查询词典 2-butene

PartⅡ:Effect of bicyclol on hepatocyte apoptosis in alcohol-intoxicated mice and related mechanismsThree consecutive intragastric administration of alcohol(6g/kg)in 12h interval resulted in an obvious liver injury and inflammation in mice,as indicated by the elevation of serum alanine transaminase(2.2 fold of control),increased hepatic COX-2 protein expression(2.2 fold of control),as well as liver pathological changes characterized by myelonic degeneration,vacuolar degeneration and inflammatory infiltration.

双环醇对酒精中毒小鼠肝脏细胞凋亡的保护作用及机制研究小鼠连续三次酒精(6g/kg)灌胃后可导致明显肝损伤，变现为血清ALT水平升高(为对照组的2.2倍)，肝脏炎症相关蛋白环氧合酶-2(cyclooxygenase-2，COX-2)表达增加(为对照组的2.2倍)，肝组织出现髓样变性、小空泡变性和炎性细胞浸润。

Density Functional Theory method was used to optimize the geometries of 209 PCDE molecules, 209 PBDE molecules and 75 PCDD molecules at the B3LYP/6-31G* level. Using computed structural parameters as theoretical descriptors, the forward stepwise multiple regression technique was adopted to obtain QSPR models of environmental partition properties for these POPs by using GQSARF 2.0 and SPSS12.0 for windows programs. The obtained QSPR models are as follows:(1) QSPR models for predicting subcooled liquid vapor pressure, n-octanol/water partition coefficients lgK_(ow and subcooled liquid water solubilities -lgS_(w,l of PCDEs, of which correlative coefficients (R~2) are 0.988, 0.958 and 0.959 and the root-mean-square-error of estimation are 0.134, 0.116 and 0.327 respectively.(2) QSPR models of lgPL and n-octanol/air partition coefficients lgK_(oa for PBDEs, which both contain three structural parameters. The values of R2 for the two models are both 0.997 while the values of RMSEE are 0.073 and 0.062 respectively.(3) QSPR models of lgKow and–lgS_ for PCDEs, which both have one variable (mean molecular polarizability,α). The values of R~2 for the two models are 0.978 and 0.866 and the values of RMSEE are 0.300 and 0.270 respectively.(4) The molecular structures of 24 substituted naphthaline compounds were optimized using Hartree-Fock and DFT methods at four different levels and the same means was used to obtain four three-parameter (EHOMO, q~+ andα) QSPR models of lgK_. The model at the HF/6-311G** level is the best one of which R2 is 0.9662 and RMSEE is 0.380.(5) QSPR study for environmental partition properties of PCDEs was also performed using position of Cl substitution method in which simple parameters of substitution position were taken as descriptors. The multiple linear regression was performed with GQSARF 2.0 and SSPS 12.0 for windows programs to obtain QSPR models of lgP_L, lgK_ and–lgS_ for PCDEs of which R~2 are 0.991, 0.983 and 0.965 and RMSEE are 0.311, 0.100 and 0.300 respectively.

采用密度泛函理论方法在B3LYP/6-31G*水平上对PCDEs、PBDEs和PCDDs的分子结构进行了全优化计算，以计算得到的量子化学参数作为理论描述符，采用GQSARF 2.0和SPSS 12.0 for windows统计程序进行正向逐步回归分析，建立了这些POPs的环境分配性质的QSPR模型：(1) PCDEs的过冷液体蒸汽压、正辛醇/水分配系数lgK_(ow和水溶解度-lgS_(w，l的QSPR模型，这3个QSPR模型的相关系数(R2)分别为0.988、0.958和0.959，估计的均方根误差分别为0.134、0.116和0.327；(2) PBDEs的lgPL和正辛醇/空气分配系数lgK_(oa的QSPR模型，这两个模型都包含三个分子结构参数，其R~2都为0.997，RSMEE分别为0.073和0.062；(3) PCDDs类化合物的lgK_和-lgS_w的QSPR模型，两个模型都只含一个变量，其R~2分别为0.978和0.866，RSMEE分别为0.300和0.270；(4)采用Hartree-Fock和DFT方法，在4种不同水平上优化计算了24个取代萘系列化合物的分子结构，采用上述同样的方法分别建立了四种水平上的三变量lgK_模型，通过比较得到，在HF/6-311G**水平计算得到的模型最好，R为0.966，RSMEE为0.380；(5)同时，采用氯原子取代位置方法对PCDEs的环境分配性质进行QSPR研究，建立了PCDEs的lgPL、lgK_和-lgS_的QSPR模型，其R~2分别为0.991、0.983和0.965，RSMEE分别为0.110、0.100和0.300。

