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Methods Starting from 2-chloro-4-nitrophenol and 2- pyridine hydrochlorid, 3-chloro-4-(pyridin-2-ylmethoxy) aniline was obtained via etherization and reduction. The obtained aniline coupled with N-(4-chloro-3-cyano-7-ethoxyquinolin-6-yl) acetamide to give 4-[3-chloro-4-(2-pyridylmethoxy) phenylamino]-3-cyano-7-ethoxy-6-N-acetylaminoquinoline. And then it was deacetylated, followed by reacting with4- but-2-enoyl chloride to yield the target compound neratinib.

以2-氯－4-硝基苯酚和2-氯甲基吡啶为起始原料，经醚化、硝基还原得到3-氯－4-（吡啶－2-甲氧基）苯胺，3-氯－4-（吡啶－2-甲氧基）苯胺与3-氰基－6-乙酰氨基－7-乙氧基－4-氯喹啉反应得到3-氰基－6-乙酰氨基－4-［3-氯－4-（吡啶－2-甲氧基）苯氨基］－7-乙氧基喹啉，3-氰基－6-乙酰氨基－4-［3-氯－4-（吡啶－2-甲氧基）苯氨基］－7-乙氧基喹啉去乙酰保护基后，与-4-二甲氨基－2-丁烯酰氯经酰化反应得到ner-atinib。

At Er~(3+) doping concentration range 0.1-1.5 mol%, Er~(3+) first arrived at ~4F_(7/2) energy level by excited state absorption, then rapidly relaxed to ~2H_(11/2) and ~4S_(3/2) energy levels, the population of which increased, the remarkable upconversion green emission was obtained when Er~(3+) directly went back to ground state by radiative transition.

Er~(3+)浓度在0.1-1.5 mol％时，Er~(3+)通过激发态吸收跃迁到~4F_(7／2)能级，后迅速无辐射弛豫到~2H_(11／2)、~4S_(3／2)能级，~2H_(11／2)和~4S_(3／2)能级上Er~(3+)的布居数增多，Er~(3+)直接辐射跃迁回基态，上转换发射以绿光为主。

Contrast-enhanced Ultrasound(1) Renal occupied lesions: the contrast-enhanced imaging feature of renal cell carcinomas are multiformity. It was different in time of start-enhancing and start- expurgation and intensio.3 cases revealed wash-in contemporarily and 6 cases revealed wash- in quickly in time of start-enh ancing.In time of start-expurgating, 3 cases showed wash-out quickly, 3cases revealed wash-out contemporarily,3 cases showed wash-out slowly,6 cases revealed a higher contrast enhancement and 3 cases revealed a even contrast enhancement in enhancing intension; 4 cases with renal cyst s,outline had more clear and inside had no contrast media washing in and enhancing;3cases with renal angiomyolipomas washed in slowly,washed out slowly and equal or low enhanced ; 2cases with renal columnar hypertrophy were no outline appearance and the same enhancement and ech o as the nomal rena tissue.

超声造影诊断结果：(1)肾占位性病变：9例肾透明细胞癌，其超声造影表现多种多样，造影后肾脏恶性病灶造影开始增强的时间、开始廓清的时间及增强强度不等，在开始增强的时间方面，与正常肾皮质同时灌注增强的有3例，表现为快进的有6例，在开始廓清的时间方面，快退3例，同退3例，慢退3例，在增强的强度方面，6例病灶表现为高增强，3例为等增强表现；4例肾囊性病灶，超声造影轮廓较二维超声清晰，但内部始终未见增强；3例肾血管平滑肌脂肪瘤表现为慢进慢退，回声呈等、低增强表现；2例肾柱肥大超声造影无明显包块轮廓出现，造影增强的动态变化时间、强度与正常肾组织一致。

GC/MS analysis on the leaf oil indicated that the main components with a relative content of ≥3% were alloocimene (43.22%),α-pinene (13.63%),γ-terpinene (5.49%),-3, 7-dimethyl-, 2, 6-octadien-1-ol (3.58%),β-fenchyl alcohol (4.58%), and 2-amino-3, 5-dicyano-6-(4-methoxyphenoxy)-pyridine (3.67%).

