查询词典 2-butene

It was found by means of protein fluorescence detection that the number of MAP-2 masculine neurone in the hippocamp of AD rat in model group and zinc reinforce post-AD group decreased distinctly. There was not distinct difference in the MAP-2 expression and the number of MAP-2 masculine neurone between normal group and zinc reinforce pro-AD group.

模型组和AD后补锌组大鼠海马区MAP-2蛋白表达与正常组大鼠相比显著下降，MAP-2蛋白荧光检测发现模型组和AD后补锌组大鼠海马区MAP-2阳性神经元数量明显减少，AD前补锌组大鼠海马区MAP-2蛋白表达和MAP-2阳性神经元数量与正常组相比差异无显著性。

Blinded biopsies were evaluated by a histopathologist and scored according to Knodells histology activity index. Results 53.5%(54/101), 51.5%(52/101) and 31.7%(32/101) patients had a reduction of their total hepatic HAI score, necroinflammation and fibrosis scores by ≥2 points or 1 points at the end of one year of lamivudine therapy, compared with their pretreatment values, respectively.

结果 治疗后53.5%（54/101）患者肝组织学改善（治疗后HAI积分下降≥2），HAI积分由治疗前的8.0±4.7下降至治疗后5.2±3.3（t＝7.358，P.01）；其中51.5%（52/101）患者坏死炎症程度改善(治疗后积分下降≥2)，坏死炎症积分由5.9±3.8下降至3.6±2.5；31.7%（32/101）患者纤维化程度改善（治疗后积分下降≥1），纤维化积分由2.1±1.2下降至1.6±1.2（t＝3.827，P.01。

PartⅡThe mechanism elucidation about effects ofα-(2,3)/(2,6)sialic acid on the Cx43gap-junction functions.(1) Westernblotting experiment showed that the decrease of sialic acid didn\'t changethe Cx43 expression and its phospholation level.(2) Westernblotting experiment showed sialidase didn,t change the ZO-1 expression,IP and confocal experiment showed sialidase improved the interaction of Cx43 andZO-1.(3) Westernblotting experiment showed sialidase didn\'t change N-cadherin expression,IP and confocal experiment showed sialidase promoted the complex formation ofCx43 and N-Cadherin.(4)Sialidase could increase the ERK1/2 phospholation level,and enchanedintercellular homotypic adhesion,Immunofluorometric assay showed sialidase couldpromote the N-cadherin cluster on the membrance.

第二部分：α—(2，3)／(2，6)唾液酸对肿瘤细胞CX43间隙连接功能影响的机制研究1、Westernblotting结果表明降低细胞膜表面唾液酸并不改变Cx43的表达及其磷酸化水平：但Cx43连接斑形成增多；2、Westernblotting结果表明唾液酸酶作用后细胞ZO—1表达没有改变，IP及免疫荧光共定位结果表明唾液酸酶作用后促进了Cx43与ZO-1的结合；3、Westernblotting结果表明唾液酸酶作用后细胞N-cadherin表达没有改变，IP及免疫荧光共定位结果表明唾液酸酶作用后促进了Cx43与N-Cadherin复合物的形成；4、唾液酸酶作用后细胞内ERK1／2磷酸化水平明显增加，细胞间同质粘附增加，以及免疫荧光表明唾液酸降低后可促进N-cadherin的膜成簇。

Investigation of major metabolic pathways of SFZ-47 in animals The metabolites of SFZ-47 in rabbit urine following oral administration were separated and detected with HPLC and LC-MS methods. On the basis of the chromatographic behavior and mass spectra of the metabolites as well as biotransformation pathways of drugs with the partial structure of SFZ-47, the hydroxylic derivative 4-(3H-1, 2- dihydro-1-pyrrolizinone-2-methylamino benzyl alcohol and the carboxylic derivative 4-(3H-1, 2-dihydro-1-pyrrolizinone-2-methylamino benzoic acid of SFZ-47 were proposed as two potential metabolites and were synthesized.

在动物体内主要代谢途径的确定用HPLC和LC-MS对家兔口服SFZ-47后尿中的代谢物进行了分离、检测，根据代谢产物的色谱和质谱行为以及与SFZ-47有类似结构部分的其它药物的代谢途径，推测其羟基衍生物[4-（3H-1，2-二氢-1-吡咯里嗪酮-2-甲基胺基）苯甲醇]与羧基衍生物[4-（3H-1，2-二氢-1-吡咯里嗪酮-2-甲基胺基）苯甲酸]是两种可能的代谢产物，遂用化学方法合成了这两种衍生物。

Xinquan HuTwo new chiral backbones R-- and S--2-amino-2"-hydroxy-4,4",6,6"-tetra methyl-1,1"-biphenyl were synthesized via nitration, diazotation/iodination, Ulhnann coupling, selective reduction, diazotation/hydrolysis, hydrogenation and resolution from 2,4-dimethyl-aniline in seven steps.

