查询词典 2-butene

Three antioxidative parameters(SOD super oxide dismutase、MDA malondialdehyde and GSH reduced glutathione hormone)were also measured.Results:The skin elasticity and water content improved increasingly according to the MPA measurements of the two group 4 weeks after the last irradiation.The hydroxyproline of the skin in the Q-switched 1064-nm Nd:YAG laser of 0.6J/cm~2、1.5 J/cm~2 and 2.5 J/cm~2 group showed 7.1%,13.1%and 19.8%(p＜0.05)increase respectively compared to their controls,the enhancement of dermal thickness were 15.5%,29.7%and 38.4%;The hydroxyproline of the skin in the Q-switched 532-nm Nd:YAG laser of 0.5J/cm~2、1.2 J/cm~2 and 2.0 J/cm~2 group showed 6.9%,9.6%and 14.2%(p＜0.05)increase respectively compared to their controls,the enhancement of dermal thickness were 5.5%,15.1%and 29.9%,among which the Q-switched 1064-nm laser group had the greatest effect. The result of antioxidative parameters showed some juvenescence change at the radiated skin.

结果：末次照射后第4周，Q开关1064-nmNd：YAG激光组(以下简称1064 nm组)和Q开关532-nmNd：YAG激光组(以下简称532-nm组)大鼠各实验侧的皮肤弹性和含水量都明显好于对照侧；1064-nm组和532-nm组实验侧的皮肤羟脯氨酸含量和真皮内胶原厚度都较对照组显著增大(P＜0.05)，其中1064-nm组的三种不同能量密度：0.6 J/cm~2、1.5 J/cm~2、2.5 J/cm~2的激光照射的皮肤区域的羟脯氨酸含量增加率为7.1%，13.1%和19.8%，真皮厚度增加率为15.5%，29.7%和38.4%，532-nm组的三种不同能量密度：0.5 J/cm~2、1.2 J/cm~2、2.0J/cm~2的激光照射的皮肤区域的羟脯氨酸含量增加率为6.9%，9.6%和14.2%，真皮层厚度增加率为5.5%，15.1%和29.9%，相比而言1064-nm组的羟脯氨酸及真皮层厚度增加率均较高；抗氧化指标显示两组大鼠实验侧皮肤的抗氧化能力增加，呈年轻化改变。

This invention is directed to the-tartaric acid salt of 2-amino-N-{1-(2,4-difluoro-benzyloxymethyl)-2-oxo-2-3-oxo-3a-pyridin-2-ylmethyl-2-(2,2,2-trifluoroethyl-2,3,3a, 4,6,7-hexahydro-pyrazolo(4,3-c) pyridin-5-yl-ethyl}-2-methyl-propionamide which is a growth hormone secretagogue and as such is useful for increasing the level of endogenous growth hormone.

本发明涉及2－氨基－N－{1－－(2，4－二氟－卞氧甲基)－2－氧代－2－3－氧代－3a－(R－吡啶－2－基甲基－2－(2，2，2－三氟－乙基)－2，3，3a，4，6，7－六氢化－吡唑子基(4，3－c)吡啶－5－基－乙基}－2－甲基－丙酰胺的－－酒石酸盐，它是一种生长激素促分泌素，并且可用于提高内源性生长激素水平。

Corolla blue-purple to pinkish white or greenish, 1.8-2.3 cm, outside pubescent to glabrescent; tube nearly cylindric, gradually slightly ampliate from base to mouth, 1.4-2 cm X 3-6 mm; limb slightly 2-lipped; adaxial lip 2-lobed from near middle, lobes 1.5-2 X 1.5-2 mm; abaxial lip lobes 3.5-5.5 X 2.5-3 mm. Stamens adnate to corolla 5-7 mm above base, 6-13 mm; filaments slender, slightly flattened, glabrous; anthers oblong, 2-loculed, dehiscing longitudinally, connective glabrous; staminode 1, ca. 1.2 mm. Disc ca. 1.2 mm, shallowly 5-lobed to subentire.