用GC/MS联用方法，对巨尾桉挥发油进行鉴定，相对百分含量在3%以上的化合物有：α-蒎烯(13.63%)、别罗勒烯(43.22%)、γ-萜品烯(5.49%)、3，7-二甲基－2，6-辛二烯醇(3.58%)、β-小茴香醇(4.58%)和2-氨基－3，5-二氰基-6-（4-甲氧基苯氧基）－吡啶(3.67%)。

Further proceed intersection analysis and focus on children studies. The result indicates that experimental diagnosis based on RT-PCR, is homogeneity and the relation between norovirus and the symptoms of acute gastroenteritis is significant (OR, 2.7;95%CI, 2.2-3.2). Equally, the surveillance studies (OR, 2.5;95%CI, 2.1-3.0), outbreak studies(OR,4.7; 95%CI, 3.2-7.1), hospital-based studies(OR, 2.8; 95%CI, 2.0-4.1), and community-based studies(OR, 2.0; 95%CI, 1.2-3.3) have the same result as the former.

进一步将研究对象为孩童的文献进行交叉分层分析，结果发现，以孩童为研究对象的文献中，实验室诊断以基因体RNA为侦测标的的研究，其效果量具有同质性，且诺罗病毒与急性肠胃炎症状的相关性在此分层是显著的（OR=2.7，95%CI： 2.2-3.2），资料来源为监测性研究（OR=2.5，95%CI： 2.1-3.0）或疫情爆发研究（OR=4.7，95%CI： 3.2-7.1）以及研究场所为医院（OR=2.8，95%CI： 2.0-4.1）及社区（OR=2.0，95%CI： 1.2-3.3）的研究亦有相同结果。

Results Tuberculosis lymph gland inflammation coverd highest rate:546 cases (36%) in tuberculosis node was 252 cases (46.2%),lymphonode period was 184 cases (33.7%),early tuberculosis lymphagland inflammation was 233 cases (44.7%).Metastasis cancer followed it:430 cases (28.3%) in which undivided cancer was 156 cases (32.3%),glandular cancer 132 cases (30.7%),epithelial cancer 114 cases (26.3%), chronic lymph glandular inflammation was 352 cases,Non-Hodgkin's lymph-tumor 98 cases (6.5%) in which B lymphocyte type covered 70 cases (71.4%),T lymphocyte covered 17 cases (17.3%),NK cells type covered 11 cases (11.3%) tumor were sacrce.

结果 结核性淋巴腺炎发病率最高，有546例(36.0%)，结核结节期为主，252例(46.2%)，淋巴结节期184例(33.7%)，其中早期结核性淋巴腺炎233例(44.7%)，转移癌次之有430例(28.3%)，其中以未分化癌为主，156例(32.3%)，腺癌132例(30.7%)，鳞癌114例(26.3%)，而慢性淋巴腺炎352例，占第三位，非霍奇金淋巴瘤98例(6.5%)，以B淋巴细胞型为主70例(71.4%)，T淋巴细胞型17例(17.3%)，NK细胞型11例(11.3%)，其中肿瘤较少见。

Results Tuberculosis lymph gland inflammation coverd highest rate:546 cases (36%) in which tuberculosis node was 252 cases (46.2%),lymphonode period was 184 cases (33.7%),early tuberculosis lymphagland inflammation was 233 cases (44.7%).Metastasis cancer followed it:430 cases (28.3%) in which undivided cancer was 156 cases (32.3%),glandular cancer 132 cases (30.7%),epithelial cancer 114 cases (26.3%), chronic lymph glandular inflammation was 352 cases,Non-Hodgkin's lymph-tumor 98 cases (6.5%) in which B lymphocyte type covered 70 cases (71.4%),T lymphocyte covered 17 cases (17.3%),NK cells type covered 11 cases (11.3%) tumor were sacrce.

