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The expression level of metabolitic enzyme (CYP1A1, CYP1B1) and its correlation with cell differentiation /apoptosis were studied as well. The influence of resveratrol in cell cycle was determined with FCM. Results 1 Resveratrol not only suppresses the growth of medulloblastoma cells in a dose and time related fashion but also induces cell differentiation and apoptosis. Resveratrol promotes differention of UW228-1,-2 cells to forward glia, UW228-3 and Med-3 cells to neuron. A treatment of resveratrol in the concentration of 100μM for 48hrs comit most of cells die of apoptosis. 2 Among the four cell lines Fas and Caspase-3 were constantly expessed, whereas FasL was absent irrespective to the drug treatment. 3 ICC, RT-PCR, Western-blot hybridization and EROD enzymatic activity assay demonstrated that expression of CYP1A1 is different after treatment with resveratrol in four cell lines, up-regulated in three UW228 cell lines in a dose dependent manner but down-regulated in Med-3 cells. Suppressive effect of resveratrol on CYP1B1 expression is the same among four medulloblatoma cell lines. 4 Cell cycle distribution of UW228-3 was greatly changed after treatment.

结果:1、白藜芦醇以时间和剂量依赖性方式抑制髓母细胞瘤细胞生长,同时促进细胞的分化和凋亡:白藜芦醇促使UW228-1、-2靶细胞向神经胶质细胞方向成熟分化,UW228-3、Med-3细胞向神经元细胞方向成熟分化,以100μM作用48小时效果显著;2、四个细胞系均有Fas和Caspase-3表达,但无Fas-L基因表达和蛋白活性产生,因此难以形成Fas相关性死亡通路;3、白藜芦醇处理前后CYP1A1基因的表达在各细胞系略有不同:UW228-1,-2,-3三个细胞系白藜芦醇以剂量相关性方式上调CYP1A1的表达,而Med-3细胞系,白藜芦醇却抑制CYP1A1的表达;四个细胞系在白藜芦醇处理后CYP1B1的表达均受到抑制;4、UW228-3细胞系经白藜芦醇作用后细胞周期有较大改变,表现在G0/G1期在整个细胞周期中所占的比例增加,而其它时期则相应减少。

Trichogramma showed high control efficacy on cotton bollworm eggs after three times of release both in the second and in the third generation bollworm periods. The parasitism on the second and third generation bollworm eggs were 66.0%-70.7% and 76.0%-81.2%, respectively, which were significantly higher than that in the control (second generation: 7.0%-12.3%, third generation: 5.2%-7.4%). And the injury rate of cotton buds and bolls in the second and third generation bollworm were 2.2% and 3.1%, respectively, which were significantly lower than that in the control (second generation:8.5%, third generation: 20.9%). In the second generation bollworm period, number of bollworm eggs or larvae in the Trichogramma released cotton field did not differ to that in the chemically controlled field. But in the third generation, there were significantly less bollworm eggs and larvae in the Trichogramma released cotton field. There were more predators in the Trichogramma released cotton field. These results indicated that cotton boll worm in the transgenic insect-resistant cotton field can he effectively controlled by mass-releasing of T.

结果发现:棉铃虫卵在棉株不同部位的分布差异较大,2代棉铃虫卵主要分布在叶正面、叶背面和茎尖,3代棉铃虫卵主要分布于蕾铃;在放蜂田,赤眼蜂对棉株不同部位棉铃虫卵的寄生率差异较大,2,3代棉铃虫时期对叶正面、叫背面、茎尖、蕾铃的棉铃虫卵寄生率均较高,对叶柄和茎杆处卵的寄生率较低;并以3代棉铃虫时期的寄生率较高;在2,3代棉铃虫时期分别连续释放3次赤眼蜂,对棉铃虫具有很强控制作用,2,3代棉铃虫卵的被寄生率分别为66.0%~70.7%和76.0%~81.2%,均显著高于化防田的自然寄生率(2代:7.0%~12.3%,3代:5.2%~7.4%);蕾铃被害率分别为2.2%和3.1%,均显著低于化防田(2代:8.5%,3代:20.9%;2代棉铃虫时期,放蜂田和化防田的棉铃虫卵量和幼虫数量差异均不显著,但3代棉铃虫以后,放蜂田棉铃虫卵量和幼虫数量均显著低于化防田,且放蜂田的捕食性天敌数量显著高于化防田。