花冠蓝紫色到带绿色带粉红色的白色的或，1.8-2.3厘米，外面被短柔毛到后脱落；逐渐，圆筒状的近筒部稍自基部在嘴，3-6毫米的1.4 X-2厘米；瓣片有点二唇形；从近中部，耳垂1.5-2 X 1.5-2毫米2裂的正面的唇；背面的唇裂片3.5-5.5 X 2.5-3毫米雄蕊贴生于花冠超过基部，6-13毫米5-7毫米；花丝纤细，稍扁平，无毛；花药长圆形，2室，纵向开裂，药隔无毛；退化雄蕊1，大约大约1.2毫米，浅5浅裂到近全缘的1.2毫米光碟。

In this thesis,the AM1,MNDO,MINDO/3(mainly AM1)and INDO/S-CI semiempirical MO methods were used toinvestigate the excited-state intramolecular protontransfer reactions of salicylic acid derivatives—salicylic acid,methyl salicylate,salicylaldehyde,o-hydroxyaceto-phenone,salicylamide and 3-hydroxy-picolinamide (6 conformers and 2-3 anion species);2-(2'-hydroxy-5' methylphenyl) benzotriazole(4 conformers),2-(2' hydroxyphenyl) benzimidazole (3 conformers and 3anion species),Bis-2,5-(2-benzoxazolyl)hydroquinone(3 conformers),2-(2'-hydroxyphenyl)benzothiazole(2conformers) and 7-azaindole dimer (2 conformers).Theinvestigations were described as follows.Geometry optimization,relative stability andhydrogen bonding energy First,for sylicylic acid derivative molecules,the AM1,MNDO and MINDO/3 methods were used toinvestigate ground-state geometry optimization,energies,relative stabilities and hydrogen-bondingenergies on the five kinds of the molecules(designing 6 conformers and 2-3 anion species).Comparing with experimental data,the optimizedgeometry,the order of stability,the hydrogen-bonding energies and the distances between O-O in O-H..O hydrogen bonds by AM1 method were in agreementwith the experimental data,however,the C-C bondlengths optimized by MNDO and MINDO/3 were longer,C-O and O-H bond lengths were shorter;for C-N bondlengths,the results opitimized by MNDO method werethe same as those by AM1 method,nevertheless the C-Nbond lengths given by MINDO/3 method were muchshorter.For some sylicylic acid derivatives(e.g.methyl salicylate,salicylamide),the order ofstabilities on the conformers given by MNDO andMINDO/3 methods were not in agreement with theexisting conformers deduced by experimental methods,and the hydrogen bonding energies calculated by MNDO.and MINDO/3 methods were smaller.Second,the studyon the other systems found that the optimizedgeometry of the proton-transfered product with INDOmethod could not be obtained,only could theoptimized geometry of reactant be obtained,and thecalculated hydrogen bonding energies were greater.Many results of calculation indicated that the studyon the excited-state intramolecular proton transferreaction system using AM1 method was suitable andreliable.