Also associated were preeclampsia/gestational hypertension (OR, 2.29; 95% CI, 2.13 - 2.46), smoking (OR, 2.85; 95% CI, 2.53 - 3.21), and diabetes (OR, 1.96; 95% CI, 1.64 - 2.35). Nonvascular diagnoses, such as pneumonia, transfusions, postpartum infection, or hemorrhage, were not linked to migraine.

同样有关的有先兆子痫/妊娠高血压(OR为2.29； 95% CI为2.13 - 2.46)、抽菸(OR为2.85； 95% CI为2.53 - 3.21)、糖尿病(OR为1.96； 95% CI为1.64 - 2.35)；非血管方面的诊断，如肺炎、输血、产后感染或者出血，与偏头痛无关。

Both dosages of DIZ (2 mg/kg) and MID (2 mg/kg) with an increased KET dosage (from 60 to 90 mg/kg) shortened the time of diminished corneal reflex (from 5.3 ± 0.8 to 2.2 ± 0.3 min) and palpebral reflex (from 3.0 ± 0.4 to 1.3 ± 0.2 min) and significantly prolonged the duration of anesthesia (from 97.2 ± 18.0 to 187.8 ± 28.8 min vs. from 103.3 ± 9.4 to 181.8 ± 19.5 min), but did not reduce the recovery time.

於定量DIZ（2 mg/kg）和MID（2 mg/kg），KET由60 mg/kg增加至90 mg/kg，可分别缩短导入期角膜反射减弱（由5.3 ± 0.8分钟减至2.2 ± 0.3分钟）与眼睑反射减弱（由3.0 ± 0.4分钟减至1.3 ± 0.2分钟）时间，且能显著延长麻醉时间（分别由97.2 ± 18.0分钟增至187.8 ± 28.8分钟和由103.3 ± 9.4分钟增至181.8 ± 19.5分钟），但并未延长回复期。

The famciclovir was synthesized from purine by a series of steps by Acylation, Decarboxylation, Reduction ,and so on; Derivatives of these intermediates is described from the 6-chloro- 9H- purin-2-amine as raw materials in different conditions when the iodine and bromide were synthesized with the addition of two intermediate 6-bromo-9H-purin-2-amine and 6-iodo-9H-purin-2-amine; There is elaborated from the main part of a acetophenone, urineaminohydrochloride, phenylhydrazine, ethyl acetoacetate as raw material through a series of reactions to synthetic 3-phenyl-4-formylphenyl pyrazole and 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-aldehyde two pyrazole aldehyde, and then with 2-amino-6-chlorine-9-(2-methicillin-oxo-co-methyl-4-yl) purine reaction of the two new pyrazole purine Schiff bases.