The influences of the shock thickness and Alfven waves on the particle acceleration by diffusive shock waves are numerically studied through solving one-dimensional diffusive equation including the second-order Fermi effect. It is shown that the spectral index of the energetic particles strongly depends on the shock thickness. For example, the spectral index increases from 2.1 to 3.7 in the low energy range of 3-10 MeV and from 2.5 to 5.0 in the high energy range of 20-60 MeV as the thickness increases. The spectral index decreases from 4.3 to 3.1 as the particle injection energy increases. The spectral index decreases from 4.0 to 1.8 at the quasi-steady stage with the enhancement of the compression ratio from 2 to 4. The results indicate that under the influence of Alfven waves, the energetic particle spectrum at lower energy becomes flat and the spectral index decreases from 2.5 to 0.6 in the low energy range of 3-10 MeV and from 11.6 to 5.0 in the high energy range of 20-60 MeV. At the same time, the rollover energy reaches 19.6 MeV. The spectral index decreases from 5.8 to 2.9 as the energy density of Alfven waves increase. All these results are basically consistent with the theoretical models, as well as the observations of typical energetic particle events.

通过数值求解包含二阶费米加速的一维扩散方程,探讨在准平行激波条件下激波厚度和级联阿尔芬波对粒子加速的影响,研究粒子分布函数的演化与激波厚度和阿尔芬波强度的内禀关系,计算结果表明:(1)考虑激波厚度时,谱指数明显依赖于激波厚度,随着厚度从0.32增大到2.56,低能端(3-10MeV)谱指数逐渐从2.1增加到3.7,高能端(20-60MeV)谱指数从2.4增大到5.0,能谱逐渐变软;当初始注入粒子动量增大1.3倍,质子能谱指数从4.3减小到3.1,且与零厚度激波加速的谱指数差值缩小;厚度不变时,随着压缩比从2增加到4,准稳态分布时低能端(3-10MeV)粒子能谱指数逐渐从4.0减小到1.8谱变硬;(2)在级联阿尔芬波的影响下,随着时间的增大,粒子在低能处(3-10MeV)的谱指数从2.5减小到0.6高能端(20-60MeV)谱指数从11.6减小到5.0,能谱变硬,拐点能量值从7.5MeV增大到为19.6MeV;随着波的能量密度增大,谱指数从5.8减小到2.9,这表明阿尔芬波强度越大,加速效率越高,通过与激波厚度解析结果和高能粒子事件的观测能谱比较发现两者是一致的,说明数值模拟结果是可靠的。

In this thesis, 1, 5-diaryl-3-pyrazilidinones, 1, 5-diaryl-3-hydroxypyrazoles and 3-(2, 3, 4, 6-tetraacetyl-β-D-glucopyranos-1-yl)-1, 5-diaryl-1H-pyrazoles are designed and synthesized.1, 5-diaryl-3-pyrzolidinones were obtained by condensation of 3-arylpropenates and phenylhydrazine or fluorophenylhydrazine under the catalysis of sodium methylate and the yields were about 55-80%.

在本文中,设计合成了1,5-二芳基-3-吡唑烷酮化合物、1,5-二芳基-3-吡唑烷酮化合物和3-(2,3,4,6-四乙酰基-β-D-吡喃葡萄糖-1-基)-1,5-二芳基吡唑化合物。以3-芳基-2-丙烯酸酯为原料,与芳基肼在醇钠的催化作用下,反应可以生成1,5-二芳基-3-吡唑烷酮,产率在55%以上。