本论文用AM1、MNDO、MINDO/3（主要是AM1）和INDO/S-CI半经验分子轨道方法对水杨酸衍生物系列——水杨酸、水杨酸甲酯、水杨醛、O-羟基乙酰苯酮、水杨酰胺和3-羟基吡啶酰胺（6种异构体和2-3种阴离子）；2-（2'-羟基-5'-甲基苯基）苯并三〓唑（4种异构体）；2-（2'-羟基苯基）苯并咪唑（3种异构体和3种阴离子）；2，5-二间氮杂氧茚氢醌（3种异构体）；2-（2'-羟基苯基）间〓杂硫茚（2种异构体）和7-〓吲哚二体（2种异构体）的激发态分子内质子转移反应在以下几个方面进行了较系统的理论研究：几何构型优化和相对稳定性及氢键能首先以水杨酸衍生物系列分子为例，用AM1、MNDO和MINDO/3方法考察了5种分子（每种分子设计6种异构体和2-3种阴离子）的基态几何构型优化，能量、相对稳定性和氢键能计算，通过和实验数据进行比较，AM1方法给出的优化几何构型、稳定性次序、氢键能和O—H。。。O氢键的0—0距离与实验数据吻合最好，MNDO和MINDO/3方法优化的C-C键长偏长，C-O键和O-H键长偏短；对于C-N键长，MNDO和AM1优化结果差别不大，而MINDO/3给出了过短的C-N键长，MNDO和MINDO/3方法给出的有些水杨酸衍生物分子（如水杨酸甲酯和水杨酰胺）异构体的稳定性次序和实验上推测的可存在异构体结果不一致，MNDO和MINDO/3方法给出的氢键能偏低，对其他体系的研究发现INDO方法常常不能得到质子转移产物的优化几何构型，只能得到反应物的优化构型，并且估算的氢键能偏高，大量的计算结果表明AM1方法对本论文研究的激发态分子内质子转移反应体系是适宜和可靠的。

G.E.Hubb root is from 0.20mm to 0.50mm, and 95% roots, diameter is thinner than 0.40mm. The total surface areas of roots is 10139.68cm^2, and the surface areas of roots is about 2 to 3 times to soil surface areas in the surface layer. Enlacing sod concretion to soil profile of Eulaliopsis binata G.E. Hubb root and the gigantic adsorption to soil grains of root surface are the mechanism why Eulaliopsis binata G.E. Hubb can reduce null and water loss significantly. The monitoring result from 2003 to 2004 indicates that, when the gradient is 12 degrees, the runoff rate of planting Eulaliopsis binata Retz. G.E. Hubb completely after changing slope land to ladder (PECC, so as the follows is only 49.90m^3/hm^2?yr. and the soil loss rate is 155.78kg/hm^2?yr, however, the runoff rate of fanning and being not change slope land to ladder is 314.29m^3/hm^2?yr that is 6.30 times to PECC ,and the soil loss rate is 3322.50 that is 21.33 times to PECC; When the gradient is 24 degrees, the runoff rate of planting eulaliopsis binata G.E, Hubb in the ridge and border slope land after changing slope land to ladder is 248.04m^3/hm^3?yr and the soil loss rate is 612.00kg/hm^3?yr. the runoff rate of PECC is only 42.44m^3/hm^2?yr and the soil loss rate is 153.75kg/hm^2?yr, however, the runoff rate of ENC reaches to 785.73m^3/hm62?yr that is 3.17 times to PERBC and 18.52 times to PECC, and the soil lose rate reaches to 37503m^3/hm^2 yr that is 61.33 times to PERBC and 244.12 times to PECC.

蓑草根系平均直径0.20~0.50mm， 95%的根系平均直径小于0.40mm，根系总表面积10139.68cm^2，在土壤表层根系表面积高达土体表面积的2~3倍，根系表面对土壤颗粒的巨大吸附作用是蓑草显著提高土壤抗侵蚀能力的另一个重要原因。2003~2004年的监测结果表明，在12度坡度情况下，坡改梯后净作蓑草年径流量仅49.90立方公尺/hm^2，年土壤流失量为155.78kg/hm^2，而未坡改梯且农作情况下，年径流量314.29立方公尺／hm^2为前者的6.30倍，年土壤流失量3322.50Kg/hm^2为前者的21.33倍；在24度坡度情况下，坡改梯后土埂及边坡种植蓑草、坡面农作年径流量248.04立方公尺/hm^2，年土壤流失量612.00kg/hm^2，坡改梯后净作蓑草径流量42.44立方公尺/hm^2，土坡流失量l53.75kg/hm^2，而未坡改梯且农作情况下年径流量高达785.73立方公尺/hm^2，分别为处理1的3.17倍，处理2的18.52倍，年土壤流失量高达37503kg/hm^2，分别为处理1的61.33倍，处理2的244.12倍。

