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The percentage of TGF-β〓 positive cell in the pancreatic cancer tissue (43.8±5.2)% was significantly higher than that in adjacent pancreatic tissue (28.7±3.6)%, P<0.05. The worse the cancer cells differentiated and lymphy node metastasis, the more over-expression of TGF-β〓. 2. The percentage of Tr positive cell in the pancreatic cancer tissue (41±4)% was significantly higher than that in adjacent pancreatic tissue (23±3)%, P<0.05. The worse the cancer cells differentiated and lymphy node metastasis, the more over-expression of Tr, but the expression of Tr protein was not correlated with lymphy node metastasis (P>0.05). 3. The percentage of β-GCD positive cell in the pancreatic cancer tissue (62.5± 4.1)% was significantly higher than that in adjacent pancreatic tissue (33.5±2.8)%, P<0.05. The worse the cancer cells differentiated and lymphy node metastasis, the more over-expression of β-GCD in pancreatic cancer tissue, but the expression of β-GCD protein was not correlated with lymphy node metastasis. P>0.05. 4. the expression of β-GCD was significantly correlated with TGF-β〓 and Tr in the pancreatic cancer tissue.

结果如下:1、胰腺癌组织TGF-β〓阳性细胞百分率(43.8±5.2)%明显高于癌旁胰腺组织(28.7±3.6)%,P<0.05;且癌细胞分化愈差或有淋巴结转移TGF-β〓过度表达愈多。2、胰腺癌组织Tr阳性细胞百分率(41±4)%,明显高于癌旁胰腺组织(23±3)%,P<0.05;且不同分化程度胰腺癌组织Tr表达强度不同,分化程度愈低,表达强度愈高,P<0.05;但胰腺癌Tr表达强度与淋巴结是否转移无关,P>0.05.3、对于胰腺癌组织TGF-β〓和Tr表达,检测胰腺癌组织(32例)β-GCD阳性细胞百分率分别为(62.5±4.1)%或(62±4)%,分别明显高于癌旁胰腺组织β-GCD阳性细胞百分率(33.5±2.8)%或(43±3)%,P<0.05;不同分化程度胰腺癌组织β-GCD表达强度不同,分化程度越低,表达强度越高,P<0.05;但胰腺癌组织β-GCD表达强度与淋巴结是否转移无关,P>0.05.4、TGF-β〓、Tr和β-GCD在胰腺癌组织中的表达随着分化程度的改变,呈现一致性的关系,而且TGF-β〓与淋巴结转移有关,Tr和β-GCD与淋巴结是否转移无关。

The expression of subunits α5,β1,β3 was detected in normal morulas and increased in blastocysts. The expression of subunit α1 was not detected in morulas or blastocysts, but detected only in outgrowing trophocytes. 3. Expression of integrin β3 in irradiated group embryos was weaker than that of normal group. There was no expression of integrin α1 both in morulas and blastocysts in irradiated group and no difference in the expression of subunits α5 and β1 between these two groups.

结果:1、超声波照射组胚胎贴附率、滋养细胞外延生长率均显著低于正常胚胎。2、正常胚胎桑椹胚期即有α5、β1、β3整合素表达,而无α1表达;囊胚期α5、β1、β3表达增强,仍无α1表达;α1只出现在外延生长的滋养细胞。3、超声波照射组胚胎β3整合素的表达明显弱于正常组,且未见α1表达;而α5、β1的表达两组间无差异。

The results showed that the LUMO values are -3.19eV for organic oxadiazole,-3.16eV for macromolecular oxadiazole and -3.21eV for Poly(1,3,4-oxadiazole) and their HOMO values are all under -6.0eV, hinting that they show good hole-blocking characteristics.

利用循环伏安法测定了三种不同类型衍生物的带隙和HOMO、LUMO能级,噁二唑类小分子、大分子、聚合物衍生物的LUMO能级分别为-3.19eV、-3.16eV、-3.21eV,有利于电子的注入,三种噁二唑衍生物的HOMO能级都在-6.0eV以下,对空穴也有很好的阻挡作用。

In most cases, the diagnoses were based on the histopathologic examination of tissue obtained via laparotomy (7 patients, including 3 for failed medical treatment of pelvic inflammatory disease, 3 with assumed mucinous ovarian tumors, and 1 with an ovarian tumor) or peritoneoscopy (6 patients); cytologic examinations diagnosed TB for the others (3 patients).

大多数病例的诊断是基于剖腹手术(7例,包括3例按盆腔感染治疗失败的病人,3例怀疑粘连性卵巢肿瘤病人和1例怀疑卵巢肿瘤的病人)或腹腔镜(6例)所获取组织的病理学检查,另外3例的诊断是根据细胞学检查诊断TB的。10例病人中,4例先前有肺TB,3例子宫内膜TB。

In most cases, the diagnoses were based on the histopathologic examination of tissue obtained via laparotomy (7 patients, including 3 for failed medical treatment of pelvic inflammatory disease, 3 with assumed mucinous ovarian tumors, and 1 with an ovarian tumor) or peritoneoscopy (6 patients); cytologic examinations diagnosed TB for the others (3 patients).

