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Digital taboo 4,7,8,13,37,69. Do not like "7", that "7" is a negative number.

数字禁忌4、7、8、13、37、69。不喜欢"7",认为"7"是个消极数字。

Afterwards those who are called emperors began in this order: first, Caius Julius, who reigned 3 years 4 months 6 days; then Augustus, 56 years 4 months 1 day; Tiberius, 22 years; then another Caius, 3 years 8 months 7 days; Claudius, 23 years 8 months 24 days; Nero, 13 years 6 months 58 days; Galba, 2 years 7 months 6 days; Otho, 3 months 5 days; Vitellius, 6 months 22 days; Vespasian, 9 years 11 months 22 days; Titus, 2 years 22 days; Domitian, 15 years 5 months 6 days; Nerva, 1 year 4 months 10 days; Trajan, 19 years 6 months 16 days; Adrian, 20 years 10 months 28 days; Antoninus, 22 years 7 months 6 days; Verus, 19 years 10 days.

事后那些所谓的帝王,开始在这条命令:第一, caius戏剧,他在位三年四个月六天,然后奥古斯都, 56年4月1日;提庇留, 22年来,然后又caius , 3年8个月, 7天内;克劳狄斯, 23岁8个月24天; Nero的, 13年6个月58天; galba , 2岁7个月6天; otho , 3个月共5天; vitellius , 6个月22天; vespasian , 9年11个月22天;弟兄, 2年22天; domitian年, 15年5个月6天; nerva , 1年4个月10天;图拉真, 19年6个月16天;阿德里安, 20年10个月28天; antoninus , 22年7个月六天;真实的, 19岁10天。

Goal compound synthesis namely: Take the vanillic acid as outset raw material, obtains 4- hydroxyl - 3- anisole methyl formate with the methyl alcohol reflux conditions, then after the etherification, the nitration, the return to original state, the ring closure response obtains 6- methoxy - 7- animal pen oxygen radical kui zuo lin - 4- alkone, then passes through the chlorination, the substitution aniline, to escape responses again and so on animal pen oxygen radical, etherification to obtain the goal compound; The goal compound and the diethylamine had the amine substitution reaction to obtain TM1, namely 4- benzene amino - 6- methoxy - 7- [2- hydroxyl - 3-(N, N- two ethyl aminos) third oxygen radical] kui zuo lin; Through zuo has the etherification with the Austria niter to respond obtains TM2, namely 4- benzene amino - 6- methoxy - 7- [2- hydroxyl - 3-(2- methyl - 5- nitryl imidazole) third oxygen radical] kui zuo lin.

目标化合物的合成即:以香草酸为起始原料,与甲醇回流条件下得到4-羟基-3-甲氧基苯甲酸甲酯,然后经过醚化、硝化、还原、环合反应得到6-甲氧基-7-苄氧基喹唑啉-4-酮,然后再经氯化、取代苯胺、脱苄氧基、醚化等反应得到目标化合物;目标化合物与二乙胺发生胺取代反应得到了TM1,即4-苯氨基-6-甲氧基-7-[2-羟基-3-丙氧基]喹唑啉;通过与奥硝唑发生醚化反应得到TM2,即4-苯氨基-6-甲氧基-7-[2-羟基-3-(2-甲基-5-硝基咪唑)丙氧基]喹唑啉。

During the manufacturing of the critical intermediate cephalosporin nucleus --7-amino-3-chloro-cephalosporanic acid diphenylmethyl ester hydrochloride salt, first the feasibility of the one-pot synthetic route of open loop, closed loop and ozonization when chlorine is passed over is qualified by experiments. Then the critical factors that will influence this reaction are studied as follows: the mol ratio of triphenyl phosphite and Diphenylmethyl 3-hydroxy-7-phenylacetaminoceph-3-em-4-carboxylate-l-oxide is four to one; the quantity of the stablizer should be at least more than two to one. The temperature of the system must be 25℃ when chlorine is passed over so that the hydrochloride can be precipitated to obtain cephalosporin nucleus of cefaclor--7-amino-3-chloro-cephalosporanic acid diphenylmethyl ester hydrochloride salt.