KT101.1 Computer Keyboarding Lab 1.5 KT101.2 Computer Keyboarding Lab 1.5 A101.1 Accounting I Lab 1.5 A101.2 Accounting I Lab 1.5 E102.1 Business Communications 1.5 E102.2 Business Communications 1.5 C108.1 Spreadsheet Applications Lab 1.5 C108.2 Spreadsheet Applications Lab 1.5 C110.1 Computer Medical Applications Lab 1.5 C110.2 Computer Medical Applications Lab 1.5 ME101 Medical Terminology 3 ME102.1 Medical Office Procedures Lab 1.5 ME102.2 Medical Office Procedures Lab 1.5 ME104.1 Medical Insurance Records 1.5 ME104.2 Medical Insurance Records 1.5 ME106.1 Advanced Medical Coding 1.5 ME106.2 Advanced Medical Coding 1.5 MA110.1 Anatomy and Physiology/Musculoskeletal, Integumentary, Eye, Ear, and Endocrine Systems 1.5 MA110.2 Anatomy and Physiology/Musculoskeletal, Integumentary, Eye, Ear, and Endocrine Systems 1.5 MA111.1 Anatomy and Physiology/Digestive, Urinary, Reproductive, Nervous, and Cardiovascular Systems 1.5 MA111.2 Anatomy and Physiology/Digestive, Urinary, Reproductive, Nervous, and Cardiovascular Systems 1.5 MA112.1 Medical Office Administration 1.5 MA112.2 Medical Office Administration 1.5 Total Quarter Credit Hours - 36

KT101.1电脑键盘操作实验室1.5 KT101.2电脑键盘操作实验室1.5 A101.1会计本人实验室1.5 A101.2会计本人实验室1.5 E102.1企业通信1.5 E102.2企业通信1.5 C108.1电子表格应用实验室1.5 C108.2电子表格应用实验室1.5 C110.1计算机医学应用实验1。 5 C110.2计算机医学应用实验室1.5 ME101医疗术语3 ME102.1医疗办公室程序实验室1.5 ME102.2医疗办公室程序实验室1.5 ME104.1医疗保险记录1.5 ME104.2医疗保险记录1.5 ME106.1高级医疗编码1.5 ME106.2高级医疗编码1.5 MA110.1解剖生理学/骨骼，体被，眼，耳，和内分泌系统1.5 MA110。 2解剖生理学/骨骼，体被，眼，耳，和内分泌系统1.5 MA111.1解剖生理学/消化，泌尿，生殖，神经，心血管系统和1.5 MA111.2解剖生理学/消化，泌尿，生殖，神经，心血管系统和1.5 MA112.1医疗办公室行政1.5 MA112.2医疗办公室行政1。 5 总数的四分之一学时- 36

objective to evaluate efficacy of extracorporeal shock wave lithotripsyfor treating ureteral stones in situ,investigate the cause of higher re-treatment rate.methods total of 687 patients with ureteral stone were received eswl between january 2000 and december 2004,included 455 male(66.2%) and 232 female(33.8%) patients,6 cases have bilateral ureteral calculi,12 cases have unilateral multiple calculi.hence,together 709 ureteral calculi were treated.patients upper ureteral calculi were treated in the supine position,for lower ureteral calculi patients were turned prone.to reduce eswl-induced renal trauma and pain,using lower energy source,adjusted power setting from 9.8 to 13.2kv,limited 1500 shock wavs per one session.no auxiliary procedure were used before eswl.the stone size was measured as the surface area of stone length by stone width on x-ray film.the interval between two treatment sessions was two weeks.results of 709 ureteral calculi,the overall stone free rate was 97.3%(690 calculi),re-treatment rate was 34.1%(292 calculi).according to the performed treatment sessions,one session 467 calculi,the mean stone size 37.27mm2,stone free rate 65.4%(464 calculi).two sessions 138 calculi,the mean stone size 62.48mm2,stone free rate 18.4%(131calculi).three sessions 52 calculi,the mean stone size 79.60mm2,stone free rate 7.1%(50calculi).four sessions 19 calculi,the mean stone size 101.63mm2,stone free rate 2.4%(17calculi).fivesessions 33 calculi,the mean stone size 119.33mm2,stone free rate 3.9%(28 calculi).overall 19 cases(2.7%)turned to other treatment modalities.of 335 upper ureteral calculi,303 achieved stone free (95.8%),re-treatment rate was 38.5%(129 calculi).of 374 lower ureteral calculi,369 achieved stone free(98.7%),re-treatment rate was 30.2%(113 calculi).the re-treatment rate of upper ureteral calculi was higher than lower ureteral calculi(p＜0.05,χ2=5.40).the difference of stone-free rate between upper and lower ureteral calculi was no significant(p＞0.05,χ2=0.15).conclusion eswl should be considered first line therapy for ureteral stone still.stone burden are the main variable of higher re-treatment rate,upper ureteral stone may moving with respiring during eswl.so efficinet shock wave was decreared,re-treatment rate become higher.