结果 结核性淋巴腺炎发病率最高，有546例(36.0%)，结核结节期为主，252例(46.2%)，淋巴结节期184例(33.7%)，其中早期结核性淋巴腺炎233例(44.7%)，转移癌次之有430例(28.3%)，其中以未分化癌为主，156例(32.3%)，腺癌132例(30.7%)，鳞癌114例(26.3%)，而慢性淋巴腺炎352例，占第三位，非霍奇金淋巴瘤98例(6.5%)，以B淋巴细胞型为主70例(71.4%)，T淋巴细胞型17例(17.3%)，NK细胞型11例(11.3%)，其中肿瘤较少见。

N-Methyl-3,3-dimethyl spiroindoline-2,3'[3H] naphthaline [2,1-b] [1,4] oxazine was synthesized by 1,3,3-trimethyl-2-methylene indoline and 1-nitroso-2-naphthol, its UV and IR spectra and elemental analysis were carried out, and the photochromism and main influencing factors such as temperature, solvent and pH were studied.

以1，3，3-三甲基－2-亚甲基吲哚啉和1-亚硝基－2-萘酚为原料合成了N-甲基－3，3-二甲基螺吲哚啉-2，3'[3H]萘并[2，1-b][1，4]恶嗪，对其进行了紫外和红外光谱以及元素分析，并对其光致变色性质以及主要影响因素温度、溶剂和pH进行了研究。

RESULTS: Melatonin significantly reduced the anxiety scores from 5, 3.5-6 to 3, 2-3 after premedication and to 3, 2-3.5 during surgery (P = 0.04 and P = 0.005 compared with the placebo group, respectively).

结果：褪黑素显著降低焦虑评分。给药前中位数及四分位数间距为5， 3.5-6。给药后中位数及四分位数间距为3， 2-3，术中为3， 2-3.5(P=0.04并且和分别和对照组相比 P=0.005)。

The invention provides the flux-cored wire for welding the duplex stainless steel, 17 percent to 24 percent flux-cored powder is filled into stainless steel belt. The invention is characterized in that the mass percent of the components of the flux-cored is as follows: 35 percent to 40 percent of chromium powder, 11 percent to 15 percent of molybdenum powder, 2 percent to 4 percent of nickel powder, 3 percent to 5 percent of manganese powder, 1 percent to 5 percent of magnesia chrome, 1 percent to 3 percent of ferrosilicon, 4 percent to 9 percent of rock crystal, 2 percent to 6 percent of feldspar, 21 percent to 30 percent of rutile, 0.5 percent to 4 percent of Al2O3, 0 percent to 5 percent of zircon, 0.5 percent to 3 percent of Bi2O3, and 0.5 percent to 3 percent of manganese nitride.

一种用于焊接双相不锈钢的药芯焊丝，将药芯粉末以17～24％填充在不锈钢带内，其特征在于，所述的药芯质量百分比成分如下：35～40％的金属铬粉，11～15％的金属钼粉，2～4％的金属镍粉，3～5％的金属锰粉，1～5％的铝镁合金，1～3％的硅铁，4～9％的石英，2～6％的长石，21～30％的金红石，0.5～4％的Al 2 O 3 ，0～5％的锆英石，0.5～3％的Bi 2 O 3 ，0.5～3％的氮化锰。

The reasons of iron ions content overproof in grade Ⅱ desalting water system,such as variation water quality,contamination of regenerant , operation adjustment of pretreatment system and switching operation of bed were discussed.

对二级脱盐水系统中铁离子含量超标的原因，如来水水质发生波动、再生剂受到污染、预处理系统操作调整、床体运行切换等进行了论述。

You were hired to drum up new business, so go and do it.

公司雇你招徕新业务，你就做你的事好了。