本论文主是采用以鸟嘌呤为原料，经过一系列的酰基化，脱羧，还原等反应作用下最终得到了产物2-氨基-9-(4-乙酰氧基-3-乙酰氧基甲基丁基)嘌呤；其中的中间体衍生物主要是阐述从以2-氨基-6-氯鸟嘌呤为原料通过在不同的条件下进行溴代与碘代分别合成了另外两种中间体2-氨基-6-溴鸟嘌呤及2-氨基-6-碘鸟嘌呤；还有一部分主要是阐述从以苯乙酮，盐酸氨基脲，苯肼，乙酰乙酸乙酯为原料通过一系列的反应先合成3-苯基-4-醛基吡唑及5-氯-3-甲基-1-苯基-1H-吡唑-4-甲醛这两个吡唑醛，然后再与2-氨基-6-氯-9-(2-甲氧羰基丁酸甲酯-4-基)嘌呤反应得到了两个新型的吡唑嘌呤席夫碱

Var. pyramidalis is not positively correlated with ion concentration in growth environment, the capacity of selective absorption and transport of ions in Populus alba L. var. pyramidali under salt stress in drainage canal is higher than Populus alba L. var. pyramidal is of normal growth in irrigation canal. Under salt stress, the concentration of K(superscript +)、Na(superscript +) of roots and leave of Populus alba L. var. pyramidalis have changed, the concentration of K(superscript +) of roots and leave dropt the concentration of Na(superscript +) of roots markedly increased, the concentration of Ca(superscript 2+), Mg(superscript 2+) have slightly changed, the concentration of Ca(superscript 2+) of roots dropted, the concentration of Mg(superscript 2+) increased, the concentration of Ca(superscript 2+), Mg(superscript 2+) of leave increased.

主要结论为：新疆杨各器官的离子含量与生长环境中的离子浓度不存在正相关趋势；排渠盐胁迫下生长的新疆杨对离子选择吸收和运输的能力高于灌渠正常生长的新疆杨；盐胁迫下，新疆杨根和叶中K、Na的浓度发生了明显的变化，K浓度在根和叶中呈下降趋势，Na浓度在根中明显增加，根和叶中Ca(上标 2+)、Mg(上标 2+)浓度的变化趋势略缓，根中Ca(上标 2+)浓度下降，Mg(上标 2+)浓度增加，叶中Ca(上标 2+)、Mg(上标 2+)浓度有所上升。

The floatation rate of Pd (superscript 2+) reaches 100% when the concentrations of NaNO3, KBr and cetyl pyridinium bromide in solution are 0.05 g/mL, 3.0×10^(-2) mol/L, 5.0×10^(-4) mol/L(pH 4.0), respectively. Pd (superscript 2+) could be separated from Ru (superscript 3+), Al (superscript 3+), Cr (superscript 3+), Ni (superscript 2+), Ga (superscript 3+), Fe (superscript 3+) and Zn (superscript 2+) by floatation quantiatively. A method of flotation separation and enrichment of Pd (superscript 2+) was established.

当溶液中硝酸钠、溴化钾、溴化十六烷基吡啶的浓度分别为0.05 g/mL，3.0×10^(-2)mol/L，5.0×10^(-4)mol/L，在pH 4.0时，Pd(上标 2+)的浮选率达到100%，Pd(上标 2+)可与Ru(上标 3+)，Al(上标 3+)，Cr(上标 3+)，Ni(上标 2+)，Ga(上标 3+)，Fe(上标 3+)，Zn(上标 2+)定量分离，据此建立了浮选分离和富集Pd(上标 2+)的新方法。

The Results displayed: DChanges of histological morphology in treating group is superior to the other two groups.(2Expression of BMP-2 at fracture region in treating group is obviously supeior to the other two groups(p.05) and advancely reach peak valuce at first weak.(3) transcriptional level of BMP-2 mRNA in treating group is obviously supeior to the other two groups(p.05) and samely advancely reach peak valuce at first weak.(4)In every period of fracture healing, the expression of BMP-2 and transcriptional level of BMP-2 mRNA appear dynamic change and begin to go up after fracture, moreover reached to peak value in two weaks, then go down gradually.