在制备关键中间体头孢母核7-氨基-3-氯头孢烷酸二苯甲酯盐酸盐时,先通过实验验证把开环、闭环、臭氧化三步在通入氯气时并为一锅煮的合成路线的可行性之外,又研究了影响该反应的几个重要因素:亚磷酸三苯酯与3-羟基-7-头孢烷-5-亚砜-2-甲酸二苯甲酯的摩尔比为4:1;稳定剂2-甲基-2-丁烯的用量至少大于2:1,通入氯化氢气体时体系温度在25℃时盐酸盐则能够顺利析出,获得头孢克洛的头孢母核—7-氨基-3-氯头孢烷酸二苯甲酯盐酸盐。

Result:The severe pain degree has declined from 7.7% to 1.7% by improved method of opisthenar intravenous infusion, and light pain degree from 43.8% to 15%, but the painlessness has increased from 48.5% to 83.3% compared with the conventional method of intravenous infusion.

结果:改进手背静脉输液方法比常规手背静脉输液方法,患者重度疼痛由7.7%减少为1.7%,轻度疼痛由43.8%减少为15%,不痛由48.5%上升为83.3%。

Major procurement of goods: a three-chlorosilanes, dichloromethane, AE activity ester, 3-iodine Silane, special acid, pentyl chloride, triethylamine, thiadiazole, tetrazolylazo acid, 2 - Acetamide, tetrahydrofuran, the four-guanidine, isopropanol, five phosphorus trichloride, sodium vary bitter, acid, sodium phenylacetate, 6-2 silicon n-amine, Ethylacetoacetate , Methyl isobutyl ketone, potassium dihydrogen phosphate, aluminium oxide, DL methionine, N, N-dimethylaniline, NN-diethyl aniline, 4 sodium EDTA, Anhydrous sodium sulfate, ammonium sulfate, potassium sulfate, sodium acetate, sodium carbonate, DMC, formic acid, sodium chloride medicinal, oxalate, protopine, acetone, alcohol, acetic acid, vinegar Ethyl, butyl acetate, methanol, ethanol (anhydrous, industrial, medicinal), formaldehyde, Ye Jian (30%), hydrochloride (industrial-grade, refined grade, reagent level), sulfate (98%), Ammonia, calcium carbonate, chlorine dioxide, 6 - APA ,7-ACA ,7-ADCA ,7-ANCA, sulbactam, ceftazidime activity ester, Deng salt (hydroxymethyl-K, acid precursors Potassium, sodium dihydrogen methyl), resin, the enzyme, water treatment agent, Xiao Mo agent, demulsifier, flocculants, activated carbon, all kinds of medicinal materials, All kinds of additives

三甲基一氯硅烷、二氯甲烷、AE活性酯、三甲基碘硅烷、特戊酸、特戊酰氯、三乙胺、噻二唑、四氮唑乙酸、二甲基乙酰胺、四氢呋喃、四甲基胍、异丙醇、五氯化磷、异辛酸钠、苯乙酸、苯乙酸钠、六甲基二硅胺烷、乙酰乙酸乙酯、甲基异丁酮、磷酸二氢钾、三氧化二铝、DL蛋氨酸、N,N-二甲基苯胺、NN-二乙基苯胺、乙二胺四乙酸四钠、无水硫酸钠、硫酸铵、硫酸钾、醋酸钠、碳酸钠、碳酸二甲酯、甲酸、药用氯化钠、草酸、片碱、丙酮、正丁醇、冰醋酸、醋酸乙酯、醋酸丁酯、甲醇、乙醇、甲醛、液碱(30%)、盐酸(工业级、精制级、试剂级)、硫酸(98%)、氨水、碳酸钙、二氧化氯、6-APA、7-ACA、7-ADCA 、7-ANCA、舒巴坦、头孢他啶活性酯、邓盐(羟甲基钾、前体酸钾、二氢甲基钠)、树脂、生物酶、水处理剂、消沫剂、破乳剂、絮凝剂、活性碳、各种药用辅料、各种添加剂

In a system consisting of 20% PEG 400 and 12% magnesium sulfate, the partition coefficient of PGA was less than 0.01, PGA almost completely partitioned into the magnesium sulfate-rich bottom phase. Meanwhile, the partition coefficient of cephalexin was 6.7, the partition coefficients of phenylglycine methyl ester and 7-ADCA were 1.5 and 1.2, respectively.