As a whole,the notable characteristic of primary productivity in size-fractioned structure was that nanoplankton occupied comparatively significant advantage in Beibu Gulf.Nanoplankton has the largest contribution to gross primary productivity,and picoplankton was the secondary contributor,while microplankton the least.The contribution of microplankton for primary productivity in the north Gulf was more than that in the other waters.Nanoplankton and picoplankton contribute more to the gross primary productivity in offshore deep waters than in inshore shallow waters3.The Beibu Gulf can be divided into three ecoregions:Region-Ⅰis the ecoregion in inshore shallow waters of the north Gulf.In average,the water depth is 18m,DIN is 1.88μmol/L,DIP is 0.20μmol/L,N:P is 9.4:1,dissolved silicate is 5.17μmol/L,the Chl a conentration in surface layer is 2.27mg·m~(-3),the assimilation index in surface layer is 3.80mg/,the primary productivity is 198.78mgC/(m~2·d), and potential fishery production is estimated to be 0.24gC/(m~2·a) according to the primary productivity.The ecoregion is mainly affected by the northern coastal water systems,and may be fit for aquaculture;Region-Ⅱis the ecoregion in offshore deep waters of the north Gulf and the coastal shallow waters to the west Hainan Island.In average,the water depth is 35m,DIN is 2.01μmol/L,DIP is 0.18μmol/L,N:P is 11.2:1,disovled silicate is 4.23μmol/L,the chlorophyll a of surface layer concentration is 1.45mg·m~(-3),the assimilation index of surface layer is 4.12 mg/,the primary productivity is 276.60mgC/(m~2·d),and the estimated potential fishery production is 0.34gC/(m~2·a) according to the primary productivity. The ecoregion was mainly influenced by ocean current from the South China Sea, rivers in the west coast of Hainan Island and the water from Qiongzhou Strait.It may be fit for aquaculture and fishery;Region-Ⅲis the ecoregion in offshore deep waters of the mid and south Gulf.In average,the water depth is 75m,DIN is 0.77μmol/L, DIP is 0.15μmol/L,N:P is 5.1:1,disovled silicate is 3.05μmol/L,the chlorophyll a of surface layer concentration is 0.70mg·m~(-3),the assimilation index of surface layer averaged is 3.69mg/,the primary productivity is 350.89mgC/(m~2·d),and the estimated potential fishery production is 0.43gC/(m~2·a) according to the primary productivity.The ecoregion was mainly affected by the circulation inside Beibu Gulf, and may be fit for fishery.

初级生产力的粒级结构的一个显著特点是总体上微型浮游生物在全调查海区均占较明显优势,对总初级生产力的平均贡献最大;微微型浮游生物对初级生产力的平均贡献次之;小型浮游生物对总初级生产力的平均贡献最小;湾北部小型浮游生物对初级生产力的平均贡献高于湾中部和湾南部,而湾中部和湾南部微型和微微型浮游生物对初级生产力的平均贡献高于湾北部,远岸深水区高于近岸浅水区。3、北部湾可以分为三个生态区:湾北部近岸浅水区,该区的环境主要特点是平均水深19m,DIN浓度平均值为1.88μmol/L,DIP浓度平均值为0.20μmol/L,N:P为9.4:1,硅酸盐浓度平均值为5.17μmol/L,表层叶绿素a平均值高达2.27 mg·m~(-3),表层同化指数平均为3.80 mg/,初级生产力平均值198.78mgC/(m~2·d),根据初级生产力计算潜在渔业资源碳生产量平均为0.24 gC/(m~2·a),该区主要受湾北部沿岸水系影响,适合作为水产养殖区;湾北部深水区和海南岛西部沿岸浅水区,该区的环境主要特点是平均水深35m,DIN浓度平均值为2.01μmol/L,DIP浓度平均值为0.18μmol/L,N:P为11.2:1,硅酸盐浓度平均值为4.23μmol/L,表层叶绿素a平均值1.45 mg·m~(-3),表层同化指数平均为4.12mg/,初级生产力平均值276.60 mgC/(m~2·d),根据初级生产力计算潜在渔业资源碳生产量平均为0.34 gC/(m~2·a),该区主要受南部湾口区海流向湾内延伸,沿岸海南岛河流注入湾内和琼州海峡过道水的影响,适合作为渔业作业区和水产养殖区;湾中部和南部远岸深水区,该区的环境主要特点是平均水深75m,DIN浓度平均值为0.77μmol/L,DIP浓度平均值为0.15μmol/L,N:P为5.1:1,硅酸盐浓度平均值为3.05μmol/L,表层叶绿素a平均值0.70 mg·m~(-3),表层同化指数平均为3.69 mg/,初级生产力平均值350.89 mgC/(m~2·d),根据初级生产力计算潜在渔业资源碳生产量平均为0.43 gC/(m~2·a),该区主要受北部湾环流影响,适合作为渔业作业区。