目的 评估体外震波碎石治疗输尿管结石的疗效，探讨再治疗率高的原因及输尿管结石的治疗选择。方法回顾2000年1月～2004年12月间eswl治疗输尿管结石的临床资料687例，男455例（66.2%），女232例（33.8%），平均年龄46.6岁（15～83岁）。有双侧输尿管结石6例，单侧多发性输尿管结石12例（4颗1例，3颗2例，2颗9例），共计输尿管结石709颗（含透光结石13颗）。应用上海爱申公司生产的desunit6030型碎石机，c臂x线球管做结石定位。上段输尿管结石（肾盂输尿管交界处至骶髂关节上缘）取仰卧位，下段输尿管结石（骶髂关节上缘下至输尿管口）取俯卧位。为减少eswl引起的肾损伤和疼痛，应用较低的能量，震波发生器电压从9.8～13.2kv，震波频率1.5s。每次治疗设定为1500次震波。治疗后3天摄腹部平片或b超，以后每隔7日重复检查。假如结石未碎或有残留结石最长径＞3mm以上，再次eswl，两次治疗的间隔时间为两周。结石的大小用x线片上的表面积（mm2表示。结果 709颗输尿管结石总的治愈率为97.3%（690颗），再治疗率34.1%（242颗）。其中一次治疗467颗，平均结石大小37.27mm2，治愈464颗（65.4%），3颗改治疗；两次治疗138颗，平均结石大小62.48mm2，治愈131颗（18.5%），7颗改治疗；第1和第2次治疗治愈率（1个月治愈率）为83.8%。3次治疗52颗，平均结石大小79.60mm2，治愈50颗（7.1%），2颗改治疗；4次治疗19颗，平均结石大小101.63mm2，治愈17颗（2.4%），2颗改治疗；5次及5次以上治疗33颗，平均结石大小119.33mm2，治愈28颗（3.9%），5颗改治疗。总计19颗（2.7%）结石改变治疗方式。上段输尿管结石335颗，治愈321颗（95.8%），再治疗129颗（38.5%）。下段输尿管结石374颗，治愈369颗（98.7%），再治疗113颗（30.2%）。经χ2检验，上、下段输尿管结石的再治疗率差异有显著性（χ2=5.40，p＜0.05），治愈率差异无显著性（χ2=0.15，p＞0.05）。不良反应：血压升高13例（1.9%），震波区域疼痛26例（3.8%），震波进入处皮肤点状淤血33例（4.8%），肉眼血尿128例（18.6%），均于第2、3天自行消失。结论 eswl目前仍是输尿管结石的第一线治疗，结石的大小是再治疗率高的主要因素。结石的位置有影响，上段输尿管结石可随呼吸移动，有效震波次数减少，再治疗率比下段输尿管结石高。eswl前注重病例筛选可降低再治疗率。