结果发现：(1)治疗组组织形态学检查明显优于其它二组；(2)治疗组骨折部位骨形态发生蛋白-2(BMP-2)的表达水平比其它二组明显提高(P＜0.05)，并在一周时提前达到高峰；(3)治疗组骨折部位骨形态发生蛋白-2(BMP-2)mRNA的转录水平比其它二组明显提高(P＜0.05)，同样在一周时提前达到高峰；(4)在骨折愈合的不同时期，BMP-2的表达及其mRNA的转录水平呈动态变化，即骨折后开始升高，2周左右达到高峰，以后逐渐下降。

There was a good correlation between Ptw,AVCtw,MVOtw,PTV,PUV,UntwR and age.2.Assessment of left ventricular twisting and untwisting of DCM patients19 DCM patients(range 18-80 yr,mean age 50.52±17.52 yr,2 females) and 21 age- and sex-matched normal controls(range18-80 yr,mean age 49.05±16.94 yr,5 females) were enrolled into this study.Then DCM patients were divided into two groups:E/A＜2 group and E/A＞2 group.The routine echo showed the left ventricle dilated and EF decreased.The results show that LV rotation degree, rotation velocity at baseline and apex were irregular changeable with the cardiac cycle;the rotation direction was clockwise at the base and counterclockwise at the apex,and are combined to yield a systolic counterclockwise twisting as seen from the apex,but the rotation at the basal and apex were the same direction in some patients.

扩心病患者左室扭转及解旋特征的研究选择扩张型心肌病(Dilated Cardiomyopathy，DCM)组患者19例(男性17例，女性2例，年龄18～82岁，平均50.52±17.52岁)，健康体检者21例(男性16例，女性5例，年龄18～80岁，平均49.05±16.94岁)作为对照组，扩心病患者按照E/A分为E/A＜2、E/A＞2两个亚组，结果显示：常规超声显示DCM组LVDd值增大，EF值减小；DCM患者左室心底部与心尖部心肌旋转角度、旋转速度随心动周期变化曲线明显紊乱；与正常组比较，DCM患者左室整体扭转角度和速度分别为(6.49±1.82)°、(67.84±15.60)°/s，较正常人显著减低P＜0.01左室舒张末及收缩末扭转角度DCM患者较正常人显著减低(P＜0.01，左室舒张末及收缩末时间在DCM-E/A＞2组较正常人及DCM-E/A＜2组显著缩短P＜0.01DCM患者左室解旋速度较正常人亦显著减低(P＜0.01，左室功能轻中度减低(DCM-E/A＜2)患者解旋率[(0.29±0.07)%]较正常人[(0.42±0.11)%]明显减低，但当左室功能重度减低(DCM-E/A＞2)时左室解旋率[(0.63±0.35)%]较正常人反而增加；左室整体扭转角度、舒张末扭转角度、收缩末扭转角度、解旋与左室射血分数未见明显相关性。3。

The best of them were 4c and 8d which exhibited 87% and 89% inhibition of Penicilium digitatum . And benzothieno[3,2-d]imidazol[1,2-a]pyrimidin-2,5(1H, 3H)-diones or benzothieno[3,2-d][1,2,4]triazol[1,5-a]pyrimidin-10(3H)-one only exhibited moderate inhibition.

而苯并噻吩并[3，2-d]嘧啶-4(3H)-酮和苯并噻吩并[3，2-d]咪唑并[1，2-a]嘧啶-2，5(1H，3H)-二酮以及苯并噻吩并[3，2-d][1，2，4]三唑[1，5-a]嘧啶-10(3H)-酮衍生物以及三唑醇衍生物均只表现出中等的抑制率。

By the time of its fall, most of the prisoners were writers who had written against the corruptions of the government.

到它被攻陷的时候，里面多数的犯人是写了反对政府贪污文章的作家。

The most obvious variation to ovum morphological character was that the color was changed from light green to sepiaceous in embryonic development, and all the ovums were almost hatched after 96h.

在胚胎发育过程中卵的形态特征最明显的变化是颜色从淡绿到深褐色，卵在发育96h后卵基本全部孵化。