Missirlis in article [1]. At the same time, a sufficient condition for convergence of the PSD method is given to be compared when the coefficient matrix A of the linear system Ax = b is a symmetric, positively defective matrix. In §3.2, an example is given to state that the range of our sufficient condition is wider than theorem 3.3 of article [1]. On the other hand, following a.n analogous approach of [14] and starting the functional relationshipwe have a perfect analysis for the PSD method to converge and optimum valves for the involved parameters under different conditions.Under the assumptions that A is a consistent ordered matrix with nonvanishing diagonal elements and the eigenvalues of the Jacobi matrix of A are real,we get necessary and sufficient conditions for the PSD method to convergence.The result is equal to theorem 1 of article [9].Under the same condition, we can see the optimal parameter and of corresponding spectral radius of thePSD method in [8]:(2)When A is a consistent ordered matrix with nonvanishing diagonal elements and the eigenvalues of the Jacobi matrix of A are imaginary or zero,we get necessary and sufficient conditions for the PSD method to convergence.In chapter 3, the optimal parameter and of corresponding spectral radius of the PSD method are given by table 3.3. Moreover, under the assumption 0

Missirlis在文献[1]中定理3.3的不准确,同时给出了当线性方程组Ax=b的系数矩阵A为对称正定阵时,PSD迭代法收敛的一个充分条件与之比较,并且在§2.3中用实例说明了对于一部分矩阵而言本文得到的充分条件广于[1]中定理3.3的充分条件;另一方面,按照文献[14]的方法,我们从PSD迭代法的特征值λ与其Jacobi迭代矩阵B的特征值μ的关系式:出发,在不同条件下对PSD迭代法的收敛性和最优参数以及最优谱半径进行了完整的分析:(1)在系数矩阵A为(1,1)相容次序矩阵且对角元全不为零,其Jacobi迭代矩阵B的特征值全为实数的条件下,给出了PSD迭代法收敛的充分必要条件,此结果与[9]中的定理1等价,此时最优参数及最优谱半径由[8]得:(2)第三章表3.3中给出了,当系数矩阵A为(1,1)相容次序矩阵且对角元全不为零,其Jacobi迭代矩阵B的特征值全为纯虚数或零时的PSD迭代法的收敛范围和最优参数,并且我们可以得到当0

The results showed that the number of chromosome, which was from the cultured seedlings of meristem tip and the rank seedlings of meristem tip, was not altered, both the number were 2n=16,the hereditary stability of callus and regeneration plant was poor; and the variation percentage of chromosome in callus was 43.4%, among which haploid accounted for 6.7%, triploid accounted for 2.5%,tetraploid accounted for 10%,pentaploid accounted for 4.2%,hexaploid accounted for 3.3%,septuploid accounted for 4.2%,octoploid accounted for 3.3%,dysploid accounted for 9.2%;the chromosome variation percentage of differentiation seedlings derived from callus was11.7%,among which haploid was 6.7%,triploid accounted for 1.7%,tetraploid was 3.3%.

结果表明,茎尖分生组织培养的幼苗及丛生苗遗传稳定,其染色体未发生倍性变异,均为2n=16;愈伤组织及其再生苗遗传稳定性较差,愈伤组织染色体数变异率为43.4%,其中单倍体占6.7%、三倍体占2.5%、四倍体占10%、五倍体占4.2%、六倍体占3.3%、七倍体占4.2%、八倍体占3.3%、非整倍体占9.2%;愈伤组织分化苗染色体变异率为11.7%,其中单倍体占6.7%,三倍体占1.7%,四倍体占3.3%。

Two kinds of dsDNA intercalating fluorescent dyes, [Ru2]2+(phen = 1,10-phenanlinthroline; dppz = dipyrido [3,2-a:2',3'-c] phenazine) and BOBO-3 2,2\'-1,3-propanediylbis[(dimethyliminio-3,1-propanediyl -1(4H)-pyridinyl-4-ylidenemethy-lidynebis[3-methyl]-benzothiazoe were employed in this chapter, and two non-covalent labeled fluorescence sensing systems for thrombin determination were successfully developed and compared based on its 29-mer aptamer.