通过考察头孢氨苄、苯甘氨酸甲酯和7-氨基脱乙酰氧基头孢烷酸(7-ADCA)在ATPS中的分配行为建立了一个含20%PEG 400和12%硫酸镁的ATPS,在此体系中头孢氨苄的分配系数为6.7,苯甘氨酸甲酯的分配系数为1.5,7-ADCA的分配系数为1.2,且青霉素酰化酶的分配系数小於0.01。

The results indicated that the area of SOC increase after 20 years was 621.3 km2 and the increase was 0~5 g/kg and 5~10 g/kg, but that of decrease was 38.4 km2 .The areas of SOC changes in soils derived from phyllite, granite, red sandstone, Quaternary red clay and purple shale were 361.7 km2, 144.7 km2, 76.5 km2, 48.7 km2 and 27.8 km2, respectively. The areas of SOC changes in soils with elevations below 300 m, 300~500m, 500~800m and above 800 m were 358.9 km2, 200.2 km2, 62.9 km2 and 28.0 km2, respectively.

结果表明, 20 a来,兴国县农田土壤中土壤有机碳增加的面积为621.3 km2,减少的面积为38.4 km2,增幅主要在0~5 g/kg和5~10 g/kg;千枚岩、花岗岩、红砂岩、第四纪红粘土和紫色砂页岩发育的土壤中有机碳变化量分布的面积分别为361.7 km2、 144.7 km2、 76.5 km2、 48.7 km2和18.0 km2,海拔在300 m以下、 300~500 m、 500~800 m和800 m以上的土壤中有机碳变化量分布的面积分别为358.9 km2、 200.2 km2、 62.9 km2、 28.0 km2。

They have A/CNK values of 0.9~1.2, suggesting aluminum saturation or ersaturation, and are enriched in LREE and LILEs and depleted in HFSEs. Their δEu values are 0.11~0.32, evidently indicating plagioclase fractional crystallization.(87Sr/86Sr)i ratios and εNdvalues are 0.707?9~0.716?1 and -6.90~-7.70 for volcanic rocks, and 0.7086~0.7098 and -7.10~-7.68 for quartz syenitic porphyrite, respectively, implying that all the igneous rocks from the Yandang Mountain were evolutional products of co-magmas, and derived mainly from the crust, mixed however with mantle components.

岩石富集轻稀土元素和大离子亲石元素,相对亏损高场强元素;δEu值为0.11~0.32,表明岩浆经历了以斜长石为主的强烈结晶分异作用;火山岩(87Sr/86Sr)i为0.707 9~0.716 1,εNd为-6.90~-7.70,中央侵入体石英正长斑岩(87Sr/86Sr)i为0.708 6~0.709 8,εNd为-7.10~-7.68,表明它们是同源岩浆不同阶段分异演化的产物,物质来源主要为陆壳,但也有地幔物质参与。

Results: The total effective rate in union treatment group was 92.8%, the rate of purpuric nephritis is 7.1% after 4 weeks treatment, and the Recurring rate is 10.7% after 6 months. The effective rate of normal dose gamma globulin group was 89.7%, the rate of purpura nephritis is 10.3% after 4 weeks treatment, and the Recurring rate is 13.8% after 6 months.

结果:联合治疗组有效率为92.9%,治疗后4周紫癜性肾炎发生率为7.1%,随访6个月后复发率为10.7%;丙球治疗组有效率为89.7%,治疗后4周紫癜性肾炎发生率为10.3%,随访6个月后复发率为13.8%;对照组有效率为73.3%,紫癜性肾炎发生率及复发率均为33.3%。

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