Equipment: 2 meters in diameter has a film blowing machine Units 1, 1 m film blowing machine 2 Units, 800-type film blowing machine 2 Units, 600 Units 5 film blowing machine, film blowing machine 400 Units 8, self-styled pocket machine 2 Units , bubble machine BAG 3 Units, 1000-type computer high-speed 8-color printing press 1, 800 computer-based 6-color press 2 Units, 600 computer-based 6-color press 2 Units, 600 2-color presses 5 Units, 600 single - Units 6 color printing press, 800-type compound machine 2 Units, 600-type compound machine 2 Units, 600 Units 2 computer triangular closure .600 PC .600 scalding machine 10 Units self-sealing machine hot computer 2 Units, 600-type computer hot bubble bag machine 3 Units, 1000 Units 1 computer perm machine perm machine .800 PC .600 Units 1 type bag machine automatic hot computer 3 Units, 3 Units polypropylene film blowing machine, poly bag machine hot 20 Units, contraction Film Blown Machine 2 Units, hot shrink film machine 12 Units, demolition machine, in closing down the machines, machine, granulating machine, grinder of the Units 1, as well as other equipment and so on

拥有2米直径吹膜机1台，1米吹膜机2台，800型吹膜机2台，600型吹膜机5台，400型吹膜机8台，自封口袋机2台，气泡袋机3台，1000型电脑8色高速印刷机1台，800型电脑6色印刷机2台，600型电脑6色印刷机2台，600型2色印刷机5台，600型单色印刷机6台，800型复合机2台，600型复合机2台，600型电脑三边封2台。600型电脑烫机10台。600型自封口电脑烫机2台，600型电脑气泡袋烫机3台，1000型电脑烫机1台。800型电脑烫机1台。600型手提袋全自动电脑烫机3台，聚丙吹膜机3台，聚丙袋烫机20台，收缩膜吹膜机2台，收缩膜烫机12台，拆边机，中封机，分切机，造粒机，粉碎机各一台，还有其它设备等等

Small bottle: 10 ml, 6 individuals; medical gloves: No. 2 pay; stainless steel Yashe Ban: 16 cm, 2 branches card button tourniquet: a single valve of the ventilator: 20 x20cm, 2 tablets; T - Flashlight: an electronic thermometer: 1; blood pressure Table: 1 Taiwan; Stethoscope: single: 1; roll splint fracture: 46 x11cm, 1 vol; finger fracture splint: 5 x11cm, 4 tablets; Yiyong Yang cylinders: 1.4 l, 1 sets of medical scissors: straight round 14 cm, 1把; medical scissors: straight sharp 14 cm, 1把; medical Yong Niezi: 14 cm have teeth, one; bleeding clamp: straight-mosquito, 2 To; scalpels films: 20 #, 2; surgical knife handle:# 4, 1; a needle clamp: 14 cm, 1把; medical suture needle round: 1 / 2 arc, 0.8x20mm, 2枚; medical 1.30 suture needle: 1/2arc, 0.9x24mm, 2枚; medical thread: 1 #, a beam; medical cotton ball: 5 tablets / bag, 2 packets; povidone iodine disinfectant solution: a bottle; compound alcohol disinfection Shijin: 21 x14cm, 4片; Alcohol cotton: 30 Tablets / bag, 1 cylinder; iodine cotton: five tablets / package bag, 4 packets; iodine Mianbang: single-cartridge, 20; wound paste: 72 x19mm, 20 tablets; Butterfly - Shaped wound paste: 4; self-adhesive wound Application: 6 x7cm, 4 tablets

