lymphadenopathy was demonstrated in 7 cases (70%).

结果 9例（90％）病灶位于左下叶基底段，其中7例（70％）位于左下叶后基底段，1例（10％）位于右下叶后基底段；7例（70％）病灶表现为含液/气的薄壁多房囊腔，增强后囊壁无明显强化，3例（30％）表现为不规则团块，增强后有中等强化，其内有粘液嵌塞的扩张支气管，也可有钙化或液性区；MPR、MIP及VR等三维重建显示10例（100％）均为降主动脉发出异常分支供血，并通过肺静脉回流入左房，血管显示情况与手术相符；7例（70％）患侧肺门淋巴结有增大。

The myelinization of cerebellar white matter,middle cerebellar peduncles,anterior limb of internal capsule,splenium and genu of corpus callosum,centrum semiovale,the white matter in parietal-occipital area and frontal-temporal area were documented at birth to 5,2～4,3～7,3～5,4～7,2～7,3～9 and 4～12 months old,respectively.

髓鞘形成至成熟时间：小脑上下脚、桥脑背侧、丘脑腹外侧和内囊后肢后部出生时已成熟，小脑自出生至5个月，小脑中脚2～4个月，内囊前肢3～7个月，胼胝体后部、膝部分别是3～5个月、4～7个月，半卵圆中心2～7个月，枕顶叶白质3～9个月，额颞叶白质4～12个月。

The calculated results show that the binding affinity between Myricetin and MMP-7 is higher than that between Pyrogallic acid and MMP-7 when they bind to MMP-7, thus Myricetin is more potent on MMP-7 than Pyrogallic acid. This is in agreement with the inhibitory activity order from experiments.

研究结果表明，在与MMP-7结合时，杨梅黄酮比焦性没食子酸具有更高的亲合性，因此杨梅黄酮对MMP-7有更好的效能，这与实验测得的活性顺序相符。

Based on the results of 1H-NMR, 13C-NMR, ESI-MS and UV spectra, the structures of three compounds with antitumor activity were identified as Prodigiosin、7-Hexadecenoic acid、7,10-Octadecadienoic acid, respectively; another compounds (no activity to above tumor cells)was identified as Myristic acid.

运用核磁共振（1H-NMR、13C-NMR）、质谱、紫外光谱等现代波谱技术分析，将其中3种具有抗肿瘤活性的化合物分别鉴定为灵菌红素、7-十六碳烯酸（7-Hexadecenoic acid）、7，10-十八碳二烯酸（7，10-Octadecadienoic acid）；鉴定另一种对上述肿瘤细胞无活性的化合物为肉豆蔻酸。

Hypoxia increased the percentage of intra-acinar muscular and decreased the one of nonmuscular artery. 764-3 could reduce MA% from 33.75±11.26 (H2w) to 21.25±5.86 (7-H2w, p＜0.05) and from 41.50±10.70 (H4w) to 26.67±10.92 (7-H4w, P＜0.05), respectively; meanwhile, increase NMA% from 35.42±9.00 (H2w) to 45.42±2.92 (7-H2w, p＜0.05) and from 21.50±9.29 (H4w) to 33.33±5.40 (7-H4w), p＜0.05, respectively.

与正常组大鼠相比，缺氧2周、4周后MA％明显增加，分别为33.75±11.26(＜0.001)和41.50±10.70(p＜0.01)；NMA％显著减少，分别为35.42±9.00(p＜0.001)和21.50±9.29(p＜0.001)。764-3处理的大鼠其三型血管比例的失调得到部分改善。7-H2w组与7-H4w组MA％分别为21.25±5.86和26.67±10.92(p均＜0.05)，NMA％为45.42±2.92和33.33±5.40(p均＜0.05)。

It seems likely that Kraft will return with a better offer.

看起来卡夫要重新考虑一个更好的出价了。

But he'd rather burn off my feelers and watch me squirm.

可他却放任那个家伙对我为所欲为！