本章利用dsDNA嵌入式荧光染料[Ru2]2+(phen = 1,10-二氮菲; dppz =吡啶[3,2-a:2',3'-c]吩嗪)及BOBO-32,2\'-1,3-丙二基二[(二甲基亚氨基-3,1-丙二基-1(4H)-吡啶基-4-(丙-1,3-二烯基二[3-甲基]-苯并噻唑),基于适配体29-mer,分别建立了两种凝血酶检测体系[Ru(phen2]2+及BOBO-3检测体系。

Results Of 61 cases, 4 cases (7%) in center 3 mm zone of cornea had mean thickness:(0.439±0.071) mm and polar distance:(3.108±0.904) nun; 8 cases (13%) in 3~5 mm zone had T:(0.328±0.088) mm and p:(3.108±0.904) mm; 28 cases (46%) in 5~7 mm zone had T:(0.320±0.093) mm and p:(3.233±0.381) mm; 21 cases (34%) in 7~9 mm zone had T:(0.340±0.128) mm and p:(3.756±0.539) mm; 61 cases (100%) in 0~9 mm zone had T:(0.336±0.112) mm and p:(3.108±0.904) mm.

结果 61例角膜最薄点平均厚度为(0.336±0.112)mm且平均极距为(3.108±0.904)mm;其中最薄点分布,角膜中央3mm区4例(7%)T为(0.439±0.071)mm且p为(3.108±0.904)mm;角膜3~5mm区8例(13%)T为(0.328±0.088)mm且p为(3.108±0.904)mm;角膜5~7mm区28例(46%)T为(0.320±0.093)mm且p为(3.233±0.381)mm;角膜7~9mm区21例(34%)T为(0.340±0.128)mm且p为(3.756±0.539)mm。

We focused the study on the synthesis methods of quinoxaline, nitration of its aromatic ring and chlorination of its heterocycle. In this paper, we thought about environmental protection, the cost of material, the feasibility of industrialization, workup easily, and obtained 2,3(1H,4H)-quinoxalinedion, 6-nitro-2,3(1H,4H)-quinoxalinedion, 6,7-dinitro-2,3(1H,4H)–quinoxalinedion, 2,3-dichlo- roquinoxaline, 6–nitro-2,3-dichloroquinoxaline,and 6,7- initro-2,3-dichloro-quinoxaline. A more reasonable, easily, efficient and simple reactive route to synthesize above-mentioned compounds was developed by systematically investigating the yield, the purity and physical character of intermediates.

本文针对喹喔啉及其芳环硝化、杂环氯代的合成进行研究,主要考虑了环保性、原料成本、产业化的可行性、反应操作的简便性等问题,获得了2,3(1H,4H)-喹喔啉二酮、6-硝基-2,3(1H,4H)-喹喔啉二酮、6,7-二硝基-2,3(1H,4H)-喹喔啉二酮、2,3-二氯喹喔啉、6-硝基-2,3-二氯喹喔啉和6,7-二硝基-2,3-二氯喹喔啉等六个中间体,考察了反应产物的产率、纯度和性状等因素,得到了更为合理、方便、实用、简洁的可供产业化的合成路线。

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推荐网络例句

The reasons of iron ions content overproof in grade Ⅱ desalting water system,such as variation water quality,contamination of regenerant , operation adjustment of pretreatment system and switching operation of bed were discussed.

对二级脱盐水系统中铁离子含量超标的原因,如来水水质发生波动、再生剂受到污染、预处理系统操作调整、床体运行切换等进行了论述。

You were hired to drum up new business, so go and do it.

公司雇你招徕新业务,你就做你的事好了。

Who is in possession of this?

这是谁的?