大部分数病例的诊断是基于剖腹手术(7例,包括3例按骨盆内部空腔感染治疗掉败的病人,3例怀疑粘连性卵巢肿瘤病人和1例怀疑卵巢肿瘤的病人)或腹腔镜(6例)所获取组织的病理学检查,另外3例的诊断是根据细胞学检查诊断TB的。10例病人中,4例先前有肺TB,3例子宫内膜TB。

In most cases, the diagnoses were based on the histopathologic examination of tissue obtained ia laparotomy (7 patients, including 3 for failed medical treatment of pelic inflammatory disease, 3 with assumed mucinous oarian tumors, and 1 with an oarian tumor) or peritoneoscopy (6 patients); cytologic examinations diagnosed TB for the others (3 patients).

大多数病例的诊断是基于剖腹手术(7例,包括3例按盆腔感染治疗失败的病人,3例怀疑粘连性卵巢肿瘤病人和1例怀疑卵巢肿瘤的病人)或腹腔镜(6例)所获取组织的病理学检查,另外3例的诊断是根据细胞学检查诊断TB的。10例病人中,4例先前有肺TB,3例子宫内膜TB。

The polyspermy rate was significantly decreased when the semen samples were stored for longer (3 days). Some cleavage embryos were collected to identify their sexes in 3-4 days after in vitro fertilization. The ratio of male embryos, produced from the BTS semens stored for 1 and 3 days, were 60 % and 41 %, respectively, and 35 % and 48 % in the MIII semens.

使用不同稀释液,保存1与3日之精液进行体外受精,在培养3 - 4日后收集卵裂胚进行性别鉴定,在保存1日与3日之稀释液BTS组,雄胚性比率分别为60 %与41 %;在稀释液MIII组,保存1日与3日之雄性比率分别为35 %与48 %。

In the third chapter, the synthesis of5-[(1"S)-1",2"-diacetyl-oxyethyl]-1-phenylpyrazol-3-carboxaldehyde oxime(2) from5-[(1"S)-1",2"-diacetyl-oxyethyl]-1-phenylpyrazol-3-carboxaldehyde(1) and phenyl-hydrazine were introduced firstly. The synthesis of nine dioxapyrrolino[3,4-c]pyrazoles containing chiral pyrazolyl moiety(6a-i) from 2 with N-substituted-phenylmaleimide by nonmetal oxidant IBD-initiated intermolecular 1,3-dipolarcycloaddition was described in detail.

第三章首先以5-[(1′S)-1′,2′-二乙酰氧基乙基]-1-苯基吡唑-3-醛(1)和苯肼为原料,合成了化合物5-(1′S)-1′,2′-二乙酰氧基乙基1-1-苯基吡唑-3-醛-苯腙(2);再用化合物(2)与N-取代苯基马来酰亚胺反应,利用无金属氧化剂—IBD引发1,3-偶极反应,发生分子间的环加成,合成了9种新型手性吡唑连二氧代吡咯啉并

A novel complex of Ni (3-PyOH)4Cl2 (3-PyOH=-pyridone) was synthesized by the reaction of NiCl26H2O and 3-hydroxypyridine in an alcohol solution, and characterized by elemental analysis, IR spectrum and single crystal X-ray diffraction.

利用氯化镍和3-羟基吡啶在乙醇溶液中反应得到了配合物Ni(3-PyOH)4Cl2(3-Pyon=3-羟基吡啶),并对其进行了元素分析、红外和单晶X射线的表征。

Our results indicate that 1 NSC606985, at nanomolar level, can effectively induce apoptosis in AML cells NB4 and U937 and significantly inhibit the proliferation without cell death in breakpoint cluster region–Abelson murine leukemia kinase-carrying leukemic K562 cells; 2 At such low concentrations, this agent also significantly inhibits the clonogenic activity of hematopoietic progenitors from patients with AML; 3 For apoptosis induction, NSC606985 rapidly induces the proteolytic activation of protein kinase Cδ with loss of mitochondrial transmembrane potential and caspase-3 activation; 4 Co-treatment with rottlerin, a PKCδ-specific inhibitor, completely blocks NSC606985-induced mitochondrial m loss and caspase-3 activation, while the

结果显示:(1)纳摩尔浓度的NSC606985即可有效诱导AML细胞系NB4和U937细胞凋亡并显著抑制含有bcr-abl融合蛋白激酶的K562细胞的增殖;(2)低浓度的NSC606985也显著抑制来自AML病人骨髓的新鲜白血病细胞的克隆形成能力;(3)除了迅速诱导线粒体跨膜电位的崩塌及Caspase-3的活化外,NSC60698也导致蛋白激酶Cδ的水解激活;(4)PKCδ特异的抑制剂rottlerin能够完全抑制NSC606985诱导的线粒体跨膜电位的崩塌和Caspase-3的活化,而Caspase-3特异的抑制剂z-DEVD-fmk仅能部分削弱PKCδ的活化及细胞的凋亡;(5)以移植PML-RARα转基因小鼠产生的白血病细胞建立的模型研究了该化合物对白血病可能的治疗作用。

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What would he tell Judith and the children?

他将怎样告诉朱迪丝和孩子们呢?

I this is at that time, the opinion with peacockish true girl is full of in a heart.

这就是当时的我,一个心中布满虚荣的女孩子真实的想法。

Oh, and I bought myself a new laptop," he said."

哦,我还给我自己买了一个新笔记本"他说。"