小药瓶：10ml，6只；医用手套：中号，2付；不锈钢压舌板：16cm，2支；卡扣式止血带：1条；单相阀式呼吸器：20x20cm，2片；笔式手电筒：1支；电子体温计：1支；血压表：1台；听诊器：单头：1只；卷式骨折夹板：46x11cm，1卷；手指骨折夹板：5x11cm，4片；医用氧气瓶：1.4l，1套；医用剪刀：直圆14cm，1把；医用剪刀：直尖14cm，1把；医用镊子：14cm 有齿，1支；止血钳：直蚊式，2把；手术刀片：20#，2片；手术刀柄：4#，1把；持针钳：14cm，1把；医用圆缝合针：1/2arc，0.8x20mm，2枚；医用三角缝合针：1/2arc，0.9x24mm，2枚；医用丝线：1#，1束；医用棉球：5tablets／bag，2包；聚维酮碘消毒液：1瓶；复方酒精消毒湿巾：21x14cm，4片；酒精棉球：30粒Tablets／bag，1筒；碘酒棉球：5粒tablets／包bag，4包；碘酒棉棒：单支装，20支；创口贴：72x19mm，20片；蝶形创口贴：4片；自粘伤口敷贴：6x7cm，4片；自粘伤口敷贴：10x10cm，4片；自粘伤口敷贴：10x15cm，4片；吸血垫：10x10cm(1片／包)，4包；医用纱布绷带：6x600cm，2卷；自粘弹性绷带： 2.5x450cm，2卷；自粘弹性绷带：5x450cm，2卷；自粘弹性绷带：7.5x450cm，1卷；医用纱布三角绷带：90x90x129cm，2卷；急救毯：140x204cm银色，1条；降温贴：单片装，2片；活络油：5ml，1瓶；云南白药：4g，1瓶；绿药膏：10g，2瓶；急救手册：1本；铝合金箱：1个。

The results showed that (1) COX-2 mRNA and protein existed in the mature male rat testis. COX-2 was localized in spermatocytes by immunohistochemistry.(2) COX-2 also existed in adult man testis. COX-2 protein was positively stained in spermatocytes and Leydig cells.(3) 2 weeks after administration of rofecoxib, the level of testosterone in the whole testis reached its lower values, being only 50% of control values. However, testosterone level recovered during 4 weeks. After such treatment, histologic examination of these testes showed atrophy of the seminiferous tubules and maturation arrest of spermatogenesis.(4) 2 weeks post-EDS, expression of COX-2 decreased significantly (P.005), in comparison with vehicle-treatment control. 4 weeks after treatment, a new generation of fetal like Leydig cells repopulated in the testicular interstitium resulting in COX-2 expression partially recovered. Although the expression of COX-2 mRNA and protein are enhanced at 8th week after using external testosterone, it wasn't significant higher than control group.

实验研究证明：(1)正常成年雄性大鼠睾丸组织中COX-2在mRNA和蛋白质水平均存在表达，免疫组织化学结果显示COX-2定位于曲细精管内的生精细胞；正常成年男性睾丸组织中同样存在COX-2表达，免疫组织化学结果显示COX-2定位于曲细精管内的生精细胞和Leydig细胞；(2)服用特异性COX-2酶抑制剂rofecoxib 2周后，实验组大鼠睾丸组织内睾酮的含量减少，为正常对照组的50％；持续用药4周后睾丸组织内睾酮浓度逐渐恢复至正常水平；COX-2酶活性降低后病理组织切片显示睾丸内曲细精管萎缩，生精紊乱，持续用药4周时影响最明显；(3)注射特异性Leydig细胞杀灭剂EDS 2周后，实验组大鼠睾丸组织内睾酮浓度降至极低水平时，COX-2的蛋白和基因表达水平也显著低于正常空白对照组（P.005）；使用EDS后第4周，睾丸组织中的睾酮浓度逐渐回升，同样组织中COX-2蛋白表达和mRNA表达水平也相应提高接近正常水平；使用EDS后4周开始给予外源性睾酮，6周和8周时COX-2表达水平的绝对值虽有提高，但与正常大鼠空白对照组比较并无显著性差异，说明外源性雄激素刺激睾丸合成COX-2的作用并不明显。

For a big chunk of credit-card losses; the number of filings (and thus charge-off rates) would be rising again, whether

年美国个人破产法的一个改动使得破产登记急速下降，而后引起了信用卡大规模的亏损。

Eph. 4:23 And that you be renewed in the spirit of your mind

弗四23 而在你们心思的灵里得以更新