以2，4-二甲基苯胺为起始原料，经过硝化反应、重氮化碘代反应、Ullmann缩合反应、选择性双硝基单还原反应、重氮化水解反应、催化氢化反应和拆分，首次合成了--2-氨基-2'-羟基-4，4'，6，6'-四甲基-1，1'-联苯和--2-氨基-2'-羟基-4，4'，6，6'-四甲基-1，1'-联苯两个对映体。

The results were expressed in mean±1SD. Pearson X~2 test and One-way ANOVA test were used. The data analyzed using the SPSS (version 11.5). Results: The sensitivity, specificity, positive and negative value of US for the LPEH model on the children cadaver were 88%, 84%, 79%, 91%, respectively. With regard to the thickness of femora head cartilage, the thickness of the anterior layer or posterior layer, there were no significant differences among three groups. However, the anterior layer was thicker than the posterior layer in three groups. The fluid in hip joint was detected in all of 21 symptomatic hips, which was clear commonly (90%) in early procedure. The amount of fluid in anterior recess showed a positive correlation with age (p .05). No fluid was detected in the asymptomatic and normal hips (2mm). The mean maximum width of inferomedial recess was significantly larger than that of anterior recess (12.50±4.04mm vs.4.35±0.8mm, p 0.05) in the symptomatic hip joints. The echogenic entrapped labral plicaes were demonstrated in the inferomedial recess in all of 21 children with LPEH, whose length and width ranged from 5.3mm-25.0mm (mean,15.6±5.6mm) and from 4.0mm-17.0mm (mean,8.9±7.8mm).

结果1，尸体LPEH髋关节模型的超声诊断敏感性、特异性分别为88％、84％，阳性预测值、阴性预测值分别为79％、91％。2，21例患儿的LPEH患髋(21侧)、健髋(21侧)，以及21例正常儿童健髋(42侧)的超声检查显示：髋关节周围软组织及股骨头无形态结构差别；股骨头软骨厚度无统计学差异(3.5±0.5mm vs.3.6±0.4mm vs.3.6±0.5mm，p＞0.05)；关节囊前层及后层厚度无统计学差异(前层厚度2.79±0.74 mm vs.2.56±0.40mm vs.2.56±0.72mm；后层厚度2.70±0.82mm vs.2.48±0.54mm vs.2.44±0.58mm，p＞0.05)，但LPEH患髋关节囊前、后层均较后二组有增厚趋势。3，LPEH患髋均存在关节腔内积液，且早期较为清晰；积液以髋关节内下间隙明显，内下间隙较前间隙明显增宽(12.50±4.04mm vs.4.35±0.8mm，p＜0.05)，其内见嵌顿滑膜唇皱襞呈稍强回声的占位性团块，长约15.6±5.6mm，宽约8.9±7.8mm，90.5％(19／21)嵌顿皱襞内未见血流信号。4，所有LPEH患髋治疗后超声复诊均显示正常。

Petiole densely brown villous to lanate; leaf blade abaxially rust-brown villous, base narrowly cuneate to truncate; lateral veins 6-10 on each side of midrib; pedicel 1-2.2 cm; corolla 0.8-2 cm, tube narrowly urceolate, ca. 3 mm in diam., lobes 1-2 mm; s

浓密的叶柄棕色具长柔毛到具绵状毛；叶片背面锈棕色具长柔毛，基部狭楔形到截形；侧脉6-10在中脉每边各；花梗1-2.2厘米；花冠0.8-2厘米，狭瓶形的筒部，直径约3毫米，裂片1-2毫米； s 9 Isometrum lancifolium 紫花金盏苣苔

In the water samples from Gudao, and No. 1 and 2 wastewater stations of the Shengli Oil Field, the ratios of amount of iron bacterial cells to total microbial cells, detected by the combination of the 4 probes and DAPI staining, were 11.0%, 12.8% and 9.0%, respectively. In the iron bacterial community, Leptothrix, Sphaerotilus and L. ferriphilum were dominant in the 3 stations, and Leptothrix and Sphaerotilus, and L. ferriphilum cells to accounted for 2.94%±0.52%~3.39%±0.52% and 2.24%±0.16%~2.63%±0.49% of the total microbial cells, respectively, while L.

结果表明，利用基因探针能快速对胜利油田外排水中的铁细菌进行检测：在孤岛采油厂、胜利采油厂1号和2号综合处理站的外排水中，利用4种探针的组合探针检测到的铁细菌细胞数量分别占样品中微生物总细胞数量的11.0%、 12.8%和9.0%，其中Leptothrix和Sphaerotilus，以及Leptospirillum ferriphilum为胜利油田外排水中的3种优势铁细菌，分别占水样中总微生物细胞数的2.94%±0.52%~3.39%±0.52%和2.24%±0.16%~2.63%±0.49%；而Leptospirillum ferrooxidans和Acidithiobacillus spp。

Corolla adaxial lip 2-lobed; petiole to 4 cm; leaf blade 2.2-4 X 2-3 cm, margin crenate to dentate or serrate, not lobulate; peduncle 4-7 cm, brown villous

花冠正面的唇2裂；叶柄到4厘米；叶片2.2 2-3-4 X厘米，边缘具圆齿在具牙齿的或有锯齿，不具小裂片；花序梗4-7厘米，棕色具长柔毛 7 Ancylostemon gamosepalus 黄花直瓣苣苔

Mylabris phalerata, Meloidae family of Coleoptera, has been known since antiquity to produce a potent toxic defensive agent, known as cantharidin (exo,exo-2,3-dimethyl-7-oxabicyclo [2.2.1] heptane-2,3- dicarboxylic anhydride), but well-known as Spanish Fly. In the past, Cantharidin has used as anticancer, herbicidal, pesticide and treatment of hepatic carcinoma and molluscum contagiosum activities.

斑蝥为翘翅目芫青科斑芫青属的昆虫，主要成分为斑蝥素(Cantharidin； exo，exo-2，3-Dimethyl- 7-oxabicyclo [2，2，1] heptane-2，3-dicarboxylic anhydride)，研究中指出斑蝥素具有发泡、抗肿瘤的作用，或当作除草剂、杀虫剂、毛发生长刺激剂，目前临床上则用於治疗原发性肝癌及传染性疣。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